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Cleft Lip

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2681. Median clefting of the upper lip associated with cutaneous polyps. Full Text available with Trip Pro

Median clefting of the upper lip associated with cutaneous polyps. Details are presented of a patient with median clefting of the upper lip and cutaneous polyps. Four similar published case reports are considered to share the same condition. The spectrum of the disorder encompassed by these five cases is discussed.

1990 Journal of Medical Genetics

2682. Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate. Full Text available with Trip Pro

Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate. Complex segregation analysis of pedigrees having nonsyndromic cleft lip with or without cleft palate (CL/P) (Chung et al. 1986; Marazita et al. 1986) has shown that a major-locus model best explains the observed recurrence of CL/P in Caucasian families. To identify this major gene, we compared the frequencies of 12 RFLPs at five loci-epidermal growth factor, transforming growth factor-alpha (...) , epidermal growth factor receptor, glucocorticoid receptor, and estrogen receptor-in both a group of 80 subjects with nonsyndromic CL/P and 102 controls. These candidate genes were selected because studies in rodents had suggested their possible involvement in palatogenesis. A significant association was observed between two RFLPs at the transforming-growth-factor-alpha (TGFA) locus and the occurrence of clefting (P = .0047 and P = .0052). This suggests that either the TGFA gene itself or DNA sequences

1989 American Journal of Human Genetics

2683. Services for cleft lip and palate. Maxillofacial surgeons use strict surgical protocol. Full Text available with Trip Pro

Services for cleft lip and palate. Maxillofacial surgeons use strict surgical protocol. 7646674 1995 07 27 2018 11 13 0959-8138 310 6991 1995 May 27 BMJ (Clinical research ed.) BMJ Services for cleft lip and palate. Maxillofacial surgeons use strict surgical protocol. 1406 Booth P W PW eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Apr 15;310(6985):1006 7728003 BMJ. 1995 Apr 15;310(6985):1006 7794380 BMJ. 1994 Dec 10;309(6968):1552 7819898 Cleft Lip surgery Cleft Palate

1995 BMJ : British Medical Journal

2684. Services for cleft lip and palate. Surgical caseload is only one variable that influences outcome. Full Text available with Trip Pro

Services for cleft lip and palate. Surgical caseload is only one variable that influences outcome. 7787559 1995 07 27 2018 11 13 0959-8138 310 6991 1995 May 27 BMJ (Clinical research ed.) BMJ Services for cleft lip and palate. Surgical caseload is only one variable that influences outcome. 1406 Penfold C C eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Apr 15;310(6985):1006 7728003 BMJ. 1994 Dec 10;309(6968):1552 7819898 BMJ. 1995 Apr 15;310(6985):1006 7794380 Cleft Lip (...) surgery Cleft Palate surgery Humans Treatment Outcome Workload 1995 5 27 1995 5 27 0 1 1995 5 27 0 0 ppublish 7787559 PMC2549768 BMJ. 1994 Dec 10;309(6968):1552 7819898 Cleft Palate Craniofac J. 1992 Sep;29(5):413-8 1472519 BMJ. 1995 Apr 15;310(6985):1006 7794380

1995 BMJ : British Medical Journal

2685. Services for cleft lip and palate. All patients should have access to plastic surgery. Full Text available with Trip Pro

Services for cleft lip and palate. All patients should have access to plastic surgery. 7728003 1995 05 31 2018 11 13 0959-8138 310 6985 1995 Apr 15 BMJ (Clinical research ed.) BMJ Services for cleft lip and palate. All patients should have access to plastic surgery. 1006 Goldin J H JH eng Letter Comment England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 May 27;310(6991):1406 7646674 BMJ. 1995 Sep 9;311(7006):685-6 7549648 BMJ. 1995 May 27;310(6991):1406 7787559 BMJ. 1994 Dec 10;309(6968):1552 (...) 7819898 Cleft Lip surgery Cleft Palate surgery Health Services Accessibility Humans Surgery, Plastic United Kingdom 1995 4 15 1995 4 15 0 1 1995 4 15 0 0 ppublish 7728003 PMC2549385 BMJ. 1994 Dec 10;309(6968):1552 7819898

1995 BMJ : British Medical Journal

2686. Services for cleft lip and palate. Plastic surgeons support centralisation of services. Full Text available with Trip Pro

Services for cleft lip and palate. Plastic surgeons support centralisation of services. 7794380 1995 05 31 2018 11 13 0959-8138 310 6985 1995 Apr 15 BMJ (Clinical research ed.) BMJ Services for cleft lip and palate. Plastic surgeons support centralisation of services. 1006 Sykes P J PJ eng Letter Comment England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Sep 9;311(7006):685-6 7549648 BMJ. 1995 May 27;310(6991):1406 7646674 BMJ. 1995 May 27;310(6991):1406 7787559 BMJ. 1994 Dec 10;309(6968):1552 (...) 7819898 Cleft Lip surgery Cleft Palate surgery Humans Patient Care Team organization & administration Surgery, Plastic organization & administration United Kingdom 1995 4 15 1995 4 15 0 1 1995 4 15 0 0 ppublish 7794380 PMC2549386 BMJ. 1994 Dec 10;309(6968):1552 7819898

1995 BMJ : British Medical Journal

2687. Managing cleft lip and palate. Full Text available with Trip Pro

Managing cleft lip and palate. 7580431 1995 11 28 2018 11 13 0959-8138 311 7008 1995 Sep 23 BMJ (Clinical research ed.) BMJ Managing cleft lip and palate. 765-6 Markus T T Booth P W PW eng Comparative Study Editorial England BMJ 8900488 0959-8138 AIM IM BMJ. 1996 Jan 27;312(7025):252-3 8563614 BMJ. 1995 Nov 25;311(7017):1431-2; author reply 1432-3 8520284 BMJ. 1995 Nov 25;311(7017):1431; author reply 1432-3 8520282 BMJ. 1995 Nov 25;311(7017):1431; author reply 1432-3 8520283 BMJ. 1995 Nov (...) 25;311(7017):1432; author reply 1432-3 8520285 BMJ. 1995 Nov 25;311(7017):1432-3 8520286 Cleft Lip therapy Cleft Palate therapy Europe Humans Specialties, Surgical United Kingdom 1995 9 23 1995 9 23 0 1 1995 9 23 0 0 ppublish 7580431 PMC2550784 Br J Oral Maxillofac Surg. 1995 Jun;33(3):137-8 7654655 Cleft Palate Craniofac J. 1992 Sep;29(5):413-8 1472519 Br J Oral Maxillofac Surg. 1992 Oct;30(5):296-304 1390561 Br J Oral Maxillofac Surg. 1992 Oct;30(5):287-95 1390560 N Engl J Med. 1990 Jul 5;323(1):1

1995 BMJ : British Medical Journal

2688. Managing cleft lip and palate. Language outcomes are important. Full Text available with Trip Pro

Managing cleft lip and palate. Language outcomes are important. 8520285 1996 01 22 2018 11 13 0959-8138 311 7017 1995 Nov 25 BMJ (Clinical research ed.) BMJ Managing cleft lip and palate. Language outcomes are important. 1432; author reply 1432-3 Harding A A Harland K K eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Sep 23;311(7008):765-6 7580431 Cleft Lip complications surgery Cleft Palate complications surgery Humans Speech Disorders etiology rehabilitation Speech Therapy (...) 1995 11 25 1995 11 25 0 1 1995 11 25 0 0 ppublish 8520285 PMC2544391 Cleft Palate J. 1988 Jan;25(1):3-7 3422597 BMJ. 1995 Sep 23;311(7008):765-6 7580431

1995 BMJ : British Medical Journal

2689. Managing cleft lip and palate. An invitation for Markus to present his results. Full Text available with Trip Pro

Managing cleft lip and palate. An invitation for Markus to present his results. 8520286 1996 01 22 2018 11 13 0959-8138 311 7017 1995 Nov 25 BMJ (Clinical research ed.) BMJ Managing cleft lip and palate. An invitation for Markus to present his results. 1432-3 Sell D A DA Sommerlad B C BC Christie F B FB Ferguson M J MJ Fastassen L L Russell V J VJ Milling M A MA Moos K F KF Moss J P JP Fenton O O eng Letter Comment England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Sep 23;311(7008):765-6 7580431 (...) BMJ 1995 Dec 16;311(7020):1645 Cleft Lip surgery Cleft Palate surgery Humans Societies, Medical United Kingdom 1995 11 25 1995 11 25 0 1 1995 11 25 0 0 ppublish 8520286 PMC2544398 BMJ. 1995 Sep 23;311(7008):765-6 7580431

1995 BMJ : British Medical Journal

2690. Managing cleft lip and palate. Trials of management are inevitably long. Full Text available with Trip Pro

Managing cleft lip and palate. Trials of management are inevitably long. 8520283 1996 01 22 2018 11 13 0959-8138 311 7017 1995 Nov 25 BMJ (Clinical research ed.) BMJ Managing cleft lip and palate. Trials of management are inevitably long. 1431; author reply 1432-3 Pigott R W RW eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Sep 23;311(7008):765-6 7580431 BMJ. 1996 Jan 27;312(7025):252-3 8563614 Cleft Lip surgery Cleft Palate surgery Clinical Trials as Topic Humans 1995 11 25 (...) 1995 11 25 0 1 1995 11 25 0 0 ppublish 8520283 PMC2544411 Cleft Palate Craniofac J. 1995 May;32(3):194-8 7605786 BMJ. 1995 Sep 23;311(7008):765-6 7580431 Br J Plast Surg. 1992 Aug-Sep;45(6):454-9 1393249

1995 BMJ : British Medical Journal

2691. Managing cleft lip and palate. Editorial proves controversial. Full Text available with Trip Pro

Managing cleft lip and palate. Editorial proves controversial. 8520282 1996 01 22 2018 11 13 0959-8138 311 7017 1995 Nov 25 BMJ (Clinical research ed.) BMJ Managing cleft lip and palate. Editorial proves controversial. 1431; author reply 1432-3 Timmons M J MJ eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Sep 23;311(7008):765-6 7580431 BMJ. 1996 Jan 27;312(7025):252-3 8563614 Cleft Lip surgery Cleft Palate surgery Humans 1995 11 25 1995 11 25 0 1 1995 11 25 0 0 ppublish (...) 8520282 PMC2544413 Clin Plast Surg. 1990 Jan;17(1):27-36 2406096 Br J Plast Surg. 1990 May;43(3):318-21 2350638 Br J Plast Surg. 1991 Nov-Dec;44(8):557-61 1773214 Br J Plast Surg. 1993 Jan;46(1):7-12 8431745 Br J Plast Surg. 1993 Dec;46(8):681-5 8298782 Plast Reconstr Surg. 1994 Apr;93(5):948-53 8134487 Eur J Disord Commun. 1994;29(1):1-15 8032102 BMJ. 1995 Sep 23;311(7008):765-6 7580431 Br J Plast Surg. 1994 Jul;47(5):301-5 8087366 Br J Plast Surg. 1994 Sep;47(6):406-10 7952806 Cleft Palate Craniofac

1995 BMJ : British Medical Journal

2692. Managing cleft lip and palate. Specialised multidisciplinary team can solve problems of distance. Full Text available with Trip Pro

Managing cleft lip and palate. Specialised multidisciplinary team can solve problems of distance. 8520284 1996 01 22 2018 11 13 0959-8138 311 7017 1995 Nov 25 BMJ (Clinical research ed.) BMJ Managing cleft lip and palate. Specialised multidisciplinary team can solve problems of distance. 1431-2; author reply 1432-3 Carre A A Gibbin K P KP Henley M M Nashed R N RN eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Sep 23;311(7008):765-6 7580431 BMJ. 1996 Jan 27;312(7025):252-3 (...) 8563614 Cleft Lip surgery Cleft Palate surgery Humans Patient Care Team 1995 11 25 1995 11 25 0 1 1995 11 25 0 0 ppublish 8520284 PMC2544427 BMJ. 1995 Sep 23;311(7008):765-6 7580431 Br J Oral Maxillofac Surg. 1995 Aug;33(4):205-6 8736743

1995 BMJ : British Medical Journal

2693. Provision of services for cleft lip and palate. Full Text available with Trip Pro

Provision of services for cleft lip and palate. 7549648 1995 11 07 2018 11 13 0959-8138 311 7006 1995 Sep 09 BMJ (Clinical research ed.) BMJ Provision of services for cleft lip and palate. 685-6 Shaw W C WC Devlin H B HB Williams A A eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Apr 15;310(6985):1006 7728003 BMJ. 1994 Dec 10;309(6968):1552 7819898 BMJ. 1995 Apr 15;310(6985):1006 7794380 Cleft Lip therapy Cleft Palate therapy Health Services supply & distribution Humans 1995 (...) 9 9 1995 9 9 0 1 1995 9 9 0 0 ppublish 7549648 PMC2551450 Cleft Palate Craniofac J. 1992 Sep;29(5):413-8 1472519 Cleft Palate Craniofac J. 1991 Apr;28(2):141-9 1829965 BMJ. 1994 Dec 10;309(6968):1552 7819898

1995 BMJ : British Medical Journal

2694. Managing cleft lip and palate. Full Text available with Trip Pro

Managing cleft lip and palate. 8563614 1996 03 06 2018 11 13 0959-8138 312 7025 1996 Jan 27 BMJ (Clinical research ed.) BMJ Managing cleft lip and palate. 252-3 Davies G G Partridge J J eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Sep 23;311(7008):765-6 7580431 BMJ. 1995 Nov 25;311(7017):1431; author reply 1432-3 8520282 BMJ. 1995 Nov 25;311(7017):1431-2; author reply 1432-3 8520284 BMJ. 1995 Nov 25;311(7017):1431; author reply 1432-3 8520283 Cleft Lip surgery Cleft Palate

1996 BMJ : British Medical Journal

2695. Van der Woude syndrome and nonsyndromic cleft lip and palate. Full Text available with Trip Pro

Van der Woude syndrome and nonsyndromic cleft lip and palate. 1642245 1992 09 01 2018 11 13 0002-9297 51 2 1992 Aug American journal of human genetics Am. J. Hum. Genet. Van der Woude syndrome and nonsyndromic cleft lip and palate. 442-4 Hecht J T JT Wang Y Y Blanton S H SH Daiger S P SP eng Letter United States Am J Hum Genet 0370475 0002-9297 IM VWS Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 2 Cleft Lip genetics Cleft Palate genetics Genes, Dominant Genetic Linkage Humans Lod Score

1992 American Journal of Human Genetics

2696. Confirmation of an association between RFLPs at the transforming growth factor-alpha locus and non-syndromic cleft lip and palate. Full Text available with Trip Pro

Confirmation of an association between RFLPs at the transforming growth factor-alpha locus and non-syndromic cleft lip and palate. Three RFLPs at the TGFA locus were studied in 60 unrelated British Caucasian subjects with non-syndromic cleft lip/palate and 60 controls. A highly significant association between the TaqI RFLP and the occurrence of clefting was found (chi 2 = 15.04, p = less than 0.001). No significant association was found with the two other RFLPs studied (BamHI and RsaI (...) ). Haplotypes derived from the three RFLPs at the TGFA locus also showed an over-representation of the C2A2B2 haplotype in cases compared to controls. Analyses of genotypes according to type of cleft and the presence or absence of a family history of clefting were also carried out. These results provide further support for the role of TGFA as a gene of major effect in the development of orofacial clefts in humans.

1992 Journal of Medical Genetics

2697. No evidence of linkage between the transforming growth factor-alpha gene in families with apparently autosomal dominant inheritance of cleft lip and palate. Full Text available with Trip Pro

No evidence of linkage between the transforming growth factor-alpha gene in families with apparently autosomal dominant inheritance of cleft lip and palate. Eight families have been identified with cleft lip, with or without cleft palate (CL/P), inherited in an apparently autosomal dominant manner. Transforming growth factor-alpha (TGFA) has been tested as a candidate gene for clefting in these families. Negative lod scores were generated in an autosomal dominant model with 80% penetrance (Z

1992 Journal of Medical Genetics

2698. Selection bias in genetic-epidemiological studies of cleft lip and palate. Full Text available with Trip Pro

Selection bias in genetic-epidemiological studies of cleft lip and palate. The possible impact of selection bias in genetic and epidemiological studies of cleft lip and palate was studied, using three nationwide ascertainment sources and an autopsy study in a 10% sample of the Danish population. A total of 670 cases were identified. Two national record systems, when used together, were found suitable for ascertaining facial cleft in live births. More than 95% ascertainment was obtained by means (...) of surgical files for cleft lip (with or without cleft palate) without associated malformations/syndromes. However, surgical files could be a poor source for studying isolated cleft palate (CP) (only a 60% and biased ascertainment), and they cannot be used to study the prevalence of associated malformations or syndromes in facial cleft cases. The male:female ratio was 0.88 in surgically treated cases of CP and was 1.5 in nonoperated CP cases, making the overall sex ratio for CP 1.1 (95% confidence limits

1992 American Journal of Human Genetics

2699. Height and weight achievement in cleft lip and palate. Full Text available with Trip Pro

Height and weight achievement in cleft lip and palate. Growth was studied in 83 children with cleft lip and/or palate aged 0-4 years attending a specialist regional centre. Information was collected by a personal interview, postal questionnaire, and record review. The group as a whole grew relatively poorly in early infancy but subsequently recovered, attaining both expected weight and height by last follow up at age 25.5 months (range 3 to 47). However, the group proved heterogeneous (...) , with children with isolated clefts of the secondary palate showing the most abnormal growth. Children with underlying syndromes were significantly more likely to be short at follow up, while type or severity of cleft was not significantly related to follow up height. Therefore, while cleft palate was associated with significant growth faltering in early infancy, rapid recovery took place following surgical repair and appears to have resulted in no residual growth deficit.

1996 Archives of Disease in Childhood

2700. Syndactyly, ectodermal dysplasia, and cleft lip/palate. Full Text available with Trip Pro

Syndactyly, ectodermal dysplasia, and cleft lip/palate. 7891379 1995 04 20 2018 11 13 0022-2593 31 12 1994 Dec Journal of medical genetics J. Med. Genet. Syndactyly, ectodermal dysplasia, and cleft lip/palate. 957-9 Zlotogora J J Department of Human Genetics, Hadassah Medical Centre, Hebrew University, Jerusalem, Israel. eng Journal Article England J Med Genet 2985087R 0022-2593 IM Abnormalities, Multiple genetics Cleft Lip genetics Cleft Palate genetics Diagnosis, Differential Ectodermal

1994 Journal of Medical Genetics

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