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Ciclopirox

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101. Tinea Versicolor (Follow-up)

initiated. Recurrence is common, and prophylactic therapy may help reduce the high rate of recurrence. Tinea versicolor can be successfully treated with various agents. [ ] Effective topical agents include selenium sulfide, zinc-pyrithione, sodium sulfacetamide, ciclopirox olamine, [ ] , tacrolimus, [ ] as well as azole and allylamine antifungals. [ , , , , ] Even if a small area of skin is involved, treating with topicals from the neck to the knees may make treatment more successful. [ ] Various (...) of Pityriasis versicolor. Mycopathologia . 1997. 139(2):71-4. . Gupta AK, Lyons DC. Pityriasis versicolor: an update on pharmacological treatment options. Expert Opin Pharmacother . 2014 Aug. 15(12):1707-13. . Gupta AK, Skinner AR. Ciclopirox for the treatment of superficial fungal infections: a review. Int J Dermatol . 2003 Sep. 42 Suppl 1:3-9. . Sepaskhah M, Sadat MS, Pakshir K, Bagheri Z. Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor

2014 eMedicine.com

102. Tinea Faciei (Follow-up)

ciclopirox and terbinafine possess additional anti-inflammatory effects, which are especially important in the therapy for infections caused by zoophilic dermatophytes in which inflammatory reactions are usually prominent. Topical azoles are effective. Isoconazole nitrate and diflucortolone valerate combination therapy has been used successfully. [ ] Although rare, chronic and/or multiple lesions may require systemic therapy. Next: Prevention The isolation and treatment of infected pets is of great

2014 eMedicine.com

103. Tinea Corporis (Follow-up)

of this enzyme causes squalene, a substance toxic to fungal cells, to accumulate intracellularly and leads to rapid cell death. Allylamines bind effectively to the stratum corneum because of their lipophilic nature. They also penetrate deeply into hair follicles. [ ] Ciclopirox olamine is a topical fungicidal agent. It causes membrane instability by accumulating inside fungal cells and interfering with amino acid transport across the fungal cell membrane. A low-to-medium potency topical corticosteroid can

2014 eMedicine.com

104. Erythropoietic Porphyria (Follow-up)

-overview Diseases & Conditions Diseases & Conditions 2010 loprox-penlac-ciclopirox-topical-343484 Drugs Drugs Need a Curbside Consult? Share cases and questions with Physicians on Medscape consult.

2014 eMedicine.com

105. Hand, Paronychia Drainage

. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Media Gallery Classic presentation of paronychia, with erythema and pus surrounding the nail bed. In this case, the paronychia was due to infection after a hangnail was removed. In this case of paronychia, no pus or fluctuance is involved in the nail bed itself. Typical appearance of paronychia. Depicted

2014 eMedicine.com

106. Hand Infections (Follow-up)

):513-6. . Antosia RE, Lyn E. Hand. Rosen, ed. Emergency Medicine Concepts and Clinical Practice . 5th ed. 2002. 493-535. Butler, KH. Incision and drainage. Roberts JR, Hedges JR, eds. Clinical Procedures in Emergency Medicine . 4th ed. 2004. 739-744. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Gill MJ, Arlette J, Buchan K. Herpes simplex virus

2014 eMedicine Emergency Medicine

107. Tinea (Diagnosis)

. Combination of oral terbinafine and topical ciclopirox compared to oral terbinafine for the treatment of onychomycosis. J Dermatolog Treat . 2005. 16(5-6):327-30. . Bahamdan K, Mahfouz AA, Tallab T, et al. Skin diseases among adolescent boys in Abha, Saudi Arabia. Int J Dermatol . 1996 Jun. 35(6):405-7. . Brodell RT, Elewski BE. Clinical pearl: systemic antifungal drugs and drug interactions. J Am Acad Dermatol . 1995 Aug. 33(2 Pt 1):259-60. . Degreef HJ, DeDoncker PR. Current therapy of dermatophytosis

2014 eMedicine Emergency Medicine

108. Paronychia (Treatment)

. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Media Gallery Classic presentation of paronychia, with erythema and pus surrounding the nail bed. In this case, the paronychia was due to infection after a hangnail was removed. In this case of paronychia, no pus or fluctuance is involved in the nail bed itself. Typical appearance of paronychia. Depicted

2014 eMedicine Emergency Medicine

109. Pediatrics, Diaper Rash (Treatment)

of nystatin/benzalkonium chloride/dimethicone/hydrocortisone preparation, both were found to improve the appearance of diaper dermatitis. If oral thrush or perianal candidiasis is present or if repeated bouts of candidal dermatitis have occurred, oral nystatin should also be prescribed. Ciclopirox was used and studied for the treatment of candidal diaper dermatitis and was found to be safe and effective. [ ] A 2013 study examined the efficacy and safety of sertaconazole cream (2%) in diaper dermatitis (...) of the mildness of baby wipe and water in infant skin. J Eur Acad Dermatol Venereol . 2001 Sep. 15 Suppl 1:16-21. . Gallup E, Plott T. A multicenter, open-label study to assess the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans. J Drugs Dermatol . 2005 Jan-Feb. 4(1):29-34. . Bonifaz A, Tirado-Sánchez A, Graniel MJ, Mena C, Valencia A, Ponce-Olivera RM. The efficacy and safety of sertaconazole cream (2 %) in diaper dermatitis candidiasis

2014 eMedicine Emergency Medicine

110. Pediatrics, Diaper Rash (Diagnosis)

of the mildness of baby wipe and water in infant skin. J Eur Acad Dermatol Venereol . 2001 Sep. 15 Suppl 1:16-21. . Gallup E, Plott T. A multicenter, open-label study to assess the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans. J Drugs Dermatol . 2005 Jan-Feb. 4(1):29-34. . Bonifaz A, Tirado-Sánchez A, Graniel MJ, Mena C, Valencia A, Ponce-Olivera RM. The efficacy and safety of sertaconazole cream (2 %) in diaper dermatitis candidiasis

2014 eMedicine Emergency Medicine

111. Paronychia (Diagnosis)

. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Media Gallery Classic presentation of paronychia, with erythema and pus surrounding the nail bed. In this case, the paronychia was due to infection after a hangnail was removed. In this case of paronychia, no pus or fluctuance is involved in the nail bed itself. Typical appearance of paronychia. Depicted

2014 eMedicine.com

112. Seborrheic Dermatitis (Diagnosis)

-term use and at risk for tachyphylaxis when used as monotherapy) For skin involvement, ketoconazole, naftifine, or ciclopirox creams and gels [ , , ] ; alternatively, calcineurin inhibitors (ie, pimecrolimus, tacrolimus), [ , , ] sulfur or sulfonamide combinations, or propylene glycol [ , , , , ] For acute flares, class IV or lower corticosteroid creams, lotions, or solutions For severe or unresponsive lesions, systemic fluconazole [ ] Treatment of dandruff may involve the following: More frequent (...) shampooing or longer lathering Discontinuance of hair spray or hair pomades Use of shampoos containing salicylic acid, tar, selenium, sulfur, or zinc [ , ] ; selenium sulfide (2.5%), ketoconazole, and ciclopirox shampoos may help by reducing Malassezia yeast scalp reservoirs [ , , ] ; an alternative to a shampoo with zinc is a conditioner rinse with zinc, 0.01% fluocinolone, and acetonide topical oil Overnight application of tar, bath oil, or Baker’s P&S solution; Derma-Smoothe F/S oil is especially

2014 eMedicine.com

113. Onychomycosis (Diagnosis)

of topical and systemic treatment increases the cure rate. Adjunctive surgical measures may also be used. Topical therapy for onychomycosis is as follows: Ciclopirox olamine 8% nail lacquer solution Amorolfine or bifonazole/urea (available outside the United States) Efinaconazole 10% topical solution (the first FDA-approved topical triazole for toenail onychomycosis) Tavaborole 0.5% topical solution, an oxaborole solution (boron-containing compound) Can be used in WSO and DLSO limited to the distal nail (...) as and . Previous References Andre J, Achten G. Onychomycosis. Int J Dermatol . 1987 Oct. 26(8):481-90. . Baran R, Hay RJ, Tosti A, Haneke E. A new classification of onychomycosis. Br J Dermatol . 1998 Oct. 139(4):567-71. . Bohn M, Kraemer K. The dermatopharmacologic profile of ciclopirox 8% nail lacquer. J Am Podiatr Med Assoc . 2000 Nov-Dec. 90(10):491-4. . Leverone AP, Guimarães DA, Bernardes-Engemann AR, Orofino-Costa R. Laser treatment of onychomycosis due to Neoscytalidium dimidiatum: An open prospective

2014 eMedicine.com

114. Tinea Versicolor (Diagnosis)

. 2014 Aug. 15(12):1707-13. . Gupta AK, Skinner AR. Ciclopirox for the treatment of superficial fungal infections: a review. Int J Dermatol . 2003 Sep. 42 Suppl 1:3-9. . Sepaskhah M, Sadat MS, Pakshir K, Bagheri Z. Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial. Mycoses . 2017 Jan 25. . Hull CA, Johnson SM. A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium

2014 eMedicine.com

115. Tinea (Treatment)

. Int J Dermatol . 2006 Mar. 45(3):215-9. . Avner S, Nir N, Henri T. Combination of oral terbinafine and topical ciclopirox compared to oral terbinafine for the treatment of onychomycosis. J Dermatolog Treat . 2005. 16(5-6):327-30. . Bahamdan K, Mahfouz AA, Tallab T, et al. Skin diseases among adolescent boys in Abha, Saudi Arabia. Int J Dermatol . 1996 Jun. 35(6):405-7. . Brodell RT, Elewski BE. Clinical pearl: systemic antifungal drugs and drug interactions. J Am Acad Dermatol . 1995 Aug. 33(2 Pt

2014 eMedicine Emergency Medicine

116. Hand Infections (Treatment)

):513-6. . Antosia RE, Lyn E. Hand. Rosen, ed. Emergency Medicine Concepts and Clinical Practice . 5th ed. 2002. 493-535. Butler, KH. Incision and drainage. Roberts JR, Hedges JR, eds. Clinical Procedures in Emergency Medicine . 4th ed. 2004. 739-744. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Gill MJ, Arlette J, Buchan K. Herpes simplex virus

2014 eMedicine Emergency Medicine

117. Hand Infections (Diagnosis)

aureus in community-acquired hand infections. Ann Plast Surg . 2009 May. 62(5):513-6. . Antosia RE, Lyn E. Hand. Rosen, ed. Emergency Medicine Concepts and Clinical Practice . 5th ed. 2002. 493-535. Butler, KH. Incision and drainage. Roberts JR, Hedges JR, eds. Clinical Procedures in Emergency Medicine . 4th ed. 2004. 739-744. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis

2014 eMedicine Emergency Medicine

118. Paronychia (Diagnosis)

. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Media Gallery Classic presentation of paronychia, with erythema and pus surrounding the nail bed. In this case, the paronychia was due to infection after a hangnail was removed. In this case of paronychia, no pus or fluctuance is involved in the nail bed itself. Typical appearance of paronychia. Depicted

2014 eMedicine Emergency Medicine

119. Tinea (Follow-up)

. Int J Dermatol . 2006 Mar. 45(3):215-9. . Avner S, Nir N, Henri T. Combination of oral terbinafine and topical ciclopirox compared to oral terbinafine for the treatment of onychomycosis. J Dermatolog Treat . 2005. 16(5-6):327-30. . Bahamdan K, Mahfouz AA, Tallab T, et al. Skin diseases among adolescent boys in Abha, Saudi Arabia. Int J Dermatol . 1996 Jun. 35(6):405-7. . Brodell RT, Elewski BE. Clinical pearl: systemic antifungal drugs and drug interactions. J Am Acad Dermatol . 1995 Aug. 33(2 Pt

2014 eMedicine Emergency Medicine

120. Tinea (Overview)

. Combination of oral terbinafine and topical ciclopirox compared to oral terbinafine for the treatment of onychomycosis. J Dermatolog Treat . 2005. 16(5-6):327-30. . Bahamdan K, Mahfouz AA, Tallab T, et al. Skin diseases among adolescent boys in Abha, Saudi Arabia. Int J Dermatol . 1996 Jun. 35(6):405-7. . Brodell RT, Elewski BE. Clinical pearl: systemic antifungal drugs and drug interactions. J Am Acad Dermatol . 1995 Aug. 33(2 Pt 1):259-60. . Degreef HJ, DeDoncker PR. Current therapy of dermatophytosis

2014 eMedicine Emergency Medicine

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