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Chronic Wound

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1. NATROX oxygen wound therapy for managing diabetic foot ulcers and complex or chronic non-healing wounds

NATROX oxygen wound therapy for managing diabetic foot ulcers and complex or chronic non-healing wounds NATROX oxygen wound therapy for managing diabetic foot ulcers and complex or chronic non-healing wounds Medtech innovation briefing Published: 17 March 2020 www.nice.org.uk/guidance/mib208 pathways Summary Summary • The technology technology described in this briefing is NATROX. It is used to treat chronic non-healing and complex wounds, including diabetic foot ulcers. • The innovative (...) aspects innovative aspects are that the device delivers 98% humidified oxygen directly to the wound bed to stimulate and improve wound healing. • The intended place in therapy place in therapy would be in addition to standard care in people with chronic non-healing wounds. • The main points from the evidence main points from the evidence summarised in this briefing are from 3 studies, a randomised controlled trial and 2 observational studies – a total of 172 adults in secondary care. They show

2020 National Institute for Health and Clinical Excellence - Advice

2. LQD Spray for treating acute and chronic wounds

LQD Spray for treating acute and chronic wounds LQD Spray for treating acute and chronic wounds Medtech innovation briefing Published: 17 December 2019 www.nice.org.uk/guidance/mib202 pathways Summary Summary The technology technology described in this briefing is LQD Spray. It is for the external, local treatment of a range of acute and chronic wounds. This includes chronic leg ulcers, superficial partial thickness burns and self-harm wounds. The inno innovativ vative aspects e aspects (...) are that it is the only biopolymer wound dressing, and can be used without a secondary dressing (unless it is clinically indicated). Also, it is a natural antimicrobial and it can be used in patient self-management, although there is no published evidence on this use. The intended place in ther place in therap apy y would be instead of or in addition to other primary wound dressing options, such as foam dressings, film dressings or hydrofibre dressings for people with acute and chronic wounds. It could replace

2020 National Institute for Health and Clinical Excellence - Advice

3. EpiFix for chronic wounds

EpiFix for chronic wounds EpiFix for chronic wounds EpiFix for chronic wounds Medtech innovation briefing Published: 30 January 2018 nice.org.uk/guidance/mib139 pathways Summary Summary The technology technology described in this briefing is EpiFix, an amniotic membrane allograft comprised of dehydrated human amniotic membrane. This briefing focuses on its use in treating chronic wounds such as diabetic foot ulcers and venous leg ulcers. The inno innovativ vative aspect e aspect (...) is that it is an allograft of human amniotic membrane. It therefore differs from most wound-care products in being regulated as a human tissue product. The intended place in ther place in therap apy y would be as an alternative to other advanced wound dressings for chronic, difficult-to-heal wounds in addition to standard treatments. The main points from the e main points from the evidence vidence summarised in this briefing are from 5 studies, including 3 studies in people with difficult-to-heal diabetic foot ulcers

2018 National Institute for Health and Clinical Excellence - Advice

4. Negative pressure wound therapy for chronic wounds: home use

Negative pressure wound therapy for chronic wounds: home use Negative pressure wound therapy for chronic wounds: home use Negative pressure wound therapy for chronic wounds: home use HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Negative pressure wound therapy for chronic wounds: home use. Lansdale: HAYES, Inc.. Directory Publication (...) . 2016 Authors' objectives Negative pressure wound therapy (NPWT) is a treatment for acute, subacute, and chronic wounds that involves the application of subatmospheric pressure to the open wound, with the goal of creating a controlled, closed wound amenable to surgical closure, grafting, or healing by secondary intention. NPWT is intended as an adjunct treatment for wounds that are refractory to standard treatment. This report evaluates the effectiveness and safety of the home use of NPWT

2017 Health Technology Assessment (HTA) Database.

5. Chronic wounds: advanced wound dressings and antimicrobial dressings

Chronic wounds: advanced wound dressings and antimicrobial dressings Chronic wounds: advanced wound dressings and Chronic wounds: advanced wound dressings and antimicrobial dressings antimicrobial dressings Evidence summary Published: 30 March 2016 nice.org.uk/guidance/esmpb2 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2016. See summaries of product characteristics (SPCs), British national formulary (BNF (...) ) or the MHRA or NICE websites for up-to-date information. Overall summary This evidence summary discusses the best available evidence for advanced wound dressings and antimicrobial dressings for managing common chronic wounds (diabetic foot ulcers, pressure ulcers, venous leg ulcers and infected wounds). It includes evidence and recommendations from national guidance (if available) and the most up-to-date systematic reviews and meta-analyses (search date July 2015). Dressings should provide the optimal

2016 National Institute for Health and Clinical Excellence - Advice

6. Single-use negative pressure wound therapy for chronic and acute wounds

Single-use negative pressure wound therapy for chronic and acute wounds Single-use negative pressure wound therapy for chronic and acute wounds Single-use negative pressure wound therapy for chronic and acute wounds Klappenbach R, Ciapponi A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has (...) been made for the HTA database. Citation Klappenbach R, Ciapponi A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, López A, Rey-Ares L. Single-use negative pressure wound therapy for chronic and acute wounds. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No. 477. 2016 Authors' conclusions The evidence on the use of single use negative pressure wound therapy in chronic or acute wounds is scarce and of low-quality

2017 Health Technology Assessment (HTA) Database.

7. Oxyzyme and Iodozyme 2-layer hydrogel wound dressings with iodine for treating chronic wounds

Oxyzyme and Iodozyme 2-layer hydrogel wound dressings with iodine for treating chronic wounds Oxyzyme and Iodozyme 2-la Oxyzyme and Iodozyme 2-lay yer h er hy ydrogel wound drogel wound dressings with iodine for treating chronic wounds dressings with iodine for treating chronic wounds Medtech innovation briefing Published: 19 November 2014 nice.org.uk/guidance/mib11 pathways Summary Summary Oxyzyme and Iodozyme are chronic wound dressings that release iodine and oxygen onto the wound surface (...) and standard care. Three non-comparative case series using Oxyzyme or Iodozyme dressings for chronic wounds reported a reduction in the mean wound area over the study period. Results for case series should be interpreted with caution because of the large numbers of withdrawals, incomplete reporting of outcomes and lack of comparator. Adv Adverse e erse ev vents and safety ents and safety There were 8 withdrawals from the RCT, 2 in the control arm and 6 in the patients receiving Oxyzyme or Iodozyme

2014 National Institute for Health and Clinical Excellence - Advice

8. Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update

Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update | CADTH.ca Find the information you need Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update Published (...) on: February 2, 2017 Project Number: RB1064-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of specialist-led advanced care for chronic lower extremity wounds? What are the evidence-based guidelines regarding the multidisciplinary management of chronic lower extremity wounds Key Message Two evidence-based guidelines were identified regarding the clinical effectiveness of specialist-led advanced care

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

9. Negative pressure wound therapy for wounds healing by secondary intention

compared with each other in patients with acute or chronic skin wounds of any aetiology or localization with regard to patient-relevant outcomes. A total of 12 randomized controlled trials (RCTs) and 16 non-randomized trials up to December 2006 were found to be relevant for the benefit assessment. Each of these studies compared negative pressure wound therapy in patients with acute and chronic wounds of different aetiologies with a conventional form of wound care. These studies included a total of 1082 (...) Negative pressure wound therapy for wounds healing by secondary intention 1 Translation of Chapters 1 to 6 of the final report Vakuumversiegelungstherapie von Wunden mit intendierter sekundärer Wundheilung (Version 1.1; Status: 25 June 2019 [German original] / 20 September 2019 [English translation]). Please note: This document was translated by an external translator and is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

10. Negative pressure wound therapy for wounds healing by primary intention

therapy [1, 2]. This benefit assessment already discussed the consequences of wounds for patients, treatment options, and the fundamentals of negative pressure wound therapy (NPWT). The objective of the investigation underlying Final Report N04-03 and Rapid Report N06-02 was to assess the benefit of ? negative pressure wound therapy in comparison with conventional forms of wound care and ? different forms of negative pressure wound therapy compared with each other in patients with acute or chronic (...) skin wounds of any aetiology and localization with regard to patient-relevant outcomes. A total of 12 randomized controlled trials (RCTs) and 16 non-randomized trials up to December 2006 were found to be relevant for the benefit assessment. Each of these studies compared negative pressure wound therapy in patients with acute and chronic wounds of different aetiologies with a conventional form of wound care. These studies included a total of 1082 patients, of which 596 were included in RCTs and 486

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

11. Effectiveness of biofilm-based wound care system on wound healing in chronic wounds. (Abstract)

Effectiveness of biofilm-based wound care system on wound healing in chronic wounds. A biofilm plays a crucial role in delaying wound healing. Sharp debridement, a possible effective method for eliminating biofilms, can only be applied to the wound with visible necrotic tissue; thus, no option has been available for eliminating biofilms that are not accompanied by necrotic tissue. Wound blotting was recently developed to visualize biofilm noninvasively and quickly, and ultrasonic debridement (...) for healing of chronic wounds [Study 2]. The proportions of wound healing between wounds treated with BWCS and those with standard care in the home-visiting clinic were compared by Kaplan-Meier curve, and the Cox proportional hazard modeling was used to assess the effect of BWCS on wound healing. In Study 1, the median of biofilm removal proportion was 38.9% (interquartile range, 12.9-68.0%) for pressure ulcers treated with standard care and 65.2% (41.1-78.8%) for those treated with ultrasonic debridement

2019 Wound Repair and Regeneration

12. UrgoStart for chronic wounds

UrgoStart for chronic wounds UrgoStart for chronic wounds | Advice | NICE UrgoStart for chronic wounds Medtech innovation briefing [MIB82] Published date: October 2016 Advice This advice has been updated and replaced by . Explore © NICE [year]. All rights reserved. Subject to .

2016 National Institute for Health and Clinical Excellence - Advice

13. Woundchek Protease Status for assessing elevated protease status in chronic wounds

Woundchek Protease Status for assessing elevated protease status in chronic wounds W Woundchek Protease Status for assessing oundchek Protease Status for assessing ele elevated protease status in chronic wounds vated protease status in chronic wounds Medtech innovation briefing Published: 5 October 2016 nice.org.uk/guidance/mib83 pathways Summary Summary The technology technology described in this briefing is the Woundchek Protease Status point-of-care diagnostic test. It is designed (...) to qualitatively assess protease activity (the presence of which may impair healing) in chronic wounds. The potential inno innovativ vative e aspect aspect is that it is currently the only commercially available test that can detect whether a wound has an elevated protease status. The intended place in ther place in therap apy y would be for use by clinical staff treating chronic wounds, to aid decision-making on wound dressings. Protease modulating dressings could be chosen for wounds where elevated protease

2016 National Institute for Health and Clinical Excellence - Advice

14. [Negative pressure therapy in chronic wounds]

[Negative pressure therapy in chronic wounds] [Negative pressure therapy in chronic wounds] [Negative pressure therapy in chronic wounds] Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F (...) , García Martí S, Alcaraz A, Ciapponi A. [Negative pressure therapy in chronic wounds] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rapida No 537. 2017 Authors' conclusions Moderate-quality evidence shows that negative pressure wound therapy in patients with refractory diabetic foot ulcers shows a slight increase in healing rates, when compared with standard of care, also a slight decrease

2017 Health Technology Assessment (HTA) Database.

15. Topical oxygen therapy for chronic wound healing

Topical oxygen therapy for chronic wound healing Topical oxygen therapy for chronic wound healing Topical oxygen therapy for chronic wound healing HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Topical oxygen therapy for chronic wound healing. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Health Problem: Chronic (...) wounds are those that fail to heal with at least 30 days of optimized standard wound therapy, which usually includes cleaning, debridement, infection control, dressing, and offloading. Poor circulation is a common cause across etiologies, including diabetes. Chronic foot ulcers in people with diabetes may occur when foot injuries, such as cuts, blisters, or sores, develop, worsen, and do not heal. Sequelae can include poor healing of wounds, particularly on the feet, which can lead to amputation

2017 Health Technology Assessment (HTA) Database.

16. Best Practice Statement: Improving holistic assessment of chronic wounds

Best Practice Statement: Improving holistic assessment of chronic wounds

2018 Wounds UK

17. Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds

Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03686904 Recruitment Status : Recruiting First Posted : September 27, 2018 Last Update Posted : January

2018 Clinical Trials

18. A prospective, randomized, controlled clinical trial on the efficacy of a single-use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities. Full Text available with Trip Pro

A prospective, randomized, controlled clinical trial on the efficacy of a single-use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities. Multicenter, phase-4, randomized, comparative-efficacy study in patients with VLUs or DFUs comparing for noninferiority the percentage change in target ulcer dimensions (area, depth, and volume) a single-use negative pressure wound therapy (s-NPWT) system (...) versus traditional NPWT (t-NPWT) over a 12-week treatment period or up to confirmed healing. Baseline values were taken at the randomization visit. Randomized by wound type and size, 164 patients with non-infected DFUs and VLUs were included. The ITT population was composed of 161 patients (101 with VLUs, 60 with DFUs) and 115 patients completed follow-up (64 in the s-NPWT group and 51 in the t-NPWT group) (PP population). The average age for all patients was 61.5 years, 36.6% were women

2019 Wound Repair and Regeneration Controlled trial quality: uncertain

19. The Versajet II hydrosurgery system for surgical debridement of acute and chronic wounds and burns

The Versajet II hydrosurgery system for surgical debridement of acute and chronic wounds and burns The V The Versajet ersajet II h II hy ydrosurgery system for surgical drosurgery system for surgical debridement of acute and chronic wounds and debridement of acute and chronic wounds and burns burns Medtech innovation briefing Published: 4 February 2014 nice.org.uk/guidance/mib1 pathways Summary Summary Effectiv Effectiveness eness Six randomised controlled trials and 3 non- randomised (...) debridement (acute and chronic wounds and burns) and soft tissue debridement in people who need sharp debridement. The Versajet II hydrosurgery system is a modification of an earlier version, Versajet. No clinical evidence was found for the Versajet II hydrosurgery system. The limited information found on the differences between the Versajet II and Versajet hydrosurgery systems suggests that the clinical evidence for Versajet is likely to apply to Versajet II. There were 6 randomised controlled trials (3

2014 National Institute for Health and Clinical Excellence - Advice

20. A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen Therapy (TWO2) in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study (Abstract)

A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen Therapy (TWO2) in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study Topical oxygen has been used for the treatment of chronic wounds for more than 50 years. Its effectiveness remains disputed due to the limited number of robust high-quality investigations. The aim of this study was to assess the efficacy of multimodality cyclical pressure (...) Topical Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed to heal with standard of care (SOC) alone.Patients with diabetes and chronic DFUs were randomized (double-blind) to either active TWO2 therapy or sham control therapy-both in addition to optimal SOC. The primary outcome was the percentage of ulcers in each group achieving 100% healing at 12 weeks. A group sequential design was used for the study with three predetermined analyses and hard

2019 EvidenceUpdates

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