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Ciclopirox

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21. Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies. (Abstract)

Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies. The antimycotic ciclopirox olamine is an intracellular iron chelator that has anticancer activity in vitro and in vivo. We developed an oral formulation of ciclopirox olamine and conducted the first-in-human phase I study of this drug in patients with relapsed or refractory hematologic malignancies (Trial registration ID: NCT00990587). Patients were treated with 5-80 mg/m (...) ² oral ciclopirox olamine once daily for five days in 21-day treatment cycles. Pharmacokinetic and pharmacodynamic companion studies were performed in a subset of patients. Following definition of the half-life of ciclopirox olamine, an additional cohort was enrolled and treated with 80 mg/m² ciclopirox olamine four times daily. Adverse events and clinical response were monitored throughout the trial. Twenty-three patients received study treatment. Ciclopirox was rapidly absorbed and cleared

2014 American journal of hematology

22. A multicenter, randomized, open-label, controlled study comparing the efficacy, safety and cost-effectiveness of a sequential therapy with RV4104A ointment, ciclopiroxolamine cream and ciclopirox film-forming solution with amorolfine nail lacquer alone in (Abstract)

A multicenter, randomized, open-label, controlled study comparing the efficacy, safety and cost-effectiveness of a sequential therapy with RV4104A ointment, ciclopiroxolamine cream and ciclopirox film-forming solution with amorolfine nail lacquer alone in The efficacy of topical antifungals is controversial.To compare the efficacy and safety of a sequential(SEQ) treatment with chemical nail avulsion and topical antifungals to amorolfine nail lacquer in dermatophytic onychomycosis.This (...) was a randomized,parallel-group, controlled study comparing a 36-week SEQ treatment with chemical nail avulsion with RV4104A ointment(class I medical device containing 40% urea) followed by ciclopirox cream for 8 weeks and ciclopirox nail lacquer for 25 weeks (SEQ group) to amorolfine nail lacquer for 36 weeks (AMO group). Patients had to have a big toenail onychomycosis,sparing the matrix. The primary efficacy criterion was complete cure at week 48. A cost-effectiveness analysis was performed.A total of 142

2014 Dermatology (Basel, Switzerland) Controlled trial quality: uncertain

23. Nail penetration and predicted mycological efficacy of an innovative hydrosoluble ciclopirox nail lacquer vs. a standard amorolfine lacquer in healthy subjects. (Abstract)

Nail penetration and predicted mycological efficacy of an innovative hydrosoluble ciclopirox nail lacquer vs. a standard amorolfine lacquer in healthy subjects. In a previous study a new hydrosoluble nail lacquer (P-3051) containing 8% ciclopirox (CPX) showed higher nail penetration compared to a water-insoluble 5% amorolfine (MRF) lacquer. To our knowledge, in vivo human data on a similar topic are not available.To compare fingernail penetration of P-3051 with that of MRF reference in humans

2013 Journal of the European Academy of Dermatology and Venereology : JEADV Controlled trial quality: uncertain

24. Impact of the antiproliferative agent ciclopirox olamine treatment on stem cells proteome Full Text available with Trip Pro

Impact of the antiproliferative agent ciclopirox olamine treatment on stem cells proteome To investigate the proteome changes of stem cells due to ciclopirox olamine (CPX) treatment compared to control and retinoic acid treated cells.Stem cells (SCs) are cells, which have the ability to continuously divide and differentiate into various other kinds of cells. Murine embryonic stem cells (ESCs) and multipotent adult germline stem cells (maGSCs) were treated with CPX, which has been shown to have

2013 World journal of stem cells

25. Ciclopirox

Ciclopirox Ciclopirox Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ciclopirox Ciclopirox Aka: Ciclopirox , Loprox , Penlac From (...) Related Chapters II. Indications Dermatophyte Infection ( ) III. Preparations Cutaneous dermatophytes: Ciclopirox olamine 1% (Loprox) : Ciclopirox 8% lacquer (Penlac) IV. Mechanism: Broad-spectrum activity for dermatophytes and yeast Some antibacterial activity in vitro V. Efficacy (Loprox) More effective than OTC ( ) (Penlac) NOT recommended Requires 48 week application Minimally better than for cure rates Partial clearance rates are also poor Images: Related links to external sites (from Bing

2015 FP Notebook

26. Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children

Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety Study (...) of Ciclopirox Olamine Cream for Dermatomycoses in Children The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01646580 Recruitment Status : Terminated (Low recruitment rate. with the final sample primary endpoint could be assessed.) First Posted : July 20, 2012 Last Update Posted : July 20, 2012 Sponsor: Ferrer

2012 Clinical Trials

27. Comparative clinical evaluation of efficacy and safety of a formulation containing ciclopirox 8% in the form of a therapeutic nail lacquer in two different posologies for the treatment of onychomycosis of the toes. (Abstract)

Comparative clinical evaluation of efficacy and safety of a formulation containing ciclopirox 8% in the form of a therapeutic nail lacquer in two different posologies for the treatment of onychomycosis of the toes. The use of topical antifungal agents in the treatment of onychomycosis is of great value in clinical practice as there are different limitations regarding the use of systemic treatment.To evaluate the efficacy and safety of a nail lacquer formulation containing ciclopirox 8% in two (...) of treatment resistance by T. mentagrophytes infection in both groups, without any predilection for sex, age, proportion of the nail affected at the beginning of the study, duration of the clinical disease and quantity of nails affected per person. Both groups had significant levels of mycological cure, clinical response and therapeutic success and there was no statistically significant difference between groups I and II (p >0.05).The nail lacquer containing ciclopirox 8% was equally effective at a weekly

2012 Anais brasileiros de dermatologia Controlled trial quality: uncertain

28. Ciclopirox: a new topical pyrodonium antimycotic agent. A double-blind study in superficial dermatomycoses. (Abstract)

Ciclopirox: a new topical pyrodonium antimycotic agent. A double-blind study in superficial dermatomycoses. One percent Ciclopirox solution, a new topical antimycotic agent, was used in a double-blind controlled trial in 105 dermatomycosis patients. Twelve of the patients were lost to follow-up. Of the remaining ninety-three patients, forty-four were treated with the active drug, forty-nine with a placebo. The cure rate amongst those using ciclopirox was significantly superior

1976 The British journal of dermatology Controlled trial quality: uncertain

29. Overview of dermatitis

treatments when seborrhoeic dermatitis is confined to the scalp. Shuster S, Meynadier J, Kerl H, et al. Treatment and prophylaxis of seborrheic dermatitis of the scalp with antipityrosporal 1% ciclopirox shampoo. Arch Dermatol. 2005 Jan;141(1):47-52. https://jamanetwork.com/journals/jamadermatology/fullarticle/392182 http://www.ncbi.nlm.nih.gov/pubmed/15655141?tool=bestpractice.com Cradle cap in infants can usually be managed using emollients such as topical olive oil. Systemic antifungals should

2018 BMJ Best Practice

30. Overview of dermatitis

treatments when seborrhoeic dermatitis is confined to the scalp. Shuster S, Meynadier J, Kerl H, et al. Treatment and prophylaxis of seborrheic dermatitis of the scalp with antipityrosporal 1% ciclopirox shampoo. Arch Dermatol. 2005 Jan;141(1):47-52. https://jamanetwork.com/journals/jamadermatology/fullarticle/392182 http://www.ncbi.nlm.nih.gov/pubmed/15655141?tool=bestpractice.com Cradle cap in infants can usually be managed using emollients such as topical olive oil. Systemic antifungals should

2018 BMJ Best Practice

31. Putting the FUN in Fungi: Toenail onychomycosis treatments

-induced liver injury: ~1 in 50,000-120,000 prescriptions. 14 • Medication Costs: 15 o Oral (12 weeks): ? Terbinafine: ~$90 ? Itraconazole: ~$850 o Topical (48 weeks): 2 bottles per treatment. ? Ciclopirox: ~$150 ? Efinaconazole: ~$250 • Terbinafine treatment without confirmatory testing is likely most cost-effective approach. 16 • Although not always statistically different, some RCTs found clinically relevant improvements with 4-6-month oral treatment regimens compared to 3 months. 3,17 Authors

2019 Tools for Practice

32. Onychomycosis

Not evaluated for more extensive OM (when > 50% of the nail is involved) Safety in pediatrics (less than 18 years of age), pregnant and lactating women has not been evaluated Apply once daily to affected nail(s) for 48 weeks No debridement required Available in a 6 ml container which provides 80 applications Ciclopirox 8% nail lacquer (not appropriate for pharmacist prescribing) Ciclopirox is not approved for pharmacist prescribing due to limited effectiveness and cost Limited efficacy for toenail

2018 medSask

34. Neodymium-doped yttrium aluminium garnet laser treatment for onychomycosis

(milliseconds), short-pulsed (microseconds), and Qswitched (nanoseconds). Patient Population: Laser therapy is indicated for patients with toenail or fingernail onychomycosis. Clinical Alternatives: Onychomycosis may be treated with oral (e.g., terbinafine, itraconazole, fluconazole, posaconazole, griseofulvin) or topical (e.g., ciclopirox olamine, efinaconazole, amorolfine, bifonazole, tioconazole, tavaborate) antifungal agents or nonpharmacologic treatments (e.g., laser treatment, photodynamic therapy

2017 Health Technology Assessment (HTA) Database.

35. A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. (Abstract)

A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Our objective was to compare the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Forty children aged 1-11 years with clinically diagnosed tinea capitis were randomized to receive selenium sulfide shampoo 1% or ciclopirox shampoo 1% twice a week as adjuncts (...) to an 8-week course of ultramicronized griseofulvin dosed at 10-12 mg/kg/day. At weeks 2, 4, and 8, subjects returned to the clinic for evaluation and scalp cultures. Subjects then returned for follow-up visits 4 weeks after completing treatment. Overall, by 8 weeks, 30 of 33 (90.9%) treated children demonstrated mycological cure. Selenium sulfide shampoo 1% and ciclopirox shampoo 1% were equally effective as adjunctive treatments for tinea capitis in children in our study.© 2010 Wiley Periodicals

2010 Pediatric dermatology Controlled trial quality: uncertain

36. Comparison of tumor related signaling pathways with known compounds to determine potential agents for lung adenocarcinoma Full Text available with Trip Pro

in the search for potential LUAD treatments, most importantly, the p53 signaling pathway. Some compounds, such as ciclopirox and AG-028671, may have potential roles for LUAD treatment but require further experimental verification.© 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

2018 Thoracic cancer

39. Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis. Full Text available with Trip Pro

% nail lacquer versus once-daily ciclopirox 8% nail lacquer (Study A) or once-daily urea 40% ointment/bifonazole 1% cream combination regimen (Study B). Study A: Subjects received amorolfine and ciclopirox on opposite feet for 12 weeks. Study B: Subjects received amorolfine and urea/bifonazole on opposite feet for 6-7 weeks. Assessments included subject adherence as per label, treatment preference and questionnaire. Study A: More subjects adhered to amorolfine (85%) than to ciclopirox (60%) (P = .025

2018 Mycoses Controlled trial quality: uncertain

40. Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer Full Text available with Trip Pro

strategy. The use of hydro-ethanolic mixtures (>50% ethanol) and the reduction of the poloxamer concentration significantly improved the lacquer drying speed by reducing the stickiness and promoting film formation on the nail surface. Additionally, in a surprising way, the use of hydro-ethanolic vehicles further enhanced the permeation of ciclopirox olamine and clobetasol propionate, used for the treatment of onychomycosis and nail psoriasis respectively, into the nail and hooves.

2018 Pharmaceutics

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