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Ciclopirox

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121. Hand Infections (Overview)

aureus in community-acquired hand infections. Ann Plast Surg . 2009 May. 62(5):513-6. . Antosia RE, Lyn E. Hand. Rosen, ed. Emergency Medicine Concepts and Clinical Practice . 5th ed. 2002. 493-535. Butler, KH. Incision and drainage. Roberts JR, Hedges JR, eds. Clinical Procedures in Emergency Medicine . 4th ed. 2004. 739-744. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis

2014 eMedicine Emergency Medicine

122. Pediatrics, Diaper Rash (Overview)

of the mildness of baby wipe and water in infant skin. J Eur Acad Dermatol Venereol . 2001 Sep. 15 Suppl 1:16-21. . Gallup E, Plott T. A multicenter, open-label study to assess the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans. J Drugs Dermatol . 2005 Jan-Feb. 4(1):29-34. . Bonifaz A, Tirado-Sánchez A, Graniel MJ, Mena C, Valencia A, Ponce-Olivera RM. The efficacy and safety of sertaconazole cream (2 %) in diaper dermatitis candidiasis

2014 eMedicine Emergency Medicine

123. Paronychia (Overview)

. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Media Gallery Classic presentation of paronychia, with erythema and pus surrounding the nail bed. In this case, the paronychia was due to infection after a hangnail was removed. In this case of paronychia, no pus or fluctuance is involved in the nail bed itself. Typical appearance of paronychia. Depicted

2014 eMedicine Emergency Medicine

124. Paronychia (Follow-up)

. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Media Gallery Classic presentation of paronychia, with erythema and pus surrounding the nail bed. In this case, the paronychia was due to infection after a hangnail was removed. In this case of paronychia, no pus or fluctuance is involved in the nail bed itself. Typical appearance of paronychia. Depicted

2014 eMedicine Emergency Medicine

125. Pediatrics, Diaper Rash (Follow-up)

and water in infant skin. J Eur Acad Dermatol Venereol . 2001 Sep. 15 Suppl 1:16-21. . Gallup E, Plott T. A multicenter, open-label study to assess the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans. J Drugs Dermatol . 2005 Jan-Feb. 4(1):29-34. . Bonifaz A, Tirado-Sánchez A, Graniel MJ, Mena C, Valencia A, Ponce-Olivera RM. The efficacy and safety of sertaconazole cream (2 %) in diaper dermatitis candidiasis. Mycopathologia . 2013

2014 eMedicine Emergency Medicine

127. Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison meta-analysis involving 14 treatments. (PubMed)

differences among the antifungals concerning the outcome of mycologic cure at the end of treatment. Regarding the sustained cure outcome, butenafine hydrochloride and terbinafine hydrochloride were significantly more efficacious than were clotrimazole, oxiconazole nitrate, and sertaconazole nitrate. Terbinafine also demonstrated statistical superiority when compared with ciclopirox (ciclopiroxolamine), and naftifine hydrochloride showed better response compared with oxiconazole. No inconsistency

2013 JAMA dermatology (Chicago, Ill.)

128. Efficacy of topical 4% Quassia amara gel in facial seborrheic dermatitis:a randomized, double-blind, comparative study. (PubMed)

% ketoconazole and 1% topical ciclopiroxolamine in the treatment of facial SD.A group of 60 patients displaying facial SD were randomly distributed in 3 groups and given either a topical gel with 4% Quassia amara extract, a topical gel with 2% ketoconazole, or a topical gel with 1% ciclopirox olamine for 4 weeks. Disease severity was assessed at the start and weekly along treatment, as well as 4 weeks after the end of treatment. In each selected area, severity of erythema, scaling, pruritus, and papules were

2013 Journal of drugs in dermatology : JDD

129. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis. (PubMed)

used in onychomycosis, including amorolfine, ciclopirox, itraconazole, and terbinafine. In 13 T. rubrum toenail isolates from onychomycosis patients who were treated daily with topical efinaconazole for 48 weeks, there were no apparent increases in susceptibility, suggesting low potential for dermatophytes to develop resistance to efinaconazole. The activity of efinaconazole was further evaluated in another 8 dermatophyte, 15 nondermatophyte, and 10 yeast species (a total of 109 isolates from

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2013 Antimicrobial Agents and Chemotherapy

130. Onychomycosis Does Not Always Require Systemic Treatment for Cure: A Trial Using Topical Therapy. (PubMed)

is efficacious for pediatric onychomycosis. Forty patients ages 2 to 16 years with nonmatrix onychomycosis were randomized 1:3 to ciclopirox lacquer or vehicle lacquer. Ciclopirox lacquer or vehicle was applied daily for 32 weeks, with weekly removal of the lacquer and mechanical trimming. Those with poor response were crossed over to active drug at week 12. Thirty-seven patients completed the 32-week study, and follow-up data were collected 1 year after completion of the study from 24 patients. Mycologic (...) cure, effective treatment, and complete cure were assessed, as well as adverse events and effect on quality of life. Mycologic cure was 70% in the treated group and 20% in the vehicle arm (p = 0.03) at week 12. At end of the study (week 32), 77% of treated patients achieved mycologic cure and 71% effective treatment, compared with 22% of the control group. Ninety-two percent of those who were cured and followed for 1 year remained clear. Topical antifungal lacquer (ciclopirox) can be an effective

2013 Pediatric dermatology

131. Laser Treatment for Onychomycosis in Diabetes

less than 0.6 on either lower extremity; Presence of peripheral neuropathy defined as a biothesiometry score of less than 20 volts on either lower extremity; Treatment with oral terbinafine (Lamisil), itraconazole (Sporanox), or griseofulvin within 12 months of the proposed study start date; Treatment with any topical antifungal medications including ciclopirox, itraconazole, or other over-the-counter remedies for toenail infection within 1 month of randomization; Female of childbearing potential

2013 Clinical Trials

132. Tacrolimus Ointment Interest (PROTOPIC ®) in the Maintenance Treatment of Severe Seborrheic Dermatitis

) Protopic® 0.1% ointment - 2 applications per week for 6 months Other Name: Tacrolimus Active Comparator: Mycoster Arm 2 applications per week for 6 months Drug: Mycoster (R) Mycoster 1% - 2 applications per week for 6 months Other Name: Ciclopirox olamine Outcome Measures Go to Primary Outcome Measures : duration of the maintenance of complete or almost complete clinical remission [ Time Frame: 18 months after inclusion (Visit (V) 4 last visit) ] The primary endpoint will be the duration (...) Hospital, Rouen: local immunosuppressive Maintenance therapy Additional relevant MeSH terms: Layout table for MeSH terms Dermatitis Dermatitis, Seborrheic Skin Diseases Sebaceous Gland Diseases Skin Diseases, Eczematous Skin Diseases, Papulosquamous Tacrolimus Ciclopirox Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs Calcineurin Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Antifungal Agents Anti-Infective Agents

2013 Clinical Trials

133. Systematic review of nondermatophyte mold onychomycosis: diagnosis, clinical types, epidemiology, and treatment. (PubMed)

NDMs. The treatment with the greatest quantity of data and highest reported cure rates is terbinafine, for the treatment of Scopulariopsis brevicaulis and Aspergillus species infections. Topicals such as ciclopirox nail lacquer may also be effective (data originating from Scopulariopsis brevicaulis and Acremonium species infections), especially when combined with chemical or surgical avulsion of the nail. We recommend that future studies use (and clearly indicate) at least 3 of the main criteria

2012 Journal of the American Academy of Dermatology

134. Topical antifungal agents for seborrheic dermatitis: systematic review and meta-analysis.

assessed the present study articles. When there was a disagreement between the two reviewers, a consensus was made by the third reviewer. Pooled relative risk (PRR) statistical analysis was used to determine the efficacy of treatment.One thousand ninety five studies were reviewed and nine studies were included. Four reports studied the efficacy of ketoconazole, two of metronidazole, two of ciclopirox, and one of bifonazole. Ketoconazole was more effective than vehicle [PRR is 5.78 (95% CI, 2.17-15.40 (...) )], as was metronidazole [PRR is 1.83 (95% CI: 1.05-3.17)] ciclopirox [PRR is 3.00 (95% CI, 1.86-4.84)], and bifonazole [PRR is 1.86 (95% CI: 0.96-3.59)].The meta-analysis in the present study showed that the topical antifungal agents that demonstrated strong and moderate evidence of the efficacy for seborrheic dermatitis treatment were ketoconazole and ciclopirox, respectively. They could be used as an alternative treatment for seborrheic dermatitis.

2011 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

135. Topical antifungal agents for seborrheic dermatitis: systematic review and meta-analysis.

assessed the present study articles. When there was a disagreement between the two reviewers, a consensus was made by the third reviewer. Pooled relative risk (PRR) statistical analysis was used to determine the efficacy of treatment.One thousand ninety five studies were reviewed and nine studies were included. Four reports studied the efficacy of ketoconazole, two of metronidazole, two of ciclopirox, and one of bifonazole. Ketoconazole was more effective than vehicle [PRR is 5.78 (95% CI, 2.17-15.40 (...) )], as was metronidazole [PRR is 1.83 (95% CI: 1.05-3.17)] ciclopirox [PRR is 3.00 (95% CI, 1.86-4.84)], and bifonazole [PRR is 1.86 (95% CI: 0.96-3.59)].The meta-analysis in the present study showed that the topical antifungal agents that demonstrated strong and moderate evidence of the efficacy for seborrheic dermatitis treatment were ketoconazole and ciclopirox, respectively. They could be used as an alternative treatment for seborrheic dermatitis.

2011 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

136. Establishment of a novel model of onychomycosis in the rabbit for evaluation of antifungal agents. (PubMed)

method and histopathological examination. Two topical antifungal drugs, 8% ciclopirox nail lacquer and 5% amorolfine nail lacquer, were applied to the nail for 4 weeks in each group. On histopathological examination, two antifungal treatment groups showed no significant difference against the nontreated control group. However, there were a significantly low fungus-positive rate and intensity of the recovery of fungi on culture between antifungal treatment and nontreated control groups. We therefore

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2011 Antimicrobial Agents and Chemotherapy

137. Topical Penlac Nail Lacquer for Onychomycosis in Children

Description Go to Brief Summary: Five months of therapy is sufficient to treat onychomycosis in children. Topical therapy of onychomycosis in children with Penlac nail lacquer has comparable efficacy and a superior cost and safety profile compared to systemic therapy. Condition or disease Intervention/treatment Phase Onychomycosis Drug: Ciclopirox Drug: Placebo Phase 4 Detailed Description: Therapeutic trials for the treatment of onychomycosis have been conducted in the adult population (...) 2002 Actual Primary Completion Date : December 2005 Actual Study Completion Date : May 2006 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: topical Penlac nail lacquer 3-1 randomization of active to placebo Drug: Ciclopirox Placebo Comparator: Placebo Drug: Placebo Outcome Measures Go to Primary Outcome Measures : Mycological cure or global evaluation of 2 or less Mycological Cure [ Time Frame

2011 Clinical Trials

138. Overview of Dermatophytoses

or ciclopirox may be better if candidal infection cannot be excluded. Other adequate OTC topical treatments include clotrimazole and miconazole . Oral antifungals are used for most nail and scalp infections, resistant skin infections, and patients unwilling or unable to adhere to prolonged topical regimens; doses and duration differ by site of infection. Corticosteroids are sometimes used in addition to antifungal creams to help relieve itching and inflammation. However, combining topical corticosteroids

2013 Merck Manual (19th Edition)

139. Candidiasis (Mucocutaneous)

tablets (oropharyngeal, GI) Miscellaneous Carbolfuchsin Solution Chronic , Ciclopirox 0.77% gel, 8% lacquer solution , , , Clioquinol 3% cream Gentian violet 1 or 2% solution , especially ; sometimes Griseofulvin 125-, 165-, 250-, 330-, and 500-mg tablets Tolnaftate 1% liquid, powder, liquid or aerosol spray, cream, or solution , Zinc Undecylenate/undecylenate acid 25% solution, 10% tincture Superficial dermatophyte infections (eg, ) *Advantages of one topical drug over another for most infections

2013 Merck Manual (19th Edition)

140. Onychomycosis

, efinaconazole, tavaborole, ciclopirox 8%, amorolfine) Onychomycosis is not always treated because many cases are asymptomatic or mild and unlikely to cause complications, and the oral drugs that are the most effective treatments can potentially cause hepatotoxicity and serious drug interactions. Some proposed indications for treatment include the following: Previous ipsilateral or other risk factors for cellulitis Presence of bothersome symptoms Psychosocial impact Desire for cosmetic improvement (...) will not revert to normal; however, newly growing nail will appear normal. The newer topical agents efinaconazole and tavaborole can penetrate the nail plate and are more effective than older topical agents . Investigative treatments that have less frequent and/or less severe adverse effects include laser therapy, new formulations of topical agents (including efinaconazole), and new delivery systems for terbinafine . Topical antifungal nail lacquer containing ciclopirox 8% or amorolfine 5% (not available

2013 Merck Manual (19th Edition)

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