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Cleft Lip

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2701. Provision of services for cleft lip and palate in England and Wales. Full Text available with Trip Pro

Provision of services for cleft lip and palate in England and Wales. 7819898 1995 02 15 2018 11 13 0959-8138 309 6968 1994 Dec 10 BMJ (Clinical research ed.) BMJ Provision of services for cleft lip and palate in England and Wales. 1552 Williams A A Surgical Audit Unit, Royal College of Surgeons, London. Shaw W C WC Devlin H B HB eng Journal Article England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Apr 15;310(6985):1006 7728003 BMJ. 1995 Sep 9;311(7006):685-6 7549648 BMJ. 1995 May 27;310(6991):1406 (...) 7787559 BMJ. 1995 May 27;310(6991):1406 7646674 BMJ. 1995 Apr 15;310(6985):1006 7794380 BMJ 1995 Jan 7;310(6971):26 Child Child Health Services statistics & numerical data supply & distribution Child, Preschool Cleft Lip surgery Cleft Palate surgery England Health Services Accessibility Humans Wales 1994 12 10 1994 12 10 0 1 1994 12 10 0 0 ppublish 7819898 PMC2541776 Ann R Coll Surg Engl. 1990 Jan;72(1 Suppl):3-14 2405767

1994 BMJ : British Medical Journal

2702. Height and weight achievement in cleft lip and palate Full Text available with Trip Pro

Height and weight achievement in cleft lip and palate 9301377 1997 10 14 2010 05 20 1468-2044 77 2 1997 Aug Archives of disease in childhood Arch. Dis. Child. Height and weight achievement in cleft lip and palate. 187-8 Azcona C C Stanhope R R eng Comment Letter England Arch Dis Child 0372434 0003-9888 AIM IM Arch Dis Child. 1997 Jan;76(1):70-2 9059168 Child, Preschool Cleft Lip physiopathology Cleft Palate physiopathology Growth Disorders physiopathology Humans Pituitary Gland physiopathology

1997 Archives of Disease in Childhood

2703. Report on cleft lip and palate surgery: UK results could soon surpass those elsewhere Full Text available with Trip Pro

Report on cleft lip and palate surgery: UK results could soon surpass those elsewhere 9572772 1998 06 04 2018 11 13 0959-8138 316 7142 1998 May 09 BMJ (Clinical research ed.) BMJ Report on cleft lip and palate surgery. Uk results could soon surpass those elsewhere. 1461-2 Morgan B D BD eng Letter Comment England BMJ 8900488 0959-8138 AIM IM BMJ. 1998 Mar 7;316(7133):723 9529399 Cleft Lip surgery Cleft Palate surgery Humans Oral Surgical Procedures Surgery, Plastic United Kingdom 1998 6 6 1998 6 (...) 6 0 1 1998 6 6 0 0 ppublish 9572772 PMC1113131 BMJ. 1995 Sep 23;311(7008):765-6 7580431 Cleft Palate Craniofac J. 1992 Sep;29(5):393-7 1472515 Plast Reconstr Surg. 1993 Jun;91(7):1334-6 8497536 BMJ. 1998 Mar 7;316(7133):723 9529399 BMJ. 1995 Nov 25;311(7017):1431; author reply 1432-3 8520282 Eur J Orthod. 1997 Apr;19(2):165-70 9183066

1998 BMJ : British Medical Journal

2704. Rhinoplasty in cleft lip/palate deformity Full Text available with Trip Pro

Rhinoplasty in cleft lip/palate deformity 23119392 2012 11 30 2018 11 13 2231-3796 50 1 1998 Jan Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India Indian J Otolaryngol Head Neck Surg Rhinoplasty in cleft lip/palate deformity. 95-8 10.1007/BF02996788 Ghosh P P 40/60, C. R. Park, 110 019 New Delhi. eng Journal Article India Indian J Otolaryngol Head Neck Surg 9422551 2231-3796 2012 11 3 6 0 1998 1 1 0 0 1998 1 1 0 1

1998 Indian Journal of Otolaryngology and Head & Neck Surgery

2705. An Otorhinological study of patients with cleft lip and palate Full Text available with Trip Pro

An Otorhinological study of patients with cleft lip and palate 32 patients of cleft palate with or without cleft lip were subjected to otorhinological study from January 1998 to September 2000, with special attention to the rhinological anomalies, ear pathology, any deafness, discharge or any other findings relevant to the middle ear. Hearing loss and ear changes were not seen in any patient with cleft lip alone, hence these patients were not included in this study. These changes were confined (...) to the patients with cleft palate only, with or without cleft lip. High incidence of otological anomalies (75%) and rhinological anomalies (deviated nasal septum in 40.6%) were seen in patients with cleft palate with or without cleft lip. Hearing loss has been seen (37.5%) in patients with cleft palate and was purely conductive in nature.

2001 Indian Journal of Otolaryngology and Head & Neck Surgery

2706. Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate Full Text available with Trip Pro

Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate 12011160 2002 05 28 2017 11 16 1468-6244 39 5 2002 May Journal of medical genetics J. Med. Genet. Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate. 368-9 Prescott N J NJ Winter R M RM Malcolm S S eng Letter England J Med Genet 2985087R 0022-2593 EC 1.5.- Oxidoreductases Acting on CH-NH Group Donors EC 1.5.1.20 Methylenetetrahydrofolate Reductase (NADPH2) IM Cleft Lip (...) genetics Cleft Palate genetics Female Gene Frequency Genetic Carrier Screening Genetic Predisposition to Disease Genotype Humans Methylenetetrahydrofolate Reductase (NADPH2) Oxidoreductases Acting on CH-NH Group Donors genetics Polymorphism, Single Nucleotide Syndrome 2002 5 16 10 0 2002 5 29 10 1 2002 5 16 10 0 ppublish 12011160 PMC1735125

2002 Journal of Medical Genetics

2707. Median cleft of upper lip and pedunculated skin masses associated with de novo reciprocal translocation 46,X,t(X;16)(q28;q11.2). Full Text available with Trip Pro

Median cleft of upper lip and pedunculated skin masses associated with de novo reciprocal translocation 46,X,t(X;16)(q28;q11.2). We describe a de novo apparently balanced reciprocal translocation, 46,X,t(X;16)(q28;q11.2), in a 13 year old girl with median cleft of the upper lip, pedunculated skin masses on the nasal septum, short stature, and mental retardation. Pai syndrome is characterised by median cleft of the upper lip, pedunculated skin mass(es) on the face, and midline lipoma(s (...) ) of the central nervous system. The cause of this syndrome is unknown, although autosomal dominant inheritance has been proposed. The translocation breakpoints in the present patient may be candidate regions for a gene responsible for median cleft of the upper lip and pedunculated skin mass(es) on the face, including Pai syndrome.

1997 Journal of Medical Genetics

2708. Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip Full Text available with Trip Pro

Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip 12746418 2003 08 05 2008 11 20 1468-6244 40 5 2003 May Journal of medical genetics J. Med. Genet. Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip. e64 Shotelersuk V V Division of Medical Genetics and Metabolism, Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. vorasuk.s@chula.ac.th Ittiwut C C Siriwan P P Angspatt A A eng Journal (...) Article Research Support, Non-U.S. Gov't England J Med Genet 2985087R 0022-2593 EC 1.5.- Oxidoreductases Acting on CH-NH Group Donors EC 1.5.1.20 Methylenetetrahydrofolate Reductase (NADPH2) IM Cleft Lip complications genetics Cleft Palate complications genetics Female Gene Frequency Genetic Predisposition to Disease genetics Haplotypes Humans Male Methylenetetrahydrofolate Reductase (NADPH2) Mothers Odds Ratio Oxidoreductases Acting on CH-NH Group Donors genetics Polymorphism, Genetic genetics

2003 Journal of Medical Genetics

2709. Cleft lip and palate services still need to be improved Full Text available with Trip Pro

Cleft lip and palate services still need to be improved 12742938 2003 05 27 2016 11 24 1756-1833 326 7397 2003 May 10 BMJ (Clinical research ed.) BMJ Cleft lip and palate services still need to be improved. 1038 Roberts-Harry D D eng Letter England BMJ 8900488 0959-8138 AIM IM Cleft Lip therapy Cleft Palate therapy Health Plan Implementation Humans Quality of Health Care United Kingdom 2003 5 14 5 0 2003 5 28 5 0 2003 5 14 5 0 ppublish 12742938 10.1136/bmj.326.7397.1038/a 326/7397/1038

2003 BMJ : British Medical Journal

2710. Management of cleft lip and palate. Full Text available with Trip Pro

Management of cleft lip and palate. The complex nature of treatment for CL/P, a condition that requires a large multidisciplinary team treating patients from birth to maturity, has been outlined. Subjecting centres' outcomes to audit should precede heeding the current siren calls for paediatricians to refer children exclusively to a particular surgical speciality. A growing body of evidence has shown a close correlation between quality of outcome and the availability of high volume centralised

1996 Archives of Disease in Childhood

2711. Spina bifida and cleft lip among newborns of Norwegian women with epilepsy: changes related to the use of anticonvulsants. Full Text available with Trip Pro

Spina bifida and cleft lip among newborns of Norwegian women with epilepsy: changes related to the use of anticonvulsants. This study examined the connection between the use of anticonvulsants for epilepsy during or before pregnancy and the risk of spina bifida and cleft lip in newborns.Among mothers registered from 1967 to 1992 by the Medical Birth Registry of Norway, 7588 who had epilepsy were identified and their newborns' prevalence of spina bifida and cleft lip examined.The odds ratio (...) of spina bifida in children of mothers with epilepsy compared with other children increased from 1.5 in 1967 through 1980 (95% confidence interval [CI] = 0.3, 4.5) to 4.4 in 1981 through 1992 (95% CI = 2.0, 8.5). The odds ratio of cleft lip, however, decreased from 3.0 before 1981 (95% CI = 1.6, 5.1) to 1.1 after 1981 (95% CI = 0.4, 2.3).This shift toward more serious birth defects is consistent with the different teratogenic effects of newer and older anticonvulsants.

1996 American Journal of Public Health

2712. Height and weight achievement in cleft lip and palate Full Text available with Trip Pro

Height and weight achievement in cleft lip and palate Growth was studied in 83 children with cleft lip and/or palate aged 0-4 years attending a specialist regional centre. Information was collected by a personal interview, postal questionnaire, and record review. The group as a whole grew relatively poorly in early infancy but subsequently recovered, attaining both expected weight and height by last follow up at age 25.5 months (range 3 to 47). However, the group proved heterogeneous (...) , with children with isolated clefts of the secondary palate showing the most abnormal growth. Children with underlying syndromes were significantly more likely to be short at follow up, while type or severity of cleft was not significantly related to follow up height. Therefore, while cleft palate was associated with significant growth faltering in early infancy, rapid recovery took place following surgical repair and appears to have resulted in no residual growth deficit.

1997 Archives of Disease in Childhood

2713. Bilateral infraorbital nerve block is superior to peri-incisional infiltration for analgesia after repair of cleft lip. (Abstract)

Bilateral infraorbital nerve block is superior to peri-incisional infiltration for analgesia after repair of cleft lip. Cleft lip repair is a common operation in infants and requires that the child is pain-free during the postoperative period so that handling does not affect the integrity of the delicate surgical site. This study was designed to compare the efficacy and duration of effect of 0.125% bupivacaine given preoperatively as a bilateral infraorbital nerve block with peri-incisional (...) infiltration of the same local anaesthetic for postoperative analgesia in cleft lip repair. It was a randomised, double blind, prospective study in 30 children aged 4-20 months (ASA grade 1). After a standard induction, group A (n = 15) were given a bilateral infraorbital nerve block with 0.125% bupivacaine and group B (n = 15) had peri-incisional infiltration with the same solution. No additional systemic analgesics were given before or during the operation. Intraoperative monitoring comprised measurement

1999 Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi Controlled trial quality: uncertain

2714. A randomized prospective clinical trial of the effect of infant orthopedics in unilateral cleft lip and palate: prevention of collapse of the alveolar segments (Dutchcleft). Full Text available with Trip Pro

A randomized prospective clinical trial of the effect of infant orthopedics in unilateral cleft lip and palate: prevention of collapse of the alveolar segments (Dutchcleft). To study the effect of infant orthopedics (IO) on maxillary arch form and position of the alveolar segments.Prospective two-arm randomized, controlled trial in parallel with three participating academic cleft palate centers. Treatment was assigned by means of a computerized balanced allocation method.Cleft palate centers (...) of Amsterdam, Nijmegen, and Rotterdam, the Netherlands.Infants with complete unilateral cleft lip and palate and no other malformations.One group (IO+) wore passive maxillary plates during the first year of life; the other group (IO-) did not. All other interventions were the same.The presence of contact and/or overlap (collapse) between the maxillary segments at maxillary casts made shortly after birth, at 15, 24, 48, 58, and 78 weeks. Survival experience of contact and collapse with time as well

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2715. Language skills of young children with unilateral cleft lip and palate following infant orthopedics: a randomized clinical trial. Full Text available with Trip Pro

Language skills of young children with unilateral cleft lip and palate following infant orthopedics: a randomized clinical trial. To investigate the effects of infant orthopedics (IO) on the language skills of children with complete unilateral cleft lip and palate (UCLP).In a prospective randomized clinical trial (Dutchcleft), two groups of children with complete UCLP were followed up longitudinally: one group was treated with IO based on a modified Zurich approach in the first year of life (IO

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2716. An appraisal of three methods of rating facial deformity in patients with repaired complete unilateral cleft lip and palate. Full Text available with Trip Pro

An appraisal of three methods of rating facial deformity in patients with repaired complete unilateral cleft lip and palate. To evaluate the reliability of clinical assessment, two-dimensional color transparencies and three-dimensional imaging for evaluating the residual facial deformity in patients with repaired complete unilateral cleft lip and palate (UCLP) and compare the ratings of facial deformity made by health care professionals with those made by lay assessors. PATIENTS (...) AND PARTICIPANTS Thirty-one randomly selected subjects aged 10 to 30 years with repaired complete UCLP. Five professionals and five laypersons evaluated each subject's residual cleft-related facial deformity using clinical assessment, two-dimensional color transparencies, and three-dimensional images.The facial deformity of the full face, lip, nose, and midface were scored using a 5-point ordinal scale on two occasions with a 1-month interval. Intra- and interexaminer agreements were calculated from weighted

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2717. The effects of active infant orthopedics on occlusal relationships in unilateral complete cleft lip and palate. Full Text available with Trip Pro

The effects of active infant orthopedics on occlusal relationships in unilateral complete cleft lip and palate. To evaluate the effects of active infant orthopedic treatment on dental arch relationships and determine the effect on maxillary growth in children born with unilateral complete cleft lip and palate (UCCLP).The GOSLON Yardstick was used to assess dental models taken on patients treated with and without active infant orthopedics.Two groups of nonsyndromic Caucasian children born (...) with UCCLP (total n = 40), all treated by the same surgeon and ranging from 5 to 10 years of age, were evaluated.One group had a Latham dentomaxillary alignment (DMA) appliance inserted at 5 to 6 weeks of age, after which a lip-nasal adhesion was performed at an average age of 3.5 months. This was followed by more definitive nasolabial repair at the average age of 5.9 months. Those patients treated without preoperative orthopedics underwent a lip-nasal adhesion at average age 1.5 months followed

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2718. Phonological development of toddlers with unilateral cleft lip and palate who were treated with and without infant orthopedics: a randomized clinical trial. Full Text available with Trip Pro

Phonological development of toddlers with unilateral cleft lip and palate who were treated with and without infant orthopedics: a randomized clinical trial. To investigate the phonological development of toddlers from 2 to 3 years of age with complete unilateral cleft lip and palate (UCLP) treated during the first year of life with and without infant orthopedics (IO).In a randomized clinical trial (Dutchcleft), two groups of children were followed up: one treated with IO (IO group) and another (...) of a minimum of 2500 g, and gestation time of a minimum of 38 weeks.IO treatment based on a modified Zurich approach was started within 2 weeks after birth and used until soft palate closure at 12 months of age. Children in the non-IO group visited the clinic for an extra check-up at 6 weeks as well as before and after lip repair and soft palate closure. All other interventions were the same across groups.Phonological development of most 2.5-year-old IO children was normal or delayed. Most children

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2719. An intelligibility assessment of toddlers with cleft lip and palate who received and did not receive presurgical infant orthopedic treatment. (Abstract)

An intelligibility assessment of toddlers with cleft lip and palate who received and did not receive presurgical infant orthopedic treatment. A randomized, prospective, clinical study was performed investigating the effects of presurgical infant orthopedic treatment (PIO) in children with unilateral cleft lip and palate (UCLP). The influence of PIO on speech intelligibility was evaluated with two groups, each consisting of 10 children with UCLP. One group used PIO during the first year of life (...) group. However, data obtained by means of transcriptions indicated that, in fact, there were no group differences in actual intelligibility. Only in comparison with their noncleft peers were the children with cleft lip and palate significantly less well understood.

2001 Journal of communication disorders Controlled trial quality: uncertain

2720. Use of a perceptual evaluation instrument to assess the effects of infant orthopedics on the speech of toddlers with cleft lip and palate. Full Text available with Trip Pro

Use of a perceptual evaluation instrument to assess the effects of infant orthopedics on the speech of toddlers with cleft lip and palate. To investigate the effects of infant orthopedics (IO) administered in the first year of life on the speech characteristics of 2.5-year-old children with complete unilateral cleft lip and palate (UCLP) using a perceptual evaluation instrument with equal-appearing interval (EAI) scales.In a prospective randomized clinical trial (Dutchcleft), two groups (...) in a blinded perceptual rating procedure. They judged 13 specific speech characteristics and indicated their total impression of speech on EAI scales.The reliability and consistency of 11 of the rating scales was good. The intelligibility rating scale was the single speech characteristic that distinguished the IO group from the non-IO group; the IO group was judged to be superior. The cleft groups differed from the noncleft group on 9 of the 11 scales.Evaluation of speech by means of the present newly

2003 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

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