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Circadian Rhythm Sleep Disorder

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1. Use of Actigraphy in the Evaulation of Sleep and Circadian Rhythm Sleep-Wake Disorders

recommendations are intended as a guide for clinicians using actigraphy in evaluating patients with sleep disorders and circadian rhythm sleep-wake disorders, and only apply to the use of FDA-approved devices. Each recommendation statement is assigned a strength (“Strong” or “Conditional”). A “Strong” recommendation (ie, “We recommend…”) is one that clinicians should follow under most circumstances. A “Conditional” recommendation (ie, “We suggest…”) reflects a lower degree of certainty regarding the outcome (...) disorder. (Conditional) We suggest that clinicians use actigraphy in the assessment of adult patients with circadian rhythm sleep-wake disorder. (Conditional) We suggest that clinicians use actigraphy in the assessment of pediatric patients with circadian rhythm sleep-wake disorder. (Conditional) We suggest that clinicians use actigraphy integrated with home sleep apnea test devices to estimate total sleep time during recording (in the absence of alternative objective measurements of total sleep time

2018 American Academy of Sleep Medicine

2. Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep Wake Rhythm Disorder (N24SWD), and Irregular Sleep-W

Disorders, Third Edition (ICSD-3) nomenclature is referenced throughout the manuscript. Important modifications to the International Classification of Sleep Disorders include incorporation of the word “wake” (the ICSD-2 referred solely to circadian rhythm sleep disorders), which highlights the significant impairments these conditions exert on daytime functioning. Caregiver input is also emphasized in the ICSD-3, particularly with respect to diagnostic assessments among cognitively impaired and pediatric (...) alter the phase relationships between internal rhythms and the light/dark cycle, which may manifest in the form of circadian rhythm sleep-wake disorders (CRSWDs). The intrinsic CRSWDs refer to those conditions that are thought to exist predominantly due to innate phenomena, although exogenous components contribute to varying degrees in all of these disorders. The intrinsic CRSWDs are briefly characterized as follows. DSWPD manifests as a delay of the major sleep episode with respect to the patient's

2015 American Academy of Sleep Medicine

3. Practice Parameters for the Clinical Evaluation and Treatment of Circadian Rhythm Sleep Disorders

and children with and without comorbid psychiatric conditions. The clinical practice guideline is an essential update to the practice parameter document: Auger RR, Burgess HJ, Emens JS, Deriy LV, Thomas SM, Sharkey KM. Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep- wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleepwake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD (...) a general introduc- tion to circadian biology, addresses “exogenous” circadian rhythm sleep disorders, including shift work disorder (SWD) and jet lag disorder (JLD). The second review paper addresses the “endogenous” circadian rhythm sleep disorders, including advanced sleep phase disorder (ASPD), de- layed sleep phase disorder (DSPD), irregular sleep-wake rhythm (ISWR), and the non–24-hour sleep-wake syndrome (nonentrained type) or free- running disorder (FRD). These practice parameters were developed

2017 American Academy of Sleep Medicine

4. Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease. (Abstract)

Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease. Sleep disorders are common among PD patients and affect quality of life. They are often under-recognized and under-treated. Mechanisms of sleep disorders in PD remain relatively poorly understood. Improved awareness of common sleep problems in PD. Tailored treatment and evidence for efficacy are lacking. The purpose of this review is to provide an overview and update on the most common sleep disorders in PD. We review (...) specific features of the most common sleep disorders in PD, including insomnia, excessive daytime sleepiness, sleep-disordered breathing, restless legs syndrome, circadian rhythm disorders and REM sleep behavior disorders.Copyright © 2019 Elsevier Inc. All rights reserved.

2020 Clinics in Geriatric Medicine

5. Hetlioz (tasimelteon) - To treat non-24- hour sleep-wake disorder (?non-24?) in totally blind individuals. Non-24 is a chronic circadian rhythm (body clock) disorder in the blind that causes problems with the timing of sleep

Hetlioz (tasimelteon) - To treat non-24- hour sleep-wake disorder (?non-24?) in totally blind individuals. Non-24 is a chronic circadian rhythm (body clock) disorder in the blind that causes problems with the timing of sleep Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - HETLIOZ (tasimelteon) 20 mg oral Capsules Company: Vanda Pharmaceuticals, Inc. Application No.: 205677 Approval Date: 1/31/2014

2014 FDA - Drug Approval Package

6. Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline Full Text available with Trip Pro

actigraphy in evaluating patients with sleep disorders and circadian rhythm sleep-wake disorders, and only apply to the use of FDA-approved devices. Each recommendation statement is assigned a strength ("Strong" or "Conditional"). A "Strong" recommendation (ie, "We recommend…") is one that clinicians should follow under most circumstances. A "Conditional" recommendation (ie, "We suggest…") reflects a lower degree of certainty regarding the outcome and appropriateness of the patient-care strategy for all (...) use actigraphy in the assessment of adult patients with circadian rhythm sleep-wake disorder. (Conditional). We suggest that clinicians use actigraphy in the assessment of pediatric patients with circadian rhythm sleep-wake disorder. (Conditional). We suggest that clinicians use actigraphy integrated with home sleep apnea test devices to estimate total sleep time during recording (in the absence of alternative objective measurements of total sleep time) in adult patients suspected of sleep

2018 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

7. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update

syndrome (RLS), periodic limb movements in sleep (PMLS)) ? Do you sometimes fall asleep in the daytime completely without warning? Do you have collapses or extreme muscle weakness triggered by emotion, for instance when you’re laughing? (narcolepsy) ? Do you tend to sleep well but just at the ‘wrong times’; and are these sleeping and waking times regular? (circadian rhythm sleep disorder; evidence also from sleep diary) ? Do you have unusual behaviours associated with your sleep that trouble you (...) , whichrepresents the views of all participants although the authors take final responsibility for the document. Keywords Sleep, insomnia, parasomnia, circadian rhythm disorder, consensus, treatment Introduction Sleepdisordersarecommoninthegeneralpopulationandeven more so in clinical practice, yet are relatively poorly under- stood by doctors and other health care practitioners. These BritishAssociationforPsychopharmacology(BAP)guidelines aredesignedtoaddressthisproblembyprovidinganaccessible yetup

2019 British Association for Psychopharmacology

8. The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer's disease. (Abstract)

The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer's disease. Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer's disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated (...) protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer's disease in humans.Copyright © 2019 Elsevier Inc. All rights reserved.

2019 Frontiers in Neuroendocrinology

9. Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder? (Abstract)

Teens Who Can't Sleep: Insomnia or Circadian Rhythm Disorder? Maggie is a 16-year-old girl who came to see me because she wanted help with her longstanding difficulties falling asleep at night and waking up in the morning. She goes to bed between midnight and 3 am and usually lies awake worrying until falling asleep at 3 to 4 am. She often video-calls or texts her boyfriend before sleep. Her wakeup time is 8 am; she typically wakes exhausted, having slept 4 to 5 hours. Although a good student (...) of training in sleep medicine, I would have misdiagnosed Maggie as having insomnia rather than delayed sleep phase disorder (DSPD), a circadian rhythm disorder.Copyright © 2018 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

2019 Journal of the American Academy of Child and Adolescent Psychiatry

10. Impact of adult attention deficit hyperactivity disorder and medication status on sleep/wake behavior and molecular circadian rhythms. (Abstract)

Impact of adult attention deficit hyperactivity disorder and medication status on sleep/wake behavior and molecular circadian rhythms. Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition that has been strongly associated with changes in sleep and circadian rhythms. Circadian rhythms are near 24-h cycles that are primarily generated by an endogenous circadian timekeeping system, encoded at the molecular level by a panel of clock genes. Stimulant and non (...) -stimulant medication used in the management of ADHD has been shown to potentially impact on circadian processes and their behavioral outputs. In the current study, we have analyzed circadian rhythms in daily activity and sleep, and the circadian gene expression in a cohort of healthy controls (N = 22), ADHD participants not using ADHD-medication (N = 17), and participants with ADHD and current use of ADHD medication (N = 17). Rhythms of sleep/wake behavior were assessed via wrist-worn actigraphy, whilst

2019 Neuropsychopharmacology

11. Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease Full Text available with Trip Pro

Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease Parkinson's disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin-containing retinal ganglion cells are involved in the control and regulation of these processes and may be affected in PD, as other retinal and visual implications have been described in the disease (...) . Number and morphology of human melanopsin-containing retinal ganglion cells were evaluated by immunohistochemistry in eyes from donors with PD or control. The Sholl number of intersections, the number of branches, and the number of terminals from the Sholl analysis were significantly reduced in PD melanopsin ganglion cells. Also, the density of these cells significantly decreased in PD compared to controls. Degeneration and impairment of the retinal melanopsin system may affect to sleep and circadian

2018 Acta neuropathologica communications

12. Metabolic syndrome and actigraphy measures of sleep and circadian rhythms in bipolar disorders during remission. (Abstract)

Metabolic syndrome and actigraphy measures of sleep and circadian rhythms in bipolar disorders during remission. This study explored the correlations between sleep and circadian rhythm measures and the metabolic syndrome (MetS) components in remitted patients with bipolar disorder (BD).Euthymic patients with BD (n = 67) were recorded by 3 weeks with actigraphy. We used nonparametric correlations to study the links between the MetS parameters, atherogenic index of plasma (AIP), sleep efficacy (...) , sleep latency, fragmentation index, and phase and amplitude of rhythms. We performed multivariable analyses to take into account potential confounding factors such as sleep apnea risk, antipsychotics use, and smoker status.We found correlations between lower sleep efficiency and higher triglyceride levels (P = 0.002), lower M10 onset (beginning of the 10 most active hours during the 24-h cycle) and higher systolic blood pressure (P = 0.03), higher fragmentation index and higher systolic blood

2018 Acta Psychiatrica Scandinavica

13. Sleep and circadian rhythms as possible trait markers of suicide attempt in bipolar disorders: An actigraphy study. (Abstract)

Sleep and circadian rhythms as possible trait markers of suicide attempt in bipolar disorders: An actigraphy study. The poor prognostic of Bipolar disorders (BD) is closely linked to deaths by suicide. Sleep and circadian abnormalities are observed during all phases of BD and are also associated with suicide attempt (SA). In this context, this study sought to identify specific sleep and circadian rhythms markers associated with suicidal attempt in euthymic patients with BD.The sample (N = 236 (...) ) comprised 3 groups: 147 patients with BD including 57 with a history of SA and 90 without (NoSA), and 89 healthy controls (HC). All participants were recorded during 21 days with actigraphy.SA was associated with women gender (p = 0.03), familial history of SA (p = 0.03), mixed episodes (p = 0.001), and benzodiazepines (p = 0.019). SA, compared to noSA, had a morning phase preference (p = 0.04), and were more vigorous on the circadian type inventory (p = 0.04), and tended to suffer more from insomnia

2018 Journal of Affective Disorders

14. Non-24-Hour Sleep-Wake Circadian Rhythm Disorder in a Sighted Male With Normal Functioning Full Text available with Trip Pro

Non-24-Hour Sleep-Wake Circadian Rhythm Disorder in a Sighted Male With Normal Functioning This is a rare case of non-24-hour sleep-wake rhythm disorder in a sighted male with normal functioning. The patient, a 23-year-old doctorate graduate student, presented with difficulty falling asleep and excessive daytime sleepiness. He reported variable sleep and wake times. Overnight baseline polysomnography was unremarkable and his Multiple Sleep Latency Test was significant for short mean sleep (...) latency. Sleep diary and actigraphy were obtained, which demonstrated a pattern of delaying of sleep and wake times each day. He had excellent symptom response to nightly melatonin.© 2018 American Academy of Sleep Medicine.

2018 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

15. Non-benzodiazepine drug interventions for sleep and circadian rhythm disruption in bipolar disorder

Non-benzodiazepine drug interventions for sleep and circadian rhythm disruption in bipolar disorder Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external (...) cell dose (linear); blinding of outcome assessment reported (stratified yes vs no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome

2020 PROSPERO

16. Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders Full Text available with Trip Pro

Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep disorders (CRSDs) by measuring clock gene expression rhythms in fibroblast cells derived from individual patients. Bmal1-luciferase (Bmal1-luc) expression rhythms were measured in the primary fibroblast (...) , in vitro period was associated with response to chronotherapy in the N24SWD group. Longer in vitro periods were observed in the non-responders (mean±s.d.: 23.59±0.89 h) compared with the responders (mean±s.d.: 22.97±0.47 h) in the N24SWD group. Our results indicate that prolonged circadian periods contribute to the onset and poor treatment outcome of N24SWD. In vitro rhythm assays could be useful for predicting circadian phenotypes and clinical prognosis in patients with CRSDs.

2017 Translational psychiatry

17. Circadian rhythm sleep-wake disorders as predictors for bipolar disorder in patients with remitted mood disorders. (Abstract)

Circadian rhythm sleep-wake disorders as predictors for bipolar disorder in patients with remitted mood disorders. Circadian rhythm dysfunction is thought to play a key role in the pathogenesis of bipolar disorder (BD). We focused on circadian rhythm sleep-wake disorders (CRSWD) as possible predictors for bipolar disorder in patients with remitted mood disorders.One hundred four BD (41 type I and 63 type II) outpatients and 73 age- and sex-matched major depressive disorder (MDD) outpatients (...) participated in this study. The subjects were asked to answer questionnaires including demographic variables, clinical course of the disorder, and family history of psychiatric disorders. Severity of mood status was evaluated by the Montgomery-Åsberg Depression Rating Scale and Young Mania Rating Scale. CRSWD was diagnosed by clinical interview and sleep logs based on the International Classification of Sleep Disorders, third edition.The rate of CRSWD in BD subjects was significantly higher than

2017 Journal of Affective Disorders

18. Circadian Rhythm Sleep-Wake Disorders Predict Shorter Time to Relapse of Mood Episodes in Euthymic Patients With Bipolar Disorder: A Prospective 48-Week Study. (Abstract)

Circadian Rhythm Sleep-Wake Disorders Predict Shorter Time to Relapse of Mood Episodes in Euthymic Patients With Bipolar Disorder: A Prospective 48-Week Study. Circadian rhythm dysfunction has been considered to be common in bipolar disorder (BD) and plays an important role in mood dysregulation in this disorder. However, no study has investigated whether circadian rhythm dysfunction would affect the clinical course of BD. The aim of this study was to test the hypothesis that circadian rhythm (...) dysfunction could be a predictor of relapse in euthymic BD patients.One hundred four euthymic outpatients with BD diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), participated in this prospective follow-up study from August 2014 to April 2015. At baseline, data on demographic variables and clinical descriptive variables of bipolar disorder were ascertained via clinical interviews. The diagnoses of circadian rhythm sleep-wake disorders

2017 Journal of Clinical Psychiatry

19. SLEEP AND CIRCADIAN RHYTHM DISORDERS IN PARKINSON’S DISEASE Full Text available with Trip Pro

in the PD population.We discuss the specific considerations related to the common sleep problems in Parkinson's disease including insomnia, rapid eye movement sleep behavior disorder, restless legs syndrome, sleep disordered breathing, excessive daytime sleepiness and circadian rhythm disorders. Within each of these sleep disorders, we present updated definitions, epidemiology, etiology, diagnosis, clinical implications and management. Furthermore, areas of potential interest for further research (...) SLEEP AND CIRCADIAN RHYTHM DISORDERS IN PARKINSON’S DISEASE Sleep disorders are among the most challenging non-motor features of Parkinson's disease (PD) and significantly affect quality of life. Research in this field has gained recent interest among clinicians and scientists and is rapidly evolving. This review is dedicated to sleep and circadian dysfunction associated with PD.Most primary sleep disorders may co-exist with PD; majority of these disorders have unique features when expressed

2017 Current Sleep Medicine Reports

20. Young children with Down syndrome show normal development of circadian rhythms, but poor sleep efficiency: a cross-sectional study across the first 60 months of life Full Text available with Trip Pro

Young children with Down syndrome show normal development of circadian rhythms, but poor sleep efficiency: a cross-sectional study across the first 60 months of life To evaluate sleep consolidation and circadian activity rhythms in infants and toddlers with Down syndrome (DS) under light and socially entrained conditions within a familiar setting. Given previous human and animal data suggesting intact circadian regulation of melatonin across the day and night, it was hypothesized (...) alongside these values. Sleep efficiency was also estimated based on the actigraphy recordings.This study provided further evidence that general sleep quality is poor in infants and toddlers with DS, a population that has sleep apnea prevalence as high as 50% during the preschool years. Despite poor sleep quality, circadian rhythm and phase were preserved in children with DS and displayed similar developmental trajectories in cross-sectional comparisons with a typically developing (TD) cohort. In line

2017 Sleep medicine

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