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Cleft Lip

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321. Not All Clefts Are Created Equal: Patterns of Hospital-Based Care Use among Children with Cleft Lip and Palate within 4 Years of Initial Surgery. (Abstract)

Not All Clefts Are Created Equal: Patterns of Hospital-Based Care Use among Children with Cleft Lip and Palate within 4 Years of Initial Surgery. This study compares hospital-based care and associated charges among children with cleft lip, cleft palate, or both, and identifies subgroups generating the greatest cumulative hospital charges.The authors conducted a retrospective cohort study of cleft lip, cleft palate, or cleft lip and palate who underwent initial surgery from 2006 to 2008 in four (...) U.S. states. Primary outcome was hospital-based care-emergency, outpatient, inpatient-within 4 years of surgery. Regression models compared outcomes and classification tree analysis identified patients at risk for being in the highest quartile of cumulative hospital charges.The authors identified 4571 children with cleft lip (18.2 percent), cleft palate (39.2 percent), or cleft lip and palate (42.6 percent). Medical comorbidity was frequent across all groups, with feeding difficulty (cleft lip

2016 Plastic and reconstructive surgery

322. The Use of an Inferior Pennant Flap during Unilateral Cleft Lip Repair Improves Lip Height Symmetry. Full Text available with Trip Pro

The Use of an Inferior Pennant Flap during Unilateral Cleft Lip Repair Improves Lip Height Symmetry. To improve the rotation of Cupid's bow and achieve sufficient vertical lip height, several variations of the Millard rotation-advancement have incorporated a small laterally based triangular flap above the cutaneous roll. This study uses three-dimensional photogrammetry to evaluate the outcomes of unilateral cleft lip repairs performed with and without pennant flaps.Three-dimensional photographs (...) were analyzed to assess postoperative lip height asymmetry in 90 unilateral cleft lip patients (58 complete and 32 incomplete) treated between 2001 and 2012. Cleft lip repairs were performed by three pediatric cleft surgeons using different techniques. Thirty-nine of 90 procedures (43 percent) used an inferiorly placed triangular flap. All patients were photographed at least 9 months postoperatively (mean, 4.2 years). Lip height asymmetry was based on the vertical distances from the subnasale

2015 Plastic and reconstructive surgery

323. Prevalence, diagnosis and outcome of cleft lip with or without cleft palate in the Netherlands. Full Text available with Trip Pro

Prevalence, diagnosis and outcome of cleft lip with or without cleft palate in the Netherlands. To examine the accuracy and timing of diagnosis of fetal cleft lip with or without cleft palate (CL ± P) in the years following the introduction of a national screening program, and to assess the completeness and accuracy of information in The Netherlands Perinatal Registry.A list was obtained of cases with a prenatal or postnatal diagnosis of CL ± P from two fetal medicine units between 2008

2015 Ultrasound in Obstetrics and Gynecology

324. A cross-sectional survey of 5-year-old children with non-syndromic unilateral cleft lip and palate: the Cleft Care UK study. Part 1: background and methodology Full Text available with Trip Pro

A cross-sectional survey of 5-year-old children with non-syndromic unilateral cleft lip and palate: the Cleft Care UK study. Part 1: background and methodology We describe the methodology for a major study investigating the impact of reconfigured cleft care in the United Kingdom (UK) 15 years after an initial survey, detailed in the Clinical Standards Advisory Group (CSAG) report in 1998, had informed government recommendations on centralization.This is a UK multicentre cross-sectional study (...) of 5-year-olds born with non-syndromic unilateral cleft lip and palate. Children born between 1 April 2005 and 31 March 2007 were seen in cleft centre audit clinics.Consent was obtained for the collection of routine clinical measures (speech recordings, hearing, photographs, models, oral health, psychosocial factors) and anthropometric measures (height, weight, head circumference). The methodology for each clinical measure followed those of the earlier survey as closely as possible.We identified

2015 Orthodontics & craniofacial research

325. A retrospective audit of population service access trends for cleft lip and cleft palate patients. (Abstract)

A retrospective audit of population service access trends for cleft lip and cleft palate patients. Population prevalence of orofacial clefts (OFCs) is well documented but the service utilisation patterns of these patients have received limited consideration.To analyse 10-year trends in the utilisation of subsidised OFC related services in Australia.Retrospective audit of service utilisation and claims datasets.Using state-wide hospital admission data, all persons treated for Cleft Palate Only (...) (CPO) and Cleft Lip Only (CLO) as their primary diagnosis from 1999 to 2009 in Western Australia were included in the data frameset. Additionally, National Medicare out-of-hospital claims from 2003 to 2013 were added to the data frameset. The socioeconomic status and accessibility to services were analysed as effectors of service-mix such as age group, gender and geographic location.Of 721 in-hospital care episodes in Western Australia, 69% had CPO and 31% CLO as their principal diagnosis

2015 Community dental health

326. Identification of Functional Variants for Cleft Lip with or without Cleft Palate in or near PAX7, FGFR2, and NOG by Targeted Sequencing of GWAS Loci. Full Text available with Trip Pro

Identification of Functional Variants for Cleft Lip with or without Cleft Palate in or near PAX7, FGFR2, and NOG by Targeted Sequencing of GWAS Loci. Although genome-wide association studies (GWASs) for nonsyndromic orofacial clefts have identified multiple strongly associated regions, the causal variants are unknown. To address this, we selected 13 regions from GWASs and other studies, performed targeted sequencing in 1,409 Asian and European trios, and carried out a series of statistical (...) disrupted the DNA binding of the encoded transcription factor in an in vitro assay. The second, a non-coding mutation, disrupted the activity of a neural crest enhancer downstream of FGFR2 both in vitro and in vivo. This targeted sequencing study provides strong functional evidence implicating several specific variants as primary contributory risk alleles for nonsyndromic clefting in humans.Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

2015 American Journal of Human Genetics

327. Bilateral optic disc pit with maculopathy in a patient with cleft lip and cleft palate Full Text available with Trip Pro

Bilateral optic disc pit with maculopathy in a patient with cleft lip and cleft palate Optic disc pit (ODP) is small, gray-white, oval depression found at the optic nerve head. It is a congenital defect that occurs due to imperfect closure of superior edge of the embryonic fissure. Cleft lip and palate are also congenital midline abnormalities occurring due to defect in the fusion of frontonasal prominence, maxillary prominence and mandibular prominence. There is only one case report describing (...) the occurrence of ODP in a young patient with cleft lip and palate who also had basal encephalocele. We describe a 52-year-old patient with congenital cleft lip and palate with bilateral ODP with maculopathy but without any other midline abnormality.

2015 Indian journal of ophthalmology

328. Evidence of the involvement of the polymorphisms near MSX1 gene in non-syndromic cleft lip with or without cleft palate. (Abstract)

Evidence of the involvement of the polymorphisms near MSX1 gene in non-syndromic cleft lip with or without cleft palate. Non-syndromic cleft lip, with or without cleft palate (NSCL/P) is a common craniofacial birth defect, characterised by an incomplete separation between nasal and oral cavities without any other congenital anomaly in humans. Several genes which play a role in cell differentiation, migration, growth and apoptosis, have been associated with clefting. The purpose of this study

2015 International Journal of Pediatric Otorhinolaryngology

329. GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk Full Text available with Trip Pro

GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk The transforming growth factor alpha (TGFA) Taq I polymorphism has been indicated to be correlated with cleft lip with or without cleft palate (CL/P) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted. We conducted a comprehensive search of Embase, Ovid, Web of Science, the Cochrane database, PubMed, the Chinese Biomedical Literature Database (CBM-disc, 1979-2014), the database (...) and CL/P risk (OR = 1.52; 95% CI 1.14-2.02; P = 0.004). However, no significant association was found between this his polymorphism and CL/P risk in African and Hispanic populations. According to a specific CL/P type, increased clip lip and palate risk and clip palate risk were found (OR = 1.38; 95% CI 1.10-1.73; P = 0.005; OR = 1.29; 95% CI 1.01-1.66; P = 0.042). In conclusion, the present meta-analysis found that the TGFA Taq I polymorphism may be associated with CL/P susceptibility.

2015 International journal of clinical and experimental medicine

330. Comparing caries risk profiles between 5- and 10- year-old children with cleft lip and/or palate and non-cleft controls. Full Text available with Trip Pro

Comparing caries risk profiles between 5- and 10- year-old children with cleft lip and/or palate and non-cleft controls. Previous studies have suggested that children with oral clefts may have higher caries prevalence in comparison with non-cleft controls but the relative importance of the potential risk factors is not clear. The aim of this study was to compare the caries risk profiles in a group of cleft lip and/or palate (CL(P)) children with non-cleft controls in the same age using (...) a computerized caries risk assessment model.The study group consisted of 133 children with CL(P) (77 subjects aged 5 years and 56 aged 10 years) and 297 non-cleft controls (133 aged 5 years and 164 aged 10 years). A questionnaire was used to collect data concerning the child's oral hygiene routines, dietary habits and fluoride exposure. Oral hygiene was assessed using Quigley-Hein plaque Index and the caries prevalence and frequency was scored according to the International Caries Detection and Assessment

2015 BMC Oral Health

331. CLEFT-Q: Detecting Differences in Outcomes among 2434 Patients with Varying Cleft Types. (Abstract)

CLEFT-Q: Detecting Differences in Outcomes among 2434 Patients with Varying Cleft Types. Measuring the patient perspective is important in evaluating outcomes of cleft care. Understanding how treatment outcomes vary depending on cleft type may allow for better planning of treatments, setting of expectations, and more accurate benchmarking efforts. The CLEFT-Q is a patient-reported outcome measure for patients with cleft lip and/or palate.The 12 CLEFT-Q scales measuring appearance (i.e., face (...) , nose, nostrils, lips, cleft lip scar, teeth, and jaws), function (i.e., speech), and health-related quality of life (i.e., psychological, school, social, and speech-related distress) were field tested in a cross-sectional study in 30 centers in 12 countries. Patients with cleft lip and/or cleft palate aged 8 to 29 years were recruited from clinical settings. Differences in CLEFT-Q scores by cleft subtypes were evaluated using one-way analysis of variance or Kruskal-Wallis H tests, with Tukey

2019 Plastic and reconstructive surgery

332. The dental health of cleft patients attending the 18-month-old clinic at a specialised cleft centre. (Abstract)

The dental health of cleft patients attending the 18-month-old clinic at a specialised cleft centre. Background Cleft lip and/or palate (CLP) patients are at high risk of developing dental caries and show a greater prevalence of dental defects.Aims To establish if CLP patients who attended the 18-month clinic had local dentists, were complying with oral hygiene instruction and had stopped bottle-feeding as per guidelines.Design Data were collected retrospectively over a 24-month period in which (...) proportions of parents/carers were not following national guidelines for prevention. This evaluation highlights that shared preventive support between primary care dentists and specialist cleft dentists is not being achieved in the majority of cases. It also recognises that parents of CLP patients are either not receiving, or are failing to implement, preventive care advice.

2019 British Dental Journal

333. Postoperative long-term results for the comparison of the symmetry of the upper lip during lip closure according to Millard and Pfeifer Full Text available with Trip Pro

Postoperative long-term results for the comparison of the symmetry of the upper lip during lip closure according to Millard and Pfeifer Clefts in newborns are associated with severe morphological and functional impairment. Especially the lip is of importance as if the treatment result is unsatisfactory, it can lead to psychological changes in the patient. Different operative procedures have been developed over the last decades. The aim of the presented study was the comparison of the surgical (...) on postoperative results.The development of the vertical symmetry of the Philtrum and the lip vermillion on the cleft side in comparison to the healthy side behaves differently depending on Pfeifer and Millard. The lip height of the cleft lip was shorter in both techniques than on the healthy side, but Pfeifer's difference was significantly more pronounced. The lip vermillion height on the cleft side was slightly shorter in the Millard group and markedly larger in the Pfeifer group. Both techniques can achieve

2018 Maxillofacial Plastic and Reconstructive Surgery

334. Efficacy of bioactive proteins in cleft lip and palate defects: systematic review and meta-analysis

Efficacy of bioactive proteins in cleft lip and palate defects: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web

2017 PROSPERO

335. Quality of life in cleft lip and/or palate patients submitted to orthodontic treatment: a systematic review

Quality of life in cleft lip and/or palate patients submitted to orthodontic treatment: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation

2017 PROSPERO

336. Relation between soft tissue and skeletal changes after maxillary advancement surgery in cleft-lip and palate patients

Relation between soft tissue and skeletal changes after maxillary advancement surgery in cleft-lip and palate patients Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2017 PROSPERO

337. Speech processing difficulties in children born with cleft lip and/or palate: a systematic review

Speech processing difficulties in children born with cleft lip and/or palate: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2017 PROSPERO

338. Comparison of three-dimensional changes of nasal soft tissue and the maxillary arch in patients with bilateral cleft lip and palate treated with presurgical orthopedic therapy. Systematic review

Comparison of three-dimensional changes of nasal soft tissue and the maxillary arch in patients with bilateral cleft lip and palate treated with presurgical orthopedic therapy. Systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2017 PROSPERO

339. ABM Clinical Protocol #18: Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate, Revised 2013 Full Text available with Trip Pro

ABM Clinical Protocol #18: Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate, Revised 2013 A central goal of the Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations

2013 Breastfeeding Medicine

340. Alveolar Bone Grafting With rhBMP2 may Benefit Patients Undergoing Surgical Correction of Cleft Lip/Palate

Alveolar Bone Grafting With rhBMP2 may Benefit Patients Undergoing Surgical Correction of Cleft Lip/Palate UTCAT2158, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Alveolar Bone Grafting With rhBMP2 May Benefit Patients Undergoing Surgical Correction of Cleft Lip/Palate Clinical Question In Cleft lip/palate patients with alveolar clefting, does the use of rhBMP2 for secondary grafting provide as good or better (...) outcomes compared to autogenous grafting from the iliac crest? Clinical Bottom Line The use of rhBMP-2 could be a promising alternative to autogenous iliac crest grafting for secondary bone alveolar cleft grafts in children with cleft lip/palate. (See Comments on the CAT below) Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Dickinson/2008 Adolescents with alveolar clefting Randomized Controlled Trial Key

2011 UTHSCSA Dental School CAT Library

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