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Cleft Lip

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2761. Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip Full Text available with Trip Pro

Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip 12746418 2003 08 05 2008 11 20 1468-6244 40 5 2003 May Journal of medical genetics J. Med. Genet. Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip. e64 Shotelersuk V V Division of Medical Genetics and Metabolism, Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. vorasuk.s@chula.ac.th Ittiwut C C Siriwan P P Angspatt A A eng Journal (...) Article Research Support, Non-U.S. Gov't England J Med Genet 2985087R 0022-2593 EC 1.5.- Oxidoreductases Acting on CH-NH Group Donors EC 1.5.1.20 Methylenetetrahydrofolate Reductase (NADPH2) IM Cleft Lip complications genetics Cleft Palate complications genetics Female Gene Frequency Genetic Predisposition to Disease genetics Haplotypes Humans Male Methylenetetrahydrofolate Reductase (NADPH2) Mothers Odds Ratio Oxidoreductases Acting on CH-NH Group Donors genetics Polymorphism, Genetic genetics

2003 Journal of Medical Genetics

2762. Cleft lip and palate services still need to be improved Full Text available with Trip Pro

Cleft lip and palate services still need to be improved 12742938 2003 05 27 2016 11 24 1756-1833 326 7397 2003 May 10 BMJ (Clinical research ed.) BMJ Cleft lip and palate services still need to be improved. 1038 Roberts-Harry D D eng Letter England BMJ 8900488 0959-8138 AIM IM Cleft Lip therapy Cleft Palate therapy Health Plan Implementation Humans Quality of Health Care United Kingdom 2003 5 14 5 0 2003 5 28 5 0 2003 5 14 5 0 ppublish 12742938 10.1136/bmj.326.7397.1038/a 326/7397/1038

2003 BMJ : British Medical Journal

2763. Management of cleft lip and palate. Full Text available with Trip Pro

Management of cleft lip and palate. The complex nature of treatment for CL/P, a condition that requires a large multidisciplinary team treating patients from birth to maturity, has been outlined. Subjecting centres' outcomes to audit should precede heeding the current siren calls for paediatricians to refer children exclusively to a particular surgical speciality. A growing body of evidence has shown a close correlation between quality of outcome and the availability of high volume centralised

1996 Archives of Disease in Childhood

2764. Spina bifida and cleft lip among newborns of Norwegian women with epilepsy: changes related to the use of anticonvulsants. Full Text available with Trip Pro

Spina bifida and cleft lip among newborns of Norwegian women with epilepsy: changes related to the use of anticonvulsants. This study examined the connection between the use of anticonvulsants for epilepsy during or before pregnancy and the risk of spina bifida and cleft lip in newborns.Among mothers registered from 1967 to 1992 by the Medical Birth Registry of Norway, 7588 who had epilepsy were identified and their newborns' prevalence of spina bifida and cleft lip examined.The odds ratio (...) of spina bifida in children of mothers with epilepsy compared with other children increased from 1.5 in 1967 through 1980 (95% confidence interval [CI] = 0.3, 4.5) to 4.4 in 1981 through 1992 (95% CI = 2.0, 8.5). The odds ratio of cleft lip, however, decreased from 3.0 before 1981 (95% CI = 1.6, 5.1) to 1.1 after 1981 (95% CI = 0.4, 2.3).This shift toward more serious birth defects is consistent with the different teratogenic effects of newer and older anticonvulsants.

1996 American Journal of Public Health

2765. Height and weight achievement in cleft lip and palate Full Text available with Trip Pro

Height and weight achievement in cleft lip and palate Growth was studied in 83 children with cleft lip and/or palate aged 0-4 years attending a specialist regional centre. Information was collected by a personal interview, postal questionnaire, and record review. The group as a whole grew relatively poorly in early infancy but subsequently recovered, attaining both expected weight and height by last follow up at age 25.5 months (range 3 to 47). However, the group proved heterogeneous (...) , with children with isolated clefts of the secondary palate showing the most abnormal growth. Children with underlying syndromes were significantly more likely to be short at follow up, while type or severity of cleft was not significantly related to follow up height. Therefore, while cleft palate was associated with significant growth faltering in early infancy, rapid recovery took place following surgical repair and appears to have resulted in no residual growth deficit.

1997 Archives of Disease in Childhood

2766. Bilateral infraorbital nerve block is superior to peri-incisional infiltration for analgesia after repair of cleft lip. (Abstract)

Bilateral infraorbital nerve block is superior to peri-incisional infiltration for analgesia after repair of cleft lip. Cleft lip repair is a common operation in infants and requires that the child is pain-free during the postoperative period so that handling does not affect the integrity of the delicate surgical site. This study was designed to compare the efficacy and duration of effect of 0.125% bupivacaine given preoperatively as a bilateral infraorbital nerve block with peri-incisional (...) infiltration of the same local anaesthetic for postoperative analgesia in cleft lip repair. It was a randomised, double blind, prospective study in 30 children aged 4-20 months (ASA grade 1). After a standard induction, group A (n = 15) were given a bilateral infraorbital nerve block with 0.125% bupivacaine and group B (n = 15) had peri-incisional infiltration with the same solution. No additional systemic analgesics were given before or during the operation. Intraoperative monitoring comprised measurement

1999 Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi Controlled trial quality: uncertain

2767. A randomized prospective clinical trial of the effect of infant orthopedics in unilateral cleft lip and palate: prevention of collapse of the alveolar segments (Dutchcleft). Full Text available with Trip Pro

A randomized prospective clinical trial of the effect of infant orthopedics in unilateral cleft lip and palate: prevention of collapse of the alveolar segments (Dutchcleft). To study the effect of infant orthopedics (IO) on maxillary arch form and position of the alveolar segments.Prospective two-arm randomized, controlled trial in parallel with three participating academic cleft palate centers. Treatment was assigned by means of a computerized balanced allocation method.Cleft palate centers (...) of Amsterdam, Nijmegen, and Rotterdam, the Netherlands.Infants with complete unilateral cleft lip and palate and no other malformations.One group (IO+) wore passive maxillary plates during the first year of life; the other group (IO-) did not. All other interventions were the same.The presence of contact and/or overlap (collapse) between the maxillary segments at maxillary casts made shortly after birth, at 15, 24, 48, 58, and 78 weeks. Survival experience of contact and collapse with time as well

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2768. Language skills of young children with unilateral cleft lip and palate following infant orthopedics: a randomized clinical trial. Full Text available with Trip Pro

Language skills of young children with unilateral cleft lip and palate following infant orthopedics: a randomized clinical trial. To investigate the effects of infant orthopedics (IO) on the language skills of children with complete unilateral cleft lip and palate (UCLP).In a prospective randomized clinical trial (Dutchcleft), two groups of children with complete UCLP were followed up longitudinally: one group was treated with IO based on a modified Zurich approach in the first year of life (IO

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2769. An appraisal of three methods of rating facial deformity in patients with repaired complete unilateral cleft lip and palate. Full Text available with Trip Pro

An appraisal of three methods of rating facial deformity in patients with repaired complete unilateral cleft lip and palate. To evaluate the reliability of clinical assessment, two-dimensional color transparencies and three-dimensional imaging for evaluating the residual facial deformity in patients with repaired complete unilateral cleft lip and palate (UCLP) and compare the ratings of facial deformity made by health care professionals with those made by lay assessors. PATIENTS (...) AND PARTICIPANTS Thirty-one randomly selected subjects aged 10 to 30 years with repaired complete UCLP. Five professionals and five laypersons evaluated each subject's residual cleft-related facial deformity using clinical assessment, two-dimensional color transparencies, and three-dimensional images.The facial deformity of the full face, lip, nose, and midface were scored using a 5-point ordinal scale on two occasions with a 1-month interval. Intra- and interexaminer agreements were calculated from weighted

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2770. The effects of active infant orthopedics on occlusal relationships in unilateral complete cleft lip and palate. Full Text available with Trip Pro

The effects of active infant orthopedics on occlusal relationships in unilateral complete cleft lip and palate. To evaluate the effects of active infant orthopedic treatment on dental arch relationships and determine the effect on maxillary growth in children born with unilateral complete cleft lip and palate (UCCLP).The GOSLON Yardstick was used to assess dental models taken on patients treated with and without active infant orthopedics.Two groups of nonsyndromic Caucasian children born (...) with UCCLP (total n = 40), all treated by the same surgeon and ranging from 5 to 10 years of age, were evaluated.One group had a Latham dentomaxillary alignment (DMA) appliance inserted at 5 to 6 weeks of age, after which a lip-nasal adhesion was performed at an average age of 3.5 months. This was followed by more definitive nasolabial repair at the average age of 5.9 months. Those patients treated without preoperative orthopedics underwent a lip-nasal adhesion at average age 1.5 months followed

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2771. Phonological development of toddlers with unilateral cleft lip and palate who were treated with and without infant orthopedics: a randomized clinical trial. Full Text available with Trip Pro

Phonological development of toddlers with unilateral cleft lip and palate who were treated with and without infant orthopedics: a randomized clinical trial. To investigate the phonological development of toddlers from 2 to 3 years of age with complete unilateral cleft lip and palate (UCLP) treated during the first year of life with and without infant orthopedics (IO).In a randomized clinical trial (Dutchcleft), two groups of children were followed up: one treated with IO (IO group) and another (...) of a minimum of 2500 g, and gestation time of a minimum of 38 weeks.IO treatment based on a modified Zurich approach was started within 2 weeks after birth and used until soft palate closure at 12 months of age. Children in the non-IO group visited the clinic for an extra check-up at 6 weeks as well as before and after lip repair and soft palate closure. All other interventions were the same across groups.Phonological development of most 2.5-year-old IO children was normal or delayed. Most children

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2772. An intelligibility assessment of toddlers with cleft lip and palate who received and did not receive presurgical infant orthopedic treatment. (Abstract)

An intelligibility assessment of toddlers with cleft lip and palate who received and did not receive presurgical infant orthopedic treatment. A randomized, prospective, clinical study was performed investigating the effects of presurgical infant orthopedic treatment (PIO) in children with unilateral cleft lip and palate (UCLP). The influence of PIO on speech intelligibility was evaluated with two groups, each consisting of 10 children with UCLP. One group used PIO during the first year of life (...) group. However, data obtained by means of transcriptions indicated that, in fact, there were no group differences in actual intelligibility. Only in comparison with their noncleft peers were the children with cleft lip and palate significantly less well understood.

2001 Journal of communication disorders Controlled trial quality: uncertain

2773. Use of a perceptual evaluation instrument to assess the effects of infant orthopedics on the speech of toddlers with cleft lip and palate. Full Text available with Trip Pro

Use of a perceptual evaluation instrument to assess the effects of infant orthopedics on the speech of toddlers with cleft lip and palate. To investigate the effects of infant orthopedics (IO) administered in the first year of life on the speech characteristics of 2.5-year-old children with complete unilateral cleft lip and palate (UCLP) using a perceptual evaluation instrument with equal-appearing interval (EAI) scales.In a prospective randomized clinical trial (Dutchcleft), two groups (...) in a blinded perceptual rating procedure. They judged 13 specific speech characteristics and indicated their total impression of speech on EAI scales.The reliability and consistency of 11 of the rating scales was good. The intelligibility rating scale was the single speech characteristic that distinguished the IO group from the non-IO group; the IO group was judged to be superior. The cleft groups differed from the noncleft group on 9 of the 11 scales.Evaluation of speech by means of the present newly

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2774. A randomised prospective clinical trial into the effect of infant orthopaedics on maxillary arch dimensions in unilateral cleft lip and palate (Dutchcleft). (Abstract)

A randomised prospective clinical trial into the effect of infant orthopaedics on maxillary arch dimensions in unilateral cleft lip and palate (Dutchcleft). Aim of the study was to evaluate the effect of infant orthopaedics (IO) on maxillary dimensions in infants with unilateral cleft lip and palate (UCLP). The study design was a prospective two-arm randomised controlled trial in parallel with three participating academic Cleft Palate Centres. Treatment was assigned by means of a computerised (...) balanced allocation method. One group (IO+) wore passive maxillary plates during the first year of life, the other group (IO-) did not. Maxillary casts, made at birth, and at 15, 24, 48, 78 wk were digitised three-dimensionally. Before lip closure alveolar, midpalatal and posterior cleft width reduced significantly more in IO(+) than in IO(-). After lip closure, the alveolar cleft width reduced significantly more in IO(-). Until soft palate closure the slope of the palatal vault flattened significantly

2001 European journal of oral sciences Controlled trial quality: uncertain

2775. [Pseudoprognathism frequency and masseter muscle activity in operated cleft lip patients]. (Abstract)

[Pseudoprognathism frequency and masseter muscle activity in operated cleft lip patients]. As a consequence of a growth inhibition of middle third of the face, cleft lip surgery could lead to a pseudoprognathism. However, this is not always the case. Also, when facial architecture is changed, the activity of muscles such as the masseter could be disturbed.To study masseter electromyographic activity in operated cleft lip patients.Forty two patients with cleft lip (25 male, aged 13 to 35 years (...) and a mean molar relation of -4.8, figures that confirm the presence of pseudoprognathism.Eighty three percent of cleft lip patients do not have cephalometric parameters of pseudoprognathism and half of the patients have a lower masseter activity.

2000 Revista médica de Chile Controlled trial quality: uncertain

2776. [Development of speech and facial skull growth after primary velopharyngoplasty in lip-jaw-palate clefts]. (Abstract)

[Development of speech and facial skull growth after primary velopharyngoplasty in lip-jaw-palate clefts]. A two-armed, prospective, randomized study was performed to evaluate the influence of primary velopharyngoplasty on speech and facial growth in patients with cleft lip and palate.Forty-two patients born between 1978 and 1982 were included. All patients were treated with an intravelar veloplasty, and 21 patients simultaneously with a velopharyngoplasty according to Sanvenero-Rosselli

2002 Mund-, Kiefer- und Gesichtschirurgie : MKG Controlled trial quality: uncertain

2777. Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. Full Text available with Trip Pro

Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. MSX1 has been proposed as a gene in which mutations may contribute to non-syndromic forms of cleft lip and/or cleft palate. Support for this comes from human linkage and linkage disequilibrium studies, chromosomal deletions resulting in haploinsufficiency, a large family with a stop codon mutation that includes clefting as a phenotype, and the Msx1 phenotype in a knockout mouse. This report describes a population (...) . These included missense mutations in conserved amino acids and point mutations in conserved regions not identified in any of 500 controls sequenced. Five different missense mutations in seven unrelated subjects with clefting are described. Evolutionary sequence comparisons of all known Msx1 orthologues placed the amino acid substitutions in context. Four rare mutations were found in non-coding regions that are highly conserved and disrupt probable regulatory regions. In addition, a panel of 18 population

2003 Journal of Medical Genetics

2778. Phonetic and otological results after early palate closure in 18 consecutive children presenting with cleft lip and palate. (Abstract)

Phonetic and otological results after early palate closure in 18 consecutive children presenting with cleft lip and palate. First, to analyze the speech and hearing results at 3.5 years of age when early palate closure has been performed. Second to assess at 7 years of age the need for speech therapy and/or additional surgery in the form of cranial-based pharyngeal flap for obtaining normal speech.Retrospective study in a tertiary teaching hospital concerning 18 consecutive cases presenting (...) cleft lip and palate with no associated abnormalities. Interventions included early palatine closure (velum at 3 months, hard palate and lip at 6 months). Speech therapy was initiated at 3.5 years of age when needed. Cranial-based pharyngeal flap was performed when normal nasal emission was not obtained by speech therapy at 7 years of age. Phonetic and otological assessment were performed in all cases.Good to excellent speech in the majority (95%) of children, with only 3/18 undergoing

2002 International Journal of Pediatric Otorhinolaryngology

2779. Mandibular reconstructive surgery in a patient with median cleft of the lower lip and mandible. (Abstract)

Mandibular reconstructive surgery in a patient with median cleft of the lower lip and mandible. A patient 15 years and 11 months of age with median cleft of the lower lip and mandible underwent mandibular reconstructive surgery using autogenous iliac bone and a titanium mesh tray. Functional and morphological results are satisfactory 4 years after surgery.

2002 International Journal of Oral and Maxillofacial Surgery

2780. A split-mouth study on periodontal and microbial parameters in children with complete unilateral cleft lip and palate. (Abstract)

A split-mouth study on periodontal and microbial parameters in children with complete unilateral cleft lip and palate. Complete unilateral cleft lip and palate (UCLP) is a hereditary or multifactorial malformation that can be corrected successfully with a combined orthodontic, surgical and restorative treatment. Such multidisciplinary treatment takes many years and demands a lot of attention to both patients' teeth and periodontium.This split-mouth study aimed to compare the periodontal health (...) as well as the microbial parameters between cleft and non-cleft region.75 patients (52 males, 23 females) between 8 and 20 years with a complete unilateral cleft lip and palate (before (n = 30), during (n = 34) and after (n = 11) the active orthodontic treatment) volunteered for this study. Four regions were defined for the split-mouth comparison: teeth neighbouring cleft (site 1), tooth in cleft (site 2), and the corresponding contra-lateral teeth, respectively, in the unaffected quadrants (sites 3

2003 Journal of Clinical Periodontology

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