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Cleft Lip

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2581. Comparative anti-caries effects of tablet and liquid fluorides in cleft children. (Abstract)

Comparative anti-caries effects of tablet and liquid fluorides in cleft children. Children with cleft lip and/or palate are at a higher risk for developing caries of the primary incisors compared with non-cleft children. To determine whether fluoride in tablet or liquid form would be more efficacious with children with cleft lip and/or palate, a two-year clinical investigation was conducted to test the anti-caries effects. One-hundred and fifteen cleft children (59 boys and 56 girls) between 22 (...) early childhood caries in the cleft children. Liquid fluoride showed slightly better numerical anti-caries effect than tablet fluoride, which is possibly due to its ease of administration with small children.

2000 The Journal of clinical dentistry Controlled trial quality: uncertain

2582. Pierre Robin sequence in a patient with ectrodactyly-ectodermal dysplasia-clefting syndrome: a case report and review of the literature. (Abstract)

Pierre Robin sequence in a patient with ectrodactyly-ectodermal dysplasia-clefting syndrome: a case report and review of the literature. Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome is a rare condition first identified in 1970. The majority of cases are reported to be autosomal dominant with variable expression and penetrance. The most common clinical feature is ectodermal dysplasia. Ectrodactyly, cleft lip with or with out cleft palate and urogenital anomalies are also main (...) clinical features of EEC syndrome. Pierre Robin (PR) sequence has the clinical findings of micro-retrognathia, retroposed tongue (glossoptosis), cleft of the secondary palate, and upper airway obstruction. Etiologically PR sequence is heterogeneous. It has been reported that less than 20% of cases are isolated, non-syndromic PR sequence. We present a case of a newborn male who was referred to our craniofacial clinic with EEC syndrome and PR sequence. This case represents a unique clinical association

2002 International Journal of Pediatric Otorhinolaryngology

2583. Congenital mid-line cervical cleft: case report and review of literature. (Abstract)

in the cervical area from the pericardial roof in the developing embryo. Histologically, the cleft usually consists of a stratified keratinized squamous epithelium with hyperkeratosis, dermal fibrosis and little or no skin appendages. Associated clinical features could include thyroglossal duct cysts, cleft lip/mandible/sternum, cervical contractures, mandibular spurs, microgenia and or bronchogenic cysts. In this article we present a patient with CMCC. An extensive review of the literature is also included. (...) Congenital mid-line cervical cleft: case report and review of literature. Congenital Mid-line Cervical Cleft (CMCC) is a rare but interesting congenital anomaly of the neck that is frequently misdiagnosed. Much controversy exist regarding its aetiology. Embryologically, the occurrence of CMCC is thought to be due to many hypotheses that include impaired mid-line fusion of the first or second branchial arches, exteriorisation of a thyroglossal duct remnant, and or increased pressure

2003 International Journal of Pediatric Otorhinolaryngology

2584. Protective effect of hyperemesis gravidarum for nonsyndromic oral clefts. (Abstract)

Protective effect of hyperemesis gravidarum for nonsyndromic oral clefts. To evaluate whether hyperemesis gravidarum is associated with a decreased risk for nonsyndromic oral clefts and to examine the relationship between hyperemesis gravidarum, birth weight, and gestational age.This was a population-based, matched case-control study of 1950 subjects with oral clefts (1368 with cleft lip with or without cleft palate; 582 with cleft palate) collected from the Hungarian Congenital Abnormality (...) Registry and 1955 controls identified from the National Birth Registry.Fewer mothers of newborns with oral clefts had early-onset hyperemesis gravidarum than did mothers of controls (cleft lip with or without cleft palate: 83 cases and 121 controls, odds ratio [OR] = 0.67, 95% confidence interval [CI] 0.50, 0.89; cleft palate: 42 cases and 64 controls, OR = 0.63, 95% CI 0.42, 0.94). The use of dimenhydrinate was more common among mothers of subjects with cleft palate (OR = 2.47, 95% CI 1.11, 5.49

2003 Obstetrics and Gynecology

2585. MSX1 and TGFB3 contribute to clefting in South America. (Abstract)

MSX1 and TGFB3 contribute to clefting in South America. MSX1 and TGFB3 have been proposed as genes in which mutations may contribute to non-syndromic forms of oral clefts; however, an interaction between these genes has not been described. The present study attempts to detect transmission distortion of MSX1 and TGFB3 in 217 South American children from their respective mothers. With transmission disequilibrium test analysis, cleft lip with/without cleft palate, cleft lip with palate plus cleft (...) palate only, and all datasets combined showed evidence of association with MSX1 (p = 0.004, p = 0.037, and p = 0.001, respectively). With likelihood ratio test analysis, "cleft lip only" showed association with MSX1 (p = 0.04) and "cleft palate only" with TGFB3 (p = 0.02). A joint analysis of MSX1 and TGFB3 suggested that there may be an interaction between these two loci to increase cleft susceptibility. These results suggest that MSX1 and TGFB3 mutations make a contribution to clefts in South

2003 Journal of Dental Research

2586. Augmentation of the nasal floor with Surgicel in primary lip repair: a prospective study showing no efficacy. (Abstract)

Augmentation of the nasal floor with Surgicel in primary lip repair: a prospective study showing no efficacy. The symmetry of the alar base and the nasal floor is very important in achieving a satisfactory result in primary lip and nasal reconstruction during cleft lip repair. The skeletal base of the nasal pyramid is usually hypoplastic even in incomplete clefts. A periosteal pocket filled with Surgicel can facilitate blood clot formation and can theoretically stimulate bone formation, thereby (...) improving the asymmetry of the bone base. To test this hypothesis, a prospective study was performed in 64 primary lip repairs by comparing the effect of subperiosteal nasal floor augmentation with Surgicel. From February 1989 to June 1993, 64 patients with incomplete cleft lips (excluding occult cleft lip and complete clefts with Simonart's band) were operated by the same surgeon. The patients were divided randomly into two groups. One group had subperiosteal nasal floor augmentation with Surgicel

1999 Annals of plastic surgery Controlled trial quality: uncertain

2587. Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate. (Abstract)

Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate. Homozygous null mice for thyroid transcription factor (TTF)-2 gene exhibit cleft palate and thyroid malformation. We performed a genetic analysis of the TTF-2 gene in 2 children with congenital hypothyroidism (CH) and cleft palate, 45 children with thyroid dysgenesis, 19 children with isolated cleft palate or cleft lip, 4 patients with thyroid

2004 Thyroid

2588. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. (Abstract)

Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. Cleft lip or palate (or the two in combination) is a common birth defect that results from a mixture of genetic and environmental factors. We searched for a specific genetic factor contributing to this complex trait by examining large numbers of affected patients and families and evaluating a specific candidate gene.We identified the gene that encodes interferon regulatory factor 6 (IRF6 (...) ) as a candidate gene on the basis of its involvement in an autosomal dominant form of cleft lip and palate, Van der Woude's syndrome. A single-nucleotide polymorphism in this gene results in either a valine or an isoleucine at amino acid position 274 (V274I). We carried out transmission-disequilibrium testing for V274I in 8003 individual subjects in 1968 families derived from 10 populations with ancestry in Asia, Europe, and South America, haplotype and linkage analyses, and case-control analyses

2004 NEJM

2589. Long term follow up study of survival associated with cleft lip and palate at birth. Full Text available with Trip Pro

Long term follow up study of survival associated with cleft lip and palate at birth. To assess the overall and cause specific mortality of people from birth to 55 years with cleft lip and palate.Long term follow up study.Danish register of deaths.People born with cleft lip and palate between 1943 and 1987, followed to 1998.Observed and expected numbers of deaths, summarised as overall and cause specific standardised mortality ratios.5331 people with cleft lip and palate were followed for 170 (...) 421 person years. The expected number of deaths was 259, but 402 occurred, corresponding to a standardised mortality ratio of 1.4 (95% confidence interval 1.3 to 1.6) for males and 1.8 (1.5 to 2.1) for females. The increased risk of mortality was nearly constant for the three intervals at follow up: first year of life, 1-17 years, and 18-55 years. The participants had an increased risk of all major causes of death.People with cleft lip and palate have increased mortality up to age 55. Children

2004 BMJ

2590. Does repairing a cleft lip neonatally have any effect on the longer-term attractiveness of the repair? (Abstract)

Does repairing a cleft lip neonatally have any effect on the longer-term attractiveness of the repair? To determine whether attractiveness and success of surgical outcome differ according to the timing of cleft lip repair.Three experiments were conducted: (1) surgeons rated postoperative medical photographs of infants having either neonatal or 3-month lip repair; (2) lay panelists rated the same photographs; (3) lay panelists rated dynamic video displays of the infants made at 12 months. Normal (...) comparison infants were also rated. The order of stimuli was randomized, and panelists were blind to timing of lip repair and the purposes of the study.Four U.K. regional centers for cleft lip and palate.Infants with isolated clefts of the lip, with and without palate.Early lip repair was conducted at median age 4 days (interquartile range [IQR] = 4), and late repair at 104 days (IQR = 57).Ratings of surgical outcome (Experiment 1 only) and attractiveness (all experiments) on 5-point Likert scales.In

2005 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Controlled trial quality: predicted high

2591. Evaluation of oral and nasal odor in patients with and without cleft lip and palate: preliminary report. (Abstract)

Evaluation of oral and nasal odor in patients with and without cleft lip and palate: preliminary report. To evaluate oral and nasal halitosis parameters in patients with and without clefts.Randomized and prospective study. Patients with and without clefts were evaluated as to oral and nasal halitosis.University of São Paulo, Bauru Dental School and Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, Brazil.Twelve patients with clefts and 12 without clefts were evaluated (...) as normal, weak, and strong, showing a statistical significant group difference (p = .003). There was no significant difference in the oral halimeter values between the two groups.Patients with cleft lip and palate had a tendency to present higher values for the nasal halimeter measurements, when compared with patients without clefts.

2005 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Controlled trial quality: uncertain

2592. Primary correction of unilateral cleft lip nasal deformity in Asian patients: anthropometric evaluation. (Abstract)

Primary correction of unilateral cleft lip nasal deformity in Asian patients: anthropometric evaluation. Previously it was thought that primary correction of nasal deformity in cleft lip patients would cause developmental impairment of the nose. It is now widely accepted that simultaneous correction of the cleft lip nasal deformity has no adverse effect on nasal growth. Thus, the authors tried to evaluate the results of primary correction of cleft lip in Asian patients. Of 412 cases of cleft (...) children with primary nasal repair. Data were analyzed using t tests, and the level of significance was 5 percent (p < 0.05). In cases of simultaneous repair, nasal tip projection and columellar length were increased 24.8 percent and 28.8 percent, respectively. Nasal width was increased 12.3 percent in the cases of simultaneous repair and 12.6 percent in the cases without primary rhinoplasty. Simultaneous repair of cleft lip and nasal deformity in Asian patients showed that more symmetry of nostril

2005 Plastic and reconstructive surgery Controlled trial quality: uncertain

2593. Use of a perceptual evaluation instrument to assess the effects of infant orthopedics on the speech of toddlers with cleft lip and palate. Full Text available with Trip Pro

Use of a perceptual evaluation instrument to assess the effects of infant orthopedics on the speech of toddlers with cleft lip and palate. To investigate the effects of infant orthopedics (IO) administered in the first year of life on the speech characteristics of 2.5-year-old children with complete unilateral cleft lip and palate (UCLP) using a perceptual evaluation instrument with equal-appearing interval (EAI) scales.In a prospective randomized clinical trial (Dutchcleft), two groups (...) in a blinded perceptual rating procedure. They judged 13 specific speech characteristics and indicated their total impression of speech on EAI scales.The reliability and consistency of 11 of the rating scales was good. The intelligibility rating scale was the single speech characteristic that distinguished the IO group from the non-IO group; the IO group was judged to be superior. The cleft groups differed from the noncleft group on 9 of the 11 scales.Evaluation of speech by means of the present newly

2004 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Controlled trial quality: uncertain

2594. [Monitoring ETCO(2) of the infants undergoing cleft lip repair under general anesthesia with autonomous respiration]. (Abstract)

[Monitoring ETCO(2) of the infants undergoing cleft lip repair under general anesthesia with autonomous respiration]. To elevate the security of general anesthesia with autonomous respiration applied for infant cleft lip repair in infants.40 infants who received cleft lip repair were divided into two groups randomly, the autonomous respiration group (group A) and control respiration group (group C). The infants in group A underwent general anesthesia with autonomous respiration, while (...) significantly on T(2) and T(3), and significantly lower than that on T0 (P<0.05). The HR of the infants in the two groups was smooth during operation.General anesthesia with autonomous respiration could be used for cleft lip repair in infants, but it was imperative to monitor ETCO2 and SpO(2), and we should assist the infants to breath if needed.

2007 Shanghai kou qiang yi xue = Shanghai journal of stomatology Controlled trial quality: uncertain

2595. TWIST Human Gene and Cleft Lips and Palates

TWIST Human Gene and Cleft Lips and Palates TWIST Human Gene and Cleft Lips and Palates - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. TWIST Human Gene and Cleft Lips and Palates The safety and scientific (...) to Brief Summary: This study uses a sequence analysis for TWIST and other craniofacial development genes, among patients presenting with facial clefting. Condition or disease Intervention/treatment Phase Cleft Lip Other: None: molecular genetics diagnosis procedure only Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 45 participants Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: None

2005 Clinical Trials

2596. A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate

A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00156442 Recruitment Status : Completed First Posted : September 12, 2005 Last Update Posted : January 12, 2010 Sponsor: University of Rochester Information provided

2005 Clinical Trials

2597. TRANSMIGRATION OF MANDIBULAR SECOND PREMOLAR IN A PATIENT WITH CLEFT LIP AND PALATE – CASE REPORT Full Text available with Trip Pro

TRANSMIGRATION OF MANDIBULAR SECOND PREMOLAR IN A PATIENT WITH CLEFT LIP AND PALATE – CASE REPORT Disturbances involving abnormalities in tooth eruption are named ectopia. Transmigration is the name assigned to ectopia in the presence of teeth in areas distant from the alveolar process. Initial angulation of the tooth bud of the second premolar and premature loss of permanent mandibular 1st molars can influence the distal migration of the second premolar. Some studies have observed (...) that ectopic teeth can be found in a variety of places around the oral cavity and also in other areas of the human body. There are records of teeth in the maxillary sinus, mandibular condyle, coronoid process, mandibular angle, orbit, palate, mentum and also the skin. The prevalence of tooth abnormalities is higher in children with cleft lip and palate compared to children without clefts. This paper presents a case report of migration of the mandibular left second premolar in a patient attending

2008 Journal of Applied Oral Science

2598. Report of Altered Sensation in Patients With Cleft Lip Full Text available with Trip Pro

Report of Altered Sensation in Patients With Cleft Lip To determine whether patients with cleft lip have normal perioral sensation.Each subject was carefully questioned about the following: sensation in the face at rest, light touch of different areas, and sensation in natural situations (e.g., exposure to cold weather) that reveal sensory abnormalities. A cotton-tip applicator stick was stroked lightly across the facial skin. The subject's descriptions of the evoked sensations were used (...) to identify and outline areas with abnormal sensation.Data were obtained from subjects participating in a longitudinal, university-based study of the functional outcomes of lip revision surgery.Seventeen patients with cleft lip and 12 control subjects (aged 7 to 22 years, mean 12.9 years) participated.In contrast to control subjects, 9 of 16 patients (56%) reported loss in sensation, described as decreased touch, scratch, tickle, or tingle intensity. Six other patients (38%) reported additional sensation

2005 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2599. Craniofacial variability and morphological integration in mice susceptible to cleft lip and palate Full Text available with Trip Pro

Craniofacial variability and morphological integration in mice susceptible to cleft lip and palate A/WySnJ mice are an inbred strain that develops cleft lip with or without cleft palate (CL/P) with a frequency of 25-30% and a predominantly unilateral expression pattern. As in humans, the pattern of incomplete penetrance, and variable and frequent unilateral expression suggests a role for altered regulation of variability (developmental stability, canalization and developmental integration (...) ) during growth. We compared both mean and variability parameters for craniofacial shape and size among A/WySnJ mice, a strain that does not develop CL/P (C57BL/6J) and their F1 cross. We show that adult A/WySnJ mice that do not express cleft lip exhibit decreased morphological integration of the cranium and that the co-ordination of overall shape and size variation is disrupted compared with both C57BL/6J mice and the F1 cross. The decrease in integration is most pronounced in the palate and face

2004 Journal of anatomy

2600. PATTERN OF DISOCCLUSION IN PATIENTS WITH COMPLETE CLEFT LIP AND PALATE Full Text available with Trip Pro

PATTERN OF DISOCCLUSION IN PATIENTS WITH COMPLETE CLEFT LIP AND PALATE To analyze the pattern of disocclusion during excursive mandibular movements and presence or absence of occlusal interferences and occlusal pathologies (gingival recession and abfraction).Examination of 120 individuals divided into two groups, as follows: Group 1 - 90 patients with complete cleft lip and palate (study group), subdivided into 30 patients with complete left unilateral cleft lip and palate, 30 patients (...) with complete right unilateral cleft lip and palate and 30 patients with complete bilateral cleft lip and palate; Group 2 - 30 individuals without clefts (control group).58.8% of patients in Group 1 presented unilateral or bilateral canine guidance, 26.6% presented unilateral or bilateral group function and 54.4% presented lateral movements through the posterior teeth. Regarding protrusive movements, 80% presented anterior guidance and 20% presented posterior guidance. In Group 2, 69.6% of individuals

2006 Journal of Applied Oral Science

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