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Chronic Nonallergic Rhinitis

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21. Endotypes of chronic rhinitis: a cluster analysis study. (Abstract)

to investigate the inflammatory patterns associated with the different clusters.Six endotype clusters of CR were defined in the Chinese CR patients. Patients in cluster 1 (38.6%) were diagnosed as allergic rhinitis (AR) without asthma, and in cluster 2 (13.5%) as AR with asthma, with all demonstrating positive results for local eosinophils and high levels of local and serum IgE. Similarly, patients in cluster 3 (18.6%) were diagnosed as nonallergic rhinitis with eosinophilia syndrome (NARES) without asthma (...) Endotypes of chronic rhinitis: a cluster analysis study. Chronic rhinitis (CR) is currently regarded as a syndrome, which presents as several endotypes. The aim of this study was to identify the CR endotype clusters and investigate the inflammatory patterns associated with the different endotypes.A total of 259 CR patients and 20 control subjects were enrolled in this prospective study. Twelve clinical variables were analyzed using cluster analysis and five inflammatory variables were measured

2018 Allergy

22. Nonallergic Rhinitis in the Elderly: A Reliable and Safe Therapeutic Approach. (Abstract)

Nonallergic Rhinitis in the Elderly: A Reliable and Safe Therapeutic Approach. Nonallergic rhinitis (NAR) causes significant functional and emotional impairment, affecting the quality of life (QoL) of elderly patients often suffering from other chronic diseases that require additional therapies to be added to the numerous daily medications. This study aimed to evaluate the effectiveness of crenotherapy with sodium chloride sulfate hyperthermal water rich in mineral salts on the QoL of elderly

2015 ORL; journal for oto-rhino-laryngology and its related specialties Controlled trial quality: uncertain

23. Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis

or sneezing upon exposure to nasal irritants) Patients with positive optical rhinometer (ORM) response with intranasal challenge with 0.5 mM capsaicin as described by Lambert et al 2012 Between 18-65 years of age Confirmed negative skin prick test to common allergens (which rules out allergic rhinitis) Exclusion Criteria: History of sinonasal surgery Chronic rhinosinusitis Inflammatory or granulomatous diseases Asthma Allergic rhinitis Immunocompromised state Radiation to the head and neck Intranasal (...) Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Intranasal Capsaicin

2014 Clinical Trials

24. Local expression of interleukin-17a is correlated with nasal eosinophilia and clinical severity in allergic rhinitis Full Text available with Trip Pro

Local expression of interleukin-17a is correlated with nasal eosinophilia and clinical severity in allergic rhinitis Interleukin (IL)-17A is a major cytokine produced by Th17 cells, which are associated with chronic inflammations. The local expression of IL-17A in allergic rhinitis (AR) remains to be characterized. We sought to determine the role of IL-17A expression in human inferior turbinate mucosa in the pathophysiology of AR. Inferior turbinate mucosa was sampled from medical treatment (...) -resistant, surgery-required patients with perennial AR (PAR, n = 21), nonallergic rhinitis with eosinophilia syndrome (NARES, n = 7), and nonallergic hypertrophic rhinitis (HR, n = 13). IL-17A expression was determined with immunohistochemical staining. The mean number of IL-17A(+) cells and eosinophils per field were counted. Total serum immunoglobulin E (IgE) levels, blood eosinophil count, and forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio were also examined in each

2014 Allergy & Rhinology

25. The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis

Intervention/treatment nonallergic rhinitis nonallergic rhinitis nasal allergen provocation test Procedure: nasal allergen provocation test nasal allergen provocation test Outcome Measures Go to Primary Outcome Measures : prevalence of local allergic rhinitis (LAR) [ Time Frame: 1 year ] positive nasal allergen provocation test with Der p1 Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor (...) The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2014 Clinical Trials

26. A double-blind clinical study with Monydrin tablets in patients with non-allergic chronic rhinitis. (Abstract)

A double-blind clinical study with Monydrin tablets in patients with non-allergic chronic rhinitis. Oral combination preparations (antihistamine + sympathomimetic) are widely used for nasal and sinus congestion without the presence of allergy. The use of antihistamine in these cases may be questioned. Evaluation of the clinical effect of only a sympathomimetic agent on patients with nonallergic rhinitis is performed in a double-blind clinical study on seventy patients. Phenylpropanolamine (50

1979 The Journal of international medical research Controlled trial quality: uncertain

27. Rhinitis, Allergic (Diagnosis)

, such as sinusitis or adenoid hypertrophy Computed tomography scanning: Can be very helpful for evaluating acute or chronic sinusitis Magnetic resonance imaging: Also can be helpful for evaluating sinusitis See for more detail. Management The management of allergic rhinitis consists of the following 3 major treatment strategies: Environmental control measures and allergen avoidance: These include keeping exposure to allergens such as pollen, dust mites, and mold to a minimum Pharmacologic management: Patients (...) prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet . 1998. 351:862. Romano-Zelekha O, Graif Y, Garty BZ, Livne I, Green MS, Shohat T. Trends in the prevalence of asthma symptoms and allergic diseases in Israeli adolescents: results from a national survey 2003 and comparison with 1997. J Asthma . 2007 Jun. 44(5):365-9. . Lima RG, Pastorino AC, Casagrande RR, et al. Prevalence of asthma, rhinitis and eczema in 6 - 7 years old students from the western districts of Sao Paulo

2014 eMedicine.com

28. Rhinitis, Allergic (Treatment)

pollen reported that SCIT is more effective than SLIT in controlling symptoms and in reducing the use of allergy medications in patients with seasonal allergic rhinoconjunctivitis to grass pollen. [ ] Next: Surgical Care Surgical care may be indicated for comorbid or complicating conditions, such as chronic sinusitis, severe septal deviation (causing severe obstruction), nasal polyps, or other anatomical abnormalities. Turbinoplasty may be effective for persistent allergic rhinitis when refractory (...) (substances to which the patient has IgE-mediated hypersensitivity) and avoidance of nonspecific, or irritant, triggers. Consider environmental control measures, when practical, in all cases of allergic rhinitis. [ ] However, global environmental control without identification of specific triggers is inappropriate. Pollens and outdoor molds Because of their widespread presence in the outdoor air, pollens can be difficult to avoid. Reduction of outdoor exposure during the season in which a particular type

2014 eMedicine.com

29. Rhinitis, Allergic (Overview)

, such as sinusitis or adenoid hypertrophy Computed tomography scanning: Can be very helpful for evaluating acute or chronic sinusitis Magnetic resonance imaging: Also can be helpful for evaluating sinusitis See for more detail. Management The management of allergic rhinitis consists of the following 3 major treatment strategies: Environmental control measures and allergen avoidance: These include keeping exposure to allergens such as pollen, dust mites, and mold to a minimum Pharmacologic management: Patients (...) prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet . 1998. 351:862. Romano-Zelekha O, Graif Y, Garty BZ, Livne I, Green MS, Shohat T. Trends in the prevalence of asthma symptoms and allergic diseases in Israeli adolescents: results from a national survey 2003 and comparison with 1997. J Asthma . 2007 Jun. 44(5):365-9. . Lima RG, Pastorino AC, Casagrande RR, et al. Prevalence of asthma, rhinitis and eczema in 6 - 7 years old students from the western districts of Sao Paulo

2014 eMedicine.com

30. Rhinitis, Allergic (Follow-up)

). Environmental control with the cat in situ [see comments]. Am Rev Respir Dis . 1991. 143:1334. Weber RW. Immunotherapy with allergens. JAMA . 1997 Dec 10. 278(22):1881-7. . Li JT. Immunotherapy for allergic rhinitis. Immunol Allergy Clin North Am . 2000. 20:383. Leynadier F, Banoun L, Dollois B, Terrier P, Epstein M, Guinnepain MT. Immunotherapy with a calcium phosphate-adsorbed five-grass-pollen extract in seasonal rhinoconjunctivitis: a double-blind, placebo-controlled study. Clin Exp Allergy . 2001 Jul (...) or exacerbate allergic rhinitis (see Medical Care). Previous Next: Complications See the list below: Possible complications include otitis media, eustachian tube dysfunction, acute sinusitis, and chronic sinusitis. [ ] Previous Next: Patient Education See the list below: Educate patients on environmental control measures, which involve both the avoidance of known allergens (substances to which the patient has IgE-mediated hypersensitivity) and the avoidance of nonspecific, or irritant, triggers (see Medical

2014 eMedicine.com

31. Allergic Rhinitis

, leukotrienes, kinins) cause early-phase symptoms such as sneezing, rhinorrhea, and congestion. Late-phase reactions begin 2-4 hours later and are caused by newly arrived inflammatory cells. Mediators released by these cells prolong the earlier reactions and lead to chronic inflammation. A study by Shahsavan et al found that patients with moderate to severe persistent allergic rhinitis demonstrated significantly greater interleukin 22 (IL-22) and IL-17A production than did healthy controls, suggesting (...) in fairly equal proportions. A study by Cazzoletti et al found gender-associated age-based differences in the prevalence of self-reported allergic and nonallergic rhinitis, with allergic rhinitis showing an age-based decrease in prevalence that was comparable in males and females (from 26.6% in persons aged 20-44 years to 15.6% in persons aged 65-84 years), and nonallergic rhinitis showing an age-based decrease in prevalence among females (from 12.0% in females aged 20-44 years to 7.5% in females aged

2014 eMedicine Surgery

32. Can patients with common variable immunodeficiency have allergic rhinitis? (Abstract)

included 72 adult CVID patients. The patients were divided into three groups according to their history: suggestive of AR, nonallergic rhinitis, and without rhinitis. They were tested for total and specific IgE (in vivo and in vitro).The patients' mean age was 38.2 years. A history of chronic rhinitis was observed in 59 (81.9%) of the cases, 31 of which (43%) had a history suggestive of AR. Patients with a history of rhinitis (whether allergic or nonallergic) presented an earlier onset of symptoms (...) and diagnosis of CVID. Total IgE was undetectable in 86.1% of patients. AR was confirmed by detection of specific IgE to aeroallergens in only 5.6% of the patients.In CVID patients, chronic rhinitis may be allergic, because many have personal and family histories suggestive of atopy. However, in this study, allergy was confirmed by specific IgE detection in only 5.6% of cases. CVID patients with a history suggestive of AR commonly present negative results on traditional testing, so additional experiments

2013 American journal of rhinology & allergy

33. Nonallergic rhinitis: common problem, chronic symptoms. Full Text available with Trip Pro

Nonallergic rhinitis: common problem, chronic symptoms. Nonallergic rhinitis can significantly affect a patient's quality of life. It is difficult to distinguish from allergic rhinitis, but it has different triggers, and its response to treatment can vary. We review its differential diagnosis, causes, and treatment.

2012 Cleveland Clinic Journal of Medicine

34. Prevalence of antigen-specific immunoglobulin E on mucosal brush biopsy of the inferior turbinates in patients with nonallergic rhinitis. (Abstract)

Prevalence of antigen-specific immunoglobulin E on mucosal brush biopsy of the inferior turbinates in patients with nonallergic rhinitis. This study investigates the prevalence of local, antigen-specific immunoglobulin E (IgE) from mucosal brush biopsy (MBB) of the inferior turbinates in people diagnosed with chronic, idiopathic, nonallergic rhinitis (NAR) based on negative skin and/or in vitro testing.A standard cytology brush was used to harvest epithelial cells from the inferior turbinates (...) in 18 of 20 (90%) participants. There was no significant association noted between QOL scores or self-reported seasonal symptoms and the presence of specific IgE to any of the study antigens, although the presence of white oak and ragweed IgE was significantly higher in patients tested during the pollen season.This study demonstrated that, using MBB of the inferior turbinates, antigen-specific IgE to at least 1 airborne allergen is detectable in 100% of the idiopathic, NAR study population

2014 International forum of allergy & rhinology

35. 6 endotypes of chronic rhinitis

6 endotypes of chronic rhinitis Allergy Notes: 6 endotypes of chronic rhinitis Allergy, Asthma and Immunology News Updated Daily by Board-certified Allergist at Cleveland Clinic Florida Pages 6 endotypes of chronic rhinitis 6 endotypes of chronic rhinitis with different inflammatory patterns, which may help in delivering individualized treatment: 1. 38.6% were diagnosed as allergic rhinitis (AR) without asthma , with positive results for local eosinophils and high levels of local and serum IgE (...) . 2. 13.5% as AR with asthma , with positive results for local eosinophils and high levels of local and serum IgE. 3. 18.6% were diagnosed as nonallergic rhinitis with eosinophilia syndrome (NARES) without asthma , with positive result for local eosinophils, and negative results for both local and serum IgE. 4. 4.6% were diagnosed as local allergic rhinitis (LAR) and showed positive results for local eosinophils and local IgE, but negative results for serum IgE 5. 5.0% as NARES with asthma

2018 Allergy Notes blog

36. Chapter 14: Nonallergic rhinitis. (Abstract)

the nonallergic rhinitis syndromes include gustatory rhinitis, nonallergic rhinitis with eosinophilia syndrome (NARES), atrophic, drug-induced (rhinitis medicamentosa), hormone induced, senile rhinitis (of the elderly), rhinitis associated with chronic rhinosinusitis with or without nasal polyps, and the idiopathic variant formerly known as vasomotor rhinitis but more accurately denoted as nonallergic rhinopathy (NAR). The prevalence of nonallergic rhinitis has been observed to be one-third that of allergic (...) Chapter 14: Nonallergic rhinitis. Rhinitis is characterized by one or more of the following nasal symptoms: congestion, rhinorrhea (anterior and posterior), sneezing, and itching. It is classified as allergic or nonallergic, the latter being a diverse syndrome that is characterized by symptoms of rhinitis that are not the result of IgE-mediated events. Excluding infectious rhinitis and underlying systemic diseases, clinical entities that can be classified among the disorders that make up

2013 American journal of rhinology & allergy

37. Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins. (Abstract)

Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins. Chronic rhinitis (CR) is characteristically divided into several major clinical phenotypes: allergic rhinitis (AR); nonallergic, noninfectious rhinopathy (NAR); and chronic rhinosinusitis (CRS). CRS has two phenotypic variants: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). An area of growing interest is to identify biologic markers that could assess

2016 Allergy and Asthma Proceedings

38. Cryosurgical ablation for treatment of rhinitis: A prospective multicenter study. Full Text available with Trip Pro

Cryosurgical ablation for treatment of rhinitis: A prospective multicenter study. To assess the efficacy and safety of cryoablation of the posterior nasal nerve (PNN) for treatment of chronic rhinitis.This was a prospective single-arm trial of 98 adult patients at six U.S. centers with chronic allergic and nonallergic rhinitis. PNN cryoablation was performed in-office under local anesthesia using a handheld device. Patients discontinued use of intranasal ipratropium 3 days prior to treatment (...) , P < 0.001), 3 months (3.0 ± 2.3, P < 0.001), 6 months (3.0 ± 2.1, P < 0.001), and 9 months (3.0 ± 2.4, P < 0.001) postprocedure. Nasal congestion and rhinorrhea subscores improved significantly at all time points (P < 0.001). Both allergic and nonallergic rhinitis subcohorts showed improvement (P < 0.001), with a comparable degree of improvement between groups. RQLQ significantly improved over pretreatment baseline (3.0 ± 1.0) at 3 months (1.5 ± 1.0, P < 0.001), and all RQLQ subdomains

2019 Laryngoscope

39. Perceived stress and severity of chronic rhinosinusitis in allergic and nonallergic patients. (Abstract)

Perceived stress and severity of chronic rhinosinusitis in allergic and nonallergic patients. Chronic stress exposure carries greater risk of onset of atopic respiratory disorders such as rhinitis and asthma. The interaction between depression, anxiety, and severity of chronic rhinosinusitis (CRS) has been suggested. We aimed to access the relationship between psychological stress, severity of CRS, and atopy. Sixty-three consecutive patients referred with CRS were asked to score the severity (...) of rhinosinusitis symptoms on a visual analog scale and to fill in questionnaires on the disease-specific quality of life and perceived stress-22-item Sino-Nasal Outcome Test (SNOT-22) and measure of perceived stress (MPS) scale, respectively. Inclusion criteria for the study were a reliable allergy evaluation and a recent computerized tomography (CT) scan of the sinuses. Patients with nasal polyps (NPs), asthma, and previous surgery were excluded. The study group consisted of 14 allergic and 18 nonallergic

2014 Allergy and Asthma Proceedings

40. Nasal hyperreactivity in rhinitis: a diagnostic and therapeutic challenge. Full Text available with Trip Pro

Nasal hyperreactivity in rhinitis: a diagnostic and therapeutic challenge. Although nasal hyperreactivity (NHR) is a common feature in patients suffering from allergic and nonallergic rhinitis, it is widely neglected during history taking, underdiagnosed in the majority of patients with rhinitis and rhinosinusitis, not considered as an outcome parameter in clinical trials on novel treatments for rhinitis and rhinosinusitis, and no target for routine treatment. In contrast to the simple nature (...) to the complex nature of understanding the development of NHR. As a consequence of the neglect of NHR as a key clinical feature of rhinitis and chronic rhinosinusitis (CRS), patients with NHR might be suboptimally controlled and/or dissatisfied with current treatment. We here aim to provide a comprehensive overview of current knowledge on the pathophysiology, and the available tools to diagnose and treat NHR.© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

2018 Allergy

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