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Cleft Lip

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2661. Evidence for an association between RFLPs at the transforming growth factor alpha (locus) and nonsyndromic cleft lip/palate in a South American population. Full Text available with Trip Pro

Evidence for an association between RFLPs at the transforming growth factor alpha (locus) and nonsyndromic cleft lip/palate in a South American population. 7825598 1995 02 13 2018 11 13 0002-9297 56 1 1995 Jan American journal of human genetics Am. J. Hum. Genet. Evidence for an association between RFLPs at the transforming growth factor alpha (locus) and nonsyndromic cleft lip/palate in a South American population. 339-41 Jara L L Blanco R R Chiffelle I I Palomino H H Carreño H H eng Letter (...) Research Support, Non-U.S. Gov't United States Am J Hum Genet 0370475 0002-9297 0 Transforming Growth Factor alpha IM Alleles Chile Cleft Lip genetics Cleft Palate genetics Female Gene Frequency Genotype Humans Male Polymorphism, Restriction Fragment Length Transforming Growth Factor alpha genetics 1995 1 1 1995 1 1 0 1 1995 1 1 0 0 ppublish 7825598 PMC1801345 Am J Hum Genet. 1992 Apr;50(4):870-1 1347971 Am J Hum Genet. 1991 May;48(5):1012-3 1673285 Nucleic Acids Res. 1986 Sep 11;14(17):7136 2876411

1995 American Journal of Human Genetics

2662. Management of children with cleft lip and palate. Full Text available with Trip Pro

Management of children with cleft lip and palate. Cleft lip or palate or both is one of the common congenital conditions in Ontario; its incidence is 1.2 to 1.6 per 1000 live births. A review of the records of 358 patients showed that 40%, particularly those with a severe defect, had other medical problems. This condition can affect the children and their families in many ways. In early life many patients undergo surgical repair and have speech, hearing and dental problems; during adolescence (...) they may have cosmetic, orthodontic and emotional problems. Many parents are concerned about the genetic implications of the defect. This variety of problems requires management by several health care disciplines. Many Canadian health sciences centres offer multidisciplinary team management in a cleft palate clinic. The child's primary care physician, with whom the team exchanges information, plays a significant role in helping the child and the family function optimally.

1980 Canadian Medical Association Journal

2663. Syndrome of polydactyly, cleft lip/palate or lingual lump, and psychomotor retardation in endogamic gypsies. Full Text available with Trip Pro

Syndrome of polydactyly, cleft lip/palate or lingual lump, and psychomotor retardation in endogamic gypsies. Six children in an inbred isolate (a gypsy colony) were found to have a syndrome of reduplication of the big toes, supernumerary fingers on the hands, cleft lip/palate or lingual nodule, and somatic and psychomotor retardation. Other features sometimes present were absence of olfactory bulbs and tracts, cryptorchidism, inguinal hernia, and congenital heart disease. The disorder has

1980 Journal of Medical Genetics

2664. Syndrome of polydactyly, cleft lip, lingual hamartomas, renal hypoplasia, hearing loss, and psychomotor retardation: variant of the Mohr syndrome or a new syndrome? Full Text available with Trip Pro

Syndrome of polydactyly, cleft lip, lingual hamartomas, renal hypoplasia, hearing loss, and psychomotor retardation: variant of the Mohr syndrome or a new syndrome? Three sibs, the proband and two monozygotic twins, have a condition including mental retardation, postnatal somatic retardation, preaxial polydactyly of the feet, bifid third metacarpal, median cleft lip, fatty hamartomas on the dorsum of the tongue, conductive hearing loss, and unilateral or bilateral renal agenesis. This probably

1983 Journal of Medical Genetics

2665. Syndactyly, ectodermal dysplasia, and cleft lip and palate. Full Text available with Trip Pro

Syndactyly, ectodermal dysplasia, and cleft lip and palate. 2845087 1988 11 17 2018 11 13 0022-2593 25 7 1988 Jul Journal of medical genetics J. Med. Genet. Syndactyly, ectodermal dysplasia, and cleft lip and palate. 503 Zlotogora J J Ogur G G eng Letter England J Med Genet 2985087R 0022-2593 IM Abnormalities, Multiple Cleft Lip Cleft Palate Consanguinity Ectodermal Dysplasia Female Humans Intellectual Disability Male Syndactyly Syndrome 1988 7 1 1988 7 1 0 1 1988 7 1 0 0 ppublish 2845087

1988 Journal of Medical Genetics

2666. The Van der Woude syndrome (dominantly inherited lip pits and clefts). Full Text available with Trip Pro

The Van der Woude syndrome (dominantly inherited lip pits and clefts). 3746828 1986 10 03 2018 11 13 0022-2593 23 4 1986 Aug Journal of medical genetics J. Med. Genet. The Van der Woude syndrome (dominantly inherited lip pits and clefts). 291-4 Schinzel A A Kläusler M M eng Journal Article Research Support, Non-U.S. Gov't England J Med Genet 2985087R 0022-2593 IM Abnormalities, Multiple diagnosis genetics Cleft Lip epidemiology genetics pathology Diagnosis, Differential Genes, Dominant Humans (...) Lip abnormalities Syndrome 1986 8 1 1986 8 1 0 1 1986 8 1 0 0 ppublish 3746828 PMC1049692 Br J Plast Surg. 1981 Jan;34(1):26-30 7459520 Cleft Palate J. 1970 Jan;7:336-46 5266345 Am J Hum Genet. 1954 Jun;6(2):244-56 13158329 J Craniofac Genet Dev Biol. 1985;5(2):181-208 4019732 Am J Hum Genet. 1967 May;19(3 Pt 2):416-32 6026934

1986 Journal of Medical Genetics

2667. Association of syndactyly, ectodermal dysplasia, and cleft lip and palate: report of two sibs from Turkey. Full Text available with Trip Pro

Association of syndactyly, ectodermal dysplasia, and cleft lip and palate: report of two sibs from Turkey. Two Turkish sibs, products of a second cousin marriage, with tetramelic syndactyly, ectodermal dysplasia, cleft lip and palate, renal anomalies, and mental retardation are reported. Similarities between these two brothers and previously reported cases and their mode of transmission are discussed.

1988 Journal of Medical Genetics

2668. Cleft lip and palate, pili torti, malformed ears, partial syndactyly of fingers and toes, and mental retardation: a new syndrome? Full Text available with Trip Pro

Cleft lip and palate, pili torti, malformed ears, partial syndactyly of fingers and toes, and mental retardation: a new syndrome? Two sibs with a syndrome including cleft lip and palate, sparse scalp hair, malformed protruding ears, and partial syndactyly of the fingers and toes are reported. The older child also has mental retardation and pili torti. This syndrome is most probably inherited as an autosomal recessive disorder.

1987 Journal of Medical Genetics

2669. Multiple malformation syndrome including cleft lip and palate and cardiac abnormalities due to an interstitial deletion of chromosome 12q. Full Text available with Trip Pro

Multiple malformation syndrome including cleft lip and palate and cardiac abnormalities due to an interstitial deletion of chromosome 12q. 3573007 1987 06 12 2018 11 13 0022-2593 24 3 1987 Mar Journal of medical genetics J. Med. Genet. Multiple malformation syndrome including cleft lip and palate and cardiac abnormalities due to an interstitial deletion of chromosome 12q. 187 Meinecke P P Meinecke R R eng Case Reports Journal Article England J Med Genet 2985087R 0022-2593 IM Abnormalities (...) , Multiple genetics Chromosome Banding Chromosome Deletion Chromosomes, Human, Pair 12 Cleft Lip genetics Cleft Palate genetics Heart Defects, Congenital genetics Humans Infant, Newborn Male 1987 3 1 1987 3 1 0 1 1987 3 1 0 0 ppublish 3573007 PMC1049959 Cleft Palate J. 1978 Oct;15(4):306-28 281275

1987 Journal of Medical Genetics

2670. Theoretical recurrence risks for cleft lip derived from a population of consecutive newborns. Full Text available with Trip Pro

Theoretical recurrence risks for cleft lip derived from a population of consecutive newborns. Theoretical recurrence risks for cleft lip with or without cleft palate (CL(P)) were calculated from heritability estimates derived from a population of 203 newborns with CL(P) in a total of 220,927 consecutive births in north-east Italy. Birth prevalence of CL(P) and the frequency of CL(P) in relatives of probands were estimated after exclusion of cases with CL(P) resulting from a known cause

1988 Journal of Medical Genetics

2671. An autosomal dominant syndrome of uveal colobomata, cleft lip and palate, and mental retardation. Full Text available with Trip Pro

An autosomal dominant syndrome of uveal colobomata, cleft lip and palate, and mental retardation. This report details a family in whom there is autosomal dominantly inherited uveal colobomata, associated eye defects, and cleft lip and palate occurring in twelve subjects over three generations. Considerable variability in expression of the gene is apparent, uveal colobomata being the most constant feature, and the full syndrome probably includes mental retardation of varying degree

1982 Journal of Medical Genetics

2672. Ectrodactyly, cleft lip and palate in two half sibs. Full Text available with Trip Pro

Ectrodactyly, cleft lip and palate in two half sibs. Two half sibs with bilateral complete cleft lip and complete cleft of the palate associated with ectrodactyly of the hands and feet, born to the same phenotypically normal mother, are reported. The younger of the two sibs also has dominantly inherited tremors (also referred to as essential heredofamilial tremors) as did her biological father. Possible genetic causes to explain the recurrence of the facial and limb malformations in the half

1981 Journal of Medical Genetics

2673. Keratoconus posticus circumscriptus, cleft lip and palate, genitourinary abnormalities, short stature, and mental retardation in sibs Full Text available with Trip Pro

Keratoconus posticus circumscriptus, cleft lip and palate, genitourinary abnormalities, short stature, and mental retardation in sibs 7143385 1983 01 19 2018 11 13 0022-2593 19 5 1982 Oct Journal of medical genetics J. Med. Genet. Keratoconus posticus circumscriptus, cleft lip and palate, genitourinary abnormalities, short stature, and mental retardation in sibs. 332-6 Young I D ID Macrae W G WG Hughes H E HE Crawford J S JS eng Case Reports Journal Article England J Med Genet 2985087R 0022 (...) -2593 IM Adult Body Height Child Cleft Lip genetics Cleft Palate genetics Female Genes, Recessive Humans Intellectual Disability genetics Keratoconus genetics Male Syndrome Urogenital Abnormalities 1982 10 1 1982 10 1 0 1 1982 10 1 0 0 ppublish 7143385 PMC1048916 J Pediatr. 1966 Oct;69(4):624-9 5921339 J Pediatr. 1967 Mar;70(3):398-406 4959856 Br J Ophthalmol. 1967 Jul;51(7):486-8 6029234 Am J Ophthalmol. 1974 Jan;77(1):80-6 4824179 Clin Genet. 1974 Jan;5(1):36-9 4839026 Ann Ophthalmol. 1975 Jun;7(6

1982 Journal of Medical Genetics

2674. Management of Cleft Lip and Palate: A Team Approach Full Text available with Trip Pro

Management of Cleft Lip and Palate: A Team Approach Cleft lip and/or palate is a common congenital malformation. The initial management of the affected infant and family begins in the delivery suite in the hands of the family physician. With patient, informed psychosocial counselling, the family should be told the origin of the malformation, practical tips on managing their child, especially feeding and attending to middle ear infections, and the work of the cleft lip and palate team

1981 Canadian Family Physician

2675. Dominantly inherited cleft lip and palate in two families. Full Text available with Trip Pro

Dominantly inherited cleft lip and palate in two families. Two families with non-syndromic cleft lip and cleft palate are described. The linear pattern of inheritance through several generations is difficult to explain by conventional multifactorial models. The pedigrees strengthen the suggestion that a dominantly inherited mutation exists with a major influence on clefting of the lip and palate alone.

1989 Journal of Medical Genetics

2676. Birth prevalence of cleft lip and palate in British Columbia between 1952 and 1986: stability of rates. Full Text available with Trip Pro

Birth prevalence of cleft lip and palate in British Columbia between 1952 and 1986: stability of rates. We examined the birth prevalence of cleft lip with or without cleft palate and of isolated cleft palate in British Columbia between 1952 and 1986 using the data of the BC Health Surveillance Registry. The rates fluctuated over the study period, but linear trend analysis showed no increase or decrease for cleft lip with or without cleft palate; however, there was a significant increase (...) for isolated cleft palate, attributed to improved ascertainment around 1963-66. Given the possible effects of newer agents used in both silviculture and agriculture, as well as the general concern over drugs and other environmental agents, such a long-term monitoring program is important. Furthermore, if significant clustering occurs, good background data are essential for comparison. The general public's perception is that the rates of birth defects are increasing. Our findings should give some

1989 CMAJ: Canadian Medical Association Journal

2677. Cleft lip and palate, sensorineural deafness, and sacral lipoma in two brothers: a possible example of the disorganisation mutant. Full Text available with Trip Pro

Cleft lip and palate, sensorineural deafness, and sacral lipoma in two brothers: a possible example of the disorganisation mutant. We report two brothers of Chinese origin who have an apparently unique syndrome of cleft lip/palate, profound sensorineural deafness, and a sacral lipoma. Additional findings which were not common to both were aberrant digital appendages on the heel and thigh of one boy and an anterior sacral meningocele and dislocated hip in the other. Intelligence is normal

1991 Journal of Medical Genetics

2678. Feeding children who have cleft lip or palate. Full Text available with Trip Pro

Feeding children who have cleft lip or palate. 2006576 1991 04 25 2018 11 13 0093-0415 154 2 1991 Feb The Western journal of medicine West. J. Med. Feeding children who have cleft lip or palate. 207 Fisher J C JC eng Journal Article United States West J Med 0410504 0093-0415 AIM IM Bottle Feeding Breast Feeding Cleft Lip physiopathology Cleft Palate physiopathology Female Humans Infant, Newborn 1991 2 1 1991 2 1 0 1 1991 2 1 0 0 ppublish 2006576 PMC1002722 Cleft Palate J. 1987 Jul;24(3):244-9

1991 Western Journal of Medicine

2679. Dominantly inherited cleft lip and palate. Full Text available with Trip Pro

Dominantly inherited cleft lip and palate. 2520157 1990 03 05 2018 11 13 0022-2593 26 12 1989 Dec Journal of medical genetics J. Med. Genet. Dominantly inherited cleft lip and palate. 794 De Paepe A A eng Case Reports Letter England J Med Genet 2985087R 0022-2593 IM J Med Genet. 1990 Sep;27(9):597 2231656 Cleft Lip genetics Cleft Palate genetics Female Humans Male Pedigree 1989 12 1 1989 12 1 0 1 1989 12 1 0 0 ppublish 2520157 PMC1015770 Clin Genet. 1987 Aug;32(2):129-32 2888553

1989 Journal of Medical Genetics

2680. Dominantly inherited cleft lip and palate. Full Text available with Trip Pro

Dominantly inherited cleft lip and palate. 2231656 1990 12 04 2018 11 13 0022-2593 27 9 1990 Sep Journal of medical genetics J. Med. Genet. Dominantly inherited cleft lip and palate. 597 Hecht J T JT eng Comment Letter England J Med Genet 2985087R 0022-2593 IM J Med Genet. 1989 Dec;26(12):794 2520157 J Med Genet. 1989 Jun;26(6):386-9 2738901 Cleft Lip genetics Cleft Palate genetics Genes, Dominant Humans Pedigree Risk Factors 1990 9 1 1990 9 1 0 1 1990 9 1 0 0 ppublish 2231656 PMC1017227 J Med

1990 Journal of Medical Genetics

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