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Ciguatera Poisoning

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61. Maitotoxin Is a Potential Selective Activator of the Endogenous Transient Receptor Potential Canonical Type 1 Channel in Xenopus laevis Oocytes Full Text available with Trip Pro

Maitotoxin Is a Potential Selective Activator of the Endogenous Transient Receptor Potential Canonical Type 1 Channel in Xenopus laevis Oocytes Maitotoxin (MTX) is the most potent marine toxin known to date. It is responsible for a particular human intoxication syndrome called ciguatera fish poisoning (CFP). Several reports indicate that MTX is an activator of non-selective cation channels (NSCC) in different cell types. The molecular identity of these channels is still an unresolved topic

2017 Marine drugs

62. Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1 Full Text available with Trip Pro

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1 Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CTXs are known as the most potent mammalian sodium channel activator toxins, the etiology of many of its neurosensory symptoms (...) transgenic mice, we revealed that the TTX-resistant voltage-gated sodium channel (VGSC) NaV1.9, but not NaV1.8 or NaV1.7 alone and the combined activation of the TTX-sensitive VGSC subtypes NaV1.7 and NaV1.1 carry the largest part of the P-CTX-1-caused CGRP release of 42% and 34%, respectively. Given the contribution of CGRP to nociceptive and itch sensing pathways, our findings contribute to a better understanding of sensory symptoms of acute and chronic ciguatera that may help in the identification

2017 Marine drugs

63. Management of Ciguatoxin Risk in Eastern Australia Full Text available with Trip Pro

Management of Ciguatoxin Risk in Eastern Australia Between 2014 and 2016, five cases of ciguatera fish poisoning (CFP), involving twenty four individuals, were linked to Spanish Mackerel (Scomberomorus commerson) caught in the coastal waters of the state of New South Wales (NSW) on the east coast of Australia. Previously, documented cases of CFP in NSW were few, and primarily linked to fish imported from other regions. Since 2015, thirteen individuals were affected across four additional CFP

2017 Toxins

64. Most medical practices are not parachutes

: Ciguatera poisoning The […] Share this: Like this: Like Loading... Published A simplified approach to the initial assessment and management of emergency department patients with retro-orbital hematoma requiring emergent lateral canthotomy Share this: Like this: Like Loading... Published The initial emergency medicine management of post-tonsillectomy bleeding Share this: Like this: Like Loading... Leave a Reply One thought on “ Most medical practices are not parachutes ” Hospitalist April 8, 2018

2018 First10EM

65. Finally, an RCT of parachutes

is that a man is never vexed to find that after all he has been in the wrong.” - William Osler You may also like Published The end of another month can only mean one thing: I have once again read too many medical articles, and I feel […] Share this: Like this: Like Loading... Published In the Rapid Review series, I briefly review the key points of a clinical review paper. The topic this time: Ciguatera poisoning The […] Share this: Like this: Like Loading... Published A monthly collection of the most

2018 First10EM

66. Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury Full Text available with Trip Pro

Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury Ciguatera fish poisoning (CFP) results from consumption of tropical reef fish containing ciguatoxins (CTXs). Pacific (P)-CTX-1 is among the most potent known CTXs and the predominant source of CFP in the endemic region responsible for the majority of neurological symptoms in patients. Chronic and persistent neurological symptoms occur in some (...) CFP patients, which often result in incomplete functional recovery for years. However, the direct effects of exposure to CTXs remain largely unknown. In present study, we exposed mice to CTX purified from ciguatera fish sourced from the Pacific region. P-CTX-1 was detected in peripheral nerves within hours and persisted for two months after exposure. P-CTX-1 inhibited axonal regrowth from axotomized peripheral neurons in culture. P-CTX-1 exposure reduced motor function in mice within the first two

2016 Scientific reports

67. Harmful Algal Blooms and Public Health Full Text available with Trip Pro

Harmful Algal Blooms and Public Health The five most commonly recognized Harmful Algal Bloom related illnesses include Ciguatera poisoning, Paralytic Shellfish poisoning, Neurotoxin Shellfish poisoning, Diarrheic Shellfish Poisoning and Amnesic Shellfish poisoning. Although they are each the product of different toxins, toxin assemblages or HAB precursors these clinical syndromes have much in common. Exposure occurs through the consumption of fish or shellfish; routine clinical tests

2016 Harmful algae

68. Fluorescent Receptor Binding Assay for Detecting Ciguatoxins in Fish Full Text available with Trip Pro

Fluorescent Receptor Binding Assay for Detecting Ciguatoxins in Fish Ciguatera fish poisoning is an illness suffered by > 50,000 people yearly after consumption of fish containing ciguatoxins (CTXs). One of the current methodologies to detect ciguatoxins in fish is a radiolabeled receptor binding assay (RBA(R)). However, the license requirements and regulations pertaining to radioisotope utilization can limit the applicability of the RBA(R) in certain labs. A fluorescence based receptor binding

2016 PloS one

69. Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin Full Text available with Trip Pro

Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin Ciguatoxins (CTXs) are polyether marine neurotoxins found in multiple reef-fish species and are potent activators of voltage-gated sodium channels. It is estimated that up to 500,000 people annually experience acute ciguatera poisoning from consuming toxic fish and a small percentage of these victims will develop a chronic (...) , multisymptom, multisystem illness, which can last years, termed a Chronic Inflammatory Response Syndrome (CIRS). Symptoms of ciguatera CIRS include fatigue, cognitive deficits, neurologic deficits, pain and sensitivity to light. There are few treatment options for ciguatera CIRS since little is known about its pathophysiology.This study characterizes the transcriptional profile in whole blood of 11 patients with ciguatera-induced CIRS and 11 normal controls run in duplicate using Agilent one color whole

2015 BMC medical genomics

70. Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae) Full Text available with Trip Pro

Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae) Marine microbial protists, in particular, dinoflagellates, produce polyketide toxins with ecosystem-wide and human health impacts. Species of Gambierdiscus produce the polyether ladder compounds ciguatoxins and maitotoxins, which can lead to ciguatera fish poisoning, a serious human illness associated with reef fish consumption. Genes associated with the biosynthesis of polyether ladder (...) be associated with maitotoxin biosynthesis. This work represents a significant step forward in our understanding of the genetic basis of polyketide production in dinoflagellates, in particular, species responsible for ciguatera fish poisoning.

2015 BMC genomics

71. Funtabulously Frivolous Friday Five 119

and the patient died after their wounds became gangrenous…bringing the mortality for a single operation to 300%. [ ] Question 2 You’re asked to see a patient who presents with a history of nausea, diarrhoea and vomiting, but then went onto develop headache, ataxia, and paraesthesia. He cooked a large snapper (fish) for dinner with his wife, but states it can’t be related to the snapper as his partner didn’t suffer any similar symptoms. What might be the cause? Ciguatera poisoning Fish that have consumed

2015 Life in the Fast Lane Blog

72. Nausea, blurry vision, hallucinations--Dx? (Abstract)

Nausea, blurry vision, hallucinations--Dx? 24475468 2014 03 18 2014 01 29 1533-7294 63 1 2014 Jan The Journal of family practice J Fam Pract Nausea, blurry vision, hallucinations--Dx? 9-10 Stacey John J Midwestern University, COM, Glendale, AZ, USA. Email: drfarricielli@cox.net. Farricielli Laurie L eng Case Reports Journal Article United States J Fam Pract 7502590 0094-3509 3OWL53L36A Mannitol AIM IM Ciguatera Poisoning diagnosis drug therapy Diagnosis, Differential Female Hallucinations

2014 Journal of Family Practice

73. Toxicity, Seafood (Diagnosis)

envenomations, are not covered here. For patient education resources, see the and , as well as the following: Next: Finfish Poisoning Ciguatera is considered by many public health institutions worldwide to be the most common food-borne disease related to the consumption of finfish (even though it is vastly underreported). It comprises over 50% of all reported cases of seafood poisoning in the United States, with 90% of the US cases being reported in Florida and Hawaii. [ ] Ciguatera poisoning is endemic (...) channels. It is lipid soluble and concentrates in the flesh, adipose tissue, and organs of the larger fish. Contaminated fish smell and taste normal. The toxin is heat stable and thus may affect humans even if fish are properly prepared. Ciguatera toxin is secreted into breast milk and freely crosses the placenta. [ ] The onset of GI and neurologic symptoms after the consumption of fish are the hallmarks of ciguatera poisoning. Symptoms are usually evident within 2-6 hours after ingestion and usually

2014 eMedicine Pediatrics

74. Toxic Neuropathy (Overview)

of neuropathy, such as sodium channel, neuromuscular transmission, or cranial neuropathies, also have toxic etiologies. In North America, sodium channel dysfunction may be the result of ciguatera toxin from reef fish or saxitoxin from shellfish. This often presents as an acute or subacute illness. Puffer fish may be intoxicated with tetrodotoxin in Japan. Neuromuscular transmission dysfunction is associated most commonly with organophosphate intoxication; however, envenomation from snake bites or botulism (...) system of workers' exposure to carbon disulfide. Neurotoxicology . 1983. 4(1):53-65. . Gross JA, Haas ML, Swift TR. Ethylene oxide neurotoxicity: report of four cases and review of the literature. Neurology . 1979 Jul. 29(7):978-83. . Fukushima T, Abe K, Nakagawa A, et al. Chronic ethylene oxide poisoning in a factory manufacturing medical appliances. J Soc Occup Med . 1986. 36(4):118-23. . Schroder JM, Hoheneck M, Weis J, Deist H. Ethylene oxide polyneuropathy: clinical follow-up study

2014 eMedicine.com

75. Toxic Neuropathy (Diagnosis)

of neuropathy, such as sodium channel, neuromuscular transmission, or cranial neuropathies, also have toxic etiologies. In North America, sodium channel dysfunction may be the result of ciguatera toxin from reef fish or saxitoxin from shellfish. This often presents as an acute or subacute illness. Puffer fish may be intoxicated with tetrodotoxin in Japan. Neuromuscular transmission dysfunction is associated most commonly with organophosphate intoxication; however, envenomation from snake bites or botulism (...) system of workers' exposure to carbon disulfide. Neurotoxicology . 1983. 4(1):53-65. . Gross JA, Haas ML, Swift TR. Ethylene oxide neurotoxicity: report of four cases and review of the literature. Neurology . 1979 Jul. 29(7):978-83. . Fukushima T, Abe K, Nakagawa A, et al. Chronic ethylene oxide poisoning in a factory manufacturing medical appliances. J Soc Occup Med . 1986. 36(4):118-23. . Schroder JM, Hoheneck M, Weis J, Deist H. Ethylene oxide polyneuropathy: clinical follow-up study

2014 eMedicine.com

76. Toxicity, Seafood (Treatment)

envenomations, are not covered here. For patient education resources, see the and , as well as the following: Next: Finfish Poisoning Ciguatera is considered by many public health institutions worldwide to be the most common food-borne disease related to the consumption of finfish (even though it is vastly underreported). It comprises over 50% of all reported cases of seafood poisoning in the United States, with 90% of the US cases being reported in Florida and Hawaii. [ ] Ciguatera poisoning is endemic (...) channels. It is lipid soluble and concentrates in the flesh, adipose tissue, and organs of the larger fish. Contaminated fish smell and taste normal. The toxin is heat stable and thus may affect humans even if fish are properly prepared. Ciguatera toxin is secreted into breast milk and freely crosses the placenta. [ ] The onset of GI and neurologic symptoms after the consumption of fish are the hallmarks of ciguatera poisoning. Symptoms are usually evident within 2-6 hours after ingestion and usually

2014 eMedicine Pediatrics

77. Toxicity, Seafood (Follow-up)

envenomations, are not covered here. For patient education resources, see the and , as well as the following: Next: Finfish Poisoning Ciguatera is considered by many public health institutions worldwide to be the most common food-borne disease related to the consumption of finfish (even though it is vastly underreported). It comprises over 50% of all reported cases of seafood poisoning in the United States, with 90% of the US cases being reported in Florida and Hawaii. [ ] Ciguatera poisoning is endemic (...) channels. It is lipid soluble and concentrates in the flesh, adipose tissue, and organs of the larger fish. Contaminated fish smell and taste normal. The toxin is heat stable and thus may affect humans even if fish are properly prepared. Ciguatera toxin is secreted into breast milk and freely crosses the placenta. [ ] The onset of GI and neurologic symptoms after the consumption of fish are the hallmarks of ciguatera poisoning. Symptoms are usually evident within 2-6 hours after ingestion and usually

2014 eMedicine Pediatrics

78. Toxicity, Seafood (Overview)

envenomations, are not covered here. For patient education resources, see the and , as well as the following: Next: Finfish Poisoning Ciguatera is considered by many public health institutions worldwide to be the most common food-borne disease related to the consumption of finfish (even though it is vastly underreported). It comprises over 50% of all reported cases of seafood poisoning in the United States, with 90% of the US cases being reported in Florida and Hawaii. [ ] Ciguatera poisoning is endemic (...) channels. It is lipid soluble and concentrates in the flesh, adipose tissue, and organs of the larger fish. Contaminated fish smell and taste normal. The toxin is heat stable and thus may affect humans even if fish are properly prepared. Ciguatera toxin is secreted into breast milk and freely crosses the placenta. [ ] The onset of GI and neurologic symptoms after the consumption of fish are the hallmarks of ciguatera poisoning. Symptoms are usually evident within 2-6 hours after ingestion and usually

2014 eMedicine Pediatrics

79. Cross-reactivity and masqueraders in seafood reactions. (Abstract)

of the several processes that may lead clinicians to draw incorrect conclusions in evaluating reported reactions to seafood. Ranging from seafood intoxications to other nonallergic or complex seafood reactions, these events can easily be misconstrued as representing a seafood IgE-mediated allergy. Among these are the more familiar topics of cross-reactivity and scombroid intoxication, and those with a still evolving understanding such as ciguatera fish poisoning and Anisakis reactions. This article seeks

2013 Allergy and Asthma Proceedings

80. Management of life-threatening hyperkalemia

resuscitation. Share this: Like this: Like Loading... Published In the Rapid Review series, I briefly review the key points of a clinical review paper. The topic this time: Ciguatera poisoning The […] Share this: Like this: Like Loading... Published Some concerns with the new sepsis definition Share this: Like this: Like Loading... Published The Rapid Review series is designed to briefly review the key emergency medicine points from a single clinical review paper. This post’s topic: Acute […] Share

2016 First10EM

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