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Cleft Lip

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321. Dental age assessment in cleft lip and palate patients: a systematic review

Dental age assessment in cleft lip and palate patients: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect

2018 PROSPERO

322. Pre-Surgical Infant Orthopedics (PSIO) And Naso-Alveolar Molding (NAM) Show Promise For Obtaining Normal Anatomy Of The Nose And Lip In Patients With Cleft Lip And Palate

Pre-Surgical Infant Orthopedics (PSIO) And Naso-Alveolar Molding (NAM) Show Promise For Obtaining Normal Anatomy Of The Nose And Lip In Patients With Cleft Lip And Palate UTCAT2163, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Pre-Surgical Infant Orthopedics (PSIO) And Naso-Alveolar Molding (NAM) Show Promise For Obtaining Normal Anatomy Of The Nose And Lip In Patients With Cleft Lip And Palate Clinical Question (...) In a child with cleft lip and palate, is there long-term benefit to pre-surgical naso-alveolar molding versus traditional surgical treatment alone? Clinical Bottom Line Long-term anthropologic studies comparing NAM to traditional treatment show equivocal results; however, pre-surgical infant orthopedics (PSIO) is gaining a body of literature to support it’s use. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1

2011 UTHSCSA Dental School CAT Library

323. The Reducing Opioid Use in Children with Clefts Protocol: A Multidisciplinary Quality Improvement Effort to Reduce Perioperative Opioid Use in Patients Undergoing Cleft Surgery. (Abstract)

The Reducing Opioid Use in Children with Clefts Protocol: A Multidisciplinary Quality Improvement Effort to Reduce Perioperative Opioid Use in Patients Undergoing Cleft Surgery. Cleft repair requires multiple operations from infancy through adolescence, with repeated exposure to opioids and their associated risks. The authors implemented a quality improvement project to reduce perioperative opioid exposure in their cleft lip/palate population.After identifying key drivers of perioperative (...) at less than 6 hours (1.78 versus 1.74; p = 0.626) or more than 6 hours postoperatively (1.50 versus 1.49; p = 0.924).Perioperative opioid administration after cleft repair can be reduced in a relatively short period by identifying key drivers and addressing perioperative education, standardization of intraoperative pain control, and postoperative prioritization of nonopioid medications and nonpharmacologic pain control. The authors' quality improvement framework has promise for adaptation in future

2020 Plastic and reconstructive surgery

324. A cleft care workshop for speech and language pathologists in resource-limited countries: The participants' experiences about cleft care in Uganda and satisfaction with the training effect. Full Text available with Trip Pro

described and measured the effect of a free, two-day cleft care workshop for SLPs in Uganda. The workshop included different topics related to the assessment and treatment of children with a cleft of the palate with or without a cleft of the lip (CP ± L).The participants who presented during the two-day course were asked to complete a pre- and post-workshop questionnaire to evaluate their satisfaction. The pre-workshop form also included some questions concerning cleft care in Uganda. Both the pre (...) A cleft care workshop for speech and language pathologists in resource-limited countries: The participants' experiences about cleft care in Uganda and satisfaction with the training effect. workshops and specialized training programs are often inaccessible for speech and language pathologists (SLPs) based in resource-limited countries given the lack of supply, the long travel distances and the excessive participation fees. To stimulate life-long learning opportunities for all, this study

2020 International Journal of Pediatric Otorhinolaryngology

325. Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate Full Text available with Trip Pro

Dental anomalies inside the cleft region in individuals with nonsyndromic cleft lip with or without cleft palate Individuals with nonsyndromic cleft lip with or without cleft palate (NSCL±P) present high frequency of dental anomalies, which may represent complicating factors for dental treatment. The aim of this study was to investigate the prevalence of dental anomalies inside cleft area in a group of Brazilians with NSCL±P.Retrospective analysis of 178 panoramic radiographs of patients aged (...) from 12 to 45 years old and without history of tooth extraction or orthodontic treatment was performed. Association between cleft type and the prevalence of dental anomalies was assessed by chi-square test with a significance level set at p≤ 0.05.Dental anomalies were found in 88.2% (n=157) of the patients. Tooth agenesis (47.1%), giroversion (20%) and microdontia (15.5%) were the most common anomalies. Individuals with unilateral complete cleft lip and palate (CLP, p<0.0001), bilateral complete

2015 Medicina oral, patología oral y cirugía bucal

326. Patients With Cleft Lip, Alveolus And Palate May Be Predisposed To Periodontal Disease, Especially In Teeth Adjacent To The Cleft

Patients With Cleft Lip, Alveolus And Palate May Be Predisposed To Periodontal Disease, Especially In Teeth Adjacent To The Cleft UTCAT2160, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Patients With Cleft Lip, Alveolus And Palate May Be Predisposed To Periodontal Disease, Especially In Teeth Adjacent To The Cleft Clinical Question Do patients with repaired cleft lip, alveolus, and palate have increased risk (...) of periodontal disease compared to normal subjects? Clinical Bottom Line While studies suggest that patient with cleft lip, palate and alveolus are predisposed to periodontal disease, especially in teeth near the cleft, further studies are required given lack of definitive evidence. Oral hygiene was also found to be poor in a majority of patients with cleft lip, alveolus, or palate, emphasizing the importance of good oral hygiene and close followup with these patients. Best Evidence (you may view more info

2011 UTHSCSA Dental School CAT Library

327. Rescue of lip switch flap at risk of necrosis due to venous congestion for cleft lip deformity Full Text available with Trip Pro

Rescue of lip switch flap at risk of necrosis due to venous congestion for cleft lip deformity In a 21-year-old male with bilateral cleft lip who developed marked venous congestion of a lip switch flap, we returned the grafted flap to the donor site to improve blood circulation of the flap and then re-transplanted it, which prevented flap necrosis. Here, we report the procedure and case.

2016 Case Reports in Plastic Surgery & Hand Surgery

328. Vermilion Only Cross-lip Flap for Treating Whistle Deformity in Secondary Bilateral Cleft Lip Repair Full Text available with Trip Pro

Vermilion Only Cross-lip Flap for Treating Whistle Deformity in Secondary Bilateral Cleft Lip Repair Bilateral cleft lip repairs can result in various secondary deformities. One more commonly seen deformity, the whistle deformity, is characterized by a reduced or absent tubercle, orbicularis muscle diastasis, and abnormalities of the philtrum with notched appearance of cupid's bow. Various techniques have been described to address these problems. One common procedure is the lip-switch flap (...) originally described by Abbe in 1898, which has been modified by various surgeons. In these procedures, lower lip vermilion, mucosa, orbicularis, and lip skin are transposed to the upper lip on a pedicle that is later divided. In all these variations of the lip-switch procedure, the transposed tissue involves the entire lower lip skin-leaving large, unsightly, and unnecessary scars. It also brings abnormal tissue into the philtrum further distorting the upper lip. A modified cross-lip flap

2016 Plastic and Reconstructive Surgery Global Open

329. Barriers to Reconstructive Surgery in Low- and Middle-Income Countries: A Cross-Sectional Study of 453 Cleft Lip and Cleft Palate Patients in Vietnam. Full Text available with Trip Pro

Barriers to Reconstructive Surgery in Low- and Middle-Income Countries: A Cross-Sectional Study of 453 Cleft Lip and Cleft Palate Patients in Vietnam. Despite health system advances, residents of low- and middle-income countries continue to experience substantial barriers in accessing health care, particularly for specialized care such as plastic and reconstructive surgery.A cross-sectional household survey of patients seeking surgical care for cleft lip and/or cleft palate was completed (...) addressed. Patients rely on charitable care outside the centralized health care system; as a result, surgical treatment of cleft lip and palate is delayed beyond the standard optimal window compared with more developed countries. Using these data, the authors developed a more evidence-based framework designed to understand health behaviors and perceptions regarding reconstructive surgical care.

2016 Plastic and reconstructive surgery

330. Correlation of vermilion symmetry to alveolar cleft defect in unilateral cleft lip repair. (Abstract)

Correlation of vermilion symmetry to alveolar cleft defect in unilateral cleft lip repair. Asymmetry is a major problem in repaired unilateral cleft lip (UCL). One of the important manifestations of this is the asymmetry of the vermilion. The aim of this study was to correlate the severity of the asymmetry in the vermilion to the size of the alveolar defect. Twenty patients aged between 6 and 18 months with complete unilateral cleft lip, alveolus, and palate were included. An impression of each (...) patient's alveolus at the time of cheiloplasty was taken using silicon rubber base material, and a study cast was prepared. The width of the cleft alveolus was measured on these casts using a transparent grid. Frontal photographs were taken at 6 months postoperative and vermilion symmetry was measured as the ratio between the cleft and non-cleft sides. The results obtained in this study showed a direct correlation between the size of the alveolar defect and the vermilion symmetry in repaired UCL

2016 International Journal of Oral and Maxillofacial Surgery

331. Cleft characteristics and treatment outcomes in hemifacial microsomia compared to non-syndromic cleft lip/palate. (Abstract)

Cleft characteristics and treatment outcomes in hemifacial microsomia compared to non-syndromic cleft lip/palate. The goal of this study was to describe the clinical characteristics and treatment outcomes of patients with hemifacial microsomia (HFM) and cleft lip/palate (CL/P), and to compare them to a historic cohort of patients with non-syndromic CL/P treated at the same centre. A retrospective review of patients with HFM and CL/P was performed; the main outcome measures assessed were cleft (...) type/side, surgical outcome, midfacial retrusion, and speech. Twenty-six patients (13 male, 13 female; mean age 22.7±14.9, range 1-52 years) with cleft lip with/without cleft palate (CL±P) were identified: three with cleft lip (12%), two with cleft lip and alveolus and an intact secondary palate (8%), and 21 with cleft lip and palate (CLP) (81%; 15 unilateral and six bilateral). Four patients (19%) had a palatal fistula after palatoplasty. Twelve of 22 patients aged >5 years (55%) had midfacial

2016 International Journal of Oral and Maxillofacial Surgery

332. Cleft sidedness and congenitally missing teeth in patients with cleft lip and palate patients Full Text available with Trip Pro

Cleft sidedness and congenitally missing teeth in patients with cleft lip and palate patients The aim of this study was to investigate the prevalence of cleft sidedness, and the number of congenitally missing teeth in regard to cleft type and gender.The charts, models, radiographs, and intraoral photographs of 201 cleft patients including 131 males with the mean age of 12.3 ± 4 years and 70 females with the mean age of 12.6 ± 3.9 years were used for the study. T test, Chi-square, and binomial (...) tests were used for assessment of the data.One hundred forty-eight of the subjects suffered from cleft lip and palate followed by 41 subjects who suffered from cleft lip and alveolus. Chi-square test did not show any significant difference between the genders. Binomial test showed that left-sided cleft was more predominant in unilateral cleft lip and palate patients (P < 0.001). This study also showed that the upper lateral incisors were the most commonly missing teeth in the cleft area.

2016 Progress in orthodontics

333. Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate Full Text available with Trip Pro

Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common congenital birth defects. NSCL/P is a complex multifactorial disease caused by interactions between multiple environmental and genetic factors. However, the causal single nucleotide polymorphism (SNP) signature profile underlying the risk of familial NSCL/P still remains

2016 Frontiers in genetics

334. MTR, MTRR, and MTHFR Gene Polymorphisms and Susceptibility to Nonsyndromic Cleft Lip With or Without Cleft Palate Full Text available with Trip Pro

MTR, MTRR, and MTHFR Gene Polymorphisms and Susceptibility to Nonsyndromic Cleft Lip With or Without Cleft Palate To examine the associations of methionine synthase (MTR), methionine synthase reductase (MTRR), and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with the susceptibility to nonsyndromic cleft lip with or without cleft palate (NSCL/P).Between May 2012 and August 2014, 147 NSCL/P patients (case group) and 129 healthy volunteers (control group) were recruited

2016 Genetic testing and molecular biomarkers

335. Genetic polymorphism of nonsyndromic cleft lip with or without cleft palate is associated with developmental dyslexia in Chinese school-aged populations Full Text available with Trip Pro

Genetic polymorphism of nonsyndromic cleft lip with or without cleft palate is associated with developmental dyslexia in Chinese school-aged populations Developmental dyslexia (DD) is a neurodevelopment disorder characterized by reading disabilities without apparent etiologies. Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a structural craniofacial malformation featured by isolated orofacial abnormalities. Despite substantial phenotypic differences, potential linkage between

2016 Journal of Human Genetics

336. A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13 Full Text available with Trip Pro

A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13 Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate (CL/P), are among the most common birth defects in humans, affecting approximately 1 in 700 newborns. CL/P is phenotypically heterogeneous and has a complex etiology caused by genetic and environmental factors. Previous genome-wide association studies

2016 Human molecular genetics

337. Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan Full Text available with Trip Pro

Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan To investigate malformations associated with cleft lip and cleft palate, we conducted surveys at neonatal intensive care units (NICUs) and other non-NICU facilities and to determine whether there are differences among facilities. The regional survey investigated NICU facilities located in Oita Prefecture, including 92 patients with cleft lip and palate (CLP) or cleft palate (CP) that occurred between (...) 2004 and 2013, and the national survey investigated oral surgery, plastic surgery, and obstetrics and gynecology facilities located in Japan, including 16,452 patients with cleft lip (CL), CLP, or CP that occurred since 2000. The incidence per 10,000 births was 4.2, 6.2, and 2.8 for CL, CLP, and CP, respectively, according to the national survey, and 6.3 and 2.9 for CLP and CP, respectively according to the regional survey. These results indicated comparable incidences between the two surveys

2016 PloS one

338. Correlations between initial cleft size and dental anomalies in unilateral cleft lip and palate patients after alveolar bone grafting Full Text available with Trip Pro

Correlations between initial cleft size and dental anomalies in unilateral cleft lip and palate patients after alveolar bone grafting Objective To determine in individuals with unilateral cleft lip and palate the correlation between initial cleft size and dental anomalies, and the outcome of alveolar bone grafting. Methods A total of 67 consecutive patients with non-syndromic unilateral complete cleft lip and palate (UCLP) were included from the cleft lip and palate-craniofacial center, Uppsala (...) University Hospital, Sweden. All patients were operated by the same surgeon and treated according to the Uppsala protocol entailing: lip plasty at 3 months, soft palate closure at 6 months, closure of the residual cleft in the hard palate at 2 years of age, and secondary alveolar bone grafting (SABG) prior to the eruption of the permanent canine. Cleft size was measured on dental casts obtained at the time of primary lip plasty. Dental anomalies were registered on radiographs and dental casts obtained

2016 Upsala journal of medical sciences

339. Sequence Variation in Folate Pathway Genes and Risks of Human Cleft Lip with or without Cleft Palate Full Text available with Trip Pro

Sequence Variation in Folate Pathway Genes and Risks of Human Cleft Lip with or without Cleft Palate In an effort to comprehensively interrogate genetic variation in the folate pathway for risk of cleft lip with or without cleft palate (CLP), we evaluated 504 common and rare variants in 35 folate-related genes in a panel of 330 infants with CLP and 367 non-malformed controls. Odds ratios (OR) with 95% confidence intervals were computed for common genotypes. A Case-Control Difference metric (...) ) was the most significant risk allele: OR = 3.8 (95%CI = 1.6-9.2) when heterozygous. In non-Hispanic white infants, we observed significant risk for AHCYL2 rs1095423 (homozygous OR = 3.0, 95%CI 1.1-7.8) and the 68 bp CBS insertion (c.844ins68; heterozygous OR = 2.4, 95%CI = 1.1-5.3). Rare variant analysis in this group revealed case-control differences in MTRR and several other methionine cycle genes, a process implicated previously in clefting risk. In women with low folate intake specifically, increased

2016 American journal of medical genetics. Part A

340. The Unilateral Cleft Lip Repair and Primary Cleft Rhinoplasty Full Text available with Trip Pro

The Unilateral Cleft Lip Repair and Primary Cleft Rhinoplasty Supplemental Digital Content is available in the text.

2016 Plastic and Reconstructive Surgery Global Open

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