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Cleft Lip

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2721. A randomised prospective clinical trial into the effect of infant orthopaedics on maxillary arch dimensions in unilateral cleft lip and palate (Dutchcleft). (Abstract)

A randomised prospective clinical trial into the effect of infant orthopaedics on maxillary arch dimensions in unilateral cleft lip and palate (Dutchcleft). Aim of the study was to evaluate the effect of infant orthopaedics (IO) on maxillary dimensions in infants with unilateral cleft lip and palate (UCLP). The study design was a prospective two-arm randomised controlled trial in parallel with three participating academic Cleft Palate Centres. Treatment was assigned by means of a computerised (...) balanced allocation method. One group (IO+) wore passive maxillary plates during the first year of life, the other group (IO-) did not. Maxillary casts, made at birth, and at 15, 24, 48, 78 wk were digitised three-dimensionally. Before lip closure alveolar, midpalatal and posterior cleft width reduced significantly more in IO(+) than in IO(-). After lip closure, the alveolar cleft width reduced significantly more in IO(-). Until soft palate closure the slope of the palatal vault flattened significantly

2001 European journal of oral sciences Controlled trial quality: uncertain

2722. [Pseudoprognathism frequency and masseter muscle activity in operated cleft lip patients]. (Abstract)

[Pseudoprognathism frequency and masseter muscle activity in operated cleft lip patients]. As a consequence of a growth inhibition of middle third of the face, cleft lip surgery could lead to a pseudoprognathism. However, this is not always the case. Also, when facial architecture is changed, the activity of muscles such as the masseter could be disturbed.To study masseter electromyographic activity in operated cleft lip patients.Forty two patients with cleft lip (25 male, aged 13 to 35 years (...) and a mean molar relation of -4.8, figures that confirm the presence of pseudoprognathism.Eighty three percent of cleft lip patients do not have cephalometric parameters of pseudoprognathism and half of the patients have a lower masseter activity.

2000 Revista médica de Chile Controlled trial quality: uncertain

2723. [Development of speech and facial skull growth after primary velopharyngoplasty in lip-jaw-palate clefts]. (Abstract)

[Development of speech and facial skull growth after primary velopharyngoplasty in lip-jaw-palate clefts]. A two-armed, prospective, randomized study was performed to evaluate the influence of primary velopharyngoplasty on speech and facial growth in patients with cleft lip and palate.Forty-two patients born between 1978 and 1982 were included. All patients were treated with an intravelar veloplasty, and 21 patients simultaneously with a velopharyngoplasty according to Sanvenero-Rosselli

2002 Mund-, Kiefer- und Gesichtschirurgie : MKG Controlled trial quality: uncertain

2724. Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. Full Text available with Trip Pro

Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. MSX1 has been proposed as a gene in which mutations may contribute to non-syndromic forms of cleft lip and/or cleft palate. Support for this comes from human linkage and linkage disequilibrium studies, chromosomal deletions resulting in haploinsufficiency, a large family with a stop codon mutation that includes clefting as a phenotype, and the Msx1 phenotype in a knockout mouse. This report describes a population (...) . These included missense mutations in conserved amino acids and point mutations in conserved regions not identified in any of 500 controls sequenced. Five different missense mutations in seven unrelated subjects with clefting are described. Evolutionary sequence comparisons of all known Msx1 orthologues placed the amino acid substitutions in context. Four rare mutations were found in non-coding regions that are highly conserved and disrupt probable regulatory regions. In addition, a panel of 18 population

2003 Journal of Medical Genetics

2725. Phonetic and otological results after early palate closure in 18 consecutive children presenting with cleft lip and palate. (Abstract)

Phonetic and otological results after early palate closure in 18 consecutive children presenting with cleft lip and palate. First, to analyze the speech and hearing results at 3.5 years of age when early palate closure has been performed. Second to assess at 7 years of age the need for speech therapy and/or additional surgery in the form of cranial-based pharyngeal flap for obtaining normal speech.Retrospective study in a tertiary teaching hospital concerning 18 consecutive cases presenting (...) cleft lip and palate with no associated abnormalities. Interventions included early palatine closure (velum at 3 months, hard palate and lip at 6 months). Speech therapy was initiated at 3.5 years of age when needed. Cranial-based pharyngeal flap was performed when normal nasal emission was not obtained by speech therapy at 7 years of age. Phonetic and otological assessment were performed in all cases.Good to excellent speech in the majority (95%) of children, with only 3/18 undergoing

2002 International Journal of Pediatric Otorhinolaryngology

2726. Mandibular reconstructive surgery in a patient with median cleft of the lower lip and mandible. (Abstract)

Mandibular reconstructive surgery in a patient with median cleft of the lower lip and mandible. A patient 15 years and 11 months of age with median cleft of the lower lip and mandible underwent mandibular reconstructive surgery using autogenous iliac bone and a titanium mesh tray. Functional and morphological results are satisfactory 4 years after surgery.

2002 International Journal of Oral and Maxillofacial Surgery

2727. A split-mouth study on periodontal and microbial parameters in children with complete unilateral cleft lip and palate. (Abstract)

A split-mouth study on periodontal and microbial parameters in children with complete unilateral cleft lip and palate. Complete unilateral cleft lip and palate (UCLP) is a hereditary or multifactorial malformation that can be corrected successfully with a combined orthodontic, surgical and restorative treatment. Such multidisciplinary treatment takes many years and demands a lot of attention to both patients' teeth and periodontium.This split-mouth study aimed to compare the periodontal health (...) as well as the microbial parameters between cleft and non-cleft region.75 patients (52 males, 23 females) between 8 and 20 years with a complete unilateral cleft lip and palate (before (n = 30), during (n = 34) and after (n = 11) the active orthodontic treatment) volunteered for this study. Four regions were defined for the split-mouth comparison: teeth neighbouring cleft (site 1), tooth in cleft (site 2), and the corresponding contra-lateral teeth, respectively, in the unaffected quadrants (sites 3

2003 Journal of Clinical Periodontology

2728. Periodontal attachment loss over 14 years in cleft lip, alveolus and palate (CLAP, CL, CP) subjects not enrolled in a supportive periodontal therapy program. (Abstract)

Periodontal attachment loss over 14 years in cleft lip, alveolus and palate (CLAP, CL, CP) subjects not enrolled in a supportive periodontal therapy program. (i) To assess the overall and (ii) cleft-associated rate of periodontal disease (PD) progression in subjects with cleft lip, alveolus and palate (CLAP) and (iii) to compare these rates with those of subjects with cleft lip (CL) and cleft palate (CP).Twenty-six subjects not enrolled in a supportive periodontal therapy (SPT) program were (...) occurred over the observation period (p<0.05). In subjects with CLAP, statistically significant increases in PPD and loss of PAL were recorded over time at sites adjacent to the cleft as well as at control sites (p<0.05). Over 14 years, however, PPD increased 1.72+/-1.08 mm (SD) at cleft sites versus 0.72+/-1.14 mm (SD) at control sites (p<0.05), and PAL amounted to 3.19+/-1.35 mm (SD) at cleft sites versus 2.41+/-1.52 mm (SD) at control sites (p<0.05).Both the CLAP and the CL/CP subjects are at high

2003 Journal of Clinical Periodontology

2729. Facial asymmetry--3D assessment of infants with cleft lip & palate. (Abstract)

Facial asymmetry--3D assessment of infants with cleft lip & palate. To determine the degree of facial asymmetry in infants with unilateral cleft lip and/or palate, and quantify improvements following primary surgery, in three dimensions.The faces of 20 infants with unilateral clefts (10 UCL; 10 UCLP), and 20 age-matched, non-cleft controls, were captured using the C3D stereophotogrammetry system prior to primary lip/nose repair (at 3 months), at 6 months and at age 1 year.Procrustes techniques (...) were applied to 3D landmark configurations to its mirror image. Mean squared distances between landmarks and their antimeres were calculated and expressed as asymmetry scores for each 3D configuration. Full-face, nose and lip median scores were compared and changes with time evaluated (P < 0.01).There were no significant changes in asymmetry scores in the control group from 3 months to 1 year. The UCLP group was more asymmetric than the UCL group, displaying greatest improvement in nasal symmetry

2003 International Journal of Paediatric Dentistry

2730. Parental evaluation of informing interviews for cleft lip and/or palate. (Abstract)

Parental evaluation of informing interviews for cleft lip and/or palate. This study was conducted to record subjective information concerning parental experiences and preferences with regard to informing interviews for cleft lip and/or palate. The analysis of these data was intended to help informants improve the way in which such conversations are conducted.The study used a self-administered questionnaire. Study participants were the biological parents of children who had cleft lip (...) retardation/learning disabilities, and to provide more referrals to other parents during the informing interview. A positive association between the degree to which parents reported knowing the health professionals and reported satisfaction was identified for 10 dimensions of health professional behavior.Parents are dissatisfied with several aspects of informing interviews for cleft lip and/or palate. The results of this study suggest ways to improve informing interviews for oral-facial clefts and other

2003 Pediatrics

2731. TGF-beta-3 promotes scarless repair of cleft lip in mouse fetuses. (Abstract)

TGF-beta-3 promotes scarless repair of cleft lip in mouse fetuses. TGF-beta3 mediates epithelial-mesenchymal transformation during normal fusion of lip and palate, but how TGF-beta3 functions during cleft lip repair remains unexplored. We hypothesize that TGF-beta3 promotes fetal cleft lip repair and fusion by increasing the availability of mesenchymal cells. In this investigation, we demonstrated that cleft lips in mouse fetuses were repaired by fetal surgery, producing scarless fusion (...) . At the site of the operation, we first observed an infusion of platelets expressing TGF-beta3, followed by increased expression of cyclin D1 and tenascin-C, and coupled with increased mesenchymal cell proliferation. In an ex vivo serumless culture system, cleft lip explants fused in the presence of exogenous TGF-beta3. Cultured lips also showed up-regulation in cyclin D1 and tenascin-C expression. These findings suggest that microsurgical repair of cleft lip in the fetus that produced scarless fusion

2002 Journal of Dental Research

2732. A novel p63 sterile alpha motif (SAM) domain mutation in a Japanese patient with ankyloblepharon, ectodermal defects and cleft lip and palate (AEC) syndrome without ankyloblepharon. (Abstract)

A novel p63 sterile alpha motif (SAM) domain mutation in a Japanese patient with ankyloblepharon, ectodermal defects and cleft lip and palate (AEC) syndrome without ankyloblepharon. We present a sporadic case of a Japanese female infant with ectodermal dysplasia, complete cleft lip and palate, severe skin erosions at birth and recurrent scalp infection. She had typical clinical features of ankyloblepharon, ectodermal defects and cleft lip and palate (AEC) syndrome without ankyloblepharon

2003 British Journal of Dermatology

2733. Three-dimensional prenatal diagnosis of frontonasal malformation and unilateral cleft lip/palate. (Abstract)

Three-dimensional prenatal diagnosis of frontonasal malformation and unilateral cleft lip/palate. Frontonasal malformation includes a spectrum of anomalies involving the eyes, nose, lips, forehead and brain. We present a case in which a fetal labial cleft was initially identified using traditional two-dimensional sonography. Three-dimensional sonography with multiplanar reconstruction and surface-rendering were essential to establish the diagnosis of frontonasal malformation with severe nasal (...) hypoplasia and unilateral complete cleft lip/palate.

2002 Ultrasound in Obstetrics and Gynecology

2734. Chlorhexidine in cleft lip and palate patients with multibracket appliances. Results of a prospective study on the effectiveness of two different chlorhexidine preparations in cleft lip and palate patients with multibracket appliances. (Abstract)

Chlorhexidine in cleft lip and palate patients with multibracket appliances. Results of a prospective study on the effectiveness of two different chlorhexidine preparations in cleft lip and palate patients with multibracket appliances. The aim of this study is to reduce the caries risk in cleft lip and palate (CLP) patients with multibracket appliances via a compliance-independent method.Sixty-eight CLP patients with multibracket appliances were submitted to professional tooth cleaning at 4

2005 Journal of orofacial orthopedics = Fortschritte der Kieferorthopädie : Organ/official journal Deutsche Gesellschaft für Kieferorthopädie Controlled trial quality: uncertain

2735. Cleft lip and palate versus cleft lip only: are they distinct defects? Full Text available with Trip Pro

Cleft lip and palate versus cleft lip only: are they distinct defects? Cleft lip defects are usually regarded as a single entity, with the assumption that an accompanying cleft palate represents the more severe form. The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set. They assessed the distribution of cleft lip only and cleft lip with cleft palate by covariate. Among 1.8 million Norwegian (...) livebirths between 1967 and 1998, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft lip only. Seventeen percent of those with cleft lip and palate had another defect compared with 9% of those with cleft lip only. For boys, the risk was greater for cleft lip and palate than for cleft lip only (odds ratio=2.4 vs. 1.8, p<0.001 for difference). The risk of cleft lip only, but not of cleft lip and palate, was increased for twins (odds ratio=1.6 vs. 1.1, p=0.11) and infants whose

2005 American Journal of Epidemiology

2736. Cleft sidedness and congenitally missing or malformed permanent maxillary lateral incisors in Korean patients with unilateral cleft lip and alveolus or unilateral cleft lip and palate. (Abstract)

Cleft sidedness and congenitally missing or malformed permanent maxillary lateral incisors in Korean patients with unilateral cleft lip and alveolus or unilateral cleft lip and palate. The purpose of this study was to investigate the differences in the prevalence of cleft sidedness, the number of congenitally missing or malformed permanent maxillary lateral incisors (MLIs), and the presence of supernumerary teeth in Korean patients with unilateral cleft lip and alveolus (UCLA) and those (...) with unilateral cleft lip and palate (UCLP).Seventy-five patients with UCLA and 129 patients with UCLP (ages, 6.0 to 13.0 years) were studied by using their charts, models, radiographs, and intraoral photographs. The chi-square test, the binomial test, and the relative risk assessment were used.There was a male dominant tendency in both UCLP (P <.001) and UCLA (P <.05) patients. The UCLP patients were 1.3 times more involved on the left side and had 2.2 times more congenital missing MLI than did the UCLA

2006 American journal of orthodontics and dentofacial orthopedics

2737. Interpreting the evidence for an association between the retinoic acid receptor locus and non-syndromic cleft lip with or without cleft palate. Full Text available with Trip Pro

Interpreting the evidence for an association between the retinoic acid receptor locus and non-syndromic cleft lip with or without cleft palate. 7914931 1994 09 22 2018 11 13 0022-2593 31 5 1994 May Journal of medical genetics J. Med. Genet. Interpreting the evidence for an association between the retinoic acid receptor locus and non-syndromic cleft lip with or without cleft palate. 425 Mitchell L E LE eng Comment Letter England J Med Genet 2985087R 0022-2593 0 Receptors, Retinoic Acid EC (...) 3.1.21.4 CTGCAG-specific type II deoxyribonucleases EC 3.1.21.4 Deoxyribonucleases, Type II Site-Specific IM J Med Genet. 1993 Sep;30(9):773-8 8411074 Chi-Square Distribution Cleft Lip genetics Cleft Palate genetics Deoxyribonucleases, Type II Site-Specific Genetic Linkage Humans Odds Ratio Polymorphism, Restriction Fragment Length Receptors, Retinoic Acid genetics Reproducibility of Results 1994 5 1 1994 5 1 0 1 1994 5 1 0 0 ppublish 7914931 PMC1049885 Am J Hum Genet. 1992 Dec;51(6):1377-85 1361101 J

1994 Journal of Medical Genetics

2738. Nonsyndromic cleft lip with or without cleft palate in west Bengal, India: evidence for an autosomal major locus. Full Text available with Trip Pro

Nonsyndromic cleft lip with or without cleft palate in west Bengal, India: evidence for an autosomal major locus. Ninety extended families having one or more individuals affected with nonsyndromic cleft lip (CL) with or without cleft palate (CL/P) were ascertained in rural West Bengal, India. These families included 138 affected people, 64% of whom had CL alone and 66% of whom were male. Multiple-affected-member ("multiplex") pedigrees were less common than single-affected-member ("simplex

1993 American Journal of Human Genetics

2739. Further evidence of a relationship between the retinoic acid receptor alpha locus and nonsyndromic cleft lip with or without cleft palate (CL +/- P) Full Text available with Trip Pro

Further evidence of a relationship between the retinoic acid receptor alpha locus and nonsyndromic cleft lip with or without cleft palate (CL +/- P) 8213839 1993 11 19 2018 11 13 0002-9297 53 5 1993 Nov American journal of human genetics Am. J. Hum. Genet. Further evidence of a relationship between the retinoic acid receptor alpha locus and nonsyndromic cleft lip with or without cleft palate (CL +/- P) 1156-7 Shaw D D Ray A A Marazita M M Field L L eng R01 DE016148 DE NIDCR NIH HHS United (...) States Letter Comment United States Am J Hum Genet 0370475 0002-9297 0 RARA protein, human 0 Receptors, Retinoic Acid 0 Retinoic Acid Receptor alpha IM Am J Hum Genet. 1992 Dec;51(6):1377-85 1361101 Alleles Child Cleft Lip genetics Cleft Palate genetics Female Genetic Linkage Humans Male Receptors, Retinoic Acid genetics Retinoic Acid Receptor alpha 1993 11 1 1993 11 1 0 1 1993 11 1 0 0 ppublish 8213839 PMC1682320 Am J Hum Genet. 1992 Dec;51(6):1377-85 1361101 Teratology. 1990 Dec;42(6):597-610

1993 American Journal of Human Genetics

2740. Exclusion of candidate genes from a role in cleft lip with or without cleft palate: linkage and association studies. Full Text available with Trip Pro

Exclusion of candidate genes from a role in cleft lip with or without cleft palate: linkage and association studies. Candidate genes and marker loci for cleft lip/palate (CL/P) were tested using linkage analyses and association studies. Eight British families with apparent autosomal dominant inheritance of non-syndromic CL/P participated in the linkage analyses while the association analyses involved 61 unrelated British white people with CL/P and 60 controls. The report of an association

1993 Journal of Medical Genetics

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