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Ciclopirox

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61. The Efficacy of CELEXT07 in the Treatment of Toenail Onychomycosis

, 2017 Last Verified: April 2017 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Additional relevant MeSH terms: Layout table for MeSH terms Onychomycosis Tinea Dermatomycoses Skin Diseases, Infectious Infection Mycoses Nail Diseases Skin Diseases Ciclopirox Antifungal Agents Anti-Infective Agents

2015 Clinical Trials

62. Treatment of Onychomycosis - a Clinical Study. Full Text available with Trip Pro

on disease severity, patients were grouped into groups with SCIO values: 6-9, and 12-16. These groups were randomly subdivided to 5 subgroups according to the given treatment protocols: fluconazole 150 mg 1x weekly, itraconazole continual therapy, itraconazole pulse therapy, terbinafine 250 mg/d, and terbinafine + ciclopirox 8% lacquer, respectively. The cure rate was evaluated at the end of 48 week.The obtained cure rates according to the above mentioned protocols were: 92.30%, 81.81%, 83.33%, 90.90

2015 Medical archives (Sarajevo, Bosnia and Herzegovina) Controlled trial quality: uncertain

63. Drug repurposing as an alternative for the treatment of recalcitrant bacterial infections Full Text available with Trip Pro

properties of gallium compounds, 5-fluorouracil, ciclopirox, diflunisal, and some other FDA-approved drugs and argue that their repurposing for the treatment of bacterial infections, including those that are multidrug resistant, is a feasible strategy.

2015 Frontiers in microbiology

64. In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species. Full Text available with Trip Pro

In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species. The in vitro activities of 11 antifungal drugs against 68 Scopulariopsis and Microascus strains were investigated. Amphotericin B, 5-fluorocytosine, fluconazole, itraconazole, ketoconazole, miconazole, posaconazole, voriconazole, and ciclopirox showed no or poor antifungal effect. The best activities were exhibited by terbinafine and caspofungin, where the MIC and MEC (minimal

2015 Antimicrobial Agents and Chemotherapy

65. In Vitro Antifungal Activity of ME1111, a New Topical Agent for Onychomycosis, against Clinical Isolates of Dermatophytes. Full Text available with Trip Pro

= 4) following repeated exposure to ME1111. Our data show that the MIC90 of ME1111 against dermatophyte strains was 0.25 μg/ml, which was equivalent to that of the comparators amorolfine and ciclopirox (0.25 and 0.5 μg/ml, respectively). ME1111 was fungicidal at clinically achievable concentrations against dermatophytes, and its MFC90s against Trichophyton rubrum and Trichophyton mentagrophytes were 8 μg/ml, comparable to those of ciclopirox. Furthermore, ME1111, as well as ciclopirox, did

2015 Antimicrobial Agents and Chemotherapy

66. Is there any evidence on what treatment is available for children aged under 12 with fungal nail infection?

itraconazole, fluconazole, and terbinafine, and the topical nail lacquers ciclopirox and amorolfine are not approved for this indication. More data are needed on the use of these antifungal agents for the treatment of onychomycosis in children.” 1. 2. 3. Answered 8 October 2013 Follow us: © 2019 Trip Database Ltd. company number 04316414. Trip is proud to be made in the UK.

2013 TRIP Answers

67. Topical treatments for seborrhoeic dermatitis of the scalp – need for more evidence

to inhibit the inflammatory reaction. In general there is limited evidence available on the treatment of seborrhoeic dermatitis of the scalp with topical agents. This is unfortunate as it is such a common condition. Only ketoconazole and ciclopirox were studied in multiple RCT’s that met the inclusion criteria for our recent systematic overview. For other topical treatments such as bifonazole, selenium sulfide, tar shampoo and corticosteroids the evidence was much sparser. For each type of topical (...) be considered in every patient that is disturbed by the symptoms of his condition. This way the physical complaints, and also the social consequences, can be decreased. One of the more established treatments for seborrhoeic dermatitis of the scalp is ketoconazole. The studies confirmed that it appears to be beneficial for both clearance of the initial flare and maintenance of the improved clinical condition. In this update of the review, ciclopirox was the only other treatment that also seemed

2015 BMJ Clinical Evidence Blog

68. Luliconazole Demonstrates Potent In vitro Activity against the Dermatophytes Recovered from Patients with Onychomycosis. Full Text available with Trip Pro

Luliconazole Demonstrates Potent In vitro Activity against the Dermatophytes Recovered from Patients with Onychomycosis. The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents

2014 Antimicrobial Agents and Chemotherapy

69. Lateral Drug Diffusion in Human Nails Full Text available with Trip Pro

Lateral Drug Diffusion in Human Nails The main objective of the current work is to demonstrate the process of passive lateral diffusion in the human nail plate and its effect on the passive transungual permeation of antifungal drug ciclopirox olamine (CPO). A water soluble dye, methyl red sodium salt (MR) was used to visualize the process of lateral diffusion using a novel suspended nail experiment. The decline in concentration of CPO correlates with that of concentration of MR from

2014 AAPS PharmSciTech

70. Potential of ergosterol synthesis inhibitors to cause (cross)resistance in Trichophyton rubrum. Full Text available with Trip Pro

of resistance to terbinafine, itraconazole, amorolfine, and ciclopirox in T. rubrum. Results demonstrated that naturally occurring mutants were isolated at a frequency of 10(-7) for itraconazole and 10(-9) for terbinafine and amorolfine. To mimic conditions of body sites in which low drug levels are reached during therapy, T. rubrum was propagated for 10 transfers in media containing subinhibitory drug concentrations. Resistance to itraconazole, terbinafine, and amorolfine emerged at a higher frequency than (...) was seen with spontaneous mutation. Itraconazole-resistant mutants also showed decreased susceptibility to amorolfine as well as to terbinafine, and amorolfine-resistant mutants were also less susceptible to terbinafine. No mutant resistant to ciclopirox was isolated, suggesting no propensity of T. rubrum to develop resistance to this drug. How different drug mechanisms of action can influence the onset of resistance is discussed.

2014 Antimicrobial Agents and Chemotherapy

71. Silicon phthalocyanine (Pc) 4 phototoxicity in Trichophyton rubrum. Full Text available with Trip Pro

Silicon phthalocyanine (Pc) 4 phototoxicity in Trichophyton rubrum. Trichophyton rubrum is the leading pathogen that causes long-lasting skin and nail dermatophyte infections. Currently, topical treatment consists of terbinafine for the skin and ciclopirox for the nails, whereas systemic agents, such as oral terbinafine and itraconazole, are also prescribed. These systemic drugs have severe side effects, including liver toxicity. Topical therapies, however, are sometimes ineffective. This led

2014 Antimicrobial Agents and Chemotherapy

72. Tinea Versicolor (Follow-up)

initiated. Recurrence is common, and prophylactic therapy may help reduce the high rate of recurrence. Tinea versicolor can be successfully treated with various agents. [ ] Effective topical agents include selenium sulfide, zinc-pyrithione, sodium sulfacetamide, ciclopirox olamine, [ ] , tacrolimus, [ ] as well as azole and allylamine antifungals. [ , , , , ] Even if a small area of skin is involved, treating with topicals from the neck to the knees may make treatment more successful. [ ] Various (...) of Pityriasis versicolor. Mycopathologia . 1997. 139(2):71-4. . Gupta AK, Lyons DC. Pityriasis versicolor: an update on pharmacological treatment options. Expert Opin Pharmacother . 2014 Aug. 15(12):1707-13. . Gupta AK, Skinner AR. Ciclopirox for the treatment of superficial fungal infections: a review. Int J Dermatol . 2003 Sep. 42 Suppl 1:3-9. . Sepaskhah M, Sadat MS, Pakshir K, Bagheri Z. Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor

2014 eMedicine.com

73. Tinea Faciei (Follow-up)

ciclopirox and terbinafine possess additional anti-inflammatory effects, which are especially important in the therapy for infections caused by zoophilic dermatophytes in which inflammatory reactions are usually prominent. Topical azoles are effective. Isoconazole nitrate and diflucortolone valerate combination therapy has been used successfully. [ ] Although rare, chronic and/or multiple lesions may require systemic therapy. Next: Prevention The isolation and treatment of infected pets is of great

2014 eMedicine.com

74. Tinea Corporis (Follow-up)

of this enzyme causes squalene, a substance toxic to fungal cells, to accumulate intracellularly and leads to rapid cell death. Allylamines bind effectively to the stratum corneum because of their lipophilic nature. They also penetrate deeply into hair follicles. [ ] Ciclopirox olamine is a topical fungicidal agent. It causes membrane instability by accumulating inside fungal cells and interfering with amino acid transport across the fungal cell membrane. A low-to-medium potency topical corticosteroid can

2014 eMedicine.com

75. Tinea Versicolor (Diagnosis)

. 2014 Aug. 15(12):1707-13. . Gupta AK, Skinner AR. Ciclopirox for the treatment of superficial fungal infections: a review. Int J Dermatol . 2003 Sep. 42 Suppl 1:3-9. . Sepaskhah M, Sadat MS, Pakshir K, Bagheri Z. Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial. Mycoses . 2017 Jan 25. . Hull CA, Johnson SM. A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium

2014 eMedicine.com

76. Seborrheic Dermatitis (Diagnosis)

-term use and at risk for tachyphylaxis when used as monotherapy) For skin involvement, ketoconazole, naftifine, or ciclopirox creams and gels [ , , ] ; alternatively, calcineurin inhibitors (ie, pimecrolimus, tacrolimus), [ , , ] sulfur or sulfonamide combinations, or propylene glycol [ , , , , ] For acute flares, class IV or lower corticosteroid creams, lotions, or solutions For severe or unresponsive lesions, systemic fluconazole [ ] Treatment of dandruff may involve the following: More frequent (...) shampooing or longer lathering Discontinuance of hair spray or hair pomades Use of shampoos containing salicylic acid, tar, selenium, sulfur, or zinc [ , ] ; selenium sulfide (2.5%), ketoconazole, and ciclopirox shampoos may help by reducing Malassezia yeast scalp reservoirs [ , , ] ; an alternative to a shampoo with zinc is a conditioner rinse with zinc, 0.01% fluocinolone, and acetonide topical oil Overnight application of tar, bath oil, or Baker’s P&S solution; Derma-Smoothe F/S oil is especially

2014 eMedicine.com

77. Paronychia (Diagnosis)

. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis . 2004 Jan. 73(1):81-5. . Media Gallery Classic presentation of paronychia, with erythema and pus surrounding the nail bed. In this case, the paronychia was due to infection after a hangnail was removed. In this case of paronychia, no pus or fluctuance is involved in the nail bed itself. Typical appearance of paronychia. Depicted

2014 eMedicine.com

78. Onychomycosis (Diagnosis)

of topical and systemic treatment increases the cure rate. Adjunctive surgical measures may also be used. Topical therapy for onychomycosis is as follows: Ciclopirox olamine 8% nail lacquer solution Amorolfine or bifonazole/urea (available outside the United States) Efinaconazole 10% topical solution (the first FDA-approved topical triazole for toenail onychomycosis) Tavaborole 0.5% topical solution, an oxaborole solution (boron-containing compound) Can be used in WSO and DLSO limited to the distal nail (...) as and . Previous References Andre J, Achten G. Onychomycosis. Int J Dermatol . 1987 Oct. 26(8):481-90. . Baran R, Hay RJ, Tosti A, Haneke E. A new classification of onychomycosis. Br J Dermatol . 1998 Oct. 139(4):567-71. . Bohn M, Kraemer K. The dermatopharmacologic profile of ciclopirox 8% nail lacquer. J Am Podiatr Med Assoc . 2000 Nov-Dec. 90(10):491-4. . Leverone AP, Guimarães DA, Bernardes-Engemann AR, Orofino-Costa R. Laser treatment of onychomycosis due to Neoscytalidium dimidiatum: An open prospective

2014 eMedicine.com

79. Tinea Versicolor (Overview)

. 2014 Aug. 15(12):1707-13. . Gupta AK, Skinner AR. Ciclopirox for the treatment of superficial fungal infections: a review. Int J Dermatol . 2003 Sep. 42 Suppl 1:3-9. . Sepaskhah M, Sadat MS, Pakshir K, Bagheri Z. Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial. Mycoses . 2017 Jan 25. . Hull CA, Johnson SM. A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium

2014 eMedicine.com

80. Erythropoietic Porphyria (Overview)

1103274-overview Diseases & Conditions Diseases & Conditions 2002 1389981-overview Diseases & Conditions Diseases & Conditions 2002 957765-overview Diseases & Conditions Diseases & Conditions 2010 loprox-penlac-ciclopirox-topical-343484 Drugs Drugs Need a Curbside Consult? Share cases and questions with Physicians on Medscape consult.

2014 eMedicine.com

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