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Clindamycin Topical

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1. Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed‐dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, inve (Full text)

Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed‐dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, inve Adapalene 0.1% (ADA) with clindamycin phosphate 1.2% (CLNP; ADA + CLNP) and the fixed-dose combination containing CLNP and benzoyl peroxide 3% (CLNP/BPO 3%) are strongly recommended for the early treatment of acne vulgaris in Japan. Here, we (...) compare the early efficacy and safety of CLNP/BPO 3% with Japanese standard topical use of ADA + CLNP in the treatment of acne vulgaris. In this phase IV, multicenter study, 351 patients were randomized to receive CLNP/BPO 3% or ADA + CLNP for 12 weeks. The primary end-point was percentage change from baseline in total lesion (TL) counts at week 2. Secondary end-points included the percentage change from baseline in TL, inflammatory and non-inflammatory lesion (IL and non-IL) counts, Investigator's

2018 The Journal of dermatology PubMed

2. Cutibacterium acnes persists despite topical clindamycin and benzoyl peroxide. (PubMed)

Cutibacterium acnes persists despite topical clindamycin and benzoyl peroxide. Cutibacterium (formerly Propionibacterium) acnes persists in the dermis despite standard skin antiseptic agents, prompting some surgeons to use topical antimicrobials such as benzoyl peroxide and clindamycin prior to shoulder arthroplasty surgery. However, the efficacy of these topical agents has not been established.The upper backs of 12 volunteers were randomized into 4 treatment quadrants: topical benzoyl peroxide (...) , topical clindamycin, combination topical benzoyl peroxide and clindamycin, and a negative control. The corresponding topical agents were applied to each site twice daily for 3 days. A 3-mm dermal punch biopsy specimen was obtained from each site and cultured for 14 days to assess for C acnes growth. Positive cultures were assessed for the hemolytic phenotype. The McNemar test was used to compare the proportion of positive cultures in each group.C acnes grew in 4 of 12 control sites (33.3%), 1 of 12

2019 Journal of Shoulder and Elbow Surgery

3. A multicentre, randomized, single-blind comparison of topical clindamycin 1%/benzoyl peroxide 5% once-daily gel versus clindamycin 1% twice-daily gel in the treatment of mild to moderate acne vulgaris in Chinese patients. (PubMed)

A multicentre, randomized, single-blind comparison of topical clindamycin 1%/benzoyl peroxide 5% once-daily gel versus clindamycin 1% twice-daily gel in the treatment of mild to moderate acne vulgaris in Chinese patients. Acne vulgaris affects up to 54% of Chinese adolescents. Combination therapy has become the recommended standard of care for acne.The aim of this study was to compare the efficacy and safety of clindamycin (1%) and benzoyl peroxide (5%) (CDP/BPO) gel once daily vs. clindamycin

2016 Journal of the European Academy of Dermatology and Venereology : JEADV

4. Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic. (PubMed)

Long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis suppurativa: a critically appraised topic. Can therapy with clindamycin and rifampicin be safely continued long term beyond the recommended 10-week course?Clindamycin and rifampicin are used in combination to treat hidradenitis suppurativa (HS). There is no data on the efficacy and safety of clindamycin/rifampicin combination therapy for HS beyond 10 weeks.We identified the following major (...) concerns that still lack a proper evidenced-based analysis: for rifampicin, drug-induced liver injury, interstitial nephritis, drug interaction and hepatic p450 3A4 enzyme induction; for clindamycin, the concern was community-acquired Clostridium difficile infection (CA-CDI); and experience with long-term treatment. Data sources were used as appropriate to answer the question. Systematic searches were used to assess the risk of CA-CDI and experience with long-term treatment with clindamycin.The risk

2018 British Journal of Dermatology

5. Bioequivalence Study of Clindamycin Phosphate Topical Lotion, 1% in Subjects With Acne Vulgaris

Bioequivalence Study of Clindamycin Phosphate Topical Lotion, 1% in Subjects With Acne Vulgaris Bioequivalence Study of Clindamycin Phosphate Topical Lotion, 1% in Subjects With Acne Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Bioequivalence Study of Clindamycin Phosphate Topical Lotion, 1% in Subjects With Acne Vulgaris The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03717506 Recruitment Status : Recruiting

2018 Clinical Trials

6. The Extinction of Topical Erythromycin Therapy for Acne Vulgaris and Concern for the Future of Topical Clindamycin. (PubMed)

The Extinction of Topical Erythromycin Therapy for Acne Vulgaris and Concern for the Future of Topical Clindamycin. This study aims to evaluate changes in topical antibiotic prescribing trends for acne.We retrospectively reviewed the National Ambulatory Medical Care Survey data from 1993 to 2012 for all visits in which acne vulgaris was the primary diagnosis.Acne vulgaris represented an estimated 94.5 million (92.3, 96.8) visits during the 20-year study period. Bivariate analysis showed (...) exceeded 100 papers for erythromycin and clindamycin resistance in 1983 and 2003, respectively, roughly corresponding to the interval between reports of their utility in acne.Our findings suggest topical erythromycin use for acne has essentially ceased. By contrast, clindamycin use is increasing. Current recommendations discourage topical antibiotic monotherapy in favor of combination therapy with benzoyl peroxide and topical retinoids. Our group's previous work demonstrated that this trend is indeed

2016 Journal of Dermatological Treatment

7. Benzoyl peroxide and clindamycin topical skin preparation decreases Propionibacterium acnes colonization in shoulder arthroscopy. (PubMed)

Benzoyl peroxide and clindamycin topical skin preparation decreases Propionibacterium acnes colonization in shoulder arthroscopy. Propionibacterium acnes is a gram-positive anaerobe that can lead to devastating postoperative shoulder infections. The objective of this study was to investigate whether a benzoyl peroxide and clindamycin preoperative skin preparation reduces the incidence of P. acnes colonization during shoulder arthroscopy.Sixty-five shoulder arthroscopy patients were (...) prospectively enrolled. A skin culture specimen was taken at the preoperative visit from standard arthroscopic portal sites. Topical benzoyl peroxide 5% and clindamycin 1.2% (BPO/C) gel was applied to the shoulder every night before surgery. Skin culture was repeated in the operating room before preparation with chlorhexidine gluconate. Shoulder arthroscopy proceeded, with final culture specimens obtained from within the shoulder.P. acnes skin colonization remained similar to prior studies at 47.7% (31

2017 Journal of Shoulder and Elbow Surgery

8. Clindamycin

. If you wanted the latest trusted evidence on clindamycin or other clinical topics then use Trip today. This page lists the very latest high quality evidence on clindamycin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care (...) resolution of systemic features, resolution of inflammatory markers, recovery of renal function, reduction in the affected area 2017 3. Clindamycin 1% / tretinoin 0.025% gel (Treclin) - for the topical treatment of acne vulgaris 2014 4. Amoxicillin/Clavulanic Acid for the Treatment of Odontogenic Infections: A Randomised Study Comparing Efficacy and Tolerability versus Clindamycin . 26300919 2015 08 24 2015 08 24 2017 02 21 1687-8728 2015 2015 International journal of dentistry Int J Dent Amoxicillin

2018 Trip Latest and Greatest

9. A multicentre, randomized, single-blind, parallel-group study comparing the efficacy and tolerability of benzoyl peroxide 3%/clindamycin 1% with azelaic acid 20% in the topical treatment of mild-to-moderate acne vulgaris. (PubMed)

A multicentre, randomized, single-blind, parallel-group study comparing the efficacy and tolerability of benzoyl peroxide 3%/clindamycin 1% with azelaic acid 20% in the topical treatment of mild-to-moderate acne vulgaris. Mild-to-moderate acne vulgaris is treated with a range of mono- and combination therapies; however, clinical evidence is still required to optimize treatment recommendations.To compare the efficacy, tolerability and safety of a combination of benzoyl peroxide 3 (...) % and clindamycin 1% (BPO + CLN) with azelaic acid 20% (AzA) for the topical treatment of mild-to-moderate acne vulgaris.This was a randomized, assessor-blinded, parallel-group, multicentre study conducted in Germany. Patients with a confirmed diagnosis of acne vulgaris, aged 12-45 years, were randomized 1 : 1 to once-daily BPO + CLN gel or twice-daily AzA cream for up to 12 weeks. The primary endpoint was the percentage change in inflammatory lesions from baseline at Week 4. Secondary endpoints included total

2016 Journal of the European Academy of Dermatology and Venereology : JEADV

10. Clindamycin Topical

Clindamycin Topical Clindamycin Topical Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Clindamycin Topical Clindamycin Topical Aka (...) : Clindamycin Topical , Cleocin-T , Benzaclin , Veltin , Ziana From Related Chapters II. Indication III. Preparations Gel, Lotion, Solution or foam 1% with gel (Benzaclin): 1%/5% or 1.2%/2.5% with gel (Veltin, Ziana) 1.2%/0.025% IV. Directions Apply a thin film qd/bid Often Used with a ( ) V. Advantages Only solution that reliably penetrates comedones Reaches bactericidal levels within comedones VI. Disadvantages Resistance develops in 25% of patients within 6 months Use in combination with (e.g. Benzaclin

2018 FP Notebook

11. Efficacy and Safety of Tazarotene 0.1% Plus Clindamycin 1% Gel Versus Adapalene 0.1% Plus Clindamycin 1% Gel in Facial Acne Vulgaris: A Randomized, Controlled Clinical Trial. (PubMed)

Efficacy and Safety of Tazarotene 0.1% Plus Clindamycin 1% Gel Versus Adapalene 0.1% Plus Clindamycin 1% Gel in Facial Acne Vulgaris: A Randomized, Controlled Clinical Trial. Acne vulgaris is a multifactorial disorder which is ideally treated with combination therapy with topical retinoids and antibiotics.The present study was conducted to compare the efficacy and safety of tazarotene plus clindamycin against adapalene plus clindamycin in facial acne vulgaris.This study is a randomized, open (...) -label, parallel design clinical trial conducted on 60 patients with facial acne at the outpatient dermatology department in a tertiary healthcare center. The main outcome measures were change in the acne lesion count, Investigator's Static Global Assessment (ISGA) score, Global Acne Grading System (GAGS) score, and Acne-Specific Quality of Life Questionnaire (Acne-QoL) at the end of 4 weeks of therapy. After randomization one group (n = 30) received tazarotene 0.1% plus clindamycin 1% gel

2018 Clinical drug investigation

12. Bioavailability of Clindamycin From a New Clindamycin Phosphate 1.2%-Benzoyl Peroxide 3% Combination Gel. (PubMed)

Bioavailability of Clindamycin From a New Clindamycin Phosphate 1.2%-Benzoyl Peroxide 3% Combination Gel. A new topical fixed-dose combination product containing clindamycin (1%, formulated as 1.2% clindamycin phosphate, CLNP 1.2%) with low strength (3%) benzoyl peroxide (BPO) in a methylparaben-free gel vehicle (CLNP 1.2%-BPO 3%-MPF) has been developed for the treatment of acne. The objective of this study was to determine the relative bioavailability of clindamycin and clindamycin sulfoxide (...) from CLNP 1.2%-BPO 3%-MPF compared with clindamycin phosphate 1.2%-BPO 5% in a methylparaben-preserved gel vehicle (CLNP 1.2%-BPO 5%-MP) and clindamycin phosphate 1.2%-BPO 5% in a methylparaben-free gel vehicle (CLNP 1.2%-BPO 5%-MPF), and to determine whether exposure is affected by BPO concentration (3% vs. 5%) when applied topically. Seventy-two subjects with moderate-severe acne were randomized to receive CLNP 1.2%-BPO 3%-MPF, CLNP 1.2%-BPO 5%-MP, or CLNP 1.2%-BPO 5%-MPF in a 5-day, open-label

2016 Clinical pharmacology in drug development

13. Tazarotene Plus Clindamycin vs. Adapalene Plus Clindamycin in the Treatment of Facial Acne Vulgaris

is multifactorial. Critical components include abnormal follicular keratinocyte desquamation leading to the formation of a follicular plug (microcomedo), increase of sebum production in pilosebaceous unit, colonization by Propionibacterium acnes, and inflammation. Topical retinoids, which target comedogenesis and have anti-inflammatory activity, are recommended as first-line therapy for both inflammatory and non-inflammatory acne. The adjunctive use of anti-acne agents like clindamycin by its complementary (...) . Adapalene is a synthetic naphthoic acid derivative with retinoid activity. Adapalene also acts through RARs and modulates cellular keratinization and inflammatory process. Clindamycin is bactericidal to Propionibacterium acnes. Due to the inhibition of P. acnes the free fatty acid levels in the pilosebaceous unit of skin is also reduced. Clindamycin phosphate applied topically penetrates to a very great extent to open comedones and thus produces a high percentage of sterile comedones. The combination

2016 Clinical Trials

14. Acne - Guidelines for Prescribing Topical Treatment

(once every 2-3 nights) maintenance treatment. Recommend that the patient also use sunscreen SPF 15-30 due to risk of photosensitization (lower risk with adapalene). Topical Antibiotics (level 1 [likely reliable] evidence) Most effective for inflammatory acne Clindamycin and erythromycin are the most useful antibiotics for topical acne treatment. Use in combination with benzoyl peroxide reduces the chance of bacterial resistance developing. Topical antibiotics are most effective for inflammatory (...) Antibiotics and Retinoid Best for cases of moderate acne or those with mixed lesion types. Combining topical antibiotics with topical retinoids is also effective against mild acne and may improve treatment outcome. Combinations available: adapalene + benzoyl peroxide tretinoin + clindamycin tretinoin + erythromycin Azelaic Acid Available as 15% gel (Finacea ® ) Antibacterial, anti-inflammatory and exfoliant effect; effective for comedonal and inflammatory acne Similar to benzoyl peroxide in efficacy

2018 medSask

15. Clindamycin Exhibits No Statistical Difference in Preoperative Compared to Postoperative Administration For The Prevention of Dry Socket

Clindamycin Exhibits No Statistical Difference in Preoperative Compared to Postoperative Administration For The Prevention of Dry Socket UTCAT2622, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Clindamycin Exhibits No Statistical Difference in Preoperative Compared to Postoperative Administration For The Prevention of Dry Socket Clinical Question For dry socket prevention is it more efficacious to administer (...) clindamycin pre-surgery compared to post-surgery? Clinical Bottom Line Clindamycin is effective in preventing dry socket occurrence following tooth extraction, but there is no significant difference in preoperative versus postoperative administration. This is supported by a retrospective study in which postoperative clindamycin administration significantly decreased the incidence of dry socket. A randomized clinical trial (RCT) demonstrated clindamycin was equally efficacious, and showed no statistical

2014 UTHSCSA Dental School CAT Library

16. To Study Generic Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Glenmark Generics, Ltd) in the Treatment of Acne Vulgaris.

To Study Generic Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Glenmark Generics, Ltd) in the Treatment of Acne Vulgaris. To Study Generic Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Glenmark Generics, Ltd) in the Treatment of Acne Vulgaris. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. To Study Generic Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Glenmark Generics, Ltd) in the Treatment of Acne Vulgaris. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02465632 Recruitment Status

2015 Clinical Trials

17. Comparative Trial of Silver Nanoparticle Gel and 1% Clindamycin Gel when Use in Combination with 2.5% Benzoyl Peroxide in Patients with Moderate Acne Vulgaris. (PubMed)

Comparative Trial of Silver Nanoparticle Gel and 1% Clindamycin Gel when Use in Combination with 2.5% Benzoyl Peroxide in Patients with Moderate Acne Vulgaris. Treatments of acne vulgaris commonly use antimicrobials and comedolytic agents. Considering bacterial resistance to topical antibiotics, the alternative treatment such as silver manufactured into nanoparticle receives an attention. Silver nanoparticle has an antibacterial effect against Propionibacterium acnes and anti-inflammation (...) . Clinical study of silver nanoparticle gel for the treatment of acne vulgaris is limited.To compare the efficacy and safety between silver nanoparticle gel and 1% clindamycin gel both combine with 2.5% benzoyl peroxide for the treatment of moderate severity of acne vulgaris.This was an experimental, double-blinded, randomized-controlled study. Sixty-four moderately severe acne patients were enrolled. They were randomized to receive either silver nanoparticle gel with 2.5% benzoyl peroxide or clindamycin

2018 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

18. A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris

Completion Date : June 2020 Estimated Study Completion Date : June 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Adapalene-Clindamycin Combination Gel Combination Product: Adapalene-Clindamycin Combination Gel 5mg Adapalene/50mg Clindamycin per 5g, applied nightly for 12 weeks Active Comparator: Adapalene Gel Drug: Adapalene Gel Differin 0.1% Gel, applied nightly for 12 weeks Other Name (...) A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2018 Clinical Trials

19. Bioequivalence Study of Clindamycin Gel 1% in Treatment of Acne Vulgaris

to Vehicle Control in the Treatment of Acne Vulgaris Actual Study Start Date : April 27, 2018 Estimated Primary Completion Date : November 28, 2018 Estimated Study Completion Date : November 28, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Clindamycin 1% gel (Akorn Pharmaceuticals) Drug: Clindamycin 1% Gel Topical gel Active Comparator: Clindamycin 1% gel (Greenstone LLC) Drug (...) : Clindamycin 1% Gel Topical gel Placebo Comparator: Placebo Drug: Placebo Topical Placebo gel Outcome Measures Go to Primary Outcome Measures : Mean Percent Change in the Number of Inflamed Lesions (Papules/Pustules) [ Time Frame: 12 weeks ] Mean percent change in the non-inflammatory (open and closed comedones) lesion counts [ Time Frame: 12 weeks ] Secondary Outcome Measures : The proportion of Subjects with a clinical response (IGA) of "success" at week 12. Success should be defined as an IGA score

2018 Clinical Trials

20. Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis

to patient's primary care provider Pregnancy: Animal studies have not reported any safety issues but human data is limited. Only small amounts of mupirocin are absorbed after topical use and there are no reports of teratogenicity—risk appears minimal. However, consider avoiding unless benefit outweighs risk. Systemic agents [penicillins, cephalosporins, clindamycin and erythromycin (except estolate)] are indicated for impetigo and are safe in pregnancy, so may be an appropriate alternative Lactation (...) the placenta when administered systemically. The effects of topical fusidic acid have not been studied in pregnancy, although there are no reports of teratogenicity. Systemic agents (penicillins, cephalosporins, clindamycin and erythromycin) are indicated for folliculitis and furuncles, and are safe in pregnancy, so may be an appropriate alternative if non-pharmacolgic treatment does not suffice Lactation: Fusidic acid is excreted to a certain extent in breast milk. The effects of topical fusidic acid have

2017 medSask

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