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Cleft Lip

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281. FOXE1 Mutation Screening in a Case with Cleft Lip, Hypothyroidism, and Thyroid Carcinoma: A New Syndrome? (PubMed)

FOXE1 Mutation Screening in a Case with Cleft Lip, Hypothyroidism, and Thyroid Carcinoma: A New Syndrome? A 26-year-old woman is referred to the Internal Medicine consultation due to increases in laboratory studies associated with Papillary Thyroid Carcinoma (PTC) that was confirmed by histopathological studies. Her clinical history revealed that, at 3 months of age, she was successfully treated with surgery for cleft lip (CL) and at the age of 24 years was diagnosed with hypothyroidism. Single (...) nucleotide polymorphisms (SNPs) in FOXE1 and its promoter regions have been associated with various etiologies related to the thyroid, including orofacial clefting, specially cleft palate (CP) and CL, hypothyroidism (HT), and thyroid cancer. The association of CL, HT, and PTC might be component of a new syndrome; however FOXE1 coding region, which has been involved with these entities, has not exhibited mutations or SNPs. Further study of other genes may help in better characterization of the possible

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2017 Case Reports in Genetics

282. Cephalometric Soft Tissue Characteristics of Unilateral Cleft Lip and Palate Patients in Relation to Missing Teeth (PubMed)

Cephalometric Soft Tissue Characteristics of Unilateral Cleft Lip and Palate Patients in Relation to Missing Teeth This study aimed to evaluate cephalometric soft tissue characteristics in individuals with unilateral complete cleft lip and palate (UCCLP) both with and without missing teeth.A retrospective investigation of patient records, who are being treated at the cleft lip and palate (CLP) clinics at the College of Dentistry. Ninety-six consecutive records of nonsyndromic UCCLP subjects (...) the two groups.In subjects with a UCCLP anomaly, missing teeth have an effect on lower lip position and length, which influenced the mentolabial sulcus. Lower lip position and length differ between cleft patients who present with either multiple missing teeth or with no missing teeth, and this needs to be considered during orthodontic treatment planning and surgical management for the cleft defect.

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2017 BioMed research international

283. Nasal Duplication Combined with Cleft Lip and Palate: Surgical Correction and Long-Term Follow-Up (PubMed)

Nasal Duplication Combined with Cleft Lip and Palate: Surgical Correction and Long-Term Follow-Up Diprosopus dirrhinus, or nasal duplication, is a rare entity of partial craniofacial duplication.The case we present is the first report of diprosopus dirrhinus associated with complete cleft lip and palate. The baby was born in Cambodia at full term by normal vaginal delivery with no significant perinatal and family history. Physical examination revealed significant facial deformity due (...) to the duplicated nose and the left complete cleft lip/palate on the right subset.There were 4 nostrils; both medial apertures including the cleft site were found to be 10-15 mm deep cul-de-sac structures without communication to the nasopharynx. The upper third of the face was notable for hypertelorism with a duplication of the soft-tissue nasion and glabella. Between the 2 nasal dorsums, there was a small cutaneous depression with a lacrimal fistula in the midline. Surgical treatment included the first stage

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2017 Plastic and Reconstructive Surgery Global Open

284. Early Cleft Lip Repair Revisited: A Safe and Effective Approach Utilizing a Multidisciplinary Protocol (PubMed)

Early Cleft Lip Repair Revisited: A Safe and Effective Approach Utilizing a Multidisciplinary Protocol The optimal timing for cleft lip repair has yet to be established. Advances in neonatal anesthesia, along with a growing body of literature, suggesting benefits of earlier cleft lip and nasal repair, have set the stage for a reexamination of current practices.In this prospective study, cleft lip and nasal repair occurred on average at 34.8 days (13-69 days). Nasal correction was achieved (...) present evidence that early cleft lip and nasal repair can be performed safely and is effective at improving nasal symmetry without the placement of any nasal sutures. Utilization of this protocol has the potential to be a paradigm shift in the treatment of cleft lip and nasal deformity.

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2017 Plastic and Reconstructive Surgery Global Open

285. A Population-Based Exploration of the Social Implications Associated with Cleft Lip and/or Palate (PubMed)

A Population-Based Exploration of the Social Implications Associated with Cleft Lip and/or Palate Clefts of the lip and/or palate (CL/P) carry a social stigma that often causes psychosocial stress. The purpose of this study was to consider the association of cleft phenotype and age with self-reported aspects of psychosocial stress.Children with nonsyndromic CL/P and unaffected children born between 1997 and 2003 were identified through the North Carolina Birth Defects Monitoring Program (...) and North Carolina birth records, respectively. The psychosocial concerns of children with CL/P were assessed via a 29-question subset of a larger survey. Responses were analyzed according to school age and cleft phenotype (cleft lip with/without cleft alveolus, CL ± A; cleft palate only, CP; or cleft lip with cleft palate, CL + P).Surveys were returned for 176 children with CL/P and 333 unaffected children. When compared with unaffected children, responses differed for CL ± A in 4/29 questions, for CP

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2017 Plastic and Reconstructive Surgery Global Open

286. Facial Aesthetics in Young Adults after Cleft Lip and Palate Treatment over Five Decades (PubMed)

Facial Aesthetics in Young Adults after Cleft Lip and Palate Treatment over Five Decades Cleft Lip and Palate (CLP) - a common facial malformation in newborns - is typically corrected by surgical intervention to allow for normal speech development, psychosocial adjustment, and facial attractiveness. The long term treatment outcome can be evaluated after a number of years, possibly in adulthood. We investigated the aesthetics of the nasolabial region by subjective ratings. To compare various

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2017 Scientific reports

287. Fordyce Happiness Program and Performance for Mothers of Children with Cleft Lip and Palate Referring Healthcare Team in Isfahan University of Medical Sciences in 2015. (PubMed)

Fordyce Happiness Program and Performance for Mothers of Children with Cleft Lip and Palate Referring Healthcare Team in Isfahan University of Medical Sciences in 2015. The present study was conducted to investigate the effect of happiness program on performance for mothers of children with cleft lip and palate.In this semi experimental study, 64 mothers of children with cleft lip and palate referring healthcare team in Isfahan University of Medical Sciences, Iran were enrolled by simple random (...) , the control group had no significant change.Given the effect of happiness, program in promoting mothers performance for children with cleft lip and palate, this program can be used in healthcare centers to empower mothers and enhance performance in taking care of children.

2017 Iranian journal of child neurology Controlled trial quality: uncertain

288. Speech outcome in young children born with unilateral cleft lip and palate treated with one- or two-stage palatal repair and the impact of early intervention. (PubMed)

Speech outcome in young children born with unilateral cleft lip and palate treated with one- or two-stage palatal repair and the impact of early intervention. The aim of this study was to describe speech at 1, 1;6 and 3 years of age in children born with unilateral cleft lip and palate (UCLP) and relate the findings to operation method and amount of early intervention received.A prospective trial of children born with UCLP operated with a one-stage (OS) palatal repair at 12 months or a two (...) -stage repair (TS) with soft palate closure at 3-4 months and hard palate closure at 12 months was undertaken (Scandcleft). At 1 and 1;6 years the place and manner of articulation and number of different consonants produced in babbling were reported in 33 children. At three years of age percentage consonants correct adjusted for age (PCC-A) and cleft speech errors were assessed in 26 of the 33 children. Early intervention was not provided as part of the trial but according to the clinical routine

2017 Logopedics, phoniatrics, vocology Controlled trial quality: uncertain

289. Three-Dimensional Upper Lip and Nostril Sill Changes After Cleft Alveolus Reconstruction Using Autologous Bone Grafting Versus Recombinant Human Bone Morphogenetic Protein-2. (PubMed)

Three-Dimensional Upper Lip and Nostril Sill Changes After Cleft Alveolus Reconstruction Using Autologous Bone Grafting Versus Recombinant Human Bone Morphogenetic Protein-2. Cleft alveolus in patients with unilateral complete cleft lip and palate has been alternatively reconstructed with recombinant human bone morphogenetic protein (rhBMP)-2. However, its effects on upper lip and nostril sill anatomy are not known. Thus, the objective of this investigation was to assess and compare upper lip (...) of the upper lip and nostril sill regions. Inter- and intragroup data of the pre and postoperative reformatted CT measurements of the upper lip and nostril sill regions did not show differences (P >0.05) in cutaneous upper lip height and projection, nostril sill elevation, and subnasale projection. There were no significant upper lip and nostril sill anatomical changes after cleft alveolus reconstruction using autologous bone grafting and rhBMP-2.

2017 The Journal of craniofacial surgery Controlled trial quality: uncertain

290. Is Early Nasal Shaping With a Limited Alar Base Incision Possible in the Repair of Cleft Lips? (PubMed)

Is Early Nasal Shaping With a Limited Alar Base Incision Possible in the Repair of Cleft Lips? The repair of cleft lips has an important place in plastic and reconstructive surgery. In the treatment of these deformities, the aim was to restore the normal lip morphology in the cleft area as well as repairing any coexisting nasal deformities. Various methods are in use for this purpose. One of the most commonly employed surgical methods is Millard repair. However, this method may lead (...) dissection performed in patients with cleft lips is an alternative method that can be employed in a wide range of patients.

2017 The Journal of craniofacial surgery Controlled trial quality: uncertain

291. The Effect of Happiness Training Based on Fordyce Model on Perceived Stress in the Mothers of Children with Cleft Lip and Palate (PubMed)

The Effect of Happiness Training Based on Fordyce Model on Perceived Stress in the Mothers of Children with Cleft Lip and Palate Introduction: A child afflicted with facial deformities such as cleft lip and palate usually affects their parents, because of difficulties in nutrition, speech, aesthetics and social connections, and also imposing a lot of stress on them. The aim of this study was to investigate the effects of a happiness program on the perceived stress in the mothers of children (...) with cleft lip and palate. Methods: This study was a quasi-experimental study in which 64 mothers of children with cleft lip and palate were divided by simple random sampling into intervention and control groups (n=64). The program of happiness training was implemented within 10 sessions and the questionnaires of demographics and Cohen perceived stress were filled out prior to and two months after the last session in intervention group. Data analysis was done using SPSS Ver.13. Results: Independent t

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2017 Journal of caring sciences Controlled trial quality: uncertain

292. The effect of happiness training on self-esteem in the mothers of children with cleft lip and palate in Isfahan 2015 (PubMed)

The effect of happiness training on self-esteem in the mothers of children with cleft lip and palate in Isfahan 2015 Birth of a child with cleft lip and palate, as a crisis, can affect family relationships and interactions seriously and hence self-esteem in family members. The present study was conducted to investigate the effect of a happiness training program on self-esteem in the mothers of children with cleft lip and palate.In this quasi-experimental study, 64 mothers of children with cleft (...) in the intervention group.In the light of the effect of happiness training on the promotion of self-esteem in children with cleft lip and palate, this program can be used as a care intervention to reduce psychological and mental problems and to enhance adjustment in parents.

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2017 Journal of education and health promotion Controlled trial quality: uncertain

293. Long-term effect of presurgical nasoalveolar molding on growth of maxillary arch in unilateral cleft lip and palate: randomized controlled trial. (PubMed)

Long-term effect of presurgical nasoalveolar molding on growth of maxillary arch in unilateral cleft lip and palate: randomized controlled trial. The objective of this study was to investigate the long-term effect of presurgical nasoalveolar molding (PNAM) on growth of the maxillary arch through early childhood until 6 years of age in complete unilateral cleft lip and palate (UCLP) patients presenting for PNAM at different ages. Complete UCLP patients who were treated at our centre were divided

2017 International Journal of Oral and Maxillofacial Surgery Controlled trial quality: uncertain

294. Evaluating the Use of Cleft Lip and Palate 3D-Printed Models as a Teaching Aid. (PubMed)

Evaluating the Use of Cleft Lip and Palate 3D-Printed Models as a Teaching Aid. Visualization tools are essential for effective medical education, to aid students understanding of complex anatomical systems. Three dimensional (3D) printed models are showing a wide-reaching potential in the field of medical education, to aid the interpretation of 2D imaging. This study investigates the use of 3D-printed models in educational seminars on cleft lip and palate, by comparing integrated "hands (...) was the test group, with the same PowerPoint presentation, but with the addition of a physical demonstration using 3D-printed models of unilateral and bilateral cleft lips and palate.The level of knowledge gained was established using a preseminar and postseminar assessment, in 2 different institutions, where the addition of the 3D-printed model resulted in a significant improvement in the mean percentage of knowledge gained (44.65% test group; 32.16%; control group; p = 0.038). Student experience

2017 Journal of Surgical Education Controlled trial quality: uncertain

295. The NAM (Nasal Alveolar Molding)appliance is effective in providing symmetrical nasal outcomes in complete unilateral cleft lip and palate.

The NAM (Nasal Alveolar Molding)appliance is effective in providing symmetrical nasal outcomes in complete unilateral cleft lip and palate. UTCAT2588, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title The NAM (Nasal Alveolar Molding)appliance is effective in providing symmetrical nasal outcomes in complete unilateral cleft lip and palate. Clinical Question Does pre-surgical nasal molding with NAM appliance improve nasal (...) symmetry in complete unilateral cleft lip and palate patients compared to surgery alone? Clinical Bottom Line Pre-surgical nasal molding with an NAM appliance can improve nostril symmetry in complete unilateral cleft lip and palate patients when compared to surgery alone. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Williams/2012 28 nasal molding cases and 14 control cases Comparative study Key results

2013 UTHSCSA Dental School CAT Library

296. Periodontal Status Among Patients With Cleft Lip (CL), Cleft Palate (CP) and Cleft Lip, Alveolus and Palate (CLAP) In Chennai, India. A Comparative Study (PubMed)

Periodontal Status Among Patients With Cleft Lip (CL), Cleft Palate (CP) and Cleft Lip, Alveolus and Palate (CLAP) In Chennai, India. A Comparative Study Long term health of the stomatognathic system as well as esthetic aspects is the therapeutic goals in patients with oro facial clefts.The aim of this study was to assess and compare the periodontal status of patients with cleft lip (CL), cleft palate (CP) and cleft lip, alveolus and palate (CLAP) reporting to a hospital in Chennai, India.The (...) study group consisted of 80 cleft patients. Subjects were divided into three groups. Group 1: patients with cleft lip (CL), Group 2: subjects with cleft palate (CP) and Group 3: subjects with cleft lip alveolus and palate (CLAP). Community Periodontal Index for Treatment needs CPITN Index was recorded.Among the 80 study subjects, 51 (63.8%) were males and 29 (36.2%) were females. Among the 26 study subjects with cleft lip, 10 (38.5%) had healthy periodontium, 4 (15.4%) had bleeding on probing and 12

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2015 Journal of clinical and diagnostic research : JCDR

297. Infraorbital nerve block for postoperative pain following cleft lip repair in children

Infraorbital nerve block for postoperative pain following cleft lip repair in children Infraorbital nerve block for postop pain following cleft lip repair Search National Elf Service Search National Elf Service » » » » Infraorbital nerve block for postoperative pain following cleft lip repair in children Apr 22 2016 Posted by Cleft lip is one of the most common craniofacial birth defects and requires early correction. It can be carried out during the neonatal period or earlier although timing (...) depends on the type and severity of the deformity, the child’s health and other factors. Pain postoperatively can be a problem and result in psychological, cardiorespiratory, and metabolic issues. The aim of this Cochrane Review was to assess the effects of infraorbital nerve block for postoperative pain following cleft lip repair in children. Methods Searches were conducted in the Cochrane Central Register of Controlled Trials (CENTRAL) , Medline, Embase, LILACS, the metaRegister of Controlled Trials

2016 The Dental Elf

298. Distraction osteogenesis or orthognathic surgery for hypoplastic maxilla in cleft lip and palate

Distraction osteogenesis or orthognathic surgery for hypoplastic maxilla in cleft lip and palate Distraction osteogenesis or orthognathic surgery for hypoplastic maxilla in cleft lip and palate - National Elf Service Search National Elf Service Search National Elf Service » » » » Distraction osteogenesis or orthognathic surgery for hypoplastic maxilla in cleft lip and palate Oct 11 2016 Posted by Cleft lip and palate (CLP) is a common birth defect with a global prevalence of between 1 in 5-700 (...) osteogenesis compared to orthognathic surgery for the treatment of hypoplastic maxilla in people with cleft lip and palate. Method Searches were conducted in the Cochrane Oral Health’s Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, LILACS, ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry databases with no language restrictions. Randomised controlled trials (RCTs) comparing maxillary distraction osteogenesis

2016 The Dental Elf

299. No Current Evidence to Suggest That Teeth Closer To A Surgically Corrected Cleft Lip And Palate Are At Increased Risk For Periodontitis

No Current Evidence to Suggest That Teeth Closer To A Surgically Corrected Cleft Lip And Palate Are At Increased Risk For Periodontitis UTCAT2147, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title No Current Evidence to Suggest That Teeth Closer To A Surgically Corrected Cleft Lip And Palate Are At Increased Risk For Periodontitis Clinical Question Do teeth in close approximation of a surgically corrected cleft palate (...) have a higher risk of periodontitis than other teeth in a patient’s mouth? Clinical Bottom Line The cleft areas do not present a higher prevalence or severity of periodontal pockets and clinical attachment loss than the other areas of their mouth. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) de Almeida/2009 400 Patients with complete cleft lip and palate Cross-Sectional Key results Comparison

2011 UTHSCSA Dental School CAT Library

300. Alveolar Bone Grafting With rhBMP2 may Benefit Patients Undergoing Surgical Correction of Cleft Lip/Palate

Alveolar Bone Grafting With rhBMP2 may Benefit Patients Undergoing Surgical Correction of Cleft Lip/Palate UTCAT2158, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Alveolar Bone Grafting With rhBMP2 May Benefit Patients Undergoing Surgical Correction of Cleft Lip/Palate Clinical Question In Cleft lip/palate patients with alveolar clefting, does the use of rhBMP2 for secondary grafting provide as good or better (...) outcomes compared to autogenous grafting from the iliac crest? Clinical Bottom Line The use of rhBMP-2 could be a promising alternative to autogenous iliac crest grafting for secondary bone alveolar cleft grafts in children with cleft lip/palate. (See Comments on the CAT below) Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Dickinson/2008 Adolescents with alveolar clefting Randomized Controlled Trial Key

2011 UTHSCSA Dental School CAT Library

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