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Chronic Nonallergic Rhinitis

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81. Adult Sinusitis Full Text available with Trip Pro

nonallergic rhinitis, vasomotor rhinitis, invasive fungal rhinosinusitis, allergic fungal rhinosinusitis, vascular headaches, and migraines. Similarly, the guideline will not consider management of rhinosinusitis in patients with the following modifying factors but will discuss the importance of assessing patients with recurrent ARS or CRS for their presence: cystic fibrosis, immotile cilia disorders, ciliary dyskinesia, immune deficiency, prior history of sinus surgery, and anatomic abnormalities (eg (...) , deviated nasal septum). Surgical management of CRS is not discussed in this guideline because of insufficient evidence (eg, randomized controlled trials) for evidence-based recommendations. Burden of Rhinosinusitis Twelve percent of the US population (nearly 1 in 8 adults) reported being diagnosed with rhinosinusitis in the prior 12 months in a 2012 national health survey. Rhinosinusitis was diagnosed more frequently than hay fever (7%), bronchitis (4%), or chronic obstructive pulmonary disease (4

2015 American Academy of Otolaryngology - Head and Neck Surgery

82. Relationship between upper airway diseases, exhaled nitric oxide, and bronchial hyperresponsiveness to methacholine. (Abstract)

suggestive of asthma requiring methacholine challenge testing (MCT) to confirm asthma diagnosis.A cross-sectional prospective study was carried out in adult patients with persistent asthma-like symptoms and negative bronchodilator testing. FeNO and MCT were performed in all patients. Asthma was confirmed based on the presence of suggestive symptoms and MCT results. Associated upper airway diseases included allergic rhinitis, nonallergic rhinitis, chronic rhinosinusitis with nasal polyps (CRSwNP (...) Relationship between upper airway diseases, exhaled nitric oxide, and bronchial hyperresponsiveness to methacholine. The "united airway disease" concept is based on the bidirectional interaction between asthma and rhinitis. The aim of this study was to determine the relationship between upper airway diseases and bronchial hyperresponsiveness (BHR), as well as their association with the fractional concentration of exhaled nitric oxide (FeNO) and atopy in patients with persistent symptoms

2018 Journal of Asthma

83. Microbiota Composition and the Integration of Exogenous and Endogenous Signals in Reactive Nasal Inflammation Full Text available with Trip Pro

Microbiota Composition and the Integration of Exogenous and Endogenous Signals in Reactive Nasal Inflammation The prevalence of reactive nasal inflammatory conditions, for example, allergic rhinitis and chronic rhinosinusitis, is steadily increasing in parallel with significant environmental changes worldwide. Allergens and as yet undefined environmental agents may trigger these conditions via the involvement of host intrinsic factors, including the innate and adaptive immune system, the nasal (...) epithelium, and the nasal nervous system. The critical role of the nasal microbiota in coordinating these components has emerged in recent studies documenting a significant association between microbial composition and the onset and progression of allergic or nonallergic inflammation. It is now clear that the local microbiota is a major player in the development of the mucosa-associated lymphoid tissue and in the regulation of such adaptive responses as IgA production and the function of effector

2018 Journal of immunology research

84. Atopic dermatitis – Diagnosis and Assessment Full Text available with Trip Pro

., Momblan-De Cabo, J. et al. Prevalence and factors linked to allergic rhinitis in 10 and 11-year-old children in Almeria. Isaac Phase II, Spain. Allergol Immunopathol (Madr) . 2010 ; 38 : 135–141 | | | , x 78 Chawes, B.L., Bonnelykke, K., Kreiner-Moller, E., and Bisgaard, H. Children with allergic and nonallergic rhinitis have a similar risk of asthma. J Allergy Clin Immunol . 2010 ; 126 : 567–573 | | | | | , x 79 Sultesz, M., Katona, G., Hirschberg, A., and Galffy, G. Prevalence and risk factors (...) in the literature search included: atopic dermatitis, atopic eczema, diagnosis, diagnostic, severity course, assessment, biomarkers, outcomes measures, morbidity, quality of life, appearance, comorbidity, food allergy, allergic rhinitis, asthma, cancer, sleep, growth effects, developmental effects, behavioral, psychological, attention deficit hyperactivity disorder (ADHD), treatment, and outcome. A total of 1417 abstracts were initially assessed for possible inclusion. After removal of duplicate data, 292 were

2014 American Academy of Dermatology

85. Atopic dermatitis – Flare prevention and use of adjunctive therapies and approaches Full Text available with Trip Pro

adults. It follows a relapsing course. AD is often associated with elevated serum immunoglobulin (IgE) levels and a personal or family history of type I allergies, allergic rhinitis, and asthma. Atopic eczema is synonymous with AD. Introduction The often protracted nature of AD necessitates setting several long-term treatment goals: the prevention of continued outbreaks, the management of comorbidities and secondary complications that arise, and minimizing adverse effects while trying to maximize (...) dermatitis is a common, chronic inflammatory dermatosis that can affect all age groups. This evidence-based guideline addresses important clinical questions that arise in its management. In this final section, treatments for flare prevention and adjunctive and complementary therapies and approaches are reviewed. Suggestions on use are given based on available evidence. Key words: , , , , , , , , , , Abbreviations used: ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ) Disclaimer

2014 American Academy of Dermatology

86. Clinical Practice Guideline for the Diagnosis and Management of Acute Bacterial Sinusitis in Children Aged 1 to 18 Years

that helps to define the severe onset of acute bacterial sinusitis. , , This presentation in children is the corollary to acute onset of headache, fever, and facial pain in adults with acute sinusitis. Allergic and nonallergic rhinitis are predisposing causes of some cases of acute bacterial sinusitis in childhood. In addition, at their onset, these conditions may be mistaken for acute bacterial sinusitis. A family history of atopic conditions, seasonal occurrences, or occurrences with exposure to common (...) allergens and other allergic diatheses in the index patient (eczema, atopic dermatitis, asthma) may suggest the presence of noninfectious rhinitis. The patient may have complaints of pruritic eyes and nasal mucosa, which will provide a clue to the likely etiology of the condition. On physical examination, there may be a prominent nasal crease, allergic shiners, cobblestoning of the conjunctiva or pharyngeal wall, or pale nasal mucosa as other indicators of the diagnosis. Key Action Statement 2A

2013 American Academy of Pediatrics

87. Exercise-induced Bronchoconstriction

to bronchoconstriction occurring as a result of exercise. Many experts advocate using the terminology “exercise-induced bronchoconstriction” instead of “exercise-induced asthma,” as it does not imply that the patient has underlying chronic asthma or that exercise actually “caused” asthma. For the purposes of this document,wewillusetheterminology“exercise-inducedbroncho- constriction” without regard to whether it occurs in patients with or without asthma. TherearesubstantialdatashowingthatEIBoccursverycom (...) of the positive studies, to also inhibit leukotrienes, thus confound- ing the speci?c role of an antihistamine effect (118). Because controlling allergies in patients with atopy with asthma leads to better asthma control in general, it seems prudent that allergic patients with asthma with EIB may bene?t from antihistamine therapy (119). Asystematicreviewoftheevidenceidenti?edthreerandom- ized trials, which were pooled. Patients with EIB who received a daily antihistamine had no signi?cant decrease

2013 American Thoracic Society

88. Allergic sensitization does not predispose to sinus inflammation in externalized paranasal sinuses. (Abstract)

assessed. Of these, 61.17% were allergically sensitized at the time of surgery. Postsurgery endoscopic assessment was similar [the modified Lund-Mackay endoscopic score allergic sensitized 0.5 (1.7) versus nonallergic sensitized 0.0 (0.9); p = 0.15]. Sinonasal symptoms were also similar between the groups' 22-item Sino-Nasal Outcome test scores, allergic sensitized versus allergic nonsensitized, (allergic 28.9 ± 20.8 versus nonallergic 33.5 ± 19.7; p = 0.31), rhinitis score (5.9 ± 5.5 versus 6.4 ± 4.7 (...) Allergic sensitization does not predispose to sinus inflammation in externalized paranasal sinuses. Chronic rhinosinusitis (CRS) has a multifactorial etiology, with a debate about the role of inhalant allergy in the pathogenesis of CRS.This study assessed the impact of allergy status on externalized paranasal sinuses after tumor resection to determine if a predisposition to inhalant allergy brought about additional inflammation after sinus surgery.A case-control study was performed on patients

2017 American journal of rhinology & allergy

89. Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end? (Abstract)

Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end? We evaluated the prognostic value of nasal cytology and clinical factors in predicting nasal polyp (NP) development in patients with history of nonallergic chronic sinonasal inflammation.This was a retrospective case-control study of 295 patients followed at our institution for a mean of 85.70 ± 19.41 months. According to the inclusion criteria we enrolled (...) 84 cases with persistent eosinophilic nonallergic sinonasal inflammation (group A) and 106 cases with neutrophilic inflammation (group B), both without evidence of NPs at the baseline. We considered as controls 105 patients affected by nonallergic noninfectious vasomotor rhinitis without evidence of inflammation at nasal cytology (group C). Patients were checked every 6 months for NPs. Temporal analyses was performed by Kaplan-Mayer curves and odds ratios were evaluated by logistic regression

2017 International forum of allergy & rhinology

90. Rhinology-specific priority setting for quality improvement: a modified Delphi study from the Quality Improvement Committee of the American Rhinologic Society. (Abstract)

final QI-prioritized list of sinonasal diseases are as follows: chronic rhinosinusitis (CRS) (mean score = 8.9), recurrent acute rhinosinusitis (RARS) (mean score = 7.9), sinonasal neoplasms (mean score = 7.0), anatomic nasal obstruction (mean score = 5.9), refractory epistaxis (mean score = 5.2), complicated acute rhinosinusitis (mean score = 5.2), chronic nonallergic rhinitis (mean score = 4.4), orbital disease (mean score = 4.3), uncomplicated acute rhinosinusitis (mean score = 4.1), and allergy (...) /allergic rhinitis (mean score = 3.7).The three most important disease categories for QI from the perspective of the specialty of rhinology were CRS, RARS, and sinonasal neoplasms. Future studies need to define and validate quality metrics for each of these important disease categories in order to facilitate appropriate measurement and improvement initiatives.© 2017 ARS-AAOA, LLC.

2017 International forum of allergy & rhinology

91. Rhinitis and sinusitis. (Abstract)

significant direct medical expenditures. Both conditions also create even greater indirect costs to society by causing lost work and school days and reduced workplace productivity and school learning. Management of allergic rhinitis involves avoidance, many pharmacologic options, and, in appropriately selected patients, allergen immunotherapy. Various types of nonallergic rhinitis are treated with avoidance measures and a more limited repertoire of medications. For purposes of this review, sinusitis (...) Rhinitis and sinusitis. Rhinitis and sinusitis are among the most common medical conditions and are frequently associated. In Western societies an estimated 10% to 25% of the population have allergic rhinitis, with 30 to 60 million persons being affected annually in the United States. It is estimated that sinusitis affects 31 million patients annually in the United States. Both rhinitis and sinusitis can significantly decrease quality of life, aggravate comorbid conditions, and require

2010 Journal of Allergy and Clinical Immunology

92. Eosinophilia Syndrome

Syndrome Aka: Eosinophilia Syndrome , Nares Syndrome , Nonallergic Rhinitis with Eosinophilia From Related Chapters II. Definitions Nonallergic Rhinitis with Eosinophilia Subtype of characterized by nasal III. Epidemiology Perennial More common in adults May represent up to a third of cases IV. Symptoms Congestion V. Labs ing ( or ) negative Nasal secretion microscopy Nasal and mast cell degranulation VI. Differential Diagnosis See Chronic See VII. Associated conditions: Triad sensitivity Non-IgE (...) -mediated s Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Eosinophilia Syndrome." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Eosinophilic non-allergic rhinitis (C0684902) Concepts Disease or Syndrome ( T047 ) SnomedCT 93447004 English NARES , Eosinophil non-allergic rhinit , Eosinophilic non-allergic rhinitis , Eosinophilic nonallergic

2018 FP Notebook

93. Rhinosinusitis

, this can block the sinuses and cause pain. There are several types of sinusitis, including Acute, which lasts up to 4 weeks Subacute, which lasts 4 to 12 weeks Chronic, which lasts more than 12 weeks and can continue for months or even years Recurrent, with several attacks within a year Acute sinusitis often starts as a cold, which then turns into a bacterial infection. Allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. Symptoms of sinusitis can include fever (...) infekce. Místní komplikace zahrnují jednak vliv na záněty okolních struktur vč. jejich chronicity (rhinitis či pharyngitis chronica). Závažné mohou být komplikace při šíření zánětu do orbity, popř. lebky. Častěji se objevují např. záněty průdušek a průduškové astma – tzv. sinobronchiální syndrom. Léčba s. zahrnuje klid, dostatečné zvlhčování vzduchu, obklady, nosní kapky ke zmírnění zduření sliznice, antibiotika. V těžších případech je nutné provést punkci dutin s jejich výplachem. V případě

2018 FP Notebook

94. Dynamic Changes in Heart Rate Variability and Nasal Airflow Resistance during Nasal Allergen Provocation Test Full Text available with Trip Pro

Dynamic Changes in Heart Rate Variability and Nasal Airflow Resistance during Nasal Allergen Provocation Test Allergic rhinitis is a major chronic respiratory disease and an immunoneuronal disorder. We aimed at providing further knowledge on the function of the neural system in nasal allergic reaction. Here, a method to assess simultaneously the nasal airflow resistance and the underlying function of autonomic nervous system (ANS) is presented and used during the nasal provocation of allergic (...) and nonallergic subjects. Continuous nasal airflow resistance and spectral heart rate variability parameters show in detail the timing and intensity differences in subjects' reactions. After the provocation, the nasal airflow resistance of allergic subjects showed a positive trend, whereas LF/HF (Low Frequency/High Frequency) ratio and LF power showed a negative trend. This could imply a gradual sympathetic withdrawal in allergic subjects after the allergen provocation. The groups differed significantly

2016 Journal of healthcare engineering

95. United airway disease: current perspectives Full Text available with Trip Pro

inflammatory diseases of the upper and lower airways, which can be induced by allergic or nonallergic reproducible mechanisms, and present several phenotypes. Management of rhinitis and asthma must be jointly carried out, leading to better control of both diseases, and the lessons of the Allergic Rhinitis and Its Impact on Asthma initiative cannot be forgotten. (...) United airway disease: current perspectives Upper and lower airways are considered a unified morphological and functional unit, and the connection existing between them has been observed for many years, both in health and in disease. There is strong epidemiologic, pathophysiologic, and clinical evidence supporting an integrated view of rhinitis and asthma: united airway disease in the present review. The term "united airway disease" is opportune, because rhinitis and asthma are chronic

2016 Journal of asthma and allergy

96. Transcriptional profiling of Th2 cells identifies pathogenic features associated with asthma Full Text available with Trip Pro

Transcriptional profiling of Th2 cells identifies pathogenic features associated with asthma Allergic asthma and rhinitis are two common chronic allergic diseases that affect the lungs and nose, respectively. Both diseases share clinical and pathological features characteristic of excessive allergen-induced type 2 inflammation, orchestrated by memory CD4(+) T cells that produce type 2 cytokines (Th2 cells). However, a large majority of subjects with allergic rhinitis do not develop asthma (...) , suggesting divergence in disease mechanisms. Because Th2 cells play a pathogenic role in both these diseases and are also present in healthy nonallergic subjects, we performed global transcriptional profiling to determine whether there are qualitative differences in Th2 cells from subjects with allergic asthma, rhinitis, and healthy controls. Th2 cells from asthmatic subjects expressed higher levels of several genes that promote their survival as well as alter their metabolic pathways to favor

2016 Journal of immunology (Baltimore, Md. : 1950)

97. Phenotyping asthma in the elderly: allergic sensitization profile and upper airways comorbidity in patients older than 65 years. (Abstract)

% of elderly subjects with asthma had rhinitis, mainly allergic and often untreated, whose onset preceded asthma symptoms by a mean of approximately 10 years. Nonallergic asthma was better controlled than allergic asthma. However, HDM sensitization was greater in subjects with asthma with features resembling chronic obstructive pulmonary disease (39% vs 28%). When restricting analysis to this group, the negative role of HDM in overall asthma control (forced expiratory volume in first second and Asthma (...) Phenotyping asthma in the elderly: allergic sensitization profile and upper airways comorbidity in patients older than 65 years. Data about allergic rhinitis in elderly patients with asthma are lacking.To investigate the presence of rhinitis and the role of sensitization of airborne allergens in elderly patients with asthma.This was a multicenter cross-sectional study involving subjects at least 65 years old with asthma. Demographic features, comorbidities, and the presence of allergic

2016 Asthma & Immunology

98. Primary Care Corner with Geoffrey Modest MD: Vitamin D and atopic dermatitis in kids

. The current study looked further into the immunologic changes and clinical effects of vitamin D supplementation in AD patients (see Arch Allergy Immunol 2015;166:91–96​ ). Details: –39 children with chronic AD (mean age 4, 38% with family history of asthma, 87% family history of allergies, 33% of the kids had asthma and 33% had rhinitis; 8% had mild AD/46% moderate and 46% severe; 90% with total IgE increased and 23% had documented food allergy, 21% for inhalants only; 38% tested positive for dust mite (...) in Th2 cells and decrease in Th1 cells in their skin, though there are differences in these T-cell subsets in the acute AD phase, with Th2 cells and their associated cytokines of IL-4, IL-5, IL-13 predominating, but in the chronic phase the Th1 cells and their associated IFN-g, IL-5,IL-12 predominate. Vitamin D receptors are all over the body, including in the skin and in the immune system, and a small RCT in AD patients randomized to vitamin D 1,600 IU/d found clinical improvement after 60 days

2015 Evidence-Based Medicine blog

99. Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis - a GA(2) LEN study. Full Text available with Trip Pro

(2) LEN European survey.On two separate occasions, 1700 subjects from 11 centers provided information on symptoms of CRS, allergic rhinitis, and asthma. CRS was defined by the epidemiological EP3OS symptom criteria. The difference in prevalence of CRS between two study points, the standardized absolute repeatability, and the chance-corrected repeatability (kappa) were determined. In two centers, 342 participants underwent nasal endoscopy. The association of symptom-based CRS with endoscopy (...) and self-reported doctor-diagnosed CRS was assessed.There was a decrease in prevalence of CRS between the two study phases, and this was consistent across all centers (-3.0%, 95% CI: -5.0 to -1.0%, I(2) = 0). There was fair to moderate agreement between the two occasions (kappa = 39.6). Symptom-based CRS was significantly associated with positive endoscopy in nonallergic subjects, and with self-reported doctor-diagnosed CRS in all subjects, irrespective of the presence of allergic rhinitis.Our findings

2010 Allergy

100. Clinical development of an advanced intranasal delivery system of azelastine hydrochloride and fluticasone propionate. (Abstract)

(i.e., halving of nasal symptom burden and complete/near-to-complete relief) days faster than those on INS or intranasal antihistamine monotherapy. MP29-02's efficacy was sustained long-term versus FP (up to 52 weeks) in chronic rhinitis patients (perennial AR or nonallergic rhinitis), with 7 out of 10 patients first becoming symptom-free following 1 month's treatment with MP29-02, and days faster than with the INS. These results confirm MP29-02's superiority over the historical gold-standard (...) Clinical development of an advanced intranasal delivery system of azelastine hydrochloride and fluticasone propionate. There is no shortage of pharmacologic treatments available for the management of allergic rhinitis (AR), but none regularly provide full relief from all symptoms. MP29-02 (Dymista®) is a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP), benefiting from an enhanced formulation and improved device characteristics compared to marketed

2014 Drugs of today (Barcelona, Spain : 1998) Controlled trial quality: predicted high

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