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Cleft Lip

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61. A Comparative Study of Oral Microbiota in Infants with Complete Cleft Lip and Palate or Cleft Soft Palate (PubMed)

A Comparative Study of Oral Microbiota in Infants with Complete Cleft Lip and Palate or Cleft Soft Palate Few reports have been published on the early microbiota in infants with various types of cleft palate. We assessed the formation of the oral microbiota in infants with complete cleft lip and palate (CLP n = 30) or cleft soft palate (CSP n = 25) in the neonatal period (T1 time) and again in the gum pad stage (T2 time). Culture swabs from the tongue, palate, and/or cleft margin at T1 and T2

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2017 BioMed research international

62. A pilot study: Screening target miRNAs in tissue of nonsyndromic cleft lip with or without cleft palate (PubMed)

A pilot study: Screening target miRNAs in tissue of nonsyndromic cleft lip with or without cleft palate Nonsyndromic cleft lip with or without cleft palate (NSCLP) has been recognized as a condition resulting from a combination of environmental and genetic factors. Studies have demonstrated that microRNAs (miRNAs) are involved in embryonic development. However, few studies have focused on screening potential target miRNAs in human NSCLP tissue. Using microarray-based miRNA expression profiling

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2017 Experimental and therapeutic medicine

63. Association studies of low-frequency coding variants in nonsyndromic cleft lip with or without cleft palate (PubMed)

Association studies of low-frequency coding variants in nonsyndromic cleft lip with or without cleft palate Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a group of common human birth defects with complex etiology. Although genome-wide association studies have successfully identified a number of risk loci, these loci only account for about 20% of the heritability of orofacial clefts. The "missing" heritability may be found in rare variants, copy number variants

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2017 American journal of medical genetics. Part A

64. Gene-gene interaction of single nucleotide polymorphisms in 16p13.3 may contribute to the risk of non-syndromic cleft lip with or without cleft palate in Chinese case-parent trios (PubMed)

Gene-gene interaction of single nucleotide polymorphisms in 16p13.3 may contribute to the risk of non-syndromic cleft lip with or without cleft palate in Chinese case-parent trios Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect with a complex and heterogeneous etiology. A recent genome-wide association study (GWAS) among Chinese populations has identified a new region at 16p13.3 as being associated with NSCL/P, which requires further replication. Here, we (...) attempted to replicate and further clarify the genetic association between this region and NSCL/P, as well as testing for potential gene-gene (G × G) and gene-environment (G × E) interactions. We conducted transmission disequilibrium tests on 69 single nucleotide polymorphisms (SNPs) mapping to 16p13.3 among 806 Chinese case-parent trios ascertained through an international consortium where a GWAS of oral clefts was conducted. G × G, as well as G × E interactions involving maternal environmental tobacco

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2017 American journal of medical genetics. Part A

65. Establishing Content Validity of the CLEFT-Q: A New Patient-reported Outcome Instrument for Cleft Lip/Palate (PubMed)

Establishing Content Validity of the CLEFT-Q: A New Patient-reported Outcome Instrument for Cleft Lip/Palate The CLEFT-Q is a new patient-reported outcome instrument designed to measure outcomes that matter to patients. The aim of this qualitative study was to establish content validity of the CLEFT-Q in patients who differ by age and culture.Patients aged between 6 and 29 years were recruited from plastic surgery clinics in Canada, India, Ireland, the Philippines, the Netherlands (...) and the United States. Healthcare providers and other experts participated in a focus group or provided individual feedback. Input was sought on all aspects of the CLEFT-Q (item wording, instructions, and response options), and to identify missing content. Patient interviews and expert feedback took place between September 2013 and September 2014.Sixty-nine patients and 44 experts participated. The first draft of the CLEFT-Q consisted of 163 items measuring 12 constructs. The first round of feedback

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2017 Plastic and Reconstructive Surgery Global Open

66. Development and Evaluation of a Blog about Cleft Lip and Cleft Palate and Hearing (PubMed)

Development and Evaluation of a Blog about Cleft Lip and Cleft Palate and Hearing Introduction  Cleft lip and cleft palate can result in impairments in communication, specifically in hearing, making the use of technological resources such as blogs a fundamental guideline for health professionals. Objective  The aim of this study was to prepare and analyze the access to a blog about cleft lip and cleft palate and hearing as a pedagogical tool for health professionals. Methods  The first stage (...) of the scales, navigation and structure presented the lowest scores. Conclusion  The blog was developed and enabled greater access to information available on the web about cleft lip and cleft palate and hearing.

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2017 International archives of otorhinolaryngology

67. Centre‐level variation of treatment and outcome in 5‐year‐old children with non‐syndromic unilateral cleft lip and palate: The Cleft Care UK study. Part 1: Methodology and results for dento‐facial outcomes (PubMed)

Centre‐level variation of treatment and outcome in 5‐year‐old children with non‐syndromic unilateral cleft lip and palate: The Cleft Care UK study. Part 1: Methodology and results for dento‐facial outcomes Outline methods used to describe centre-level variation in treatment and outcome in children in the Cleft Care UK (CCUK) study. Report centre-level variation in dento-facial outcomes.Two hundred and sixty-eight five-year-old British children with non-syndromic unilateral cleft lip

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2017 Orthodontics & craniofacial research

68. Centre‐level variation in behaviour and the predictors of behaviour in 5‐year‐old children with non‐syndromic unilateral cleft lip: The Cleft Care UK study. Part 5 (PubMed)

Centre‐level variation in behaviour and the predictors of behaviour in 5‐year‐old children with non‐syndromic unilateral cleft lip: The Cleft Care UK study. Part 5 The aims of this study were to describe child behavioural and psychosocial outcomes associated with appearance and speech in the Cleft Care UK (CCUK) study. We also wanted to explore centre-level variation in child outcomes and investigate individual predictors of such outcomes.Two hundred and sixty-eight five-year-old (...) children with non-syndromic unilateral cleft lip and palate (UCLP) recruited to CCUK.Parents completed the Strengths and Difficulties questionnaire (SDQ) and reported their own perceptions of the child's self-confidence. Child facial appearance and symmetry were assessed using photographs, and intelligibility of speech was derived from audio-visual speech recordings. Centre-level variation in behavioural and psychosocial outcomes was examined using hierarchical models, and associations with clinical

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2017 Orthodontics & craniofacial research

69. Maternal Risk Factors Associated with the Development of Cleft Lip and Cleft Palate in Mexico: A Case-Control Study (PubMed)

Maternal Risk Factors Associated with the Development of Cleft Lip and Cleft Palate in Mexico: A Case-Control Study Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate.We conducted a case control study at the Women's Hospital in Culiacan, Mexico. Medical (...) records were analyzed, including patients who delivered babies with and without cleft lip and cleft palate from January 2010 to December 2015. Multiple variables were analyzed, including gestational age, weight at birth, the use of folic acid and multivitamins during pregnancy, smoking, alcohol abuse, the use of recreational drugs, history of sexually transmitted infections, marital status, socioeconomic status, education, and nutritional status.We found that the maternal risk factors

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2017 Iranian journal of otorhinolaryngology

70. Assessment of differentially expressed plasma microRNAs in nonsyndromic cleft palate and nonsyndromic cleft lip with cleft palate (PubMed)

Assessment of differentially expressed plasma microRNAs in nonsyndromic cleft palate and nonsyndromic cleft lip with cleft palate Plasma microRNAs (miRNAs) have recently emerged as a new class of regulatory molecules that influence many biological functions. However, the expression profile of plasma microRNAs in nonsyndromic cleft palate (NSCP) or nonsyndromic cleft lip with cleft palate (NSCLP) remains poorly investigated. In this study, we used Agilent human miRNA microarray chips to monitor

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2016 Oncotarget

71. Association of TFAP2A gene polymorphism with susceptibility to non-syndromic cleft lip with or without palate risk in south Indian population (PubMed)

Association of TFAP2A gene polymorphism with susceptibility to non-syndromic cleft lip with or without palate risk in south Indian population The aetiology of non-syndromic cleft lip with or without cleft palate (NSCL/P) is complex involving multiple interacting genes and environmental factors. The primary objective of the present study was to investigate the role of TFAP2A gene single nucleotide polymorphisms (SNPs) in the pathogenesis of NSCL/P. In this study, 173 unrelated NSCL/P patients (...) and 176 controls without clefts were genotyped with TFAP2A rs1675414 (Exon 1), rs3798691 (Intron 1), and rs303050 (Intron 4) variants by allele-specific amplification using the KASPar SNP genotyping system. The method of multifactor dimensionality reduction (MDR) was used to analyze gene-gene interactions. TFAP2A polymorphisms are not found to be associated with non-syndromic cleft lip with or without cleft palate (NSCL/P) at either the genotype or allele levels. No linkage disequilibrium (LD

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2016 Meta gene

72. Distraction osteogenesis or orthognathic surgery for hypoplastic maxilla in cleft lip and palate

Distraction osteogenesis or orthognathic surgery for hypoplastic maxilla in cleft lip and palate Distraction osteogenesis or orthognathic surgery for hypoplastic maxilla in cleft lip and palate - National Elf Service Search National Elf Service Search National Elf Service » » » » Distraction osteogenesis or orthognathic surgery for hypoplastic maxilla in cleft lip and palate Oct 11 2016 Posted by Cleft lip and palate (CLP) is a common birth defect with a global prevalence of between 1 in 5-700 (...) osteogenesis compared to orthognathic surgery for the treatment of hypoplastic maxilla in people with cleft lip and palate. Method Searches were conducted in the Cochrane Oral Health’s Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, LILACS, ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry databases with no language restrictions. Randomised controlled trials (RCTs) comparing maxillary distraction osteogenesis

2016 The Dental Elf

73. Infraorbital nerve block for postoperative pain following cleft lip repair in children

Infraorbital nerve block for postoperative pain following cleft lip repair in children Infraorbital nerve block for postop pain following cleft lip repair Search National Elf Service Search National Elf Service » » » » Infraorbital nerve block for postoperative pain following cleft lip repair in children Apr 22 2016 Posted by Cleft lip is one of the most common craniofacial birth defects and requires early correction. It can be carried out during the neonatal period or earlier although timing (...) depends on the type and severity of the deformity, the child’s health and other factors. Pain postoperatively can be a problem and result in psychological, cardiorespiratory, and metabolic issues. The aim of this Cochrane Review was to assess the effects of infraorbital nerve block for postoperative pain following cleft lip repair in children. Methods Searches were conducted in the Cochrane Central Register of Controlled Trials (CENTRAL) , Medline, Embase, LILACS, the metaRegister of Controlled Trials

2016 The Dental Elf

74. No Significant Difference in Velopharyngeal Function Between Conventional Orthognathic Surgery and Maxillary distraction for advancement of the maxilla in cleft lip and palate patients.

No Significant Difference in Velopharyngeal Function Between Conventional Orthognathic Surgery and Maxillary distraction for advancement of the maxilla in cleft lip and palate patients. UTCAT2625, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title No Significant Difference in Velopharyngeal Function Between Conventional Orthognathic Surgery and Maxillary Distraction for Advancement of the Maxilla in Cleft Lip and Palate (...) Patients Clinical Question Is there a difference in the development of velopharyngeal insufficiency when maxillary advancement in the cleft patient is performed with conventional orthognathic surgery or distraction osteogenesis? Clinical Bottom Line For repaired cleft lip and palate patients, there is no significant difference in development of velopharyngeal insufficiency after maxillary advancement due to conventional orthognathic (CO) surgery or distraction osteogenesis (DO). This is supported

2014 UTHSCSA Dental School CAT Library

75. Multi-modal Characterization of the Mature Septal Deformity and Airspace Associated with Unilateral Cleft Lip and Palate. (PubMed)

Multi-modal Characterization of the Mature Septal Deformity and Airspace Associated with Unilateral Cleft Lip and Palate. The nasal deformity that accompanies cleft conditions is often acknowledged as the most difficult obstacle to restoring facial balance in affected children. Despite considerable progress in the treatment of cleft lip and palate, the outcomes of cleft septorhinoplasty have proven variable and difficult to predict, possibly because of incomplete understanding of the underlying (...) anatomical deformities. The authors sought to characterize unilateral cleft septal and dorsal deformities through a detailed morphologic model based on photogrammetric, qualitative, and quantitative computerized tomographic image analysis.Twenty-five consecutive patients with a unilateral cleft nasal deformity without prior septorhinoplasty were included.Dorsal angulation, as measured by the nasal dorsal angle, consistently deviated away from the cleft side at a mean angle of 8.9 degrees. In a majority

2018 Plastic and reconstructive surgery

76. Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients after Primary Cheiloplasty without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. (PubMed)

Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients after Primary Cheiloplasty without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. The objective of this study was to assess the efficacy of presurgical nasoalveolar molding (PNAM) on long-term nasal symmetry and shaping after primary cheiloplasty in patients with unilateral complete cleft lip/palate (UCL/P).This was a two-group, parallel, retrospective, randomized

2018 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

77. Unilateral Cleft Lip and Palate Surgical Protocols and Facial Growth Outcomes. (PubMed)

Unilateral Cleft Lip and Palate Surgical Protocols and Facial Growth Outcomes. Adequate dentofacial growth is an objective of unilateral cleft lip and palate treatment. No study exists, comparing the dental arch of 5-year-old relationship after 2 treatment protocols: one with single-stage palatoplasty and another with delayed hard palate closure (DHPC). The authors hypothesized that the DHPC protocol provides better dentofacial growth.A single-center, single-surgeon Randomized Clinical Trial

2018 The Journal of craniofacial surgery

78. The Effects of Maxillary Expansion on Late Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate. (PubMed)

The Effects of Maxillary Expansion on Late Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate. The purpose of this study was to answer the research question of whether maxillary expansion provides enough postgraft stimulation to decrease the volume loss of alveolar bone grafts in patients with cleft lip and palate (CLP) who missed the appropriate treatment time.This study was designed as a prospective controlled clinical trial. Thirty patients in the permanent-dentition

2018 Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

79. Philtrum reconstruction in unilateral cleft lip repair. (PubMed)

Philtrum reconstruction in unilateral cleft lip repair. The philtrum is an important aesthetic structure in the midface. A number of philtrum reconstruction techniques have been advocated for secondary cleft lip revision procedures. Conventional surgical management involves end-to-end orbicularis oris muscle approximation during primary cleft lip repair, often resulting in a flat lip appearance that requires secondary revision surgery at a later stage. A novel modification of the approximation (...) of the orbicularis oris muscle is described that may be implemented with any cleft lip technique in order to create an accentuated philtrum column for a natural looking philtrum. The muscle roll technique results in eversion of the orbicularis oris muscle, successfully recapturing the philtrum column topography. This is achieved by utilizing two inverted horizontal sutures, with an additional philtrum takedown suture placed in the region of the dimple to accentuate the philtrum anatomy and three-dimensional

2018 International Journal of Oral and Maxillofacial Surgery

80. Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology (PubMed)

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology There is increasing evidence that genetic risk variants for non-syndromic cleft lip/palate (nsCL/P) are also associated with normal-range variation in facial morphology. However, previous analyses are mostly limited to candidate SNPs and findings have not been consistently replicated. Here, we used polygenic risk scores (PRS) to test for genetic overlap between nsCL/P and seven biologically relevant facial

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2018 PLoS genetics

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