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Cleft Lip

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2761. Structure and function of the superior temporal plane in adult males with cleft lip and palate: pathologic enlargement with no relationship to childhood hearing deficits. (Abstract)

Structure and function of the superior temporal plane in adult males with cleft lip and palate: pathologic enlargement with no relationship to childhood hearing deficits. In a previous study from our lab, adult males with non-syndromic cleft lip and/or palate (NSCLP) were shown to have significantly lower temporal lobe gray matter volume than matched controls. The current study was designed to begin a regional analysis of specific subregions of the temporal lobe. The superior temporal plane

2006 Journal of Child Psychology and Psychiatry

2762. Postoperative pain control for primary cleft lip repair in infants: is there an advantage in performing peripheral nerve blocks? (Abstract)

Postoperative pain control for primary cleft lip repair in infants: is there an advantage in performing peripheral nerve blocks? Primary cleft lip repair is performed in infants under 1 year of age. The efficacy of an infraorbital nerve block vs intravenous fentanyl was compared in our prospective, randomized controlled trial.Forty-six infants scheduled for primary cleft lip repair were prospectively randomized to one of two groups: group F that received 2 mcg x kg(-1) of fentanyl intravenously (...) differences in feeding volumes between groups in the PACU (P = 0.46), SSU (P = 0.57) and at home (P = 0.15). There were no differences in time to initiate feeding between the two groups (P = 0.81). However, there was difficulty with feeding in the block groups compared with the fentanyl group (P = 0.01).The infraorbital nerve block can be effectively used for pain control in infants undergoing primary cleft lip repair. Although children undergoing a nerve block experienced minor difficulties in feeding

2008 Paediatric anaesthesia Controlled trial quality: uncertain

2763. Vertical changes in patients with complete unilateral and bilateral cleft lip, alveolus and palate. (Abstract)

Vertical changes in patients with complete unilateral and bilateral cleft lip, alveolus and palate. Twelve UCLP and eleven BCLP patients who had been treated according to the Hanover treatment protocol were evaluated by means of cephalometric analysis and cast measurements. The aim of this investigation was to demonstrate changes in the vertical plane and in incisor position in the course of craniofacial growth compared to age-matched non-cleft controls. Lateral cephalograms and casts were (...) analyzed for each cleft patient at age 10 and 15 and compared with corresponding data of a non-cleft control group (n = 20).A vertical growth impairment of the maxilla was registered in patients with cleft lip, alveolus and palate. The maxilla of the cleft patients showed a significant clockwise rotation while the inclination of the mandible remained virtually unchanged. Both upper and lower incisors, which were significantly retruded at the beginning of the late mixed dentition, could be protruded

2004 Journal of orofacial orthopedics = Fortschritte der Kieferorthopädie : Organ/official journal Deutsche Gesellschaft für Kieferorthopädie Controlled trial quality: uncertain

2764. The effect of infant orthopedics on the occlusion of the deciduous dentition in children with complete unilateral cleft lip and palate (Dutchcleft). (Full text)

The effect of infant orthopedics on the occlusion of the deciduous dentition in children with complete unilateral cleft lip and palate (Dutchcleft). Evaluation of the effect of infant orthopedics (IO) on the occlusion of the deciduous dentition in patients with unilateral cleft lip and palate (UCLP).Prospective, two-arm, randomized, controlled clinical trial with three participating cleft palate centers (Dutchcleft).Cleft Palate Centers of the University Medical Center Nijmegen, Academic Center

2004 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Controlled trial quality: uncertain PubMed abstract

2765. Cost-effectiveness of infant orthopedic treatment regarding speech in patients with complete unilateral cleft lip and palate: a randomized three-center trial in the Netherlands (Dutchcleft). (Full text)

Cost-effectiveness of infant orthopedic treatment regarding speech in patients with complete unilateral cleft lip and palate: a randomized three-center trial in the Netherlands (Dutchcleft). To investigate the cost-effectiveness of infant orthopedic treatment (IO), compared with no such treatment in children with complete unilateral cleft lip and palate (UCLP) focusing on the effects on speech development at age 2.5 years.In a three-center prospective, randomized clinical trial (Dutchcleft

2004 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Controlled trial quality: uncertain PubMed abstract

2766. Monosomy and trisomy of 15q24-qter with cleft lip and palate. (Abstract)

Monosomy and trisomy of 15q24-qter with cleft lip and palate. Chromosome 15 aberrations clinically present as facial dysmorphisms such as a prominent nose, low-set ears, micrognathia and a short neck; a cleft lip and palate have not been reported. This is the first reported case of de-novo terminal deletion at 15q24 with a cleft lip and palate and low-set ears. The baby boy had a complete cleft lip and palate on the left side and incomplete cleft lip and palate on the right. A chromosomal study (...) revealed partial monosomy and trisomy of the long arm of chromosome 15, with a karyotype of 46,XY,add(15)(24q) de novo. Surgery for lip plasty was performed at 6 months old and for palate plasty at 1 year and 9 months. Both operations were uneventful, although preoperative and postoperative examinations showed high creatinine phosphokinase values. At 3 years old, mild mental retardation was observed, but his physical development was normal.

2008 International Journal of Oral and Maxillofacial Surgery

2767. Morbidity of iliac crest donor site following open bone harvesting in cleft lip and palate patients. (Abstract)

Morbidity of iliac crest donor site following open bone harvesting in cleft lip and palate patients. The aim of this prospective study was to assess donor site morbidity associated with open iliac crest bone harvesting to graft secondary alveolar clefts. At a university teaching hospital, 64 Jordanian patients underwent secondary alveolar bone grafting with iliac crest bone harvest. The same standardized surgical technique was used over a 6-year period by a single maxillofacial surgeon

2008 International Journal of Oral and Maxillofacial Surgery

2768. Unraveling Human Cleft Lip and Palate Research. (Abstract)

Unraveling Human Cleft Lip and Palate Research. The focus of this work is to highlight the most recent advances in the understanding of cleft lip and palate occurrence. Information regarding research on long-term outcomes, genes and their interactions with other genes, and gene-environment interactions is compiled to provide the reader with a critical and up-to-date overview on the current knowledge of the etiology of cleft lip and palate. Recent epidemiological evidence strongly suggests (...) that individuals born with clefts have a shorter lifespan and may have a higher incidence of cancer and psychological disorders. IRF6 has been shown to be an important contributor to cleft lip and palate, but the functional variant leading to the defect has not yet been defined. Inactivation of MSX1 and genes in the FGF family has also been shown to lead to cleft lip and palate. In addition, missense mutations in several candidate genes may cause cleft lip and palate, but definitive evidence regarding

2008 Journal of Dental Research

2769. More caries in primary teeth of children who have cleft lip and palate. (Full text)

More caries in primary teeth of children who have cleft lip and palate. 18158544 2008 02 04 2007 12 25 1476-5446 8 4 2007 Evidence-based dentistry Evid Based Dent More caries in primary teeth of children who have cleft lip and palate. Do children who have cleft lip and palate have elevated caries levels in the primary and permanent dentition? 106 O'Neill Julian J Orthodontic Department, Kettering General Hospital NHS Trust, Kettering, Northamptonshire, UK. eng Comment Journal Article England

2007 Evidence Based Dentistry PubMed abstract

2770. Assessment of growth and feeding practices in children with cleft lip and palate. (Abstract)

Assessment of growth and feeding practices in children with cleft lip and palate. Feeding difficulties in cleft lip and palate (CLP) infants is commonly observed and is the most traumatic experience the family has to face. These infants are undernourished and have compromised growth. The purpose of this study was to 1) assess general health and growth parameters in children with CLP and in normal children; and 2) investigate the feeding methods of CLP infants and normal infants. A total of 221

2005 Southeast Asian Journal of Tropical Medicine and Public Health

2771. FGF signalling and SUMO modification: new players in the aetiology of cleft lip and/or palate. (Abstract)

FGF signalling and SUMO modification: new players in the aetiology of cleft lip and/or palate. Owing to the complex aetiology and the variable penetrance of cleft lip and/or palate (CL/P), understanding the molecular basis has been challenging. Recent reports have identified two independent biochemical pathways that will help to elucidate the underlying pathology. Fibroblast growth factor signalling, previously known for its involvement in craniofacial development, is now implicated (...) in the genetic basis of both syndromic and non-syndromic CL/P. At the same time, an important role in lip and palate development is beginning to emerge for small ubiquitin-like modifier modification, a widely used posttranslational regulatory mechanism. Both of these pathways might interact with environmental risk factors for CL/P. Here we review their contribution to normal and abnormal orofacial development.

2007 Trends in Genetics

2772. Cephalometric evaluation of long-term craniofacial development in unilateral cleft lip and palate patients treated with delayed hard palate closure. (Abstract)

Cephalometric evaluation of long-term craniofacial development in unilateral cleft lip and palate patients treated with delayed hard palate closure. This long-term cephalometric study aimed to evaluate the craniofacial development of patients with a complete unilateral cleft lip and palate treated with a two-stage palatal closure, including delayed closure of the hard palate. Prediction models for cephalometric outcome at age 18 years were developed with the help of cephalometric values at 9 (...) and 12 years. The objective need for surgery at age 18 was predicted from cephalometric values at age 9. Cephalograms of 43 consecutive patients with a complete unilateral cleft lip and palate were analysed at 9, 12 and 18 years. The patient group showed a retrusive craniofacial growth pattern for the maxilla and mandible, and a rather vertical growth pattern for the lower face. Using multiple linear regression, for most cephalometric variables, 40-80% of the cephalometric values at early adulthood

2007 International Journal of Oral and Maxillofacial Surgery

2773. Abnormal brain structure in children with isolated clefts of the lip or palate. (Full text)

Abnormal brain structure in children with isolated clefts of the lip or palate. To evaluate brain structure in a sample of children with isolated clefts of the lip and/or palate (ICLP).Case-control study.Tertiary care center.A large sample of 74 children aged 7 to 17 years with ICLP was compared with a healthy control group, matched by age and sex.Isolated cleft lip and/or palate.General measures of height and head circumference were obtained. Brain structure was evaluated using magnetic

2007 Archives of Pediatrics & Adolescent Medicine PubMed abstract

2774. What are the occlusal outcomes for unilateral cleft lip and palate patients? A national project in the UK. (Full text)

What are the occlusal outcomes for unilateral cleft lip and palate patients? A national project in the UK. This national project assessed the orthodontic outcome for unilateral cleft lip and palate (UCLP) patients in the UK.Six consecutively treated fixed appliance cases where orthognathic surgery was not undertaken were assessed using the peer assessment rating (PAR) index on orthodontic study models. These cases were submitted by NHS consultant orthodontists undertaking treatment on patients (...) with cleft lip and/or palate.UK NHS consultant-led hospital service.The mean reduction in PAR score was 69% + or - 22. The mean start PAR score was 41 + or - 11. The mean end of treatment PAR was 12 + or - 9. The proportion of cases where the score was worse or no different was 7.5%.The mean percentage PAR reduction compares well with other national projects looking at outcome from patients treated in the hospital service. The mean PAR reduction could be used as a benchmark for outcome in UCLP

2007 British Dental Journal PubMed abstract

2775. Satisfaction with treatment outcome in bilateral cleft lip and palate patients. (Abstract)

Satisfaction with treatment outcome in bilateral cleft lip and palate patients. The aim of this case-controlled study was to assess satisfaction with facial appearance and function, and health-related quality of life (HRQL) in bilateral cleft lip and palate patients (BCLP). The study sample was composed of adult BCLP subjects and controls matched for age, gender and socioeconomic status. Outcome measures included a self-administered questionnaire evaluating satisfaction with facial appearance (...) , function and HRQL. Bivariate statistics were computed to analyse the association between BCLP status and outcome measures. Forty-three treated adult BCLP patients (mean age 28.2 years, SD 7.8) were compared to 43 controls without clefts (mean age 28.5 years, SD 8.0). Quantitative and qualitative assessment revealed that BCLP patients were significantly less satisfied with the appearance of the upper lip, the nose and nasal breathing. Additionally, satisfaction with facial appearance correlated

2007 International Journal of Oral and Maxillofacial Surgery

2776. An analysis of quality of life in 130 families having small children with cleft lip/palate using the impact on family scale. (Abstract)

An analysis of quality of life in 130 families having small children with cleft lip/palate using the impact on family scale. Most parents are emotionally traumatized when confronted by the birth of a baby with an orofacial cleft (OFC). Affected families may have to compensate for increased financial, social and personal impacts before primary treatment is completed. This study was conducted to identify factors influencing the quality of life (QoL) of families having young children with OFC (...) . A self-administered questionnaire containing the impact on family scale was applied in 130 consecutive families having children with OFC aged between 6 and 24 months. The results were related to the type of cleft and the time of initial diagnosis using non-parametric tests and multivariate correlation analysis (P<0.05). In families having children with isolated cleft lip, financial and social impacts were reduced, but problems in coping were increased when compared to families with children having

2007 International Journal of Oral and Maxillofacial Surgery

2777. Identification of novel candidate genes associated with cleft lip and palate using array comparative genomic hybridization. (Full text)

Identification of novel candidate genes associated with cleft lip and palate using array comparative genomic hybridization. We analysed DNA samples isolated from individuals born with cleft lip and cleft palate to identify deletions and duplications of candidate gene loci using array comparative genomic hybridisation (array-CGH).Of 83 syndromic cases analysed we identified one subject with a previously unknown 2.7 Mb deletion at 22q11.21 coinciding with the DiGeorge syndrome region. Eighteen (...) from the mother, who also has a cleft lip. These deletions appear likely to be causally associated with the phenotypes of the subjects. Estrogen receptor 1 (ESR1) and fibroblast growth factor receptor 2 (FGFR2) genes from the 6q25.1-25.2 and 10q26.11-26.13, respectively, were identified as likely causative genes using a gene prioritization software.We have shown that array-CGH analysis of DNA samples derived from cleft lip and palate subjects is an efficient and productive method for identifying

2007 Journal of Medical Genetics PubMed abstract

2778. Analysis of polymorphic TGFB1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. (Full text)

Analysis of polymorphic TGFB1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. Clefts of the lip, alveolus, and palate (CLPs) rank among the most frequent and significant congenital malformations. Leu10Pro and Arg25Pro polymorphisms in the precursor region and Thr263Ile polymorphism in the prodomain of the transforming growth factor beta1 (TGF-beta1) gene have proved to be crucial to predisposition of several

2004 BMC Medical Genetics PubMed abstract

2779. Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population. (Abstract)

Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population. The aetiology of non-syndromic cleft lip with or without cleft palate (CL/P) is very complex. It has been shown that polymorphic variants of genes encoding key proteins of folate and methionine metabolism might be important maternal risk factors of having a child with this craniofacial anomaly. Therefore, in our study, mothers with CL/P children as well as control mothers were examined

2006 Clinical Genetics

2780. Genomewide scan for nonsyndromic cleft lip and palate in multigenerational Indian families reveals significant evidence of linkage at 13q33.1-34. (Full text)

Genomewide scan for nonsyndromic cleft lip and palate in multigenerational Indian families reveals significant evidence of linkage at 13q33.1-34. Nonsyndromic cleft lip with or without cleft palate (CL-P) is a common congenital anomaly with incidence ranging from 1 in 300 to 1 in 2,500 live births. We analyzed two Indian pedigrees (UR017 and UR019) with isolated, nonsyndromic CL-P, in which the anomaly segregates as an autosomal dominant trait. The phenotype was variable, ranging from

2006 American Journal of Human Genetics PubMed abstract

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