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Ciclopirox

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141. Tinea Cruris

, econazole , naftifine, and (uncommonly) ciclopirox applied bid for 10 to 14 days. Itraconazole 200 mg po once/day or terbinafine 250 mg po once/day for 3 to 6 wk may be needed in patients who have refractory, inflammatory, or widespread infections. Last full review/revision October 2018 by Denise M. Aaron, MD NOTE: This is the Professional Version. CONSUMERS: © 2018 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA) Was This Page Helpful? 0, html: helpfultext"> Yes

2013 Merck Manual (19th Edition)

142. Tinea Corporis

, and Microsporum canis . Manifestations of Tinea Corporis The border is raised and scaly and has visible tiny pustules. Both lesions are due to tinea corporis. The lesion on the right shows typical peripheral scale and slight central lesion clearing. Diagnosis Clinical evaluation Potassium hydroxide wet mount Differential diagnosis of tinea corporis includes Treatment Topical or oral antifungals (See table: .) Treatment of mild-to-moderate lesions is an imidazole, ciclopirox , naftifine, or terbinafine

2013 Merck Manual (19th Edition)

143. Tinea Capitis

or milk for 4 to 6 wk or until all signs of infection are gone. Terbinafine also may be used. Children < 20 kg are given terbinafine 62.5 mg po once/day, those 20 to 40 kg are given 125 mg po once/day, and those > 40 kg are given 250 mg po once/day. An imidazole or ciclopirox cream should be applied to the scalp to prevent spread, especially to other children, until tinea capitis is cured; selenium sulfide 2.5% shampoo should also be used at least twice/wk. Children may attend school during treatment

2013 Merck Manual (19th Edition)

144. Onychomycosis

of that treatment. Topical agents include nail paint, , and . Some topical treatments need to be applied daily for prolonged periods (at least 1 year). Topical amorolfine is applied weekly. Topical ciclopirox results in a cure in 6% to 9% of cases; amorolfine might be more effective. Ciclopirox when used with terbinafine appears to be better than either agent alone. Medications that may be taken by mouth include (76% effective), (60% effective) and (48% effective). They share characteristics that enhance

2012 Wikipedia

145. Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability (PubMed)

organisms. We validate this high-throughput system in detecting schistosomula viability using auranofin (a known inhibitor of thioredoxin glutathione reductase), praziquantel and a range of small compounds with previously-described (gambogic acid, sodium salinomycin, ethinyl estradiol, fluoxetidine hydrochloride, miconazole nitrate, chlorpromazine hydrochloride, amphotericin b, niclosamide) or suggested (bepridil, ciclopirox, rescinnamine, flucytosine, vinblastine and carbidopa) anti-schistosomal

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2010 PLoS neglected tropical diseases

146. Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea

criteria, on days 30 and 180. Data will be submitted to statistical analysis. Condition or disease Intervention/treatment Phase Seborrhea Seborrheic Dermatitis Quality of Life Drug: oral isotretinoin Drug: salicylic acid and ciclopirox olamine Phase 4 Detailed Description: Oral isotretinoin is a retinoid that controls gene expression related to cellular proliferation, differentiation, with specific action over sebocytes, reducting sebaceous gland size and secretion rate. Its binding to specific (...) and irritant action of products from lipophilic yeasts of Malassezia gender. The treatment usually involves topical use of corticosteroids, salicylic acid, ketoconazole, ciclopirox olamine, pimecrolimus and tacrolimus. The dermatosis impact on quality of life has been more and more evaluated by generic and specific questionnaires. The most used generic questionnaires are:"Dermatology Life Quality Index or DLQI" and "Medical Outcomes Study 36-Item Short-Form Health Survey or SF-36". Recently a specific

2010 Clinical Trials

147. Efficacy and Safety Study of Iontophoretic Application of Terbinafine Gel in Subjects With Onychomycosis

therapy (see below), with solid organ or bone marrow transplantation, cytotoxic chemotherapy within the previous 12 months (or planned within the next 12 months), or HIV infection. Use of topical antifungals e.g. (clotrimazole, ketoconazole, miconazole, oxiconazole (Oxistat®, Glaxo Smith Kline), sulconazole, naftifine (Naftin®, Merz), terconazole, econazole nitrate (Spectazole®, Ortho-McNeil), butoconazole ,Fluconazole, tolnaftate, haloprogin), Zeasorb-AF Ciclopirox (e.g. Penlac® Nail Lacquer, Sanofi

2010 Clinical Trials

148. A Dose Response Trial to Evaluate Clinical and Mycological Effect of Nitric Oxide in Subjects With Tinea Pedis

at a level, which in the opinion of the investigator would compromise the integrity of the study. Use of topical antifungals e.g. (clotrimazole, ketoconazole,miconazole, oxiconazole- (Oxistat®, Glaxo Smith Kline), sulconazole, naftifine (Naftin®, Merz), terconazole, econazole nitrate (Spectazole®, Ortho-McNeil), butoconazole ,Fluconazole, ciclopirox olamine-(Loprox®, Medicis), tolnaftate, haloprogin), Zeasorb-AF , antibacterials and corticosteroids in the preceding 14 days of screening visit (Day 1

2009 Clinical Trials

149. Athlete's foot (PubMed)

interventions: improved foot hygiene, including socks and hosiery; topical allylamines (naftifine and terbinafine); topical azoles (bifonazole, clotrimazole, econazole nitrate, miconazole nitrate, sulconazole nitrate, and tioconazole); and topical ciclopirox olamine.

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2009 BMJ Clinical Evidence

150. Antifungal activities of natural and synthetic iron chelators alone and in combination with azole and polyene antibiotics against Aspergillus fumigatus. (PubMed)

Antifungal activities of natural and synthetic iron chelators alone and in combination with azole and polyene antibiotics against Aspergillus fumigatus. Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy against conidia was observed (...) for combinations of ketoconazole with ciclopirox or deferiprone, lactoferrin with amphotericin B, and fluconazole with deferiprone. Iron chelation alone or combined with antifungal drugs may be useful for prevention and treatment of mycosis.

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2009 Antimicrobial Agents and Chemotherapy

151. Safety and Equivalence of a Generic Ciclopirox Olamine Cream Compared to the Reference Ciclopirox Cream 0.77% for the Treatment of Tinea Pedis

Safety and Equivalence of a Generic Ciclopirox Olamine Cream Compared to the Reference Ciclopirox Cream 0.77% for the Treatment of Tinea Pedis Safety and Equivalence of a Generic Ciclopirox Olamine Cream Compared to the Reference Ciclopirox Cream 0.77% for the Treatment of Tinea Pedis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Equivalence of a Generic Ciclopirox Olamine Cream Compared to the Reference Ciclopirox Cream 0.77% for the Treatment of Tinea Pedis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2008 Clinical Trials

152. Safety and Equivalence of a Generic Ciclopirox Olamine Topical Suspension Compared to the Reference Ciclopirox Topical Suspension 0.77% for the Treatment of Tinea Pedis

Safety and Equivalence of a Generic Ciclopirox Olamine Topical Suspension Compared to the Reference Ciclopirox Topical Suspension 0.77% for the Treatment of Tinea Pedis Safety and Equivalence of a Generic Ciclopirox Olamine Topical Suspension Compared to the Reference Ciclopirox Topical Suspension 0.77% for the Treatment of Tinea Pedis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search (...) for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Equivalence of a Generic Ciclopirox Olamine Topical Suspension Compared to the Reference Ciclopirox Topical Suspension 0.77% for the Treatment of Tinea Pedis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2008 Clinical Trials

153. Efficacy Study to Evaluate the Effect of Nitric Oxide on the Treatment of Tinea Pedis (Athlete's Foot)

over group) study period Exclusion Criteria: Has a diagnosis of either psoriasis or eczema Has a visual diagnosis, by the investigator, of onychomycosis. Use of topical antifungals e.g. (clotrimazole, ketoconazole,miconazole, oxiconazole- (Oxistat®, Glaxo Smith Kline), sulconazole, naftifine (Naftin®, Merz), terconazole, econazole nitrate (Spectazole®, Ortho-McNeil), butoconazole ,Fluconazole, ciclopirox olamine-(Loprox®, Medicis), tolnaftate, haloprogin), Zeasorb-AF , antibacterials

2008 Clinical Trials

154. Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox. (PubMed)

Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox. Aerial parts of AGERATINA PICHINCHENSIS have been used, in Mexican traditional medicine, as a remedy for the treatment of skin mycosis. Onychomycosis, also known as tinea of the nails or tinea unguium, constitutes an infection of the nails produced by dermatophytes. Clinically, onychomycosis (...) lacquer solution containing 8 % ciclopirox was used as control. Treatments were assigned randomly and administered topically for 6 months. Ninety six patients concluded the study (49 in the experimental group and 47 in the control); 71.1 % of patients from the experimental and 80.9 % from the control group showed therapeutic effectiveness, while 59.1 % and 63.8 % from the experimental and control group, respectively, achieved mycological effectiveness. Therapeutic success was observed in 55.1 and 63.8

2008 Planta medica

155. Review of antifungal therapy and the severity index for assessing onychomycosis: Part I. (PubMed)

Review of antifungal therapy and the severity index for assessing onychomycosis: Part I. This review outlines recent data on treatment modalities and outcomes with antifungal therapy in onychomycosis. Included are topical, mechanical, chemical and systemic treatments or a combination thereof. Topical treatments, or transungual drug delivery systems (TUDDS), including ciclopirox and amorolfine were shown to be effective if used alone for mild-moderate nail involvement. Specifically, superficial

2008 Journal of Dermatological Treatment

156. Ototoxic Effect of Topical Ciclopirox as an Antimycotic Preparation. (PubMed)

Ototoxic Effect of Topical Ciclopirox as an Antimycotic Preparation. To evaluate the ototoxicity of ciclopirox-containing solution as an otologic preparation for the treatment of otomycosis.Ciclopirox is a synthetic antimycotic agent available in a variety of formulations to treat superficial fungal infections. Ciclopirox has demonstrated both fungicidal and fungistatic activity in vitro against a broad spectrum of pathogenic fungi. It also possesses a broad-spectrum antibacterial properties (...) , anti-inflammatory, and antiedema effect. The ototoxic effect of ciclopirox-containing solutions has not been known, so the current study was designed to observe the ototoxic effect of this solution experimentally.Experiments were performed in 22 young male albino guinea pigs (weight, 450-550 g). The 10 animals in the experimental group received ciclopirox solution, and the control group was divided into two groups of six animals each. The first group received saline solution (negative control

2008 Otology and Neurotology

157. Fungal toenail infections (PubMed)

of evidence for interventions.In this systematic review we present information relating to the effectiveness and safety of the following interventions: amorolfine, butenafine, ciclopirox, fluconazole, griseofulvin, itraconazole, ketoconazole, mechanical debridement, terbinafine, and tioconazole.

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2008 BMJ Clinical Evidence

158. Cost-effectiveness of diagnostic tests for toenail onychomycosis: a repeated-measure, single-blinded, cross-sectional evaluation of 7 diagnostic tests

as symptoms of subungual debris with onycholysis and/or onychauxis). Patients younger than 18 years of age were excluded from the study, as were those with documented psoriasis, lichen planus, or other nail dystrophies. Also excluded were patients on oral antifugal medication for more than 2 months during the 12 months prior to enrolment, and individuals who had used topical ciclopirox nail lacquer within 6 weeks of enrolment. Setting The setting was primary care. The economic study was carried out

2006 NHS Economic Evaluation Database.

159. Evaluating costs for onychomycosis treatments: a practitioner's perspective

on the reliability of the study and the conclusions drawn. Health technology The study examined several treatments for patients with onychomycosis. Specifically, griseofulvin (GRI), itraconazole (ITRA), fluconazole (FLU), terbinafine (TERB) and 8% ciclopirox lacquer (CICLO). Some combination therapies were also considered. Different dosages and duration of treatment were also considered for each drug under analysis. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population

2006 NHS Economic Evaluation Database.

160. Pharmacoeconomic analysis of sequential treatment pathways in the treatment of onychomycosis

, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of ciclopirox (CIC) nail lacquer, itraconazole pulse treatment (ITRA pulse), terbinafine (TERB) and itraconazole continuous treatment (ITRA cont) for the treatment of onychomycosis was examined. Recommended regimens were 250 mg/day TERB for 12 to 16 weeks, 200 mg/day ITRA cont for 12 to 16 weeks, 200 mg ITRA pulse twice daily for one week per month (...) ITRA pulse was the first-line agent, the cost of ITRA was the variable with the greatest impact on the model results. Authors' conclusions A treatment pathway for toenail onychomycosis that used ciclopirox (CIC) nail lacquer solution 8% as a first-line agent was a cost-effective strategy from the perspective of the health care system. CRD COMMENTARY - Selection of comparators The authors justified the choice of the comparators, which represented commonly used agents for the treatment

2005 NHS Economic Evaluation Database.

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