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Cleft Lip

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81. Centre‐level variation in behaviour and the predictors of behaviour in 5‐year‐old children with non‐syndromic unilateral cleft lip: The Cleft Care UK study. Part 5 Full Text available with Trip Pro

Centre‐level variation in behaviour and the predictors of behaviour in 5‐year‐old children with non‐syndromic unilateral cleft lip: The Cleft Care UK study. Part 5 The aims of this study were to describe child behavioural and psychosocial outcomes associated with appearance and speech in the Cleft Care UK (CCUK) study. We also wanted to explore centre-level variation in child outcomes and investigate individual predictors of such outcomes.Two hundred and sixty-eight five-year-old (...) children with non-syndromic unilateral cleft lip and palate (UCLP) recruited to CCUK.Parents completed the Strengths and Difficulties questionnaire (SDQ) and reported their own perceptions of the child's self-confidence. Child facial appearance and symmetry were assessed using photographs, and intelligibility of speech was derived from audio-visual speech recordings. Centre-level variation in behavioural and psychosocial outcomes was examined using hierarchical models, and associations with clinical

2017 Orthodontics & craniofacial research

82. The role of speech therapy for improving the speech of children with cleft lip and/or cleft palate: a systematic review and meta-analysis

The role of speech therapy for improving the speech of children with cleft lip and/or cleft palate: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

83. Association of single-nucleotide polymorphisms of CDH1 with nonsyndromic cleft lip with or without cleft palate in a northern Chinese Han population. Full Text available with Trip Pro

Association of single-nucleotide polymorphisms of CDH1 with nonsyndromic cleft lip with or without cleft palate in a northern Chinese Han population. Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common congenital malformation among live births, and depends on race and ethnic background. The CDH1 gene plays a vital role in orofacial development. Our research was conducted to examine the association between 3 single-nucleotide polymorphisms in the CDH1 gene and NSCL/P.Three

2017 Medicine

84. International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome instrument for children and young adults with cleft lip and/or palate (CLEFT-Q). Full Text available with Trip Pro

International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome instrument for children and young adults with cleft lip and/or palate (CLEFT-Q). Patient-reported outcome (PRO) instruments should be developed according to rigorous guidelines in order to provide clinically meaningful, scientifically sound measurement. Understanding the methodology behind instrument development informs the selection of the most appropriate tool. This mixed methods (...) protocol describes the development of an internationally applicable PRO instrument, the CLEFT-Q, for evaluating outcomes of treatment for cleft lip and/or palate (CL/P).The study includes three main phases that occur iteratively and interactively. In phase I, we determine what concepts are important to patients regarding their outcome. A conceptual framework for the CLEFT-Q is formed through a systematic review and an extensive international qualitative study. The systematic review ascertains what

2017 BMJ open

85. Polymorphic variants in VAX1 and the risk of nonsyndromic cleft lip with or without cleft palate in a population from northern China. Full Text available with Trip Pro

Polymorphic variants in VAX1 and the risk of nonsyndromic cleft lip with or without cleft palate in a population from northern China. Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common craniofacial birth defects, and the etiology of NSCL/P involves both genetic and environmental factors. Genome-wide association study (GWAS) identified a novel susceptibility locus of ventral anterior homeobox 1 (VAX1) in patients with NSCL/P. However, the association of single

2017 Medicine

86. The Primary Care Pediatrician and the Care of Children With Cleft Lip and/or Cleft Palate. Full Text available with Trip Pro

The Primary Care Pediatrician and the Care of Children With Cleft Lip and/or Cleft Palate. Orofacial clefts, specifically cleft lip and/or cleft palate (CL/P), are among the most common congenital anomalies. CL/P vary in their location and severity and comprise 3 overarching groups: cleft lip (CL), cleft lip with cleft palate (CLP), and cleft palate alone (CP). CL/P may be associated with one of many syndromes that could further complicate a child's needs. Care of patients with CL/P spans (...) prenatal diagnosis into adulthood. The appropriate timing and order of specific cleft-related care are important factors for optimizing outcomes; however, care should be individualized to meet the specific needs of each patient and family. Children with CL/P should receive their specialty cleft-related care from a multidisciplinary cleft or craniofacial team with sufficient patient and surgical volume to promote successful outcomes. The primary care pediatrician at the child's medical home has

2017 Pediatrics

87. Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla?

Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? - National Elf Service Search National Elf Service Search National Elf Service » » » » Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? Sep 14 2018 Posted by Cleft lip and palate (CLP) is a common birth defect. The prevalence (...) for the treatment of hypoplastic maxilla in people with cleft lip and palate. Methods Searches were conducted in the Cochrane Oral Health’s Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, LILACS BIREME Virtual Health Library (Latin American and Caribbean Health Science Information database), the US National Institutes of Health Trials Registry (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform

2018 The Dental Elf

88. Falling through the gap: Dental treatment experiences of patients affected by cleft lip and/or palate. Full Text available with Trip Pro

Falling through the gap: Dental treatment experiences of patients affected by cleft lip and/or palate. In the UK, one in 600–700 infants is born with a cleft lip and/or palate (CL/P). Previous research has identified patients with CL/P to be at high risk of long-term oral health issues. Yet, few of these patients are currently accessing community dental care.To assess patients' dental treatment experiences and their suggestions for improving services.Five focus groups were conducted with 24 (...) adults with CL/P. Thematic analysis was performed on the data.Participants perceived local dental practitioners to lack knowledge about CL/P and its treatment. Consequently, some participants had stopped visiting a dental practice altogether. Participants were also largely unaware of the specialist CL/P services they are entitled to.Suggestions are made for the integration of improved training and resources for local dental practitioners. Closer communication between specialist cleft teams and local

2018 British Dental Journal

89. The Effects of Maxillary Expansion on Late Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate. (Abstract)

The Effects of Maxillary Expansion on Late Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate. The purpose of this study was to answer the research question of whether maxillary expansion provides enough postgraft stimulation to decrease the volume loss of alveolar bone grafts in patients with cleft lip and palate (CLP) who missed the appropriate treatment time.This study was designed as a prospective controlled clinical trial. Thirty patients in the permanent-dentition

2018 Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Controlled trial quality: uncertain

90. Unilateral Cleft Lip and Palate Surgical Protocols and Facial Growth Outcomes. (Abstract)

Unilateral Cleft Lip and Palate Surgical Protocols and Facial Growth Outcomes. Adequate dentofacial growth is an objective of unilateral cleft lip and palate treatment. No study exists, comparing the dental arch of 5-year-old relationship after 2 treatment protocols: one with single-stage palatoplasty and another with delayed hard palate closure (DHPC). The authors hypothesized that the DHPC protocol provides better dentofacial growth.A single-center, single-surgeon Randomized Clinical Trial

2018 The Journal of craniofacial surgery Controlled trial quality: uncertain

91. Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients after Primary Cheiloplasty without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. (Abstract)

Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients after Primary Cheiloplasty without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. The objective of this study was to assess the efficacy of presurgical nasoalveolar molding (PNAM) on long-term nasal symmetry and shaping after primary cheiloplasty in patients with unilateral complete cleft lip/palate (UCL/P).This was a two-group, parallel, retrospective, randomized

2018 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Controlled trial quality: uncertain

92. Letter to editor PRS regarding "Effect of One-Stage versus Two-Stage Palatoplasty on Hypernasality and Fistula Formation in Children with Complete Unilateral Cleft Lip and Palate: A randomised controlled trial." (Abstract)

Letter to editor PRS regarding "Effect of One-Stage versus Two-Stage Palatoplasty on Hypernasality and Fistula Formation in Children with Complete Unilateral Cleft Lip and Palate: A randomised controlled trial." 30601312 2019 02 28 1529-4242 143 3 2019 Mar Plastic and reconstructive surgery Plast. Reconstr. Surg. Effect of One-Stage versus Two-Stage Palatoplasty on Hypernasality and Fistula Formation in Children with Complete Unilateral Cleft Lip and Palate: A Randomized Controlled Trial. 668e (...) -669e 10.1097/PRS.0000000000005346 Parnis Juanita J Plastic Surgery, Trent Regional Cleft Network, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. Syme-Grant Jonathan J eng Journal Article United States Plast Reconstr Surg 1306050 0032-1052 2019 1 3 6 0 2019 1 3 6 0 2019 1 3 6 0 ppublish 30601312 10.1097/PRS.0000000000005346

2018 Plastic and reconstructive surgery Controlled trial quality: uncertain

93. Multi-modal Characterization of the Mature Septal Deformity and Airspace Associated with Unilateral Cleft Lip and Palate. (Abstract)

Multi-modal Characterization of the Mature Septal Deformity and Airspace Associated with Unilateral Cleft Lip and Palate. The nasal deformity that accompanies cleft conditions is often acknowledged as the most difficult obstacle to restoring facial balance in affected children. Despite considerable progress in the treatment of cleft lip and palate, the outcomes of cleft septorhinoplasty have proven variable and difficult to predict, possibly because of incomplete understanding of the underlying (...) anatomical deformities. The authors sought to characterize unilateral cleft septal and dorsal deformities through a detailed morphologic model based on photogrammetric, qualitative, and quantitative computerized tomographic image analysis.Twenty-five consecutive patients with a unilateral cleft nasal deformity without prior septorhinoplasty were included.Dorsal angulation, as measured by the nasal dorsal angle, consistently deviated away from the cleft side at a mean angle of 8.9 degrees. In a majority

2018 Plastic and reconstructive surgery

94. Outcome of Patients with Complete Unilateral Cleft Lip and Palate: 20-Years Follow-up of Treatment Protocol. (Abstract)

Outcome of Patients with Complete Unilateral Cleft Lip and Palate: 20-Years Follow-up of Treatment Protocol. The treatment plan for cleft lip and palate varies among centers and requires long-term evaluation of its final outcome.A consecutive series of patients born from 1994 to 1996 were reviewed. Inclusion criteria were complete unilateral cleft lip and palate, undergoing all treatment procedures performed by the team, and continuous follow-ups until 20 years of age. Exclusion criteria were (...) incomplete data, having microform cleft lip on the contralateral side, presence of the Simonart band, and other abnormalities.A total of 72 patients were included. Average age at final evaluation was 21.3 years; 83.3 percent of patients underwent one-stage rotation-advancement lip repair and 16.7 percent underwent two-stage repair with an initial adhesion cheiloplasty. All patients underwent palate repair using the two-flap method at an average age of 12.3 months. Velopharyngeal insufficiency occurred

2018 Plastic and reconstructive surgery

95. Hearing status and behavioural patterns among school aged children with cleft lip and/or palate. (Abstract)

Hearing status and behavioural patterns among school aged children with cleft lip and/or palate. There is a dearth of studies on long term hearing status and behavioural patterns among cleft lip and/or palate children after their primary lip and palate closure in Malaysia. This study describes the audiology status and behavioural patterns in a group of school aged children with cleft lip and/or palate.A cross sectional study was carried out where caretakers of cleft lip and/or palate were asked (...) to complete the translated Malay language version of Strength Difficulties Questionnaire. The hearing status of the children was analyzed based on recent pure tone audiometric and tympanogram results. The patients' age, gender, type of cleft pathology, age of palatal surgery and behavioural patterns were examined for their potential relationship with hearing status.A total of 74 children (148 ears) aged between 7 and 17 years with cleft lip and/or palate were recruited. The result showed 37 ears (25.0

2018 International Journal of Pediatric Otorhinolaryngology

96. Gene-Gene Interactions among SPRYs for Nonsyndromic Cleft Lip/Palate. Full Text available with Trip Pro

Gene-Gene Interactions among SPRYs for Nonsyndromic Cleft Lip/Palate. Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect with a complex genetic architecture. Gene-gene interactions have been increasingly regarded as contributing to the etiology of NSCL/P. A recent genome-wide association study revealed that a novel single-nucleotide polymorphism at SPRY1 in 4q28.1 showed a significant association with NSCL/P. In the current study, we explored the role of 3 (...) SPRY genes in the etiology of NSCL/P by detecting gene-gene interactions: SPRY1, SPRY2, and SPRY4-with SPRY3 excluded due to its special location on the X chromosome. We selected markers in 3 SPRY genes to test for gene-gene interactions using 1,908 case-parent trios recruited from an international consortium established for a genome-wide association study of nonsyndromic oral clefts. As the trios came from populations with different ancestries, subgroup analyses were conducted among Europeans

2018 Journal of Dental Research

97. Evolution of Acquired Middle Ear Cholesteatoma in Patients With Ectrodactyly, Ectodermal Dysplasia, Cleft Lip/Palate (EEC) Syndrome. (Abstract)

Evolution of Acquired Middle Ear Cholesteatoma in Patients With Ectrodactyly, Ectodermal Dysplasia, Cleft Lip/Palate (EEC) Syndrome. To review an institutional experience with the surgical and clinical management of acquired middle ear cholesteatoma in patients with ectrodactyly, ectodermal dysplasia, cleft lip/palate (EEC) syndrome.Retrospective chart review.Tertiary referral center.Eight patients with medical history significant for EEC syndrome who underwent surgery for acquired middle ear

2018 Otology and Neurotology

98. Objective Assessment for Cleft Lip Nasal Deformity Correction

Objective Assessment for Cleft Lip Nasal Deformity Correction Objective Assessment for Cleft Lip Nasal Deformity Correction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Objective Assessment for Cleft Lip (...) University Information provided by (Responsible Party): Hafsa Gamal Muhammad bakheet, Assiut University Study Details Study Description Go to Brief Summary: Rhinoplasty remains one of the most challenging procedures in plastic surgery, and patients with cleft lip nasal deformity pose an even greater challenge, in which biggest issue is to achieve caudal nose harmony and creation of symmetrical nostrils with patent normal nasal function Condition or disease Intervention/treatment Phase Nose; Anomaly

2018 Clinical Trials

99. Bilateral suprazygomatic maxillary nerve blocks vs. infraorbital and palatine nerve blocks in cleft lip and palate repair: A double-blind prospective, randomised study. (Abstract)

Bilateral suprazygomatic maxillary nerve blocks vs. infraorbital and palatine nerve blocks in cleft lip and palate repair: A double-blind prospective, randomised study. Cleft defects are common craniofacial malformations which require early surgical repair. These patients are at high risk of postoperative airway obstruction and respiratory failure. Cleft surgery may require high doses of opioids which may contribute to these complications.To compare the effectiveness of proximal and distal (...) approaches to blocking the maxillary nerve in patients undergoing cleft lip or cleft palate surgery.Randomised, controlled and double-blind study.The current study was carried out in Guwahati (Assam, India) between April 2014 and June 2014.A total of 114 patients older than 6 months who underwent cleft lip or cleft palate surgery were included. Exclusion criteria included coagulation disorders, peripheral neuropathy or chronic pain syndrome, infection in the puncture site, allergy to local anaesthetics

2018 European Journal of Anaesthesiology Controlled trial quality: predicted high

100. Influence of infancy care strategy on hearing in children and adolescents: A longitudinal study of children with unilateral lip and /or cleft palate. Full Text available with Trip Pro

Influence of infancy care strategy on hearing in children and adolescents: A longitudinal study of children with unilateral lip and /or cleft palate. To evaluate the relation between ventilation tube insertion, otitis media with effusion duration and otologic outcomes in unilateral cleft lip and/or cleft palate children from infancy to teenage age.Retrospective longitudinal charts review of patients from the multidisciplinary cleft team of the University Hospital of Lausanne over a 30-year (...) period. 146 charts from consecutive patients with non-syndromic unilateral cleft lip and/or cleft palate who were born between January 1986 and January 2003 were included.The earlier in life a cleft child experience his first otitis media with effusion (OME), the worse his long-term hearing will be. Along with the age of onset of OME, we disclosed an influence of the duration of OME without ventilation tube (VT) insertion on short and long-term hearing outcomes. Different patterns were observed

2018 International Journal of Pediatric Otorhinolaryngology

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