How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,800 results for

Cleft Lip

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. The Use of Pre-Surgical Nasoalveolar Molding (PNAM) in Unilateral Cleft Lip and Palate Patients Reduces Width of Alveolar Cleft

The Use of Pre-Surgical Nasoalveolar Molding (PNAM) in Unilateral Cleft Lip and Palate Patients Reduces Width of Alveolar Cleft UTCAT3327, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title The Use of Pre-Surgical Nasoalveolar Molding (PNAM) in Unilateral Cleft Lip and Palate Patients Reduces Width of Alveolar Cleft Clinical Question In patients with unilateral cleft lip and palate, does the use of pre-surgical (...) nasoalveolar molding (PNAM) therapy reduce the width of the alveolar cleft? Clinical Bottom Line The use of pre-surgical nasoalveolar molding in unilateral cleft lip and palate patients reduces the alveolar cleft width. This is supported by a randomized controlled trial including 120 patients (60 controls) and a case control study with 30 patients. All patients studied were previously diagnosed with unilateral cleft lip and palate and were shown to have a significant reduction in intersegmental distances

2018 UTHSCSA Dental School CAT Library

3. Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients. (PubMed)

Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients. Cleft lip and palate is one of the most common birth defects and can cause difficulties with feeding, speech and hearing, as well as psychosocial problems. Treatment of orofacial clefts is prolonged; it typically commences after birth and lasts until the child reaches adulthood or even into adulthood. Residual deformities, functional disturbances, or both, are frequently seen in adults (...) of hypoplastic maxilla in people with cleft lip and palate.Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 15 May 2018), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2018, Issue 4), MEDLINE Ovid (1946 to 15 May 2018), Embase Ovid (1980 to 15 May 2018), and LILACS BIREME Virtual Health Library (Latin American and Caribbean Health Science Information database; from 1982 to 15 May 2018). The US

Full Text available with Trip Pro

2018 Cochrane

4. Cleft lip and palate

Cleft lip and palate Cleft lip and palate - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Cleft lip and palate Last reviewed: February 2019 Last updated: January 2018 Summary Oro-facial clefts are among the most common birth defects. Cleft lip with or without cleft palate is approximately twice as common as isolated cleft palate. The majority of cleft lip deformities are associated with a varying degree of nasal (...) deformity. Oro-facial clefts can occur in isolation or as a component of an identifiable syndrome. The aetiology of cleft lip and palate involves a variety of genetic and environmental factors that result in variable expressions of oro-facial clefting. Comprehensive care involves a multi-disciplinary cleft team with specialists from fields such as facial plastic surgery, genetics, nursing, speech-language pathology, orthodontics, dentistry, oral surgery, audiology, and paediatrics. Definition An oro

2018 BMJ Best Practice

5. Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate. (PubMed)

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate. Secondary alveolar bone grafting has been widely used to reconstruct alveolar cleft. However, there is still some controversy.To compare the effectiveness and safety of different secondary bone grafting methods.The final electronic and handsearches were carried out on 11 February 2011, and included the Cochrane Oral Health Group's Trials Register, Cochrane Central Register of Controlled Trials (...) , MEDLINE, EMBASE, Chinese Biomedical Literature Database and WHO International Clinical Trials Registry Platform. All the Chinese professional journals in the oral and dental field were handsearched and conference proceedings consulted. There was no language or time restriction.Only randomized clinical trials were selected. Patients with the diagnosis of cleft lip and alveolar process only, unilateral cleft lip and palate and bilateral cleft lip and palate involving the alveolar process and greater

2011 Cochrane

6. Dentists Treating Cleft Lip and/or Palate Patients Will Need to Consider Anatomical Variations when Delivering Local Anesthetic

Dentists Treating Cleft Lip and/or Palate Patients Will Need to Consider Anatomical Variations when Delivering Local Anesthetic UTCAT3331, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Dentists Treating Cleft Lip and/or Palate Patients Will Need to Consider Anatomical Variations when Delivering Local Anesthetic Clinical Question In cleft lip and palate patients, will altered anesthetic techniques be more effective (...) than standard techniques in achieving adequate pain control? Clinical Bottom Line Low evidence to support minor alterations needed that include first anesthetize away from cleft and then at cleft margins. But similarities include the use of topical anesthetic and the guidance for slow injection. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Trindade-Suedam/2012 2 patients with cleft palate and lip

2018 UTHSCSA Dental School CAT Library

7. Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients. (PubMed)

Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients. Cleft lip and palate is one of the most common birth defects and can cause difficulties with feeding, speech and hearing, as well as psychosocial problems. Treatment of orofacial clefts is prolonged; it typically commences after birth and lasts until the child reaches adulthood or even into adulthood. Residual deformities, functional disturbances, or both, are frequently seen in adults (...) with a repaired cleft. Conventional orthognathic surgery, such as Le Fort I osteotomy, is often performed for the correction of maxillary hypoplasia. An alternative intervention is distraction osteogenesis, which achieves bone lengthening by gradual mechanical distraction.To provide evidence regarding the effects and long-term results of maxillary distraction osteogenesis compared to orthognathic surgery for the treatment of hypoplastic maxilla in people with cleft lip and palate.We searched the following

Full Text available with Trip Pro

2016 Cochrane

8. Infraorbital nerve block for postoperative pain following cleft lip repair in children. (PubMed)

Infraorbital nerve block for postoperative pain following cleft lip repair in children. Postoperative pain is a barrier to the quality of paediatric care, the proper management of which is a challenge. Acute postoperative pain often leads to adverse functional and organic consequences that may compromise surgical outcome. Cleft lip is one of the most common craniofacial birth defects and requires surgical correction early in life. As expected after a surgical intervention in such a sensitive (...) and delicate area, the immediate postoperative period of cleft lip repair may be associated with moderate to severe pain. Infraorbital nerve block associated with general anaesthesia has been used to reduce postoperative pain after cleft lip repair.To assess the effects of infraorbital nerve block for postoperative pain following cleft lip repair in children.We searched the following databases: Cochrane Central Register of Controlled Trials (CENTRAL, the Cochrane Library, Issue 6, 2015), MEDLINE, EMBASE

Full Text available with Trip Pro

2016 Cochrane

9. To Admit or Not to Admit: That is the Cleft Lip Question. Confirming the Safety of Outpatient Cleft Lip Repair. (PubMed)

To Admit or Not to Admit: That is the Cleft Lip Question. Confirming the Safety of Outpatient Cleft Lip Repair. There is no accepted protocol for inpatient versus ambulatory cleft lip surgery. The aim of this study was to review the safety of outpatient repair and develop guidelines.A retrospective review of patients younger than 2 years undergoing primary cleft lip repair from 2008 to 2015 at six centers was performed. Patients were divided into two groups: predominantly ambulatory (discharged (...) , and other congenital comorbidities had significant impact on admission rates in the predominantly ambulatory group (p < 0.05). Respiratory comorbidities and syndromes were risk factors for readmission if patients presented to the emergency department (p < 0.05).Ambulatory cleft lip repair can be performed safely in most patients with no difference in emergency department visits or readmission. Patients with comorbidities should be admitted for observation.Therapeutic, IV.

2018 Plastic and reconstructive surgery

10. The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients (PubMed)

The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients The aim was to evaluate differences in the cervical vertebral skeletal maturity of unilateral cleft lip and palate (UCLP) and non-cleft lip/palate (non-CLP) Saudi male orthodontic patients.This cross-sectional multicenter study took place at the dental school, King Saud University and King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, between (...) was significantly earlier in the non-cleft participants in comparison with the UCLP participants (p = 0.009).There is delayed skeletal maturity among the UCLP Saudi male population in comparison with their non-CLP age-matched peers.

Full Text available with Trip Pro

2018 BioMed research international

11. Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate

Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate ABM Protocol ABM Clinical Protocol #17: Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate, Revised 2013 Sheena Reilly, 1,2 Julie Reid, 1,3 Jemma Skeat, 2 Petrea Cahir, 1 Christina Mei, 2 Maya Bunik, 4 and the Academy of Breastfeeding Medicine A central goal of the Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical (...) problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breast- feeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient. De?nitions W hen a cleft lip(CL) occurs, thelipisnotcontiguous, and when a cleft palate (CP) occurs, there is communi- cation between the oral and nasal cavities. 1 Clefts can range

2013 Academy of Breastfeeding Medicine

12. Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. (PubMed)

Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. Nonsyndromic orofacial clefts (OFCs) are a heterogeneous group of common craniofacial birth defects with complex etiologies that include genetic and environmental risk factors. OFCs are commonly categorized as cleft lip with or without cleft palate (CL/P) and cleft palate alone (CP), which have historically been

Full Text available with Trip Pro

2018 Human Genetics

13. Assessment of facial asymmetry before and after the surgical repair of cleft lip in unilateral cleft lip and palate cases. (PubMed)

Assessment of facial asymmetry before and after the surgical repair of cleft lip in unilateral cleft lip and palate cases. This study was performed to assess facial asymmetry in patients with unilateral cleft lip and palate (UCLP) before and after primary lip repair. Three-dimensional facial images of 30 UCLP cases (mean age 3.7±0.8months) captured 1-2days before surgery and 4 months after surgery using stereophotogrammetry were analysed. A generic mesh - a mathematical facial mask consisting (...) the non-cleft side. The maximum vertical asymmetry was at the upper lip. The greatest anteroposterior asymmetry was at the alar base and in the paranasal area. The overall facial asymmetry improved markedly after surgery. Residual anteroposterior asymmetry was noted at the alar base, upper lip, and cheek on the cleft slide. In conclusion, dense correspondence analysis provided an insight into the anatomical reasons for the residual dysmorphology following the surgical repair of cleft lip for future

Full Text available with Trip Pro

2017 International Journal of Oral and Maxillofacial Surgery

14. Non-Syndromic Patients With Cleft Lip And/Or Palate (CLP) Tend To Have Higher Caries Prevalence Than Non-CLP Patients

Non-Syndromic Patients With Cleft Lip And/Or Palate (CLP) Tend To Have Higher Caries Prevalence Than Non-CLP Patients UTCAT2989, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Non-Syndromic Patients With Cleft Lip And/Or Palate (CLP) Tend To Have Higher Caries Prevalence Than Non-CLP Patients Clinical Question In patients with non-syndromic cleft lip/cleft palate, is there greater predisposition to caries than in non (...) -CL/P patients? Clinical Bottom Line Non-syndromic patients with cleft lip and/or palate tend to have higher caries prevalence than non-CLP patients. This is supported by a meta-analysis of several cross-sectional trials in which the decayed, missing, and filled (DMF) index was significantly higher for CLP patients than non-CLP patients. This would suggest that dentists should factor in CLP while determining caries risk status for patients. Best Evidence (you may view more info by clicking

2016 UTHSCSA Dental School CAT Library

15. Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip ± cleft palate and cleft palate only (PubMed)

Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip ± cleft palate and cleft palate only Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present results from a genome-wide imputation study of nsCL/P in which, after adding replication cohort data, four novel risk loci for nsCL/P are identified (at chromosomal regions 2p21, 14q22 (...) % contributed to by the 24 risk loci known to date. For each of these, we identify credible SNPs using a Bayesian refinement approach, with two loci harbouring only one probable causal variant. Finally, we demonstrate that there is no polygenic component of nsCL/P detectable that is shared with nonsyndromic cleft palate only (nsCPO). Our data suggest that, while common variants are strongly contributing to risk for nsCL/P, they do not seem to be involved in nsCPO which might be more often caused by rare

Full Text available with Trip Pro

2017 Human molecular genetics

16. Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla?

Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? - National Elf Service Search National Elf Service Search National Elf Service » » » » Cleft lip and palate: maxillary distraction osteogenesis or orthognathic surgery for hypoplastic maxilla? Sep 14 2018 Posted by Cleft lip and palate (CLP) is a common birth defect. The prevalence (...) for the treatment of hypoplastic maxilla in people with cleft lip and palate. Methods Searches were conducted in the Cochrane Oral Health’s Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, LILACS BIREME Virtual Health Library (Latin American and Caribbean Health Science Information database), the US National Institutes of Health Trials Registry (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform

2018 The Dental Elf

17. Non-syndromic Cleft Lip and Palate Polymorphisms Affect Normal Lip Morphology (PubMed)

Non-syndromic Cleft Lip and Palate Polymorphisms Affect Normal Lip Morphology Non-syndromic cleft lip with or without palate (NSCL/P) is a frequent malformation of the facial region. Genetic variants (SNPs) within nineteen loci have been previously associated with NSCL/P in GWAS studies of European individuals. These common variant SNPs may have subtler effects on the morphology of the lip and face in unaffected individuals. Several studies have investigated the genetic influences on facial (...) morphology using land-marking methods, but these landmarks are sparse in the lip region. The aim of this study is to assess for associations between the nineteen NSCL/P SNPs and normal lip phenotypes, using a detailed categorical scale. Three-dimensional laser scanned facial images were obtained of 4,747 subjects recruited from the Avon Longitudinal Study of Parents and Children (ALSPAC) and genetic data was available for 3,643 of them. A polygenetic risk score (PRS) combining the nineteen NSCL/P SNPs

Full Text available with Trip Pro

2018 Frontiers in genetics

18. The Skoog Lip Repair for Unilateral Cleft Lip Deformity: The Uppsala Experience. (PubMed)

The Skoog Lip Repair for Unilateral Cleft Lip Deformity: The Uppsala Experience. The Uppsala Craniofacial Center has been treating patients with unilateral cleft lip deformity using the lip repair technique described by Tord Skoog. The aim of this study was to determine complications after lip surgery and the incidence and indications for lip revisions in all patients born with unilateral cleft lip from 1960 to 2004.All patients who were born from 1960 to 2004 with unilateral cleft lip, cleft (...) lip and alveolus, or cleft lip and palate and underwent lip repair were studied retrospectively. The timing, indication, complications of the primary procedure, and type of secondary surgery were recorded. Kruskal-Wallis and Fisher's exact tests were used, with Bonferroni correction.The study included 443 patients. The total rate of early surgical complications was 6 percent (n = 26). Secondary surgery for short upper lip was performed in 3.8 percent (n = 17), 8.4 percent (n = 37) underwent

2018 Plastic and reconstructive surgery

19. 2p24.2 (rs7552) is a susceptibility locus for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. (PubMed)

2p24.2 (rs7552) is a susceptibility locus for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. The population of Brazil is highly admixed, with each individual showing variable levels of Amerindian, European and African ancestry, which may interfere in the genetic susceptibility of known risk loci to nonsyndromic cleft lip with or without cleft palate (NSCL±P). Here, we investigated 5 reported genome-wide loci for NSCL±P in an ancestry-structured case-control

2018 Clinical Genetics

20. Common polymorphism in the glycine N-methyltransferase gene as a novel risk factor for cleft lip with or without cleft palate. (PubMed)

Common polymorphism in the glycine N-methyltransferase gene as a novel risk factor for cleft lip with or without cleft palate. The objective of this study was to identify new environmental and genetic risk factors for orofacial clefts that arise during early foetal development. In this retrospective, case-control, mother-child pair study, 172 orofacial clefts cases and 199 healthy controls, and their respective mothers, were genotyped for common variants in relevant genes obtained by text (...) and database mining using STRING 10.0. Exposure to environmental risk factors was evaluated using questionnaires. Variant glycine N-methyltransferase (odds ratio (OR) 2.1, 95% confidence interval (95% CI) 1.0-4.4) and dihydrofolate reductase (OR 2.4, 95% CI 1.3-4.5) genotypes were identified as risk factors for cleft lip with or without cleft palate formation. Furthermore, synergy was detected between variant glycine N-methyltransferase and dihydrofolate reductase genotypes in promoting cleft lip

2018 International Journal of Oral and Maxillofacial Surgery

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>