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Chronic Nonallergic Rhinitis

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161. Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. (Abstract)

of diagnostic problem of rhinitis. We sought to characterize the cellular pattern of patients with allergic rhinitis (AR) and compare them with those of NAR.According to the skin prick test positivity or negativity, individuals were divided into AR and NAR groups, respectively. Allergic rhinitis group was further divided into seasonal, perennial, and mixed subgroups. Nonallergic rhinitis group was also divided into the following 5 subgroups according to the nasal smear cytologic result: basophilic (...) Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. No diagnostic test had been specifically developed to diagnose nonallergic rhinitis (NAR). Also a negative nasal smear for eosinophils does not rule out the diagnosis. There is a significant diagnostic problem in patients with NAR. How can we solve this problem?Assessment of other cells than eosinophils present in the cytogram such as basophils, neutrophils, and goblet cells may help us to classify and management

2009 American Journal of Otolaryngology

162. Effect of topical nasal corticosteroids on patients with chronic fatigue syndrome and rhinitis. (Abstract)

Effect of topical nasal corticosteroids on patients with chronic fatigue syndrome and rhinitis. Chronic fatigue syndrome (CFS) is a disabling illness of persistent fatigue. Recent studies have shown that patients with CFS have an increased prevalence of nonallergic rhinitis. Inflammation of the nasal passages due to allergic rhinitis can cause nasal congestion resulting in an increased number of sleep disturbances and daytime fatigue. While topical nasal corticosteroids have been shown (...) with CFS does not appear to alleviate daytime fatigue or associated nasal, musculoskeletal, or cognitive complaints. Therefore, it is unlikely that aggressive treatment of such symptoms with topical nasal corticosteroids will provide significant benefit to patients with CFS who do not have allergic rhinitis. These results indicate that the nonallergic rhinitis seen in patients with CFS may arise from a mechanism other than chronic inflammation.

2003 The Journal of the American Osteopathic Association Controlled trial quality: uncertain

163. Characteristics of Nonallergic Vasomotor Rhinitis Full Text available with Trip Pro

survey designed to help physicians recognize differences between allergic rhinitis and nonallergic rhinitis subtypes found that patients with symptom onset later in life (> 35 years), no family history of allergies, no seasonality or cat-induced symptoms, and symptoms induced by perfumes and fragrances had > 95% likelihood of having a physician diagnosis of NAR. Of note, clinical symptoms were not generally useful for differentiating chronic rhinitis subtypes which has also been confirmed in a more (...) recent study investigating the relationship between headaches and chronic rhinitis subtypes (Table 1). In subsequent studies it was found that a significant percentage of NAR patients did not experience irritant-induced symptoms, suggesting that these triggers are not a clinical characteristic that can be uniformly used for all NAR patients. However, a newly developed Irritant Index Scale can be used to reliably differentiate pure allergic rhinitis from nonallergic rhinitis with trigger phenotypes

2009 The World Allergy Organization journal

164. Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis. (Abstract)

Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis. Chronic noninfectious, nonallergic rhinitis (NINAR) is a complex syndrome with a principally unknown pathophysiology. New technology has made it possible to examine differentially expressed genes and according to network theory, genes connected by their function that might have key roles in the disease.Connectivity analysis was used to identify NINAR key genes. mRNA was extracted from nasal biopsies from 12

2009 Allergy

165. Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper. Full Text available with Trip Pro

, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR (...) Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper. Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology

2008 Allergy

166. Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. (Abstract)

was blindly distributed to 100 random new patients with chronic rhinitis in an allergist's office. Questionnaire and physician diagnoses were compared. Allergic triggers included cat, dog, feathers, other furry animals, and symptoms during the spring, summer, and fall seasons. Nonallergic triggers included temperature changes, diesel and car exhaust, tobacco smoke, perfumes and fragrances, incense, cleaning products, newsprint, hairspray, and alcoholic beverages, spicy foods, or eating.The construct (...) Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. Chronic rhinitis, a prevalent primary care disorder associated with significant comorbidities, is often incorrectly diagnosed. As a result, inappropriate treatment leads to higher health care costs and poor clinical outcomes.To verify whether responses to specific questions may help in the diagnosis of nonallergic vasomotor rhinitis (NAVMR).A questionnaire listing allergic and nonallergic triggers

2006 Asthma & Immunology

167. Study to Investigate Effects of CAL-101 in Subjects With Allergic Rhinitis Exposed to Allergen in an Environmental Chamber

: Age > or = 18 and < or = 55 years Has a history of seasonal allergic rhinitis for at least 2 years Has sensitivity to grass pollen demonstrated by a positive response to skin prick testing Has a positive Radio Allergen Sorbent Test (> or = class 2) for grass pollen during the previous 12 months or at screening Is otherwise healthy, that is, free from clinically significant illness or disease as determined by medical history, physical examination and laboratory tests, including a normal 12-lead (...) ) History of chronic nasal or upper respiratory tract symptoms or disorders other than allergic rhinitis History of nonallergic rhinitis, chronic sinusitis or severe asthma Has a nasal condition likely to affect the outcome of the study, i.e. nasal septal perforations, nasal polyps, sinus disease, chronic nasal obstruction, or other nasal diseases Is currently taking regular medication, whether prescribed or not, including corticosteroids, vitamins, macrolides, anti-fungal agents and herbal remedies

2009 Clinical Trials

168. Up-regulation of peroxisome proliferator-activated receptor gamma in perennial allergic rhinitis. Full Text available with Trip Pro

Up-regulation of peroxisome proliferator-activated receptor gamma in perennial allergic rhinitis. To investigate the expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) messenger RNA and protein and to localize the PPAR-gamma protein in the nasal mucosa of patients with allergic rhinitis and control subjects.Prospective study.Tertiary academic institution. Patients Twenty patients with perennial allergic rhinitis and 20 matched nonallergic patients.Inferior turbinate (...) contribution for PPAR-gamma in chronic inflammation of the nasal mucosa in perennial allergic rhinitis.

2006 Archives of Otolaryngology Head and Neck Surgery

169. Increased expression of pigment epithelium-derived factor in allergic rhinitis. Full Text available with Trip Pro

of PEDF mRNA and PEDF protein in the nasal mucosa were significantly increased in patients with allergic rhinitis compared with those in nonallergic controls. The PEDF protein was expressed in the epithelium and submucosal glands.We found that PEDF protein is expressed in the human nasal mucosa, and its expression is increased in allergic rhinitis. These results suggest a possible contribution of PEDF to the chronic inflammation of the nasal mucosa in allergic rhinitis. (...) Increased expression of pigment epithelium-derived factor in allergic rhinitis. To investigate the expression of messenger RNA (mRNA) of the gene for pigment epithelium-derived factor (PEDF) (OMIM *172860) and PEDF protein and to localize the PEDF protein in the nasal mucosa of patients with allergic rhinitis and of control subjects.Investigation of PEDF mRNA and PEDF protein expression in the nasal mucosa using reverse transcription-polymerase chain reaction, Western blotting

2008 Archives of Otolaryngology Head and Neck Surgery

170. Expression of Fas ligand and CTLA4 in adenoids has a predictive value for allergic rhinitis development in children. (Abstract)

of these molecules have a predictive value in the development of allergic rhinitis.The adenoids of 60 children, removed because of nasal obstruction, chronic rhinitis and recurrent respiratory infection, were evaluated. Patients were divided into two groups: group 1, suffering from chronic allergic rhinitis, and group 2, suffering from chronic rhinitis, where no specific IgE was detected, including children with a positive family history of allergy (group 2a) and children with neither a personal nor a family (...) Expression of Fas ligand and CTLA4 in adenoids has a predictive value for allergic rhinitis development in children. The balance of CD28/CTLA4-derived signals and Fas-dependent apoptosis activity is determined by the peripheral defense mechanisms and might play a role in the pathogenesis of allergy.The aim of the study was to investigate the expression of costimulatory and pro- and antiapoptotic molecules in adenoid T cells of children suffering from allergic rhinitis and to find out which

2006 International Archives of Allergy and Immunology

171. Is there any evidence that leukotriene antagonists have any role to play in the treatment of perennial or vasomotor rhinitis (not allergic rhinitis)? Has there been any recent peer review of the treat

: Twenty-four consecutive patients with symptomatic nasal polyposis and nonallergic or perennial rhinitis who were undergoing chronic nasal steroid therapy were prospectively evaluated for response to adjunctive oral montelukast sodium therapy. CONCLUSIONS: These results suggest that montelukast appears to be beneficial for some patients with nasal polyposis. Patients with perennial allergies and nasal polyposis seem more likely to respond to the treatment than those with nonallergic nasal polyposis (...) Is there any evidence that leukotriene antagonists have any role to play in the treatment of perennial or vasomotor rhinitis (not allergic rhinitis)? Has there been any recent peer review of the treat Is there any evidence that leukotriene antagonists have any role to play in the treatment of perennial or vasomotor rhinitis (not allergic rhinitis)? Has there been any recent peer review of the treatment of these two problems? - Trip Database or use your Google+ account Turning Research

2006 TRIP Answers

172. [Clinical observation on intranasal budesonide in chronic nonallergic rhinitis]. (Abstract)

[Clinical observation on intranasal budesonide in chronic nonallergic rhinitis]. An open randomized comparative study was conducted in order to observe the efficacy and safety about intranasal Budesonide in the treatment of chronic nonallergic rhinitis.Forty-two patients with chronic nonallergic rhinitis were treated with Budesonide aqueous nasal spray (256 microg once daily intranasally) for 8 weeks. All the patients were asked for return at week 1 and week 8. Efficacy was evaluated (...) not significant influences on the smell disturbances, dryness of the throat. No serious adverse events were reported in the study.Intranasal Budesonide is effective and safe in alleviating the symptoms of chronic nonallergic rhinitis.

2006 Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology Controlled trial quality: uncertain

173. Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. (Abstract)

Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. Azelastine hydrochloride is an antihistamine with anti-inflammatory properties that is available in the United States in a nasal spray formulation for the treatment of seasonal allergic rhinitis. Vasomotor (perennial nonallergic) rhinitis (VMR) is a noninfectious, chronic rhinitis usually not associated with inflammatory cell infiltration.Two multicenter, randomized, double-blind, placebo (...) -controlled, parallel-group clinical trials were conducted to determine whether patients with symptoms of VMR (rhinorrhea, sneezing, postnasal drip, and nasal congestion) could be effectively treated with azelastine nasal spray.All of the patients who participated in the trials had a diagnosis of VMR, symptoms for at least 1 year, negative skin tests for a mixed panel of seasonal and perennial allergens, and a nasal cytology examination negative for eosinophils. After a 1-week, single-blind, placebo lead

2001 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Controlled trial quality: predicted high

174. Treatment of nonallergic perennial rhinitis. (Abstract)

Treatment of nonallergic perennial rhinitis. Nonallergic perennial rhinitis (also commonly referred to as vasomotor rhinitis) is a chronic non-IgE-mediated condition that is characterized by symptoms which are similar to those seen in allergic rhinitis, but which persist for over nine months each year. Although treatment of vasomotor rhinitis involves the use of either intranasal corticosteroids or antihistamines, the corticosteroids are generally not effective in treatment of all the symptoms (...) allergic and/or vasomotor (nonallergic perennial) rhinitis.

2004 Allergy

175. Important aspects in management of allergic rhinitis: compliance, cost, and quality of life. (Abstract)

of the patient with allergic rhinitis. In allergy-specific questionnaires, subjects with allergic rhinitis consistently report lower quality of life than nonallergic controls. Untreated patients are embarrassed and frustrated by their allergy symptoms. Atopic individuals consistently exhibit significant declines in cognitive processing, psychomotor speed, verbal learning, and memory during allergy season. Physicians should consider compliance, cost, and quality of life issues in each and every patient (...) Important aspects in management of allergic rhinitis: compliance, cost, and quality of life. Allergic rhinitis is a highly prevalent, chronic condition. Physicians trained in the care of patients with allergic rhinitis focus on the main management points, which include environmental control, appropriate pharmacologic treatment, and allergen immunotherapy. There are other important aspects in caring for patients with allergic rhinitis that are equally important in achieving the best outcomes

2003 Allergy and Asthma Proceedings

176. Objective assessments of allergic and nonallergic rhinitis in young children. Full Text available with Trip Pro

and significantly associated with nasal eosinophilia, but this association was stronger for allergic rhinitis.Allergic rhinitis and nonallergic rhinitis are of different pathologies as suggested from their different associations not only to allergy but importantly also to irreversible nasal airway obstruction and eosinophilic inflammation. Allergic rhinitis was significantly associated with nasal eosinophilia and irreversible nasal airway obstruction suggesting chronic inflammation and structural remodeling (...) Objective assessments of allergic and nonallergic rhinitis in young children. Allergic and nonallergic rhinitis are common childhood disorders.To study nasal eosinophilia and nasal airway patency in young children with allergic and nonallergic rhinitis to assess the pathology behind such diagnoses.We investigated 255 children at six years of age from the Copenhagen Prospective Study on Asthma in Childhood birth cohort assessing rhinitis history, specific immunoglobulin E relevant to rhinitis

2009 Allergy

177. Physician perceptions of the treatment and management of allergic and nonallergic rhinitis. (Abstract)

Physician perceptions of the treatment and management of allergic and nonallergic rhinitis. Historically, rhinitis has been perceived by many clinicians in respiratory medicine as an unimportant condition. The purpose of this study was to evaluate physicians' perceptions of the impact of allergic rhinitis and chronic or nonallergic rhinitis on patients' health. This cross-sectional survey involved U.S. physicians identified from a claims database as treating patients with allergic rhinitis (...) or chronic rhinitis during a 13-month period. Responses were stratified by physicians' overall assessment of their patients' rhinitis severity, presence or absence of an allergy specialist at the practice, and agreement or disagreement that allergic rhinitis and nonallergic rhinitis should be managed similarly. Of 2614 physicians invited to participate, 766 responded. Physicians who perceived the majority of their patients as having moderate-to-severe symptoms were more likely to be prescribed more than

2009 Allergy and Asthma Proceedings

178. Reduction of TLR2 gene expression in allergic and nonallergic rhinitis. (Abstract)

Reduction of TLR2 gene expression in allergic and nonallergic rhinitis. Immunomodulators, including toll-like receptors (TLRs) and defensins, produced in response to pathogenic stimuli, can direct the developing immune system toward a T(H)1 nonallergic phenotype. Increased human beta-defensin (HBD) 4 expression is associated with infection.To determine whether reduced mucosal levels of TLRs and defensins contribute to the inflammation seen in chronic allergic and nonallergic rhinitis.Real-time (...) and nonallergic rhinitis show reduced TLR and HBD gene expression. The significant reduction in TLR2 gene expression in allergic adults supports the concept that increased TLR2 protects against the development of allergy. The low levels of HBD4 detected in both rhinitis groups suggest lack of an underlying infection pathophysiological feature.

2007 Asthma & Immunology

179. Allergic and nonallergic rhinitis: can we find the differences/similarities between the two pictures? (Abstract)

Allergic and nonallergic rhinitis: can we find the differences/similarities between the two pictures? The diagnostic challenge of rhinitis is to determine the etiology, specifically whether it is allergic or nonallergic. We therefore evaluated the general features of patients with allergic (AR) and nonallergic rhinitis (NAR), as well as health-related quality of life (HRQoL). The study group consisted of 323 patients (201 F/122 M) with a mean age of 31.79 +/- 12.64 years. Almost two thirds (...) of the population had AR (63.5%). Neither the demographic characteristics nor the duration of rhinitis was different between the two groups. Total immunoglobulin E was significantly higher in AR. Although both groups displayed a mild-intermittent rhinitis profile, patients with AR had more seasonal and NAR had more perennial symptoms (p = 0.01). Frequency of nasal obstruction was comparable in both groups, whereas patients with AR significantly complained of rhinorrhea (86.8%), followed by nasal obstruction

2009 Journal of Asthma

180. Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis

Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00783432 Recruitment Status : Completed First

2008 Clinical Trials

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