How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

178 results for

Chronic Nonallergic Rhinitis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

161. Diagnostic classification of persistent rhinitis and its relationship to exhaled nitric oxide and asthma: a clinical study of a consecutive series of patients. (Abstract)

Diagnostic classification of persistent rhinitis and its relationship to exhaled nitric oxide and asthma: a clinical study of a consecutive series of patients. Rhinitis and asthma represent the manifestation of one syndrome. Our hypothesis is that in patients with symptoms of persistent rhinitis, lower airway inflammation, lower respiratory symptoms, and lung function abnormalities compatible with asthma are more frequently associated with the diagnosis of allergic rhinitis (AR) and chronic (...) rhinosinusitis (CRS) than with nonallergic rhinitis (NAR).One hundred eight of 590 consecutive patients referred in 1 year for rhinitis were enrolled on the basis of nasal symptoms lasting > 4 weeks. Asthma was diagnosed on the basis of symptoms and a positive bronchodilation testing result and/or methacholine hyperresponsiveness. Exhaled nitric oxide (Feno) was measured with the single exhalation method at 50 mL/s.AR was diagnosed in 39%, NAR in 21%, and CRS in 40%. The prevalence of asthma

2007 Chest

162. Multi-center, double-blind, placebo-controlled trial of fluocortin butyl in perennial rhinitis. (Abstract)

Multi-center, double-blind, placebo-controlled trial of fluocortin butyl in perennial rhinitis. Fluocortin butyl (FCB) is a newly synthesized corticosteroid with a high ratio of topical to systemic activity. FCB was studied in a multi-center, double-blind, placebo-controlled trial of therapy of perennial rhinitis. The study was conducted between January and May 1981. Patients evaluated suffered from either chronic allergic or chronic nonallergic rhinitis or both. A total of 306 patients from 16

1983 The Journal of allergy and clinical immunology Controlled trial quality: uncertain

163. Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

be of at least two years' duration. Exclusion Criteria: (controls; n = 10): A significant history of chronic and/or recurrent nasal symptoms (rhinorrhea, blockage,sneezing or pruritus) in response to one or more nonallergic triggers, including: perfumes or colognes, cleaning products, environmental tobacco smoke, vehicular exhaust, paint odors, changes in temperature and/or humidity. Exclusion criteria: (all subjects; n = 24): A prior history of allergic disease (allergic rhinitis, asthma, angioedema (...) Identifier: Other Study ID Numbers: AI-005 NAR First Posted: December 25, 2006 Results First Posted: October 26, 2012 Last Update Posted: March 6, 2017 Last Verified: January 2017 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Keywords provided by Stephen A. Tilles MD, Associated Scientists to Help Minimize Allergies: rhinitis non-allergic rhinitis rhinomanometry cold air triggers: cold, dry air inhalation warm, most air inhalation Nonallergic rhinitis; normal controls

2006 Clinical Trials

164. Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy. (Abstract)

Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy. In contrast to the epidemiological and clinical association between allergic rhinitis and asthma, upper airway inflammation is less characterized in patients with nonatopic asthma and virtually unexplored in chronic obstructive pulmonary disease (COPD). Here, sinonasal pathology is studied in patients with allergic asthma, nonallergic asthma and COPD.Ninety patients with stable bronchial (...) disease were included in the study, of which 35 were diagnosed with allergic asthma, 24 with nonallergic asthma and 31 with COPD. Concurrently, 61 control subjects without pulmonary disease were included and matched for age and smoking habits respectively with the asthma and the COPD group. Sinonasal symptoms were evaluated on a visual analogue scale and rhinosinusitis-related impairment of quality of life was assessed with the sino-nasal outcome test-22 (SNOT-22) questionnaire. Nasal mucosal

2007 Allergy

165. Effect of topical nasal corticosteroids on patients with chronic fatigue syndrome and rhinitis. (Abstract)

Effect of topical nasal corticosteroids on patients with chronic fatigue syndrome and rhinitis. Chronic fatigue syndrome (CFS) is a disabling illness of persistent fatigue. Recent studies have shown that patients with CFS have an increased prevalence of nonallergic rhinitis. Inflammation of the nasal passages due to allergic rhinitis can cause nasal congestion resulting in an increased number of sleep disturbances and daytime fatigue. While topical nasal corticosteroids have been shown (...) with CFS does not appear to alleviate daytime fatigue or associated nasal, musculoskeletal, or cognitive complaints. Therefore, it is unlikely that aggressive treatment of such symptoms with topical nasal corticosteroids will provide significant benefit to patients with CFS who do not have allergic rhinitis. These results indicate that the nonallergic rhinitis seen in patients with CFS may arise from a mechanism other than chronic inflammation.

2003 The Journal of the American Osteopathic Association Controlled trial quality: uncertain

166. Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. (Abstract)

was blindly distributed to 100 random new patients with chronic rhinitis in an allergist's office. Questionnaire and physician diagnoses were compared. Allergic triggers included cat, dog, feathers, other furry animals, and symptoms during the spring, summer, and fall seasons. Nonallergic triggers included temperature changes, diesel and car exhaust, tobacco smoke, perfumes and fragrances, incense, cleaning products, newsprint, hairspray, and alcoholic beverages, spicy foods, or eating.The construct (...) Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. Chronic rhinitis, a prevalent primary care disorder associated with significant comorbidities, is often incorrectly diagnosed. As a result, inappropriate treatment leads to higher health care costs and poor clinical outcomes.To verify whether responses to specific questions may help in the diagnosis of nonallergic vasomotor rhinitis (NAVMR).A questionnaire listing allergic and nonallergic triggers

2006 Asthma & Immunology

167. Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper. Full Text available with Trip Pro

, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR (...) Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper. Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology

2008 Allergy

168. Treatment of nonallergic perennial rhinitis. (Abstract)

Treatment of nonallergic perennial rhinitis. Nonallergic perennial rhinitis (also commonly referred to as vasomotor rhinitis) is a chronic non-IgE-mediated condition that is characterized by symptoms which are similar to those seen in allergic rhinitis, but which persist for over nine months each year. Although treatment of vasomotor rhinitis involves the use of either intranasal corticosteroids or antihistamines, the corticosteroids are generally not effective in treatment of all the symptoms (...) allergic and/or vasomotor (nonallergic perennial) rhinitis.

2004 Allergy

169. Up-regulation of peroxisome proliferator-activated receptor gamma in perennial allergic rhinitis. Full Text available with Trip Pro

Up-regulation of peroxisome proliferator-activated receptor gamma in perennial allergic rhinitis. To investigate the expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) messenger RNA and protein and to localize the PPAR-gamma protein in the nasal mucosa of patients with allergic rhinitis and control subjects.Prospective study.Tertiary academic institution. Patients Twenty patients with perennial allergic rhinitis and 20 matched nonallergic patients.Inferior turbinate (...) contribution for PPAR-gamma in chronic inflammation of the nasal mucosa in perennial allergic rhinitis.

2006 Archives of Otolaryngology Head and Neck Surgery

170. Increased expression of pigment epithelium-derived factor in allergic rhinitis. Full Text available with Trip Pro

of PEDF mRNA and PEDF protein in the nasal mucosa were significantly increased in patients with allergic rhinitis compared with those in nonallergic controls. The PEDF protein was expressed in the epithelium and submucosal glands.We found that PEDF protein is expressed in the human nasal mucosa, and its expression is increased in allergic rhinitis. These results suggest a possible contribution of PEDF to the chronic inflammation of the nasal mucosa in allergic rhinitis. (...) Increased expression of pigment epithelium-derived factor in allergic rhinitis. To investigate the expression of messenger RNA (mRNA) of the gene for pigment epithelium-derived factor (PEDF) (OMIM *172860) and PEDF protein and to localize the PEDF protein in the nasal mucosa of patients with allergic rhinitis and of control subjects.Investigation of PEDF mRNA and PEDF protein expression in the nasal mucosa using reverse transcription-polymerase chain reaction, Western blotting

2008 Archives of Otolaryngology Head and Neck Surgery

171. Expression of Fas ligand and CTLA4 in adenoids has a predictive value for allergic rhinitis development in children. (Abstract)

of these molecules have a predictive value in the development of allergic rhinitis.The adenoids of 60 children, removed because of nasal obstruction, chronic rhinitis and recurrent respiratory infection, were evaluated. Patients were divided into two groups: group 1, suffering from chronic allergic rhinitis, and group 2, suffering from chronic rhinitis, where no specific IgE was detected, including children with a positive family history of allergy (group 2a) and children with neither a personal nor a family (...) Expression of Fas ligand and CTLA4 in adenoids has a predictive value for allergic rhinitis development in children. The balance of CD28/CTLA4-derived signals and Fas-dependent apoptosis activity is determined by the peripheral defense mechanisms and might play a role in the pathogenesis of allergy.The aim of the study was to investigate the expression of costimulatory and pro- and antiapoptotic molecules in adenoid T cells of children suffering from allergic rhinitis and to find out which

2006 International Archives of Allergy and Immunology

172. Is there any evidence that leukotriene antagonists have any role to play in the treatment of perennial or vasomotor rhinitis (not allergic rhinitis)? Has there been any recent peer review of the treat

: Twenty-four consecutive patients with symptomatic nasal polyposis and nonallergic or perennial rhinitis who were undergoing chronic nasal steroid therapy were prospectively evaluated for response to adjunctive oral montelukast sodium therapy. CONCLUSIONS: These results suggest that montelukast appears to be beneficial for some patients with nasal polyposis. Patients with perennial allergies and nasal polyposis seem more likely to respond to the treatment than those with nonallergic nasal polyposis (...) Is there any evidence that leukotriene antagonists have any role to play in the treatment of perennial or vasomotor rhinitis (not allergic rhinitis)? Has there been any recent peer review of the treat Is there any evidence that leukotriene antagonists have any role to play in the treatment of perennial or vasomotor rhinitis (not allergic rhinitis)? Has there been any recent peer review of the treatment of these two problems? - Trip Database or use your Google+ account Turning Research

2006 TRIP Answers

173. [Clinical observation on intranasal budesonide in chronic nonallergic rhinitis]. (Abstract)

[Clinical observation on intranasal budesonide in chronic nonallergic rhinitis]. An open randomized comparative study was conducted in order to observe the efficacy and safety about intranasal Budesonide in the treatment of chronic nonallergic rhinitis.Forty-two patients with chronic nonallergic rhinitis were treated with Budesonide aqueous nasal spray (256 microg once daily intranasally) for 8 weeks. All the patients were asked for return at week 1 and week 8. Efficacy was evaluated (...) not significant influences on the smell disturbances, dryness of the throat. No serious adverse events were reported in the study.Intranasal Budesonide is effective and safe in alleviating the symptoms of chronic nonallergic rhinitis.

2006 Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology Controlled trial quality: uncertain

174. Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. (Abstract)

Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. Azelastine hydrochloride is an antihistamine with anti-inflammatory properties that is available in the United States in a nasal spray formulation for the treatment of seasonal allergic rhinitis. Vasomotor (perennial nonallergic) rhinitis (VMR) is a noninfectious, chronic rhinitis usually not associated with inflammatory cell infiltration.Two multicenter, randomized, double-blind, placebo (...) -controlled, parallel-group clinical trials were conducted to determine whether patients with symptoms of VMR (rhinorrhea, sneezing, postnasal drip, and nasal congestion) could be effectively treated with azelastine nasal spray.All of the patients who participated in the trials had a diagnosis of VMR, symptoms for at least 1 year, negative skin tests for a mixed panel of seasonal and perennial allergens, and a nasal cytology examination negative for eosinophils. After a 1-week, single-blind, placebo lead

2001 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Controlled trial quality: predicted high

175. Important aspects in management of allergic rhinitis: compliance, cost, and quality of life. (Abstract)

of the patient with allergic rhinitis. In allergy-specific questionnaires, subjects with allergic rhinitis consistently report lower quality of life than nonallergic controls. Untreated patients are embarrassed and frustrated by their allergy symptoms. Atopic individuals consistently exhibit significant declines in cognitive processing, psychomotor speed, verbal learning, and memory during allergy season. Physicians should consider compliance, cost, and quality of life issues in each and every patient (...) Important aspects in management of allergic rhinitis: compliance, cost, and quality of life. Allergic rhinitis is a highly prevalent, chronic condition. Physicians trained in the care of patients with allergic rhinitis focus on the main management points, which include environmental control, appropriate pharmacologic treatment, and allergen immunotherapy. There are other important aspects in caring for patients with allergic rhinitis that are equally important in achieving the best outcomes

2003 Allergy and Asthma Proceedings

176. Reduction of TLR2 gene expression in allergic and nonallergic rhinitis. (Abstract)

Reduction of TLR2 gene expression in allergic and nonallergic rhinitis. Immunomodulators, including toll-like receptors (TLRs) and defensins, produced in response to pathogenic stimuli, can direct the developing immune system toward a T(H)1 nonallergic phenotype. Increased human beta-defensin (HBD) 4 expression is associated with infection.To determine whether reduced mucosal levels of TLRs and defensins contribute to the inflammation seen in chronic allergic and nonallergic rhinitis.Real-time (...) and nonallergic rhinitis show reduced TLR and HBD gene expression. The significant reduction in TLR2 gene expression in allergic adults supports the concept that increased TLR2 protects against the development of allergy. The low levels of HBD4 detected in both rhinitis groups suggest lack of an underlying infection pathophysiological feature.

2007 Asthma & Immunology

177. Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis

Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00783432 Recruitment Status : Completed First

2008 Clinical Trials

178. Allergic vs nonallergic rhinitis: which is more predisposing to chronic rhinosinusitis? (Abstract)

Allergic vs nonallergic rhinitis: which is more predisposing to chronic rhinosinusitis? The impact of allergy on chronic rhinosinusitis (CRS) is controversial.To evaluate whether a history of CRS is more prevalent in patients with allergic rhinitis than in those with nonallergic persistent rhinitis.A total of 115 patients (78 females; mean age, 31.9 years; age range, 14-64 years) with persistent rhinitis were included in the study. A 7-point analog scale was used to report the severity (...) in both groups (8 patients). However, mean Lund-Mackay staging scores, postnasal drainage, dental pain, and global CRS scores were significantly higher in patients with nonallergic rhinitis (P = .045, P = .001, P = .02, and P = .01, respectively). No significant correlations, except for dental pain (correlation coefficient, 0.250; P = .008), were found between Lund-Mackay scores and CRS symptoms. In rhinoscopy, the only conspicuous difference was nasal purulence in allergic patients (P = .002

2008 Asthma & Immunology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>