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Chronic Nonallergic Rhinitis

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41. Cryosurgical posterior nasal tissue ablation for the treatment of rhinitis. Full Text available with Trip Pro

Cryosurgical posterior nasal tissue ablation for the treatment of rhinitis. Endoscopic posterior nasal nerve (PNN) resection has been described as an efficacious surgical treatment of allergic and nonallergic rhinitis, but the requirement for surgery under general anesthesia has limited its acceptance. We report the first series of patients treated for chronic rhinitis using a novel device designed for office-based cryosurgical ablation of the PNN.Twenty-seven patients with chronic rhinorrhea (...) and/or nasal congestion for >3 months were recruited (allergic or nonallergic rhinitis), with minimum rhinorrhea and/or congestion subscores of 2 as part of the Total Nasal Symptom Score [TNSS]). Under local anesthesia, the cryotherapy device was applied endoscopically to the posterior middle meatus and was used to freeze the PNN region bilaterally. Patients were followed up after 7, 30, 90, 180, and 365 days to assess TNSS.The procedure was successfully completed in 100% of patients, with no complications

2017 International forum of allergy & rhinology

42. Allergic Rhinitis

plus an oral decongestant. Allergic rhinitis may occur seasonally or throughout the year (as a form of perennial rhinitis). Seasonal rhinitis is usually allergic. At least 25% of perennial rhinitis is nonallergic. Seasonal allergic rhinitis (hay fever) is most often caused by plant allergens, which vary by season. Common plant allergens include Spring: Tree pollens (eg, oak, elm, maple, alder, birch, juniper, olive) Summer: Grass pollens (eg, Bermuda, timothy, sweet vernal, orchard, Johnson (...) the frequency of both teratogen education and urine pregnancy... Video Overview of Type II Hypersensitivity SOCIAL MEDIA Add to Any Platform Loading Topic Resources Allergic rhinitis is seasonal or perennial itching, sneezing, rhinorrhea, nasal congestion, and sometimes , caused by exposure to pollens or other allergens. Diagnosis is by history and occasionally skin testing. First-line treatment is with a nasal corticosteroid (with or without an oral or a nasal antihistamine) or with an oral antihistamine

2013 Merck Manual (19th Edition)

43. Vasomotor Rhinitis

: Vasomotor Rhinitis , Nonallergic Rhinopathy , Idiopathic Nonallergic Rhinitis , Senile Rhinitis , Geriatric Rhinitis , Gustatory Rhinitis From Related Chapters II. Symptoms: Chronic (>3 months) Characteristics Allergic symptoms are typically absent (nasal, ocular or pharyngeal/palatal , sneezing, s) Wet or Dry Dry: Nasal obstruction, airway resistance and congestion Wet: predominates Mixed (congestion and ) Provocative (non-allergic triggers) Odors (e.g. perfumes, auto emissions, smoke) Spicy food (...) on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Rhinitis, Vasomotor (C0035460) Definition (MSH) A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage. Definition (MSHCZE) Vazomotorická rýma – rýma (rhinopathia, ev. rhinitis vasomotorica) projevující se záchvaty řídké sekrece z nosu a jeho ucpáním. Připomíná alergickou rýmu, patogeneticky se však uplatňují vegetativní

2018 FP Notebook

44. Long-term, Randomized Safety Study of MP29-02 (a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate in an Advanced Delivery System) in Subjects With Chronic Rhinitis. (Abstract)

Long-term, Randomized Safety Study of MP29-02 (a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate in an Advanced Delivery System) in Subjects With Chronic Rhinitis. MP29-02 is a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate (FP) in an advanced delivery system for the treatment of seasonal allergic rhinitis.The objective of this study was to evaluate the long-term safety of MP29-02 in subjects with chronic allergic (...) (perennial) or nonallergic (vasomotor) rhinitis.This was a 1-year, randomized, open-label, active-controlled, parallel-group study in subjects with chronic allergic or nonallergic rhinitis. A total of 612 subjects were randomized in a 2:1 ratio to (1) MP29-02, one spray per nostril twice daily (total daily doses of azelastine hydrochloride and FP were 548 mcg and 200 mcg, respectively); or (2) FP, 2 sprays per nostril once daily (total daily dose 200 mcg). Safety and tolerability assessments were made

2014 The journal of allergy and clinical immunology. In practice Controlled trial quality: uncertain

45. A new therapy (MP29-02) is effective for the long-term treatment of chronic rhinitis. (Abstract)

A new therapy (MP29-02) is effective for the long-term treatment of chronic rhinitis. MP29-02 (Dymista), a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP), is significantly better than first-line therapy for the treatment of moderate-to-severe seasonal allergic rhinitis (SAR), and is well tolerated following 52 weeks of continuous use in chronic rhinitis. The aim of this study was to evaluate the long-term efficacy of MP29-02 versus FP in patients (...) with chronic rhinitis.In total, 612 chronic rhinitis patients (perennial allergic rhinitis [PAR], n = 424; nonallergic rhinitis, n=188) aged 12 years or older were enrolled into this open-label, parallel-group study and randomized to MP29-02 (1 spray/nostril bid) or FP nasal spray (2 sprays/nostril qd) for 52 weeks. Efficacy was assessed by change from baseline in PM reflective total nasal symptom score (rTNSS), time to first achieve 100% PM rTNSS reduction from baseline, and percentage of symptom-free

2013 Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología Controlled trial quality: uncertain

46. Occupational and Environmental Contributions to Chronic Cough in Adults

to diagnosis and management of occupational and environmental components to chronic cough. The literature review as summarized below identi?ed articles relevant to chronic cough and occupational/ environmental factors that are categorized as: mechanisms; allergic environmental causes; chronic coughandtherecreationalandinvoluntaryinhalationof tobacco and marijuana smoke; nonallergic environmental triggers; laryngeal syndromes; and occupational diseases and exposure aspects. Although (...) syndrome, they found that 23% were due to allergic rhinitis. Symptoms associated with allergic rhinitis include nasal obstruction, clear to yellow rhinorrhea, postnasal drip, and nasal pruritus, with paroxysms of sneeze. Conjunctival pruritus and clear discharge may be associated with allergic rhinitis. Pertinent ?ndings on physical examination may include pale, boggy nasal mucosa with clear to yellow rhinorrhea. 37 Symptoms of allergic rhinitis may occur only seasonally or may occur perennially

2016 American College of Chest Physicians

47. Smoking and chronic rhinitis: effects of nasal irrigations with sulfurous-arsenical-ferruginous thermal water: A prospective, randomized, double-blind study. (Abstract)

of nasal irrigations with sulfurous-arsenical-ferruginous thermal water or isotonic sodium chloride solution in smokers with nonallergic chronic rhinosinusitis, based on clinical and olfactory evidence.The present study was a prospective, randomized, double-blind study performed in a tertiary academic referral center. Seventy smokers with nonallergic chronic rhinitis were enrolled. Nasal endoscopy, rhinomanometry, nasal cytology, and odor threshold measurements were performed in subjects randomized (...) Smoking and chronic rhinitis: effects of nasal irrigations with sulfurous-arsenical-ferruginous thermal water: A prospective, randomized, double-blind study. Smoking is a self-destructive behavior that is known to induce remodeling of the lower airways, leading to squamous metaplasia, but little is known about its effects on the nose and paranasal sinuses. Nasal irrigations are often mentioned as measures for treating sinonasal inflammations. The purpose of our study was to compare the effects

2012 American Journal of Otolaryngology Controlled trial quality: uncertain

48. Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. (Abstract)

Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. Patients with chronic allergic rhinitis (AR) and nonallergic rhinitis (NAR) often experience irritant-induced symptoms. The clinical relevance of the magnitude of their symptoms in response to these nonspecific stimuli remains unclear.To determine the internal consistency and validity of an irritant index questionnaire (IIQ) and whether reclassification of physician-diagnosed rhinitis subtypes based (...) on IIQ scores results in rhinitis subtypes with different clinical characteristics.Patients 18 to 65 years old with physician-diagnosed AR (n = 404), mixed rhinitis (MR; n = 129), or NAR (n = 123) completed an IIQ that rated rhinitis symptom severity in response to 21 nonallergic irritant triggers on a 1- to 10-point scale. Multistage sex-specific statistical analyses were performed using IIQ responses to reclassify physician-diagnosed AR, MR, and NAR into categories with high and low irritant

2012 Asthma & Immunology

49. Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China. (Abstract)

that EOS is an important risk factor for nasal polyps. In the univariate analysis, the adjusted OR was 2.01 (95% CI 1.08-3.72; p = 0.027). In the multivariate analysis, the adjusted OR was 2.02 (95% CI 1.08-3.76; p = 0.027). Compared to allergic rhinitis and normal EOS levels, nonallergic rhinitis and elevated EOS levels constituted a risk factor for CRSwNP (OR = 2.70; 95% CI 1.32-5.50). Compared to allergen-positive and EOS-normal status, allergen-negative and elevated-EOS status constituted a risk (...) factor for CRSwNP (OR = 2.95; 95% CI 1.38-6.33).EOS is a significant factor related to the morbidity of CRSwNP in Northwest China. Elevated EOS levels occurring in the context of nonallergic rhinitis constitute a risk factor for CRSwNP. Similarly, elevated EOS levels occurring in the context of allergen-negative rhinitis are also an important risk factor for morbidity of CRSwNP.© 2019 S. Karger AG, Basel.

2019 International Archives of Allergy and Immunology

50. Allergic rhinitis and secondhand tobacco smoke: a population-based study. (Abstract)

or reported skin test positive), and 117 nonallergic subjects from the same community were recruited and interviewed. A validated questionnaire was used to assess past and present SHS exposure as well as disease-specific quality of life.SHS was reported in 34/83 allergic subjects. Compared with AR subjects with no SHS exposure, subjects with AR and SHS were more likely to report a family history of chronic sinusitis (p = 0.04) and use nasal decongestants (p = 0.012). There was also a borderline (...) Allergic rhinitis and secondhand tobacco smoke: a population-based study. Allergic rhinitis (AR) is a common disease that affects approximately one-fifth of the U.S. population. Few studies have evaluated the association between secondhand tobacco smoke (SHS) exposure and the impacts on symptom severity in AR. In this study, we evaluated the association of SHS and AR in a community-based study of adult nonsmokers.In Washington County, Maryland, 83 subjects with AR (physician diagnosed

2011 American journal of rhinology & allergy

51. Microarray analysis of differentially expressed microRNAs in allergic rhinitis. (Abstract)

Microarray analysis of differentially expressed microRNAs in allergic rhinitis. Allergic rhinitis (AR) is a common disease characterized by chronic inflammation of the nasal mucosa, but we have not fully understood the mechanism responsible for the development of AR. MicroRNAs (miRNAs) are short endogenous noncoding RNAs regulating protein translation through a mechanism known as RNA interference. To understand the molecular mechanisms of miRNA involved in the pathogenesis of AR, expressed (...) miRNAs in AR were investigated through genomewide microarray analysis.Mammalian miRNA microarrays containing whole human mature and precursor miRNA sequences were used for analyzing eight samples of nasal mucosa of AR and eight samples of nonallergic patients. Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) of some different expressed miRNAs was used to confirm the array results.The miRNA microarray chip analysis identified 421 miRNAs differentially expressed in the nasal

2011 American journal of rhinology & allergy

52. Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. (Abstract)

mites, and a total nasal symptom score of at least 5 (congestion of at least 2) has been performed. Patients with asthma, chronic obstructive pulmonary disease, nonallergic rhinitis with clinical allergy associated with seasonal allergens, and other serious diseases were excluded. There were four 6-week treatment periods separated by 2-week washout periods. Twenty patients received either montelukast or antihistamine, a combination of montelukast and antihistamine, or placebo. The sequence (...) Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis. We assessed the course of treatment in patients with persistent allergic rhinitis (AR) treated with montelukast, levocetirizine, or desloratadine alone or combinations of antihistamine and montelukast.A 32-week randomized, double-blind, placebo-controlled, crossover, double-armed study in 40 adult patients with history of persistent AR, clinical allergy to house-dust

2011 American journal of rhinology & allergy Controlled trial quality: uncertain

53. Increase in the Level of Proinflammatory Cytokine HMGB1 in Nasal Fluids of Patients With Rhinitis and its Sequestration by Glycyrrhizin Induces Eosinophil Cell Death Full Text available with Trip Pro

extracellularly from immune cells or passively released from necrotic cells. Because of the ability of HMGB1 to sustain chronic inflammation, we investigated whether the protein is present in nasal fluids of patients with different forms of rhinitis.HMGB1 levels were evaluated in nasal fluids of healthy subjects or rhinitis patients who were treated or not treated with different treatments.We report that the level of HMGB1 was significantly increased in nasal fluids of patients with allergic rhinitis (...) Increase in the Level of Proinflammatory Cytokine HMGB1 in Nasal Fluids of Patients With Rhinitis and its Sequestration by Glycyrrhizin Induces Eosinophil Cell Death The nuclear protein high mobility group protein box 1 (HMGB1) is a proinflammatory mediator that belongs to the alarmin family of proinflammatory mediators, and it has recently emerged as a key player in different acute and chronic immune disorders. Several lines of evidence demonstrate that HMGB1 is actively released

2015 Clinical and experimental otorhinolaryngology

54. Clinical Consensus Statement: Pediatric Chronic Rhinosinusitis Full Text available with Trip Pro

for the otolaryngologist in the diagnosis and management of PCRS in uncomplicated pediatric patients. Keywords , , , , , Introduction Pediatric chronic rhinosinusitis (PCRS) is a commonly encountered condition in otolaryngological practice. Five percent to 13% of childhood viral upper respiratory tract infections may progress to acute rhinosinusitis, - with a proportion of these progressing to a chronic condition. PCRS may also coexist and/or be exacerbated by other widespread conditions such as allergic rhinitis (...) ) being a prominent factor in younger children and allergic rhinitis being a more important contributing factor in older children (statements 2, 5-7). Lastly, consensus was also reached that nasal endoscopic (flexible or rigid) is appropriate and useful in the diagnosis of PCRS (statement 3). There was no consensus regarding the contribution of gastroesophageal reflux disease (GERD) to PCRS ( , statement 8). Table 1. Definition and Diagnosis of Pediatric Chronic Rhinosinusitis Statements Reaching

2014 American Academy of Otolaryngology - Head and Neck Surgery

55. Nonallergic rhinitis and its association with smoking and lower airway disease: A general population study. (Abstract)

Nonallergic rhinitis and its association with smoking and lower airway disease: A general population study. The cause of nonallergic rhinitis (NAR) and its relation to lower airway disease remains unclear. The purpose of this study was to perform a descriptive analysis of the occurrence of rhinitis in a Danish general population with focus on NAR and its association with smoking and lower airway disease.A population-based, cross-sectional study conducted in Copenhagen, Denmark was performed (...) . A random sample from the general population (n = 7931; age, 18-69 years) was invited to a general health examination including measurements of serum-specific immunoglobulin E (IgE) to common aeroallergens; 3471 (44%) persons were accepted. For further analysis, we divided the population into the following groups: (I) negative specific IgE and no rhinitis (controls); (II) negative specific IgE and rhinitis (NAR); (III) positive specific IgE and rhinitis (allergic rhinitis [AR]); and (IV) positive

2011 American journal of rhinology & allergy Controlled trial quality: uncertain

56. Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis Full Text available with Trip Pro

Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis Allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis are multifactorial upper airway diseases with high prevalence. Several genetic and environmental factors are proposed to predispose to the pathogenesis of the inflammatory upper airway diseases. Still, the molecular mechanisms leading toward the onset and progression of upper airway diseases are largely unknown. The upper airway epithelium has an important (...) role in sensing the environment and regulating the inhaled air. As such, it links environmental insults to the host immunity. Human sinonasal epithelium serves as an excellent target for observing induced early-phase events, in vivo, and with a systems biological perspective. Actually, increasing number of investigations have provided evidence that altered homeostasis in the sinonasal epithelium might be important in the chronic upper airway inflammation.

2014 Current Allergy and Asthma Reports

57. Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis

of the inner lining of the nose and is characterized by the following symptoms: rhinorrhea, nasal blockage, nasal itching and/or sneezing. The cut-off point for defining rhinitis as chronic rhinitis is considered to be persisting symptoms for over more than twelve weeks Chronic rhinitis can be divided into three major subgroups; based on the knowledge of the major etiological factor: infectious rhinitis, allergic rhinitis and non-allergic, non-infectious rhinitis, in literature also referred (...) to as nonallergic rhinitis. Non-inferiority in efficacy of the two novel treatment regimes i.e. capsaicin nasal spray 0,01mM (2puffs/nostril/day) during 4 weeks and capsaicin nasal spray 0,001mM (2puffs/nostril/day) during 4 weeks compared to the current treatment of capsaicin nasal spray 0,1mM (5/day administered on a single day) with regard to the change from baseline in VAS for major nasal symptom on week 4. (Estimated placebo effect is 25%.) Condition or disease Intervention/treatment Phase Non-allergic

2014 Clinical Trials

58. Canadian clinical practice guidelines for acute and chronic rhinosinusitis

the document. These guidelines have been copublished in both Allergy, Asthma & Clinical Immunology and the Journal of Otolaryngology-Head and Neck Surgery . Allergic Rhinitis Sinusitis Budesonide Moxifloxacin Fluticasone Propionate Sinusitis refers to inflammation of a sinus, while rhinitis is inflammation of the nasal mucous membrane. The proximity between the sinus cavities and the nasal passages, as well as their common respiratory epithelium, lead to frequent simultaneous involvement of both structures (...) Canadian clinical practice guidelines for acute and chronic rhinosinusitis Canadian clinical practice guidelines for acute and chronic rhinosinusitis | Allergy, Asthma & Clinical Immunology | Full Text Advertisement Menu Search Search all BMC articles Search Menu We'd love your feedback. Please complete this 3 question Table of Contents , Gerald A Evans , Paul K Keith , Erin D Wright , Alan Kaplan , Jacques Bouchard , Anthony Ciavarella , Patrick W Doyle , Amin R Javer , Eric S Leith , Atreyi

2011 CPG Infobase

59. Rhinitis Medicamentosa (Overview)

for intranasal decongestant use can usually be identified, such as allergic or nonallergic rhinitis, acute or chronic rhinosinusitis, nasal polyps, night-time use of continuous positive airway pressure (CPAP), or upper respiratory tract infection. With regular daily use, some patients may develop rhinitis medicamentosa in 3 days, whereas others may not have evidence of rebound congestion after 4 to 6 weeks of use. [ ] Management of rhinitis medicamentosa is focused on withdrawal of intranasal decongestants (...) : allergic rhinitis executive summary. Otolaryngol Head Neck Surg . 2015 Feb. 152 (2):197-206. . Baroody FM, Brown D, Gavanescu L, DeTineo M, Naclerio RM. Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis. J Allergy Clin Immunol . 2011 Apr. 127 (4):927-34. . Meltzer EO, Bernstein DI, Prenner BM, Berger WE, Shekar T, Teper AA. Mometasone furoate nasal spray plus oxymetazoline nasal spray: short-term efficacy and safety in seasonal allergic

2014 eMedicine Pediatrics

60. Rhinitis Medicamentosa (Diagnosis)

for intranasal decongestant use can usually be identified, such as allergic or nonallergic rhinitis, acute or chronic rhinosinusitis, nasal polyps, night-time use of continuous positive airway pressure (CPAP), or upper respiratory tract infection. With regular daily use, some patients may develop rhinitis medicamentosa in 3 days, whereas others may not have evidence of rebound congestion after 4 to 6 weeks of use. [ ] Management of rhinitis medicamentosa is focused on withdrawal of intranasal decongestants (...) : allergic rhinitis executive summary. Otolaryngol Head Neck Surg . 2015 Feb. 152 (2):197-206. . Baroody FM, Brown D, Gavanescu L, DeTineo M, Naclerio RM. Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis. J Allergy Clin Immunol . 2011 Apr. 127 (4):927-34. . Meltzer EO, Bernstein DI, Prenner BM, Berger WE, Shekar T, Teper AA. Mometasone furoate nasal spray plus oxymetazoline nasal spray: short-term efficacy and safety in seasonal allergic

2014 eMedicine Pediatrics

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