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Cleft Lip

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101. Centre‐level variation in behaviour and the predictors of behaviour in 5‐year‐old children with non‐syndromic unilateral cleft lip: The Cleft Care UK study. Part 5 (PubMed)

Centre‐level variation in behaviour and the predictors of behaviour in 5‐year‐old children with non‐syndromic unilateral cleft lip: The Cleft Care UK study. Part 5 The aims of this study were to describe child behavioural and psychosocial outcomes associated with appearance and speech in the Cleft Care UK (CCUK) study. We also wanted to explore centre-level variation in child outcomes and investigate individual predictors of such outcomes.Two hundred and sixty-eight five-year-old (...) children with non-syndromic unilateral cleft lip and palate (UCLP) recruited to CCUK.Parents completed the Strengths and Difficulties questionnaire (SDQ) and reported their own perceptions of the child's self-confidence. Child facial appearance and symmetry were assessed using photographs, and intelligibility of speech was derived from audio-visual speech recordings. Centre-level variation in behavioural and psychosocial outcomes was examined using hierarchical models, and associations with clinical

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2017 Orthodontics & craniofacial research

102. Association of single-nucleotide polymorphisms of CDH1 with nonsyndromic cleft lip with or without cleft palate in a northern Chinese Han population. (PubMed)

Association of single-nucleotide polymorphisms of CDH1 with nonsyndromic cleft lip with or without cleft palate in a northern Chinese Han population. Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common congenital malformation among live births, and depends on race and ethnic background. The CDH1 gene plays a vital role in orofacial development. Our research was conducted to examine the association between 3 single-nucleotide polymorphisms in the CDH1 gene and NSCL/P.Three

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2017 Medicine

103. International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome instrument for children and young adults with cleft lip and/or palate (CLEFT-Q). (PubMed)

International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome instrument for children and young adults with cleft lip and/or palate (CLEFT-Q). Patient-reported outcome (PRO) instruments should be developed according to rigorous guidelines in order to provide clinically meaningful, scientifically sound measurement. Understanding the methodology behind instrument development informs the selection of the most appropriate tool. This mixed methods (...) protocol describes the development of an internationally applicable PRO instrument, the CLEFT-Q, for evaluating outcomes of treatment for cleft lip and/or palate (CL/P).The study includes three main phases that occur iteratively and interactively. In phase I, we determine what concepts are important to patients regarding their outcome. A conceptual framework for the CLEFT-Q is formed through a systematic review and an extensive international qualitative study. The systematic review ascertains what

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2017 BMJ open

104. Association between the IRF6 rs2235371 polymorphism and the risk of nonsyndromic cleft lip with or without cleft palate in Chinese Han populations: A meta-analysis. (PubMed)

Association between the IRF6 rs2235371 polymorphism and the risk of nonsyndromic cleft lip with or without cleft palate in Chinese Han populations: A meta-analysis. To investigate the association between the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and the IRF6 rs2235371 (C>T) polymorphism in Chinese Han populations.PubMed, Web of Science and EMBASE were searched through May 31, 2016, to select eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals

2017 Archives of oral biology

105. BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate: A meta-analysis. (PubMed)

BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate: A meta-analysis. Previous studies have investigated the relationship between human bone morphogenetic protein 4 gene (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, the results remained inconsistent. Therefore, we conducted a meta-analysis to assess the effect of BMP4 rs17563 polymorphism on NSCL/P.Electronic searches in 5 databases were conducted to select

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2017 Medicine

106. Maternal Risk Factors Associated with the Development of Cleft Lip and Cleft Palate in Mexico: A Case-Control Study (PubMed)

Maternal Risk Factors Associated with the Development of Cleft Lip and Cleft Palate in Mexico: A Case-Control Study Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate.We conducted a case control study at the Women's Hospital in Culiacan, Mexico. Medical (...) records were analyzed, including patients who delivered babies with and without cleft lip and cleft palate from January 2010 to December 2015. Multiple variables were analyzed, including gestational age, weight at birth, the use of folic acid and multivitamins during pregnancy, smoking, alcohol abuse, the use of recreational drugs, history of sexually transmitted infections, marital status, socioeconomic status, education, and nutritional status.We found that the maternal risk factors

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2017 Iranian journal of otorhinolaryngology

107. Transmission analysis of TGFB1 gene polymorphisms in non-syndromic cleft lip with or without cleft palate. (PubMed)

Transmission analysis of TGFB1 gene polymorphisms in non-syndromic cleft lip with or without cleft palate. Transforming growth factor beta1 (TGF-β1) plays a significant role in craniofacial development. Previous linkage studies reported that the TGF-β1-locus at 19q13.1 harbour predisposing genes for non-syndromic oral clefts. In the present study case parents triads were evaluated to find the transmission effects of genetic variants in TGF- β1 towards non-syndromic cleft lip or palate (NSCL/P (...) not significant for any of the SNPs tested. Strong linkage disequilibrium (r2 = 0.722) was found between rs1800469 and rs1800470 SNPs. Haplotype analysis ignoring parent of origin showed strong evidence of excess transmission but it is not significant (p-value = 0.293).Transmission of minor alleles were not observed from either parent indicating that the TGF-β1 gene polymorphisms by themselves do not confer risk for non-syndromic oral clefts but, rather, modify the stability and the activation process of TGF

2017 International Journal of Pediatric Otorhinolaryngology

108. Common variants in DLG1 locus are associated with non-syndromic cleft lip with or without cleft palate. (PubMed)

Common variants in DLG1 locus are associated with non-syndromic cleft lip with or without cleft palate. Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a common craniofacial anomaly with a complex and heterogeneous aetiology. Knowledge regarding specific genetic factors underlying this birth defect is still not well understood. Therefore, we conducted an independent replication analysis for the top-associated variants located within the DLG1 locus at chromosome 3q29, which (...) was identified as a novel cleft-susceptibility locus in our genome-wide association study (GWAS). Mega-analysis of the pooled individual data from the GWAS and replication study confirmed that common DLG1 variants are associated with the risk of nsCL/P. Two single nucleotide polymorphisms (SNPs), rs338217 and rs7649443, were statistically significant even at the genome-wide level (Ptrend  = 9.70E-10 and Ptrend  = 8.96E-09, respectively). Three other SNPs, rs9826379, rs6805920 and rs6583202, reached

2017 Clinical Genetics

109. Nucleotide variants of the NAT2 and EGF61 genes in patients in Northern China with nonsyndromic cleft lip with or without cleft palate. (PubMed)

Nucleotide variants of the NAT2 and EGF61 genes in patients in Northern China with nonsyndromic cleft lip with or without cleft palate. Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common orofacial congenital anomaly. The objective of the present study was to analyze the association of single nucleotide polymorphisms (SNPs) in the NAT2 and EGF61genes with NSCL/P in a Chinese population.The frequencies of NAT2 (rs1799929)and EGF61 (rs4444903) gene variations were examined

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2017 Medicine

110. The Primary Care Pediatrician and the Care of Children With Cleft Lip and/or Cleft Palate. (PubMed)

The Primary Care Pediatrician and the Care of Children With Cleft Lip and/or Cleft Palate. Orofacial clefts, specifically cleft lip and/or cleft palate (CL/P), are among the most common congenital anomalies. CL/P vary in their location and severity and comprise 3 overarching groups: cleft lip (CL), cleft lip with cleft palate (CLP), and cleft palate alone (CP). CL/P may be associated with one of many syndromes that could further complicate a child's needs. Care of patients with CL/P spans (...) prenatal diagnosis into adulthood. The appropriate timing and order of specific cleft-related care are important factors for optimizing outcomes; however, care should be individualized to meet the specific needs of each patient and family. Children with CL/P should receive their specialty cleft-related care from a multidisciplinary cleft or craniofacial team with sufficient patient and surgical volume to promote successful outcomes. The primary care pediatrician at the child's medical home has

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2017 Pediatrics

111. Polymorphic variants in VAX1 and the risk of nonsyndromic cleft lip with or without cleft palate in a population from northern China. (PubMed)

Polymorphic variants in VAX1 and the risk of nonsyndromic cleft lip with or without cleft palate in a population from northern China. Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common craniofacial birth defects, and the etiology of NSCL/P involves both genetic and environmental factors. Genome-wide association study (GWAS) identified a novel susceptibility locus of ventral anterior homeobox 1 (VAX1) in patients with NSCL/P. However, the association of single

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2017 Medicine

112. Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla?

Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? - National Elf Service Search National Elf Service Search National Elf Service » » » » Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? Sep 14 2018 Posted by Cleft lip and palate (CLP) is a common birth defect. The prevalence (...) for the treatment of hypoplastic maxilla in people with cleft lip and palate. Methods Searches were conducted in the Cochrane Oral Health’s Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, LILACS BIREME Virtual Health Library (Latin American and Caribbean Health Science Information database), the US National Institutes of Health Trials Registry (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform

2018 The Dental Elf

113. Presurgical nasoalveolar molding for cleft lip and palate repair in children

Presurgical nasoalveolar molding for cleft lip and palate repair in children Presurgical nasoalveolar molding for cleft lip and palate repair in children Presurgical nasoalveolar molding for cleft lip and palate repair in children Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Presurgical nasoalveolar molding for cleft lip and palate repair in children (...) . Lansdale: HAYES, Inc.. Health Technology Brief Publication. 2013 Authors' conclusions Cleft lip and cleft palate are birth defects affecting the upper lip and the roof of the mouth. A cleft or gap forms when the developing facial structures do not join (fuse) fully during gestation. Cleft lip affects the top lip and may present as a small gap or larger gap that extends into the nose on one or both sides. Cleft palate affects the roof of the mouth, usually the soft palate, but may also involve the hard

2013 Health Technology Assessment (HTA) Database.

114. The Effects of Age, Information, and Personal Contact on Attitudes Toward Individuals With Cleft-Lip and Palate. (PubMed)

The Effects of Age, Information, and Personal Contact on Attitudes Toward Individuals With Cleft-Lip and Palate. The aim of the study was to examine how information and brief personal contact with individuals who have a cleft lip and/or palate (CLP) affected attitudes and to compare these effects across two age cohorts.A pretest-posttest design was utilized to determine if accurate information and personal contact with an individual with CLP would affect cognitive, emotional, and behavioral (...) attitudes in participants without CLP. To assess attitudes, 189 participants without cleft lip and palate completed a modified version of the Multidimensional Attitudes Scale toward Persons with Disabilities ( Findler et al., 2007 ). The study included a child cohort (n = 78; Mean age = 10.01 years) and a young adult cohort (n = 111; Mean age = 19.58 years).Using a mixed MANCOVA, it was found that children's cognitive attitudes were significantly improved (22.54%) by information and personal contact

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2018 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Controlled trial quality: uncertain

115. The Effects of Maxillary Expansion on Late Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate. (PubMed)

The Effects of Maxillary Expansion on Late Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate. The purpose of this study was to answer the research question of whether maxillary expansion provides enough postgraft stimulation to decrease the volume loss of alveolar bone grafts in patients with cleft lip and palate (CLP) who missed the appropriate treatment time.This study was designed as a prospective controlled clinical trial. Thirty patients in the permanent-dentition

2018 Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Controlled trial quality: uncertain

116. Letter to editor PRS regarding "Effect of One-Stage versus Two-Stage Palatoplasty on Hypernasality and Fistula Formation in Children with Complete Unilateral Cleft Lip and Palate: A randomised controlled trial." (PubMed)

Letter to editor PRS regarding "Effect of One-Stage versus Two-Stage Palatoplasty on Hypernasality and Fistula Formation in Children with Complete Unilateral Cleft Lip and Palate: A randomised controlled trial." 30601312 2019 02 28 1529-4242 143 3 2019 Mar Plastic and reconstructive surgery Plast. Reconstr. Surg. Effect of One-Stage versus Two-Stage Palatoplasty on Hypernasality and Fistula Formation in Children with Complete Unilateral Cleft Lip and Palate: A Randomized Controlled Trial. 668e (...) -669e 10.1097/PRS.0000000000005346 Parnis Juanita J Plastic Surgery, Trent Regional Cleft Network, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. Syme-Grant Jonathan J eng Journal Article United States Plast Reconstr Surg 1306050 0032-1052 2019 1 3 6 0 2019 1 3 6 0 2019 1 3 6 0 ppublish 30601312 10.1097/PRS.0000000000005346

2018 Plastic and reconstructive surgery Controlled trial quality: uncertain

117. Unilateral Cleft Lip and Palate Surgical Protocols and Facial Growth Outcomes. (PubMed)

Unilateral Cleft Lip and Palate Surgical Protocols and Facial Growth Outcomes. Adequate dentofacial growth is an objective of unilateral cleft lip and palate treatment. No study exists, comparing the dental arch of 5-year-old relationship after 2 treatment protocols: one with single-stage palatoplasty and another with delayed hard palate closure (DHPC). The authors hypothesized that the DHPC protocol provides better dentofacial growth.A single-center, single-surgeon Randomized Clinical Trial

2018 The Journal of craniofacial surgery Controlled trial quality: uncertain

118. Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients after Primary Cheiloplasty without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. (PubMed)

Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients after Primary Cheiloplasty without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. The objective of this study was to assess the efficacy of presurgical nasoalveolar molding (PNAM) on long-term nasal symmetry and shaping after primary cheiloplasty in patients with unilateral complete cleft lip/palate (UCL/P).This was a two-group, parallel, retrospective, randomized

2018 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Controlled trial quality: uncertain

119. The Effects of Presurgical Nasoalveolar Molding on the Midface Symmetry of Children with Unilateral Cleft Lip and Palate: A Long-term Follow-up Study (PubMed)

The Effects of Presurgical Nasoalveolar Molding on the Midface Symmetry of Children with Unilateral Cleft Lip and Palate: A Long-term Follow-up Study Midface symmetry is an important indicator of success of complete unilateral cleft lip and palate (CUCLP) treatment. There is little literature on the long-term effects of presurgical nasoalveolar molding (PNAM) on midface symmetry in children treated for CUCLP. This study aimed to compare children with CUCLP who underwent PNAM before surgical

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2018 Plastic and Reconstructive Surgery Global Open

120. Trend of health care utilization of cleft lip and/or palate in Korea during 2007–2016 (PubMed)

Trend of health care utilization of cleft lip and/or palate in Korea during 2007–2016 This study is performed to investigate the trend of health care (HC) utilization among cleft lip and/or palate (CL/P) during 2007-2016 by using data from the Korean National Health Insurance Service (KNHIS).The KNHIS data were reorganized to count a specific patient only once for a specific year. Cleft type (cleft lip [CL], cleft palate [CP], and cleft lip and palate [CLP]), sex, and age at HC utilization (...) . The new-born patient population (n = 7,617) comprised 18.6% CLP, 30.4% CL, and 51.0% CP (CLP < CL < CP; p < 0.001). Their HC utilization rate increased from 1.12 in 2007 to 1.74 in 2016. An examination of the utilization number and rate among new-born patients revealed CP exhibited a female-dominant pattern (all p < 0.01), while CL and CLP exhibited a male-dominant pattern (all p < 0.01). However, utilization number showed no difference by sex and cleft type between 2007-2011 and 2012-2016

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2018 Korean journal of orthodontics

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