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Chronic Nonallergic Rhinitis

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61. Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. (Abstract)

Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. Patients with chronic allergic rhinitis (AR) and nonallergic rhinitis (NAR) often experience irritant-induced symptoms. The clinical relevance of the magnitude of their symptoms in response to these nonspecific stimuli remains unclear.To determine the internal consistency and validity of an irritant index questionnaire (IIQ) and whether reclassification of physician-diagnosed rhinitis subtypes based (...) on IIQ scores results in rhinitis subtypes with different clinical characteristics.Patients 18 to 65 years old with physician-diagnosed AR (n = 404), mixed rhinitis (MR; n = 129), or NAR (n = 123) completed an IIQ that rated rhinitis symptom severity in response to 21 nonallergic irritant triggers on a 1- to 10-point scale. Multistage sex-specific statistical analyses were performed using IIQ responses to reclassify physician-diagnosed AR, MR, and NAR into categories with high and low irritant

2012 Asthma & Immunology

62. Vasomotor Rhinitis

: Vasomotor Rhinitis , Nonallergic Rhinopathy , Idiopathic Nonallergic Rhinitis , Senile Rhinitis , Geriatric Rhinitis , Gustatory Rhinitis From Related Chapters II. Symptoms: Chronic (>3 months) Characteristics Allergic symptoms are typically absent (nasal, ocular or pharyngeal/palatal , sneezing, s) Wet or Dry Dry: Nasal obstruction, airway resistance and congestion Wet: predominates Mixed (congestion and ) Provocative (non-allergic triggers) Odors (e.g. perfumes, auto emissions, smoke) Spicy food (...) on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Rhinitis, Vasomotor (C0035460) Definition (MSH) A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage. Definition (MSHCZE) Vazomotorická rýma – rýma (rhinopathia, ev. rhinitis vasomotorica) projevující se záchvaty řídké sekrece z nosu a jeho ucpáním. Připomíná alergickou rýmu, patogeneticky se však uplatňují vegetativní

2015 FP Notebook

63. Allergic rhinitis and secondhand tobacco smoke: a population-based study. (Abstract)

or reported skin test positive), and 117 nonallergic subjects from the same community were recruited and interviewed. A validated questionnaire was used to assess past and present SHS exposure as well as disease-specific quality of life.SHS was reported in 34/83 allergic subjects. Compared with AR subjects with no SHS exposure, subjects with AR and SHS were more likely to report a family history of chronic sinusitis (p = 0.04) and use nasal decongestants (p = 0.012). There was also a borderline (...) Allergic rhinitis and secondhand tobacco smoke: a population-based study. Allergic rhinitis (AR) is a common disease that affects approximately one-fifth of the U.S. population. Few studies have evaluated the association between secondhand tobacco smoke (SHS) exposure and the impacts on symptom severity in AR. In this study, we evaluated the association of SHS and AR in a community-based study of adult nonsmokers.In Washington County, Maryland, 83 subjects with AR (physician diagnosed

2011 American journal of rhinology & allergy

64. Microarray analysis of differentially expressed microRNAs in allergic rhinitis. (Abstract)

Microarray analysis of differentially expressed microRNAs in allergic rhinitis. Allergic rhinitis (AR) is a common disease characterized by chronic inflammation of the nasal mucosa, but we have not fully understood the mechanism responsible for the development of AR. MicroRNAs (miRNAs) are short endogenous noncoding RNAs regulating protein translation through a mechanism known as RNA interference. To understand the molecular mechanisms of miRNA involved in the pathogenesis of AR, expressed (...) miRNAs in AR were investigated through genomewide microarray analysis.Mammalian miRNA microarrays containing whole human mature and precursor miRNA sequences were used for analyzing eight samples of nasal mucosa of AR and eight samples of nonallergic patients. Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) of some different expressed miRNAs was used to confirm the array results.The miRNA microarray chip analysis identified 421 miRNAs differentially expressed in the nasal

2011 American journal of rhinology & allergy

65. Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. (Abstract)

mites, and a total nasal symptom score of at least 5 (congestion of at least 2) has been performed. Patients with asthma, chronic obstructive pulmonary disease, nonallergic rhinitis with clinical allergy associated with seasonal allergens, and other serious diseases were excluded. There were four 6-week treatment periods separated by 2-week washout periods. Twenty patients received either montelukast or antihistamine, a combination of montelukast and antihistamine, or placebo. The sequence (...) Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. We assessed the course of treatment in patients with persistent allergic rhinitis (AR) treated with montelukast, levocetirizine, or desloratadine alone or combinations of antihistamine and montelukast.A 32-week randomized, double-blind, placebo-controlled, crossover, double-armed study in 40 adult patients with history of persistent AR, clinical allergy to house-dust

2011 American journal of rhinology & allergy Controlled trial quality: uncertain

66. Sinusitis, Chronic, Medical Treatment

sinusitis usually manifests differently from . Symptoms of chronic sinusitis include nasal stuffiness, postnasal drip, facial fullness, and malaise. (See Clinical Presentation.) Chronic sinusitis may be noninfectious and related to allergy, cystic fibrosis, gastroesophageal reflux, or exposure to environmental pollutants. [ , ] Allergic rhinitis, nonallergic rhinitis, anatomic obstruction in the ostiomeatal complex, and immunologic disorders are known risk factors for chronic sinusitis. (See Etiology (...) schenckii Alternaria species To see complete information on Fungal Sinusitis, please go to the main article by clicking . Risk factors The following conditions and risk factors predispose patients to the development of chronic sinusitis: Anatomic abnormalities of the ostiomeatal complex (eg, septal deviation, concha bullosa, deviation of uncinate process, Haller cells) Allergic rhinitis Aspirin sensitivity Asthma Nasal polyps Nonallergic rhinitis (eg, vasomotor rhinitis, rhinitis medicamentosa, cocaine

2014 eMedicine Surgery

67. Chronic Cough

of the oropharyngeal mucosa only suggest this as a cause. These findings are sensitive but not specific. [ ] PNDS has recently been broadened to UACS, referring to a myriad of rhinosinus conditions that are related to cough, [ ] including: PNDS Nonallergic rhinitis with eosinophilia (NARES) Occupational rhinitis Postinfectious rhinitis Rhinitis due to anatomic abnormalities Rhinitis due to physical or chemical irritants Rhinitis of pregnancy Vasomotor rhinitis UACS is considered the most common cause of chronic (...) has separated the upper and lower airways, with the upper airway being the domain of the otolaryngologist and the lower airway being the domain of the pulmonologist. Recent research that shows a high proportion of patients with asthma and coexisting allergic rhinitis has paved the way for the “one airway” theory, in which a continuum of inflammation that involves the entire airway can be thought of as the underlying mechanism for disorders that start from the nose and mouth and extend to the most

2014 eMedicine Surgery

68. Sinusitis, Chronic (Overview)

usually manifests differently from . Symptoms of chronic sinusitis include nasal stuffiness, postnasal drip, facial fullness, and malaise. (See Clinical Presentation.) Chronic sinusitis may be noninfectious and related to allergy, cystic fibrosis, gastroesophageal reflux, or exposure to environmental pollutants. [ , ] Allergic rhinitis, nonallergic rhinitis, anatomic obstruction in the ostiomeatal complex, and immunologic disorders are known risk factors for chronic sinusitis. (See Etiology.) Medical (...) To see complete information on Fungal Sinusitis, please go to the main article by clicking . Risk factors The following conditions and risk factors predispose patients to the development of chronic sinusitis: Anatomic abnormalities of the ostiomeatal complex (eg, septal deviation, concha bullosa, deviation of uncinate process, Haller cells) Allergic rhinitis Aspirin sensitivity Asthma Nasal polyps Nonallergic rhinitis (eg, vasomotor rhinitis, rhinitis medicamentosa, cocaine abuse) Defects

2014 eMedicine.com

69. Sinusitis, Chronic (Diagnosis)

sinusitis usually manifests differently from . Symptoms of chronic sinusitis include nasal stuffiness, postnasal drip, facial fullness, and malaise. (See Clinical Presentation.) Chronic sinusitis may be noninfectious and related to allergy, cystic fibrosis, gastroesophageal reflux, or exposure to environmental pollutants. [ , ] Allergic rhinitis, nonallergic rhinitis, anatomic obstruction in the ostiomeatal complex, and immunologic disorders are known risk factors for chronic sinusitis. (See Etiology (...) schenckii Alternaria species To see complete information on Fungal Sinusitis, please go to the main article by clicking . Risk factors The following conditions and risk factors predispose patients to the development of chronic sinusitis: Anatomic abnormalities of the ostiomeatal complex (eg, septal deviation, concha bullosa, deviation of uncinate process, Haller cells) Allergic rhinitis Aspirin sensitivity Asthma Nasal polyps Nonallergic rhinitis (eg, vasomotor rhinitis, rhinitis medicamentosa, cocaine

2014 eMedicine.com

70. Rhinitis

is classified as allergic or nonallergic. The cause of nonallergic rhinitis is usually viral, although irritants can cause it. Diagnosis is usually clinical. Treatment includes humidification of room air, sympathomimetic amines, and antihistamines. Bacterial superinfection requires appropriate antibiotic treatment. There are several forms of nonallergic rhinitis. For allergic rhinitis, see . Acute rhinitis Acute rhinitis, manifesting with edema and vasodilation of the nasal mucous membrane, rhinorrhea (...) rhinitis, is a chronic condition in which intermittent vascular engorgement of the nasal mucous membrane leads to watery rhinorrhea and sneezing. Etiology is uncertain, and no allergy can be identified. A dry atmosphere seems to aggravate the condition. Symptoms and Signs Acute rhinitis results in cough, low-grade fever, nasal congestion, rhinorrhea, and sneezing. Chronic rhinitis manifestations are similar to those of acute rhinitis, but in prolonged or severe cases, patients may also have thick, foul

2013 Merck Manual (19th Edition)

71. Nonallergic rhinitis and its association with smoking and lower airway disease: A general population study. (Abstract)

Nonallergic rhinitis and its association with smoking and lower airway disease: A general population study. The cause of nonallergic rhinitis (NAR) and its relation to lower airway disease remains unclear. The purpose of this study was to perform a descriptive analysis of the occurrence of rhinitis in a Danish general population with focus on NAR and its association with smoking and lower airway disease.A population-based, cross-sectional study conducted in Copenhagen, Denmark was performed (...) . A random sample from the general population (n = 7931; age, 18-69 years) was invited to a general health examination including measurements of serum-specific immunoglobulin E (IgE) to common aeroallergens; 3471 (44%) persons were accepted. For further analysis, we divided the population into the following groups: (I) negative specific IgE and no rhinitis (controls); (II) negative specific IgE and rhinitis (NAR); (III) positive specific IgE and rhinitis (allergic rhinitis [AR]); and (IV) positive

2011 American journal of rhinology & allergy Controlled trial quality: uncertain

72. The Role of Allergy Therapy in Chronic Rhinosinusitis: A Systematic Review Full Text available with Trip Pro

in the severity of nasal polyposis. Am J Rhinol. 2007;21:686–90. 30. Gelincik A, Buyukozturk S, Aslan I, et al. Allergic vs nonallergic rhinitis: which is more predisposing to chronic rhinosinusitis? Ann Allergy Asthma Immunol. 2008;101:18–22. 31. Keith PK, Conway M, Evans S, et al. Nasal polyps: effects of seasonal allergen exposure. J Allergy Clin Immunol. 1994;93:567–74. 32. • Peric A, Vojvodic D, Vukomanovic-Durdevid B. Influence of allergy on clinical, immunological and histological characteristics (...) was conducted by two authors (JIC and SL) using PubMed for articles from 1985 through September 2012. A Medical Subject Headings search using the subject headings “rhinitis, allergic, seasonal” or “rhinitis, allergic, perennial” or “food hypersensitivity” and “sinusitis” or “nasal polyps” yielded 426 abstracts for review. An additional PubMed free text search using the terms “allergy,” “chronic sinusitis,” “rhinosinusitis,” “nasal polyps,” “allergic rhinitis,” “atopy,” “immunotherapy,” and “food allergy

2012 Current otorhinolaryngology reports

73. Diagnosis and treatment of respiratory illness in children and adults.

as initial treatment for allergic rhinitis in children and adults. Relevant Resources : Weiner, Abramson, & Puy, 1998 Acute Sinusitis Diagnosis Consensus Recommendation : To diagnose acute bacterial rhinosinusitis (ABRS), the ICSI work group consensus is there are two clinical presentations where ABRS has a higher likelihood of being present: Persistence of symptoms consistent with acute rhinosinusitis lasting 10 days or more without evidence of improvement Symptoms are worsening – new onset of fever (...) guideline document (see the "Guideline Availability" field): Main Algorithm Acute Pharyngitis Algorithm Non-Infectious Rhinitis Algorithm Acute Sinusitis Algorithm Respiratory illnesses: Viral upper-respiratory infection Acute pharyngitis Non-infectious rhinitis (allergic and nonallergic) Acute sinusitis Diagnosis Evaluation Management Treatment Allergy and Immunology Family Practice Infectious Diseases Internal Medicine Otolaryngology Pediatrics Advanced Practice Nurses Allied Health Personnel Health

2017 National Guideline Clearinghouse (partial archive)

74. Evaluation and Management of Asthma in the Elderly

available Generally useful tool to assess asthma severity Bronchodilator responsiveness May be less pronounced Variable but generally greater eNO May be useful May be useful Methacholine challenge Less often used because of more frequent contraindications (e.g., cardiovascular disease) Useful; overall fewer contraindications Atopy Less common Common Comorbidities COPD, heart disease more common Allergic rhinitis more common Phenotypes Limited knowledge, but late-onset asthma, long-standing asthma (...) novel allergic and nonallergic models of asthma, re?ecting altered immune cell and cytokine milieu of the aging lung. Translation of aged animal studies to human studies. Establish biobanks of lung tissue, sputum, blood, and other samples fromoldersubjectswithandwithout asthma. Asthma phenotypes Lack of uniform de?nitions and incomplete characterization of longstanding versus late-onset AIE Generally not accomplished. Staphylococcal enterotoxin has been identi?ed as a potential risk factor for late

2016 American Thoracic Society

75. Characterization of nasal irrigation flow from a squeeze bottle using computational fluid dynamics. Full Text available with Trip Pro

Characterization of nasal irrigation flow from a squeeze bottle using computational fluid dynamics. Nasal saline irrigation has become standard of care in various sinonasal conditions, including allergic and nonallergic rhinitis, chronic rhinosinusitis, and in the postoperative patient. Evidence regarding the mechanisms and dynamics of liquid flow through the sinonasal cavity remains limited due to inadequate experimental models (cadaveric, 3-dimensional [3D] printed, imaging of labeled dyes

2020 International forum of allergy & rhinology

76. Adult Sinusitis Full Text available with Trip Pro

nonallergic rhinitis, vasomotor rhinitis, invasive fungal rhinosinusitis, allergic fungal rhinosinusitis, vascular headaches, and migraines. Similarly, the guideline will not consider management of rhinosinusitis in patients with the following modifying factors but will discuss the importance of assessing patients with recurrent ARS or CRS for their presence: cystic fibrosis, immotile cilia disorders, ciliary dyskinesia, immune deficiency, prior history of sinus surgery, and anatomic abnormalities (eg (...) , deviated nasal septum). Surgical management of CRS is not discussed in this guideline because of insufficient evidence (eg, randomized controlled trials) for evidence-based recommendations. Burden of Rhinosinusitis Twelve percent of the US population (nearly 1 in 8 adults) reported being diagnosed with rhinosinusitis in the prior 12 months in a 2012 national health survey. Rhinosinusitis was diagnosed more frequently than hay fever (7%), bronchitis (4%), or chronic obstructive pulmonary disease (4

2015 American Academy of Otolaryngology - Head and Neck Surgery

77. Atopic dermatitis – Diagnosis and Assessment Full Text available with Trip Pro

., Momblan-De Cabo, J. et al. Prevalence and factors linked to allergic rhinitis in 10 and 11-year-old children in Almeria. Isaac Phase II, Spain. Allergol Immunopathol (Madr) . 2010 ; 38 : 135–141 | | | , x 78 Chawes, B.L., Bonnelykke, K., Kreiner-Moller, E., and Bisgaard, H. Children with allergic and nonallergic rhinitis have a similar risk of asthma. J Allergy Clin Immunol . 2010 ; 126 : 567–573 | | | | | , x 79 Sultesz, M., Katona, G., Hirschberg, A., and Galffy, G. Prevalence and risk factors (...) in the literature search included: atopic dermatitis, atopic eczema, diagnosis, diagnostic, severity course, assessment, biomarkers, outcomes measures, morbidity, quality of life, appearance, comorbidity, food allergy, allergic rhinitis, asthma, cancer, sleep, growth effects, developmental effects, behavioral, psychological, attention deficit hyperactivity disorder (ADHD), treatment, and outcome. A total of 1417 abstracts were initially assessed for possible inclusion. After removal of duplicate data, 292 were

2014 American Academy of Dermatology

78. Atopic dermatitis – Flare prevention and use of adjunctive therapies and approaches Full Text available with Trip Pro

adults. It follows a relapsing course. AD is often associated with elevated serum immunoglobulin (IgE) levels and a personal or family history of type I allergies, allergic rhinitis, and asthma. Atopic eczema is synonymous with AD. Introduction The often protracted nature of AD necessitates setting several long-term treatment goals: the prevention of continued outbreaks, the management of comorbidities and secondary complications that arise, and minimizing adverse effects while trying to maximize (...) dermatitis is a common, chronic inflammatory dermatosis that can affect all age groups. This evidence-based guideline addresses important clinical questions that arise in its management. In this final section, treatments for flare prevention and adjunctive and complementary therapies and approaches are reviewed. Suggestions on use are given based on available evidence. Key words: , , , , , , , , , , Abbreviations used: ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ) Disclaimer

2014 American Academy of Dermatology

79. Clinical Practice Guideline for the Diagnosis and Management of Acute Bacterial Sinusitis in Children Aged 1 to 18 Years

that helps to define the severe onset of acute bacterial sinusitis. , , This presentation in children is the corollary to acute onset of headache, fever, and facial pain in adults with acute sinusitis. Allergic and nonallergic rhinitis are predisposing causes of some cases of acute bacterial sinusitis in childhood. In addition, at their onset, these conditions may be mistaken for acute bacterial sinusitis. A family history of atopic conditions, seasonal occurrences, or occurrences with exposure to common (...) allergens and other allergic diatheses in the index patient (eczema, atopic dermatitis, asthma) may suggest the presence of noninfectious rhinitis. The patient may have complaints of pruritic eyes and nasal mucosa, which will provide a clue to the likely etiology of the condition. On physical examination, there may be a prominent nasal crease, allergic shiners, cobblestoning of the conjunctiva or pharyngeal wall, or pale nasal mucosa as other indicators of the diagnosis. Key Action Statement 2A

2013 American Academy of Pediatrics

80. Exercise-induced Bronchoconstriction

to bronchoconstriction occurring as a result of exercise. Many experts advocate using the terminology “exercise-induced bronchoconstriction” instead of “exercise-induced asthma,” as it does not imply that the patient has underlying chronic asthma or that exercise actually “caused” asthma. For the purposes of this document,wewillusetheterminology“exercise-inducedbroncho- constriction” without regard to whether it occurs in patients with or without asthma. TherearesubstantialdatashowingthatEIBoccursverycom (...) of the positive studies, to also inhibit leukotrienes, thus confound- ing the speci?c role of an antihistamine effect (118). Because controlling allergies in patients with atopy with asthma leads to better asthma control in general, it seems prudent that allergic patients with asthma with EIB may bene?t from antihistamine therapy (119). Asystematicreviewoftheevidenceidenti?edthreerandom- ized trials, which were pooled. Patients with EIB who received a daily antihistamine had no signi?cant decrease

2013 American Thoracic Society

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