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Ciclopirox

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121. Tacrolimus Ointment Interest (PROTOPIC ®) in the Maintenance Treatment of Severe Seborrheic Dermatitis

) Protopic® 0.1% ointment - 2 applications per week for 6 months Other Name: Tacrolimus Active Comparator: Mycoster Arm 2 applications per week for 6 months Drug: Mycoster (R) Mycoster 1% - 2 applications per week for 6 months Other Name: Ciclopirox olamine Outcome Measures Go to Primary Outcome Measures : duration of the maintenance of complete or almost complete clinical remission [ Time Frame: 18 months after inclusion (Visit (V) 4 last visit) ] The primary endpoint will be the duration (...) Hospital, Rouen: local immunosuppressive Maintenance therapy Additional relevant MeSH terms: Layout table for MeSH terms Dermatitis Dermatitis, Seborrheic Skin Diseases Sebaceous Gland Diseases Skin Diseases, Eczematous Skin Diseases, Papulosquamous Tacrolimus Ciclopirox Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs Calcineurin Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Antifungal Agents Anti-Infective Agents

2013 Clinical Trials

122. Efficacy of topical 4% Quassia amara gel in facial seborrheic dermatitis:a randomized, double-blind, comparative study. (Abstract)

% ketoconazole and 1% topical ciclopiroxolamine in the treatment of facial SD.A group of 60 patients displaying facial SD were randomly distributed in 3 groups and given either a topical gel with 4% Quassia amara extract, a topical gel with 2% ketoconazole, or a topical gel with 1% ciclopirox olamine for 4 weeks. Disease severity was assessed at the start and weekly along treatment, as well as 4 weeks after the end of treatment. In each selected area, severity of erythema, scaling, pruritus, and papules were

2013 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

123. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis. Full Text available with Trip Pro

used in onychomycosis, including amorolfine, ciclopirox, itraconazole, and terbinafine. In 13 T. rubrum toenail isolates from onychomycosis patients who were treated daily with topical efinaconazole for 48 weeks, there were no apparent increases in susceptibility, suggesting low potential for dermatophytes to develop resistance to efinaconazole. The activity of efinaconazole was further evaluated in another 8 dermatophyte, 15 nondermatophyte, and 10 yeast species (a total of 109 isolates from

2013 Antimicrobial Agents and Chemotherapy

124. Onychomycosis Does Not Always Require Systemic Treatment for Cure: A Trial Using Topical Therapy. (Abstract)

is efficacious for pediatric onychomycosis. Forty patients ages 2 to 16 years with nonmatrix onychomycosis were randomized 1:3 to ciclopirox lacquer or vehicle lacquer. Ciclopirox lacquer or vehicle was applied daily for 32 weeks, with weekly removal of the lacquer and mechanical trimming. Those with poor response were crossed over to active drug at week 12. Thirty-seven patients completed the 32-week study, and follow-up data were collected 1 year after completion of the study from 24 patients. Mycologic (...) cure, effective treatment, and complete cure were assessed, as well as adverse events and effect on quality of life. Mycologic cure was 70% in the treated group and 20% in the vehicle arm (p = 0.03) at week 12. At end of the study (week 32), 77% of treated patients achieved mycologic cure and 71% effective treatment, compared with 22% of the control group. Ninety-two percent of those who were cured and followed for 1 year remained clear. Topical antifungal lacquer (ciclopirox) can be an effective

2013 Pediatric dermatology Controlled trial quality: uncertain

125. Onychomycosis

, efinaconazole, tavaborole, ciclopirox 8%, amorolfine) Onychomycosis is not always treated because many cases are asymptomatic or mild and unlikely to cause complications, and the oral drugs that are the most effective treatments can potentially cause hepatotoxicity and serious drug interactions. Some proposed indications for treatment include the following: Previous ipsilateral or other risk factors for cellulitis Presence of bothersome symptoms Psychosocial impact Desire for cosmetic improvement (...) will not revert to normal; however, newly growing nail will appear normal. The newer topical agents efinaconazole and tavaborole can penetrate the nail plate and are more effective than older topical agents . Investigative treatments that have less frequent and/or less severe adverse effects include laser therapy, new formulations of topical agents (including efinaconazole), and new delivery systems for terbinafine . Topical antifungal nail lacquer containing ciclopirox 8% or amorolfine 5% (not available

2013 Merck Manual (19th Edition)

126. Tinea Cruris

, econazole , naftifine, and (uncommonly) ciclopirox applied bid for 10 to 14 days. Itraconazole 200 mg po once/day or terbinafine 250 mg po once/day for 3 to 6 wk may be needed in patients who have refractory, inflammatory, or widespread infections. Last full review/revision October 2018 by Denise M. Aaron, MD NOTE: This is the Professional Version. CONSUMERS: © 2018 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA) Was This Page Helpful? 0, html: helpfultext"> Yes

2013 Merck Manual (19th Edition)

127. Tinea Corporis

, and Microsporum canis . Manifestations of Tinea Corporis The border is raised and scaly and has visible tiny pustules. Both lesions are due to tinea corporis. The lesion on the right shows typical peripheral scale and slight central lesion clearing. Diagnosis Clinical evaluation Potassium hydroxide wet mount Differential diagnosis of tinea corporis includes Treatment Topical or oral antifungals (See table: .) Treatment of mild-to-moderate lesions is an imidazole, ciclopirox , naftifine, or terbinafine

2013 Merck Manual (19th Edition)

128. Tinea Capitis

or milk for 4 to 6 wk or until all signs of infection are gone. Terbinafine also may be used. Children < 20 kg are given terbinafine 62.5 mg po once/day, those 20 to 40 kg are given 125 mg po once/day, and those > 40 kg are given 250 mg po once/day. An imidazole or ciclopirox cream should be applied to the scalp to prevent spread, especially to other children, until tinea capitis is cured; selenium sulfide 2.5% shampoo should also be used at least twice/wk. Children may attend school during treatment

2013 Merck Manual (19th Edition)

129. Overview of Dermatophytoses

or ciclopirox may be better if candidal infection cannot be excluded. Other adequate OTC topical treatments include clotrimazole and miconazole . Oral antifungals are used for most nail and scalp infections, resistant skin infections, and patients unwilling or unable to adhere to prolonged topical regimens; doses and duration differ by site of infection. Corticosteroids are sometimes used in addition to antifungal creams to help relieve itching and inflammation. However, combining topical corticosteroids

2013 Merck Manual (19th Edition)

130. Candidiasis (Mucocutaneous)

tablets (oropharyngeal, GI) Miscellaneous Carbolfuchsin Solution Chronic , Ciclopirox 0.77% gel, 8% lacquer solution , , , Clioquinol 3% cream Gentian violet 1 or 2% solution , especially ; sometimes Griseofulvin 125-, 165-, 250-, 330-, and 500-mg tablets Tolnaftate 1% liquid, powder, liquid or aerosol spray, cream, or solution , Zinc Undecylenate/undecylenate acid 25% solution, 10% tincture Superficial dermatophyte infections (eg, ) *Advantages of one topical drug over another for most infections

2013 Merck Manual (19th Edition)

131. Topical Penlac Nail Lacquer for Onychomycosis in Children

Description Go to Brief Summary: Five months of therapy is sufficient to treat onychomycosis in children. Topical therapy of onychomycosis in children with Penlac nail lacquer has comparable efficacy and a superior cost and safety profile compared to systemic therapy. Condition or disease Intervention/treatment Phase Onychomycosis Drug: Ciclopirox Drug: Placebo Phase 4 Detailed Description: Therapeutic trials for the treatment of onychomycosis have been conducted in the adult population (...) 2002 Actual Primary Completion Date : December 2005 Actual Study Completion Date : May 2006 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: topical Penlac nail lacquer 3-1 randomization of active to placebo Drug: Ciclopirox Placebo Comparator: Placebo Drug: Placebo Outcome Measures Go to Primary Outcome Measures : Mycological cure or global evaluation of 2 or less Mycological Cure [ Time Frame

2011 Clinical Trials

132. Establishment of a novel model of onychomycosis in the rabbit for evaluation of antifungal agents. Full Text available with Trip Pro

method and histopathological examination. Two topical antifungal drugs, 8% ciclopirox nail lacquer and 5% amorolfine nail lacquer, were applied to the nail for 4 weeks in each group. On histopathological examination, two antifungal treatment groups showed no significant difference against the nontreated control group. However, there were a significantly low fungus-positive rate and intensity of the recovery of fungi on culture between antifungal treatment and nontreated control groups. We therefore

2011 Antimicrobial Agents and Chemotherapy

133. Onychomycosis Full Text available with Trip Pro

of that treatment. Topical agents include nail paint, , and . Some topical treatments need to be applied daily for prolonged periods (at least 1 year). Topical amorolfine is applied weekly. Topical ciclopirox results in a cure in 6% to 9% of cases; amorolfine might be more effective. Ciclopirox when used with terbinafine appears to be better than either agent alone. Medications that may be taken by mouth include (76% effective), (60% effective) and (48% effective). They share characteristics that enhance

2012 Wikipedia

134. Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea

criteria, on days 30 and 180. Data will be submitted to statistical analysis. Condition or disease Intervention/treatment Phase Seborrhea Seborrheic Dermatitis Quality of Life Drug: oral isotretinoin Drug: salicylic acid and ciclopirox olamine Phase 4 Detailed Description: Oral isotretinoin is a retinoid that controls gene expression related to cellular proliferation, differentiation, with specific action over sebocytes, reducting sebaceous gland size and secretion rate. Its binding to specific (...) and irritant action of products from lipophilic yeasts of Malassezia gender. The treatment usually involves topical use of corticosteroids, salicylic acid, ketoconazole, ciclopirox olamine, pimecrolimus and tacrolimus. The dermatosis impact on quality of life has been more and more evaluated by generic and specific questionnaires. The most used generic questionnaires are:"Dermatology Life Quality Index or DLQI" and "Medical Outcomes Study 36-Item Short-Form Health Survey or SF-36". Recently a specific

2010 Clinical Trials

135. Efficacy and Safety Study of Iontophoretic Application of Terbinafine Gel in Subjects With Onychomycosis

therapy (see below), with solid organ or bone marrow transplantation, cytotoxic chemotherapy within the previous 12 months (or planned within the next 12 months), or HIV infection. Use of topical antifungals e.g. (clotrimazole, ketoconazole, miconazole, oxiconazole (Oxistat®, Glaxo Smith Kline), sulconazole, naftifine (Naftin®, Merz), terconazole, econazole nitrate (Spectazole®, Ortho-McNeil), butoconazole ,Fluconazole, tolnaftate, haloprogin), Zeasorb-AF Ciclopirox (e.g. Penlac® Nail Lacquer, Sanofi

2010 Clinical Trials

136. Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability Full Text available with Trip Pro

organisms. We validate this high-throughput system in detecting schistosomula viability using auranofin (a known inhibitor of thioredoxin glutathione reductase), praziquantel and a range of small compounds with previously-described (gambogic acid, sodium salinomycin, ethinyl estradiol, fluoxetidine hydrochloride, miconazole nitrate, chlorpromazine hydrochloride, amphotericin b, niclosamide) or suggested (bepridil, ciclopirox, rescinnamine, flucytosine, vinblastine and carbidopa) anti-schistosomal

2010 PLoS neglected tropical diseases

137. Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis

Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary (...) Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis (ONICO

2009 Clinical Trials

138. Study Evaluating the Tolerance and Biologic Activity of Oral Ciclopirox Olamine in Patients With Relapsed or Refractory Hematologic Malignancy

Study Evaluating the Tolerance and Biologic Activity of Oral Ciclopirox Olamine in Patients With Relapsed or Refractory Hematologic Malignancy Study Evaluating the Tolerance and Biologic Activity of Oral Ciclopirox Olamine in Patients With Relapsed or Refractory Hematologic Malignancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study Evaluating the Tolerance and Biologic Activity of Oral Ciclopirox Olamine in Patients With Relapsed or Refractory Hematologic Malignancy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2009 Clinical Trials

139. A Dose Response Trial to Evaluate Clinical and Mycological Effect of Nitric Oxide in Subjects With Tinea Pedis

at a level, which in the opinion of the investigator would compromise the integrity of the study. Use of topical antifungals e.g. (clotrimazole, ketoconazole,miconazole, oxiconazole- (Oxistat®, Glaxo Smith Kline), sulconazole, naftifine (Naftin®, Merz), terconazole, econazole nitrate (Spectazole®, Ortho-McNeil), butoconazole ,Fluconazole, ciclopirox olamine-(Loprox®, Medicis), tolnaftate, haloprogin), Zeasorb-AF , antibacterials and corticosteroids in the preceding 14 days of screening visit (Day 1

2009 Clinical Trials

140. Athlete's foot Full Text available with Trip Pro

interventions: improved foot hygiene, including socks and hosiery; topical allylamines (naftifine and terbinafine); topical azoles (bifonazole, clotrimazole, econazole nitrate, miconazole nitrate, sulconazole nitrate, and tioconazole); and topical ciclopirox olamine.

2009 BMJ Clinical Evidence

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