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Cleft Lip

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401. Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate

Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate (PROTRACTSURG) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02789787 Recruitment Status : Recruiting First Posted : June 3, 2016 Last Update

2016 Clinical Trials

402. A comparison of health-related quality of life in 5- and 10-year-old Swedish children with and without cleft lip and/or palate. (Abstract)

A comparison of health-related quality of life in 5- and 10-year-old Swedish children with and without cleft lip and/or palate. The current understanding on health-related quality of life (HRQoL) in young Swedish children with cleft lip and/or palate (CL/P) is sparse, and therefore, research on impact of CL/P on HRQoL in children is needed.To investigate HRQoL in 5- and 10-year-old Swedish children with CL/P in comparison with non-cleft controls. Also to analyse whether there were any (...) differences in HRQoL between children with cleft lip (with or without cleft palate, CL ± P) and cleft palate only (CP) and/or gender differences.A total of 137 children with CL/P and 305 non-cleft controls participated. HRQoL was measured with KIDSCREEN-52.All children in the study exhibited HRQoL within or above the age-matched reference interval of the method with similar results in both groups; however, in the dimension 'social support and peers', the 10-year-old children with CL/P perceived lower

2016 International Journal of Paediatric Dentistry

403. Factors contributing to hearing impairment in patients with cleft lip/palate in Malaysia: A prospective study of 346 ears. (Abstract)

Factors contributing to hearing impairment in patients with cleft lip/palate in Malaysia: A prospective study of 346 ears. To determine the factors contributing towards hearing impairment in patients with cleft lip/palate.A prospective analysis was conducted on 173 patients (346 ears) with cleft lip and palate (CL/P) who presented to the combined cleft clinic at University Malaya Medical Centre (UMMC) over 12 months. The patients' hearing status was determined using otoacoustic emission (OAE (...) ), pure tone audiometry (PTA) and auditory brainstem response (ABR). These results were analysed against several parameters, which included age, gender, race, types of cleft pathology, impact and timing of repair surgery.The patients' age ranged from 1-26 years old. They comprised 30% with unilateral cleft lip and palate (UCLP), 28% with bilateral cleft lip and palate (BCLP), 28% with isolated cleft palate (ICP) and 14% with isolated cleft lip (ICL). Majority of the patients (68.2%) had normal

2016 International Journal of Pediatric Otorhinolaryngology

404. Chinese children with nonsyndromic cleft lip/palate: Factors associated with hearing disorder. (Abstract)

Chinese children with nonsyndromic cleft lip/palate: Factors associated with hearing disorder. This study examined the auditory status of Chinese children with nonsyndromic cleft lip/palate (NSCL/P), investigated factors associated with peripheral hearing loss and compared results with earlier studies in western countries.Case history profiles and audiological data from 148 Chinese children with NSCL/P, aged between 6 and 15 years, who attended the Cleft Lip and Palate Clinic Center in a major (...) was noted in 12% of children and in 5% of cases bilateral hearing loss was noted. In the majority of cases the hearing loss was slight and conductive in nature. Age, gender, residential locality and school achievement were found to have no relationship with severity of hearing loss. Children with cleft lip showed a lower degree of hearing impairment than children with cleft palate or cleft lip and palate.Similar to studies for western children, Chinese children with CL/P associated with no known

2016 International Journal of Pediatric Otorhinolaryngology

405. Nasal airway dysfunction in children with cleft lip/palate: Results of a cross-sectional population-based study, with anatomic and surgical considerations. (Abstract)

Nasal airway dysfunction in children with cleft lip/palate: Results of a cross-sectional population-based study, with anatomic and surgical considerations. The aesthetic aspects of the cleft lip nasal deformity have been appreciated for over a century, but the functional implications have remained largely underappreciated or misunderstood. This study describes the frequency and severity of nasal obstructive symptoms among children with cleft lip and/or cleft palate, addressing the hypotheses (...) that age, cleft type, and severity are associated with the development of nasal obstructive symptoms.Children with nonsyndromic cleft lip and/or cleft palate and a comparison group of unaffected children born from 1997 to 2003 were identified through the North Carolina Birth Defects Monitoring Program and birth certificates. Nasal airway obstruction was measured using the validated Nasal Obstruction Symptom Evaluation scale.The survey was completed by parental proxy for 176 children with cleft lip

2016 Plastic and reconstructive surgery

406. Slow versus rapid maxillary expansion in bilateral cleft lip and palate: a CBCT randomized clinical trial. (Abstract)

Slow versus rapid maxillary expansion in bilateral cleft lip and palate: a CBCT randomized clinical trial. The purpose of this "two-arm parallel" trial was to compare the orthopedic, dental, and alveolar bone plate changes of slow (SME) and rapid (RME) maxillary expansions in patients with complete bilateral cleft lip and palate (BCLP).Forty-six patients with BCLP and maxillary arch constriction in the late mixed dentition were randomly and equally allocated into two groups. Computer-generated (...) randomization was used. Allocation was concealed with sequentially, numbered, sealed, opaque envelopes. The SME and RME groups comprised patients treated with quad-helix and Haas/Hyrax-type expanders, respectively. Cone-beam computed tomography (CBCT) exams were performed before expansion and 4 to 6 months post-expansion. Nasal cavity width, maxillary width, alveolar crest width, arch width, palatal cleft width, inclination of posterior teeth, alveolar crest level, and buccal and lingual bone plate

2016 Clinical oral investigations Controlled trial quality: uncertain

407. Multivariate analysis on unilateral cleft lip and palate treatment outcome by EUROCRAN index: A retrospective study. (Abstract)

Multivariate analysis on unilateral cleft lip and palate treatment outcome by EUROCRAN index: A retrospective study. This study is to evaluate the dental arch relationship and palatal morphology of unilateral cleft lip and palate patients by using EUROCRAN index, and to assess the factors that affect them using multivariate statistical analysis.A total of one hundred and seven patients from age five to twelve years old with non-syndromic unilateral cleft lip and palate were included (...) , site, type and, family history of unilateral cleft lip and palate; absence of lateral incisor on cleft side, cheiloplasty and palatoplasty technique used. Associations between various factors and dental arch relationships were assessed using logistic regression analysis.Dental arch relationship among unilateral cleft lip and palate in local population had relatively worse scoring than other parts of the world. Crude logistics regression analysis did not demonstrate any significant associations

2016 International Journal of Pediatric Otorhinolaryngology

408. Evaluating the Rule of 10s in Cleft Lip Repair: Do Data Support Dogma? (Abstract)

Evaluating the Rule of 10s in Cleft Lip Repair: Do Data Support Dogma? Cleft lip represents one of the most common birth defects in the world. Although the timing of cleft lip repair is contingent on a number of factors, the "rule of 10s" remains a frequently quoted safety benchmark. Initially reported by Wilhelmsen and Musgrave in 1966 and modified by Millard in 1976, this rule referred to performing surgery once patients had reached cutoffs in weight, hemoglobin, and age/leukocyte count (...) . Despite significant advances in both surgical and anesthetic technique, the oft-quoted "rule of 10s" has not been systematically investigated since its inception.Patients who underwent primary cleft lip repair were identified from the National Surgical Quality Improvement Program Pediatric database. Multivariate logistic regression models were used to determine the independent effect of each rule of 10 metric or violation of the rule of 10s as a whole on postoperative complications, and to determine

2016 Plastic and reconstructive surgery

409. Skeletal stability of maxillary advancement with and without a mandibular reduction in the cleft lip and palate patient. (Abstract)

Skeletal stability of maxillary advancement with and without a mandibular reduction in the cleft lip and palate patient. The stability of surgical maxillary advancement in a consecutive series of patients with cleft lip and palate who underwent Le Fort I osteotomy with and without simultaneous mandibular setback surgery was evaluated. Preoperative, postoperative, and follow-up lateral cephalograms of 21 patients were assessed to compare differences in surgical movement and postoperative relapse (...) between two groups: those who underwent maxillary surgery alone and those who underwent bimaxillary surgery. Differences in the number of patients who experienced relapse of <2mm, 2-4mm, and >4mm between the groups were also compared. Mean advancement of the cleft maxilla was 5.5mm in the maxilla only group and 3.6mm in the bimaxillary group, with a mean horizontal relapse of 0.8mm and 0.2mm, respectively. Mean surgical movement in the vertical dimension was comparable in the two groups

2016 International Journal of Oral and Maxillofacial Surgery

410. Nasal Septal Anatomy in Skeletally Mature Patients With Cleft Lip and Palate. Full Text available with Trip Pro

Nasal Septal Anatomy in Skeletally Mature Patients With Cleft Lip and Palate. Septal deviation commonly occurs in patients with cleft lip and palate (CLP); however, the contribution of the cartilaginous and bony septum to airway obstruction in skeletally mature patients is poorly understood.To describe the internal nasal airway anatomy of skeletally mature patients with CLP and to determine the contributors to airway obstruction.This single-center retrospective review included patients (...) undergoing cone-beam computed tomography (CBCT) from November 1, 2011, to July 6, 2015, at the cleft lip and palate division of a major academic tertiary referral center. Patients met inclusion criteria for the study if they were at least 15 years old at the time of CBCT, and images were used only if they were obtained before Le Fort I osteotomy and/or formal septorhinoplasty. Twenty-four skeletally mature patients with CLP and 16 age-matched control individuals were identified for the study.Septal

2016 JAMA facial plastic surgery

411. Distraction osteogenesis: little evidence available of effectiveness in maxillary hypoplasia in cleft lip and palate patients

Distraction osteogenesis: little evidence available of effectiveness in maxillary hypoplasia in cleft lip and palate patients Distraction osteogenesis: little evidence of effectiveness Search National Elf Service Search National Elf Service » » » » Distraction osteogenesis: little evidence available of effectiveness in maxillary hypoplasia in cleft lip and palate patients Jan 29 2015 Posted by Maxillary hypoplasia is a common problem in patients with cleft lip and palate. Traditionally this has (...) been managed by single-stage orthognathic surgery. The 1990s saw the development of maxillary distraction osteogenesis and a potential alternative method of surgical correction. The aim of this review was to compare the effectiveness of distraction osteogenesis to conventional orthognathic surgery for the treatment of maxillary hypoplasia in patients with cleft lip and palate. Methods Searches were conducted in the Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus

2015 The Dental Elf

412. TP63-related disorders (ectrodactyly-ectodermal dysplasia-clefting [EEC3] syndrome; acro-dermato-ungual-lacrimal-tooth [ADULT] syndrome; ankyloblepharon-ectodermal dysplasia-clefting [AEC; hay-wells] syndrome; limb-mammary syndrome (LMS); nonsyndromic spl

of orofacial clefting and limb malformations may also be incorporated into treatment. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Cleft Lip; Cleft Palate; Ectodermal Dysplasia; Humans; Transcription Factors; Tumor Suppressor Proteins Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA (...) TP63-related disorders (ectrodactyly-ectodermal dysplasia-clefting [EEC3] syndrome; acro-dermato-ungual-lacrimal-tooth [ADULT] syndrome; ankyloblepharon-ectodermal dysplasia-clefting [AEC; hay-wells] syndrome; limb-mammary syndrome (LMS); nonsyndromic spl TP63-related disorders (ectrodactyly-ectodermal dysplasia-clefting [EEC3] syndrome; acro-dermato-ungual-lacrimal-tooth [ADULT] syndrome; ankyloblepharon-ectodermal dysplasia-clefting [AEC; hay-wells] syndrome; limb-mammary syndrome (LMS

2012 Health Technology Assessment (HTA) Database.

413. Polymorphic variants near 1p22 and 20q11.2 loci and the risk of non-syndromic cleft lip and palate in South Indian population. (Abstract)

Polymorphic variants near 1p22 and 20q11.2 loci and the risk of non-syndromic cleft lip and palate in South Indian population. Recent genome-wide association studies (GWAS) have reported multiple genetic risk loci for non-syndromic orofacial clefts (NSOFCs) in many populations. However, the contribution of these loci to NSOFC in India, which comprises one-fifth of the global population, is completely lacking. Our aim was to replicate the association of the SNPs located on 1p22 chromosomal loci (...) are not found to be associated with cleft lip with or without non-syndromic cleft palate (NSCL/P) and non-syndromic cleft palate only (NSCPO) at either the genotype or allele levels. Further, there is no LD observed between these variants. The polymorphic variants near 20q11.2 (rs13041247, rs11696257) are in complete linkage disequilibrium (LD) and are significantly associated with only NSCL/P in genotypic (p=0.013) and allelic models (p=0.029). In the genotypic model significance persisted even after

2015 International Journal of Pediatric Otorhinolaryngology

414. Analysis of the dentoalveolar effects of slow and rapid maxillary expansion in complete bilateral cleft lip and palate patients: a randomized clinical trial. (Abstract)

Analysis of the dentoalveolar effects of slow and rapid maxillary expansion in complete bilateral cleft lip and palate patients: a randomized clinical trial. The purpose of this study was to compare the dentoalveolar effects of slow (SME) and rapid (RME) maxillary expansions in patients with complete bilateral cleft lip and palate (BCLP).A sample of 50 patients with BCLP and maxillary arch constriction was randomly and equally allocated into two groups. Group SME comprised patients (mean age

2015 Clinical oral investigations Controlled trial quality: uncertain

415. Reconstruction of Philtrum Using Partial Splitting and Folding of Orbicularis Oris Muscle in Secondary Unilateral Cleft Lip. (Abstract)

Reconstruction of Philtrum Using Partial Splitting and Folding of Orbicularis Oris Muscle in Secondary Unilateral Cleft Lip. The reconstruction of the philtrum during unilateral cleft lip repair remains a surgical challenge. The authors introduce a modified surgical technique for the reconstruction of the philtrum that allows for both the deepening of the philtral dimple and augmentation of the philtral ridge.Between January of 2011 and June of 2012, 37 patients, including 22 male and 15 female (...) patients (mean age, 25.6 years), underwent secondary unilateral cleft lip repair. The philtrum was reconstructed by the partial splitting and folding of the orbicularis oris muscle. The aesthetic outcome of the philtrum and the scar after the operation was scored to evaluate the effectiveness of the procedure.The patients were evaluated for the appearance of the philtrum and scar at 12 to 18 months (mean, 14.6 months). Good symmetry of the bilateral philtral ridges was achieved in 35 of the 37 patients

2015 Plastic and reconstructive surgery

416. Description of total population hospital admissions for cleft lip and/or palate in Australia. Full Text available with Trip Pro

Description of total population hospital admissions for cleft lip and/or palate in Australia. Orofacial clefts are a group of frequently observed congenital malformations often requiring multiple hospital admissions over the lifespan of affected individuals. The aim of this study was to describe the total-population hospital admissions with principal diagnosis of cleft lip and/or palate in Australia over a 10 year period.Data for admissions to hospitals were obtained from the Australian (...) Institute of Health and Welfare National Hospital Morbidity Database (July 2000 to June 2010). The outcome variable was a hospital separation with the principal diagnosis of cleft palate, cleft lip or cleft lip and palate (ICD-10-AM diagnosis codes Q35-Q37 respectively). Trends in rates of admission and length of stay by age, gender and cleft type were investigated.A total of 11, 618 admissions were identified; cleft palate (4,454; 0.22 per 10,000 people per year), cleft lip (2,251; 0.11) and cleft lip

2015 BMC Oral Health

417. Columella Lengthening with a Full-Thickness Skin Graft for Secondary Bilateral Cleft Lip and Nose Repair Full Text available with Trip Pro

Columella Lengthening with a Full-Thickness Skin Graft for Secondary Bilateral Cleft Lip and Nose Repair Various techniques for lengthening short columellae have been used for bilateral cleft nose repair. However, previous methods have not yielded satisfactory results. We performed a full-thickness skin graft to lengthen short columellae during secondary cleft nose repair in adult patients.Ten bilateral cleft lip and nose patients underwent secondary cheiloplasty with open rhinoplasty between (...) July 2008 and August 2014. The patients underwent a full-thickness skin graft on the medial crura to elongate the columella. The average age of the patients at the time of surgery was 22.2 years. Nasal profiles were evaluated before and after the operation using the photogrammetric method.The nasal profiles were improved in all patients, and all skin grafts were well taken, with the exception of one patient. Columellar height, nostril height, and columella-lip angle increased, and nasal width

2015 Archives of plastic surgery

418. Identification of Proximal and Distal 22q11.2 Microduplications among Patients with Cleft Lip and/or Palate: A Novel Inherited Atypical 0.6 Mb Duplication Full Text available with Trip Pro

Identification of Proximal and Distal 22q11.2 Microduplications among Patients with Cleft Lip and/or Palate: A Novel Inherited Atypical 0.6 Mb Duplication Misalignments of low-copy repeats (LCRs) located in chromosome 22, particularly band 22q11.2, predispose to rearrangements. A variety of phenotypic features are associated with 22q11.2 microduplication syndrome which makes it challenging for the genetic counselors to recommend appropriate genetic assessment and counseling for the patients (...) . In this study, multiplex ligation probe dependent amplification (MLPA) analysis was performed on 378 patients with cleft lip and/or palate to characterize rearrangements in patients suspected of 22q11.2 microduplication and microdeletion syndromes. Of 378 cases, 15 were diagnosed with a microdeletion with various sizes and 3 with duplications. For the first time in this study an atypical 0.6 Mb duplication is reported. Illustration of the phenotypes associated with the microduplications increases

2015 Genetics research international

419. Presurgical nasoalveolar moulding: A boon in the management of cleft lip and palate Full Text available with Trip Pro

Presurgical nasoalveolar moulding: A boon in the management of cleft lip and palate 28050103 2019 02 26 0377-1237 72 Suppl 1 2016 Dec Medical journal, Armed Forces India Med J Armed Forces India Presurgical nasoalveolar moulding: A boon in the management of cleft lip and palate. S164-S168 10.1016/j.mjafi.2015.09.004 Chaudhary Dinesh Chander DC Classified Specialist (Orthodontics), Army Dental Centre (R&R), Delhi Cantt, New Delhi 110 010, India. Sharma Rohit R Associate Professor (Oral (...) and Maxillofacial Surgery), Dept of Dental Surgery, Armed Forces Medical College, Pune 411040, India. Sharma Vineet V Commandant and Command Dental Adviser (Northern Command), C/O 56 APO, India. Kaur Simrat S Associate Professor (Prosthodontics), SGRD Institute of Dental Sciences & Research, Amritsar, Punjab, India. eng Case Reports 2015 12 02 India Med J Armed Forces India 7602492 0377-1237 Alveolar defect Cleft lip and palate Deficient columella PNAM appliance Presurgical nasoalveolar moulding (PNAM) 2015 02

2015 Medical journal, Armed Forces India

420. Patients and professionals have different views on online patient information about cleft lip and palate (CL/P). (Abstract)

Patients and professionals have different views on online patient information about cleft lip and palate (CL/P). Parents of children with a cleft lip and/or palate (CL/P) and patients with CL/P actively search for online information about CL/P. The quality of this information has not been sufficiently evaluated. The aim of this study was to define quality criteria for online information about CL/P and assess the quality of frequently accessed websites. Patients, parents, and professionals were

2015 International Journal of Oral and Maxillofacial Surgery

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