How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,752 results for

Cleft Lip

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. The Use of Pre-Surgical Nasoalveolar Molding (PNAM) in Unilateral Cleft Lip and Palate Patients Reduces Width of Alveolar Cleft

The Use of Pre-Surgical Nasoalveolar Molding (PNAM) in Unilateral Cleft Lip and Palate Patients Reduces Width of Alveolar Cleft UTCAT3327, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title The Use of Pre-Surgical Nasoalveolar Molding (PNAM) in Unilateral Cleft Lip and Palate Patients Reduces Width of Alveolar Cleft Clinical Question In patients with unilateral cleft lip and palate, does the use of pre-surgical (...) nasoalveolar molding (PNAM) therapy reduce the width of the alveolar cleft? Clinical Bottom Line The use of pre-surgical nasoalveolar molding in unilateral cleft lip and palate patients reduces the alveolar cleft width. This is supported by a randomized controlled trial including 120 patients (60 controls) and a case control study with 30 patients. All patients studied were previously diagnosed with unilateral cleft lip and palate and were shown to have a significant reduction in intersegmental distances

2018 UTHSCSA Dental School CAT Library

2. Cleft lip and palate

Cleft lip and palate Cleft lip and palate - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Cleft lip and palate Last reviewed: February 2019 Last updated: January 2018 Summary Oro-facial clefts are among the most common birth defects. Cleft lip with or without cleft palate is approximately twice as common as isolated cleft palate. The majority of cleft lip deformities are associated with a varying degree of nasal (...) deformity. Oro-facial clefts can occur in isolation or as a component of an identifiable syndrome. The aetiology of cleft lip and palate involves a variety of genetic and environmental factors that result in variable expressions of oro-facial clefting. Comprehensive care involves a multi-disciplinary cleft team with specialists from fields such as facial plastic surgery, genetics, nursing, speech-language pathology, orthodontics, dentistry, oral surgery, audiology, and paediatrics. Definition An oro

2018 BMJ Best Practice

3. Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients. Full Text available with Trip Pro

Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients. Cleft lip and palate is one of the most common birth defects and can cause difficulties with feeding, speech and hearing, as well as psychosocial problems. Treatment of orofacial clefts is prolonged; it typically commences after birth and lasts until the child reaches adulthood or even into adulthood. Residual deformities, functional disturbances, or both, are frequently seen in adults (...) of hypoplastic maxilla in people with cleft lip and palate.Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 15 May 2018), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2018, Issue 4), MEDLINE Ovid (1946 to 15 May 2018), Embase Ovid (1980 to 15 May 2018), and LILACS BIREME Virtual Health Library (Latin American and Caribbean Health Science Information database; from 1982 to 15 May 2018). The US

2018 Cochrane

5. Dentists Treating Cleft Lip and/or Palate Patients Will Need to Consider Anatomical Variations when Delivering Local Anesthetic

Dentists Treating Cleft Lip and/or Palate Patients Will Need to Consider Anatomical Variations when Delivering Local Anesthetic UTCAT3331, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Dentists Treating Cleft Lip and/or Palate Patients Will Need to Consider Anatomical Variations when Delivering Local Anesthetic Clinical Question In cleft lip and palate patients, will altered anesthetic techniques be more effective (...) than standard techniques in achieving adequate pain control? Clinical Bottom Line Low evidence to support minor alterations needed that include first anesthetize away from cleft and then at cleft margins. But similarities include the use of topical anesthetic and the guidance for slow injection. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Trindade-Suedam/2012 2 patients with cleft palate and lip

2018 UTHSCSA Dental School CAT Library

6. To Admit or Not to Admit: That is the Cleft Lip Question. Confirming the Safety of Outpatient Cleft Lip Repair. (Abstract)

To Admit or Not to Admit: That is the Cleft Lip Question. Confirming the Safety of Outpatient Cleft Lip Repair. There is no accepted protocol for inpatient versus ambulatory cleft lip surgery. The aim of this study was to review the safety of outpatient repair and develop guidelines.A retrospective review of patients younger than 2 years undergoing primary cleft lip repair from 2008 to 2015 at six centers was performed. Patients were divided into two groups: predominantly ambulatory (discharged (...) , and other congenital comorbidities had significant impact on admission rates in the predominantly ambulatory group (p < 0.05). Respiratory comorbidities and syndromes were risk factors for readmission if patients presented to the emergency department (p < 0.05).Ambulatory cleft lip repair can be performed safely in most patients with no difference in emergency department visits or readmission. Patients with comorbidities should be admitted for observation.Therapeutic, IV.

2018 Plastic and reconstructive surgery

7. The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients Full Text available with Trip Pro

The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients The aim was to evaluate differences in the cervical vertebral skeletal maturity of unilateral cleft lip and palate (UCLP) and non-cleft lip/palate (non-CLP) Saudi male orthodontic patients.This cross-sectional multicenter study took place at the dental school, King Saud University and King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, between (...) was significantly earlier in the non-cleft participants in comparison with the UCLP participants (p = 0.009).There is delayed skeletal maturity among the UCLP Saudi male population in comparison with their non-CLP age-matched peers.

2018 BioMed research international

8. Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate

Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate ABM Protocol ABM Clinical Protocol #17: Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate, Revised 2013 Sheena Reilly, 1,2 Julie Reid, 1,3 Jemma Skeat, 2 Petrea Cahir, 1 Christina Mei, 2 Maya Bunik, 4 and the Academy of Breastfeeding Medicine A central goal of the Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical (...) problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breast- feeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient. De?nitions W hen a cleft lip(CL) occurs, thelipisnotcontiguous, and when a cleft palate (CP) occurs, there is communi- cation between the oral and nasal cavities. 1 Clefts can range

2013 Academy of Breastfeeding Medicine

9. Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients. Full Text available with Trip Pro

Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients. Cleft lip and palate is one of the most common birth defects and can cause difficulties with feeding, speech and hearing, as well as psychosocial problems. Treatment of orofacial clefts is prolonged; it typically commences after birth and lasts until the child reaches adulthood or even into adulthood. Residual deformities, functional disturbances, or both, are frequently seen in adults (...) with a repaired cleft. Conventional orthognathic surgery, such as Le Fort I osteotomy, is often performed for the correction of maxillary hypoplasia. An alternative intervention is distraction osteogenesis, which achieves bone lengthening by gradual mechanical distraction.To provide evidence regarding the effects and long-term results of maxillary distraction osteogenesis compared to orthognathic surgery for the treatment of hypoplastic maxilla in people with cleft lip and palate.We searched the following

2016 Cochrane

10. Combined correction of the nasal tip and upper lip in bilateral cleft lip patients: A novel approach. (Abstract)

Combined correction of the nasal tip and upper lip in bilateral cleft lip patients: A novel approach. Secondary nasal deformity in bilateral cleft lip is one of the great surgical challenges. The problems are an under projected tip, an infra-tip lobule merging with the pro-labium and a short columella. Upper lip vermillion border deformity is a further significant problem. We demonstrate our novel approach to management by classifying patients into 3 groups depending on the status of important (...) features such as the anatomy of the prolabial skin island, length of columella and upper lip width and fullness. We demonstrate that cleft patients with nasal deformity and poor upper lip aesthetics can be managed with a single operation.Crown Copyright © 2019. Published by Elsevier B.V. All rights reserved.

2019 International Journal of Pediatric Otorhinolaryngology

11. Investigation of candidate genes of non-syndromic cleft lip with or without cleft palate, using both case-control and family-based association studies. Full Text available with Trip Pro

Investigation of candidate genes of non-syndromic cleft lip with or without cleft palate, using both case-control and family-based association studies. Non-syndromic cleft of the lip and/or palate (NSCL/P) is one of the most common polygenic diseases. In this study, both case-control and family-based association study were used to confirm whether the Single Nucleotide Polymorphisms (SNPs) were associated with NSCL/P.A total of 37 nuclear families and 189 controls were recruited, whose blood DNA

2019 Medicine

12. Palatal morphology in unilateral cleft lip and palate patients: Association with infant cleft dimensions and timing of hard palate repair. (Abstract)

Palatal morphology in unilateral cleft lip and palate patients: Association with infant cleft dimensions and timing of hard palate repair. To assess the impact of cleft severity and timing of hard palate repair on palatal dimensions in unilateral cleft lip and palate (UCLP) children.Single-centre analysis within a multicenter RCT of primary surgery; 122 UCLP randomized to early hard palate closure (EHPC) at 12 months or delayed hard palate closure (DHPC) at 36 months; 28 frequency-matched (...) with palatal height (P = 0.01).Unilateral cleft lip and palate palates differ from controls in width and height. DHPC may represent an advantage for the transversal dimension, but a disadvantage for palatal height. Infant cleft dimensions partially explain differences in palatal height.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2019 Orthodontics & craniofacial research Controlled trial quality: uncertain

13. Assessment of facial asymmetry before and after the surgical repair of cleft lip in unilateral cleft lip and palate cases. Full Text available with Trip Pro

Assessment of facial asymmetry before and after the surgical repair of cleft lip in unilateral cleft lip and palate cases. This study was performed to assess facial asymmetry in patients with unilateral cleft lip and palate (UCLP) before and after primary lip repair. Three-dimensional facial images of 30 UCLP cases (mean age 3.7±0.8months) captured 1-2days before surgery and 4 months after surgery using stereophotogrammetry were analysed. A generic mesh - a mathematical facial mask consisting (...) the non-cleft side. The maximum vertical asymmetry was at the upper lip. The greatest anteroposterior asymmetry was at the alar base and in the paranasal area. The overall facial asymmetry improved markedly after surgery. Residual anteroposterior asymmetry was noted at the alar base, upper lip, and cheek on the cleft slide. In conclusion, dense correspondence analysis provided an insight into the anatomical reasons for the residual dysmorphology following the surgical repair of cleft lip for future

2017 International Journal of Oral and Maxillofacial Surgery

14. Non-syndromic Cleft Lip and Palate Polymorphisms Affect Normal Lip Morphology Full Text available with Trip Pro

Non-syndromic Cleft Lip and Palate Polymorphisms Affect Normal Lip Morphology Non-syndromic cleft lip with or without palate (NSCL/P) is a frequent malformation of the facial region. Genetic variants (SNPs) within nineteen loci have been previously associated with NSCL/P in GWAS studies of European individuals. These common variant SNPs may have subtler effects on the morphology of the lip and face in unaffected individuals. Several studies have investigated the genetic influences on facial (...) morphology using land-marking methods, but these landmarks are sparse in the lip region. The aim of this study is to assess for associations between the nineteen NSCL/P SNPs and normal lip phenotypes, using a detailed categorical scale. Three-dimensional laser scanned facial images were obtained of 4,747 subjects recruited from the Avon Longitudinal Study of Parents and Children (ALSPAC) and genetic data was available for 3,643 of them. A polygenetic risk score (PRS) combining the nineteen NSCL/P SNPs

2018 Frontiers in genetics

15. The Skoog Lip Repair for Unilateral Cleft Lip Deformity: The Uppsala Experience. (Abstract)

The Skoog Lip Repair for Unilateral Cleft Lip Deformity: The Uppsala Experience. The Uppsala Craniofacial Center has been treating patients with unilateral cleft lip deformity using the lip repair technique described by Tord Skoog. The aim of this study was to determine complications after lip surgery and the incidence and indications for lip revisions in all patients born with unilateral cleft lip from 1960 to 2004.All patients who were born from 1960 to 2004 with unilateral cleft lip, cleft (...) lip and alveolus, or cleft lip and palate and underwent lip repair were studied retrospectively. The timing, indication, complications of the primary procedure, and type of secondary surgery were recorded. Kruskal-Wallis and Fisher's exact tests were used, with Bonferroni correction.The study included 443 patients. The total rate of early surgical complications was 6 percent (n = 26). Secondary surgery for short upper lip was performed in 3.8 percent (n = 17), 8.4 percent (n = 37) underwent

2018 Plastic and reconstructive surgery

16. Epidemiology and clinical profile of individuals with cleft lip and palate utilising specialised academic treatment centres in South Africa. Full Text available with Trip Pro

Epidemiology and clinical profile of individuals with cleft lip and palate utilising specialised academic treatment centres in South Africa. The study was conducted to determine the epidemiology and clinical profile of individuals with cleft lip and/or palate (CLP) utilizing specialized academic treatment centres in South Africa's public health sector.The Human Research Ethics Committee of the University of the Witwatersrand in Johannesburg provided ethical approval for the study. We conducted (...) per 1000 live births, with provincial variation of 0.1/1000 to 1.2/1000. The distribution of clefts was: 35.3% cleft palate; 34.6% cleft lip and palate; 19.0% cleft lip and other cleft anomalies at 2%. Of the total number of CLP, 47.5% were male and 52.5% female, and this difference was statistically significant (p<0.001). The majority of clefts occurred on the left for males (35.5%) and palate for females (43.4%), with a male predominance of unilateral cleft lip and palate (53.3%).The study

2019 PLoS ONE

17. Psychometric findings and normative values for the CLEFT-Q based on 2434 children and young adult patients with cleft lip and/or palate from 12 countries Full Text available with Trip Pro

Psychometric findings and normative values for the CLEFT-Q based on 2434 children and young adult patients with cleft lip and/or palate from 12 countries Patients with cleft lip and/or palate can undergo numerous procedures to improve appearance, speech, dentition and hearing. We developed a cleft-specific patient-reported outcome instrument to facilitate rigorous international measurement and benchmarking.Data were collected from patients aged 8-29 years with cleft lip and/or palate at 30 (...) hospitals in 12 countries between October 2014 and November 2016. Rasch measurement theory analysis was used to refine the scales and to examine reliability and validity. Normative CLEFT-Q values were computed for age, sex and cleft type.Analysis led to the refinement of an eating and drinking checklist and 12 scales measuring appearance (of the face, nose, nostrils, teeth, lips, jaws and cleft lip scar), health-related quality of life (psychological, social, school, speech distress) and speech function

2018 CMAJ : Canadian Medical Association Journal

18. Novel GREM1 Variations in Sub-Saharan African Patients With Cleft Lip and/or Cleft Palate Full Text available with Trip Pro

Novel GREM1 Variations in Sub-Saharan African Patients With Cleft Lip and/or Cleft Palate Cleft lip and/or cleft palate (CL/P) are congenital anomalies of the face and have multifactorial etiology, with both environmental and genetic risk factors playing crucial roles. Though at least 40 loci have attained genomewide significant association with nonsyndromic CL/P, these loci largely reside in noncoding regions of the human genome, and subsequent resequencing studies of neighboring candidate (...) genes have revealed only a limited number of etiologic coding variants. The present study was conducted to identify etiologic coding variants in GREM1, a locus that has been shown to be largely associated with cleft of both lip and soft palate.We resequenced DNA from 397 sub-Saharan Africans with CL/P and 192 controls using Sanger sequencing. Following analyses of the sequence data, we observed 2 novel coding variants in GREM1. These variants were not found in the 192 African controls and have never

2018 The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

19. A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in ESRRG Full Text available with Trip Pro

A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in ESRRG Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these gene-environment (GxE) interactions at a genome-wide level is still lacking (...) . Although there were potential GxVitamin effects with rs17734557 and rs1316471 and GxAlcohol effects with rs9653456 and rs921876 in the European sample, respectively, none of the SNPs was located in or near genes with strong links to orofacial clefts. GxAlcohol and GxSmoke effects were not assessed in the Asian sample because of a lack of observations for these exposures. Discussion/Conclusion: We identified significant interactions between vitamin use and variants in ESRRG in the pooled analysis

2018 Frontiers in genetics

20. The impact of nonsyndromic cleft lip with or without cleft palate on oral health-related quality of life Full Text available with Trip Pro

The impact of nonsyndromic cleft lip with or without cleft palate on oral health-related quality of life Nonsyndromic cleft lip with or without cleft palate (NSCL±P) compromises oral health, leading to missing or malformed teeth, and hampering oral hygiene. Apart from anatomic damages, NSCL±P also culminates in an impact on the routine quality of life with social privation and psychological embarrassment.To evaluate the impact of NSCL±P on oral health-related quality of life.The study (...) was classified as exploratory and descriptive, with quantitative approach. Patients with NSCL±P treated between August 2013 and September 2014 at the Cleft Lip and Palate Integral Care Center (CAIF), Curitiba, Brazil, were invited to participate. Age and sex-related data were collected, as well as level of education, financial income, type of orofacial cleft, use of orthodontic and prosthetic appliances, and number of previous orofacial surgeries. Selected patients were asked to answer the Oral Impact

2018 Journal of Applied Oral Science

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>