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Chronic Wound

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1. Single-use negative pressure wound therapy for chronic and acute wounds

Single-use negative pressure wound therapy for chronic and acute wounds Single-use negative pressure wound therapy for chronic and acute wounds Single-use negative pressure wound therapy for chronic and acute wounds Klappenbach R, Ciapponi A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has (...) been made for the HTA database. Citation Klappenbach R, Ciapponi A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, López A, Rey-Ares L. Single-use negative pressure wound therapy for chronic and acute wounds. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No. 477. 2016 Authors' conclusions The evidence on the use of single use negative pressure wound therapy in chronic or acute wounds is scarce and of low-quality

2017 Health Technology Assessment (HTA) Database.

2. Negative pressure wound therapy for chronic wounds: home use

Negative pressure wound therapy for chronic wounds: home use Negative pressure wound therapy for chronic wounds: home use Negative pressure wound therapy for chronic wounds: home use HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Negative pressure wound therapy for chronic wounds: home use. Lansdale: HAYES, Inc.. Directory Publication (...) . 2016 Authors' objectives Negative pressure wound therapy (NPWT) is a treatment for acute, subacute, and chronic wounds that involves the application of subatmospheric pressure to the open wound, with the goal of creating a controlled, closed wound amenable to surgical closure, grafting, or healing by secondary intention. NPWT is intended as an adjunct treatment for wounds that are refractory to standard treatment. This report evaluates the effectiveness and safety of the home use of NPWT

2017 Health Technology Assessment (HTA) Database.

3. Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update

Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update | CADTH.ca Find the information you need Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update Specialist-Led Management of Chronic Lower Extremity Wounds: Clinical Effectiveness and Guidelines - An Update Published (...) on: February 2, 2017 Project Number: RB1064-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of specialist-led advanced care for chronic lower extremity wounds? What are the evidence-based guidelines regarding the multidisciplinary management of chronic lower extremity wounds Key Message Two evidence-based guidelines were identified regarding the clinical effectiveness of specialist-led advanced care

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Effectiveness of biofilm-based wound care system on wound healing in chronic wounds. (PubMed)

Effectiveness of biofilm-based wound care system on wound healing in chronic wounds. A biofilm plays a crucial role in delaying wound healing. Sharp debridement, a possible effective method for eliminating biofilms, can only be applied to the wound with visible necrotic tissue; thus, no option has been available for eliminating biofilms that are not accompanied by necrotic tissue. Wound blotting was recently developed to visualize biofilm noninvasively and quickly, and ultrasonic debridement (...) for healing of chronic wounds [Study 2]. The proportions of wound healing between wounds treated with BWCS and those with standard care in the home-visiting clinic were compared by Kaplan-Meier curve, and the Cox proportional hazard modeling was used to assess the effect of BWCS on wound healing. In Study 1, the median of biofilm removal proportion was 38.9% (interquartile range, 12.9-68.0%) for pressure ulcers treated with standard care and 65.2% (41.1-78.8%) for those treated with ultrasonic debridement

2019 Wound Repair and Regeneration

5. Negative pressure wound therapy for wounds healing by secondary intention

compared with each other in patients with acute or chronic skin wounds of any aetiology or localization with regard to patient-relevant outcomes. A total of 12 randomized controlled trials (RCTs) and 16 non-randomized trials up to December 2006 were found to be relevant for the benefit assessment. Each of these studies compared negative pressure wound therapy in patients with acute and chronic wounds of different aetiologies with a conventional form of wound care. These studies included a total of 1082 (...) Negative pressure wound therapy for wounds healing by secondary intention 1 Translation of Chapters 1 to 6 of the final report Vakuumversiegelungstherapie von Wunden mit intendierter sekundärer Wundheilung (Version 1.1; Status: 25 June 2019 [German original] / 20 September 2019 [English translation]). Please note: This document was translated by an external translator and is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

6. Negative pressure wound therapy for wounds healing by primary intention

therapy [1, 2]. This benefit assessment already discussed the consequences of wounds for patients, treatment options, and the fundamentals of negative pressure wound therapy (NPWT). The objective of the investigation underlying Final Report N04-03 and Rapid Report N06-02 was to assess the benefit of ? negative pressure wound therapy in comparison with conventional forms of wound care and ? different forms of negative pressure wound therapy compared with each other in patients with acute or chronic (...) skin wounds of any aetiology and localization with regard to patient-relevant outcomes. A total of 12 randomized controlled trials (RCTs) and 16 non-randomized trials up to December 2006 were found to be relevant for the benefit assessment. Each of these studies compared negative pressure wound therapy in patients with acute and chronic wounds of different aetiologies with a conventional form of wound care. These studies included a total of 1082 patients, of which 596 were included in RCTs and 486

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

7. Topical oxygen therapy for chronic wound healing

Topical oxygen therapy for chronic wound healing Topical oxygen therapy for chronic wound healing Topical oxygen therapy for chronic wound healing HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Topical oxygen therapy for chronic wound healing. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Health Problem: Chronic (...) wounds are those that fail to heal with at least 30 days of optimized standard wound therapy, which usually includes cleaning, debridement, infection control, dressing, and offloading. Poor circulation is a common cause across etiologies, including diabetes. Chronic foot ulcers in people with diabetes may occur when foot injuries, such as cuts, blisters, or sores, develop, worsen, and do not heal. Sequelae can include poor healing of wounds, particularly on the feet, which can lead to amputation

2017 Health Technology Assessment (HTA) Database.

8. [Negative pressure therapy in chronic wounds]

[Negative pressure therapy in chronic wounds] [Negative pressure therapy in chronic wounds] [Negative pressure therapy in chronic wounds] Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F (...) , García Martí S, Alcaraz A, Ciapponi A. [Negative pressure therapy in chronic wounds] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rapida No 537. 2017 Authors' conclusions Moderate-quality evidence shows that negative pressure wound therapy in patients with refractory diabetic foot ulcers shows a slight increase in healing rates, when compared with standard of care, also a slight decrease

2017 Health Technology Assessment (HTA) Database.

9. Autologous platelet-rich plasma for treating chronic wounds. (PubMed)

Autologous platelet-rich plasma for treating chronic wounds. Autologous platelet-rich plasma (PRP) is a treatment that contains fibrin and high concentrations of growth factors with the potential to improve the healing of chronic wounds. This is the first update of a review first published in 2012.To determine whether autologous PRP promotes the healing of chronic wounds.In June 2015, for this first update, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register (...) or alternative treatments for any type of chronic wound in adults. We did not apply any date or language restrictions.We used standard Cochrane methodology, including two reviewers independently selecting studies for inclusion, extracting data, and assessing risk of bias.The search identified one new RCT, making a total of 10 included RCTs (442 participants, 42% women). The median number of participants per RCT was 29 (range 10 to 117). Four RCTs recruited people with a range of chronic wounds; three RCTs

2016 Cochrane

10. A prospective, randomized, controlled clinical trial on the efficacy of a single-use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities. (PubMed)

A prospective, randomized, controlled clinical trial on the efficacy of a single-use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities. Multicenter, phase-4, randomized, comparative-efficacy study in patients with VLUs or DFUs comparing for noninferiority the percentage change in target ulcer dimensions (area, depth, and volume) a single-use negative pressure wound therapy (s-NPWT) system (...) versus traditional NPWT (t-NPWT) over a 12-week treatment period or up to confirmed healing. Baseline values were taken at the randomization visit. Randomized by wound type and size, 164 patients with non-infected DFUs and VLUs were included. The ITT population was composed of 161 patients (101 with VLUs, 60 with DFUs) and 115 patients completed follow-up (64 in the s-NPWT group and 51 in the t-NPWT group) (PP population). The average age for all patients was 61.5 years, 36.6% were women

2019 Wound Repair and Regeneration

11. Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds

Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03686904 Recruitment Status : Recruiting First Posted : September 27, 2018 Last Update Posted : January

2018 Clinical Trials

12. Best Practice Statement: Improving holistic assessment of chronic wounds

Best Practice Statement: Improving holistic assessment of chronic wounds

2018 Wounds UK

13. Chronic wounds: advanced wound dressings and antimicrobial dressings

Chronic wounds: advanced wound dressings and antimicrobial dressings Chronic wounds: advanced wound dressings and Chronic wounds: advanced wound dressings and antimicrobial dressings antimicrobial dressings Evidence summary Published: 30 March 2016 nice.org.uk/guidance/esmpb2 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2016. See summaries of product characteristics (SPCs), British national formulary (BNF (...) ) or the MHRA or NICE websites for up-to-date information. Overall summary This evidence summary discusses the best available evidence for advanced wound dressings and antimicrobial dressings for managing common chronic wounds (diabetic foot ulcers, pressure ulcers, venous leg ulcers and infected wounds). It includes evidence and recommendations from national guidance (if available) and the most up-to-date systematic reviews and meta-analyses (search date July 2015). Dressings should provide the optimal

2016 National Institute for Health and Clinical Excellence - Advice

14. Negative pressure wound therapy technologies for chronic wound care in the home setting

Negative pressure wound therapy technologies for chronic wound care in the home setting Negative pressure wound therapy technologies for chronic wound care in the home setting Negative pressure wound therapy technologies for chronic wound care in the home setting Rhee SM, Valle MF, Wilson LM, Lazarus G, Zenilman J, Robinson KA Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been (...) made for the HTA database. Citation Rhee SM, Valle MF, Wilson LM, Lazarus G, Zenilman J, Robinson KA. Negative pressure wound therapy technologies for chronic wound care in the home setting. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment. 2014 Authors' objectives To systematically review the efficacy and safety of negative pressure wound therapy (NPWT) for treatment of chronic wounds in the home setting. Authors' conclusions We were unable

2014 Health Technology Assessment (HTA) Database.

15. CelluTome Epidermal Harvesting System for the treatment of acute or chronic wounds

CelluTome Epidermal Harvesting System for the treatment of acute or chronic wounds Health Policy Advisory Committee on Technology Technology Brief CelluTome TM Epidermal Harvesting System for the treatment of acute or chronic wounds August 2016 © State of Queensland (Queensland Department of Health) 2016 This work is licensed under a Creative Commons Attribution Non-Commercial No Derivatives 3.0 Australia licence. In essence, you are free to copy and communicate the work in its current form (...) Committee (HPC). AHMAC supports HealthPACT through funding. This brief was prepared by Hong Ju from the QH HTAE unit, and Paul Hassed from the HealthPACT Secretariat. CelluTome TM Epidermal Harvesting System: October 2016 i Summary of findings The CelluTome™ Epidermal Harvesting System is a minimally invasive skin harvesting system that produces autologous epidermal skin grafts for the treatment of acute or chronic wounds. The treatment can be used in a variety of clinical locations, including inpatient

2016 COAG Health Council - Horizon Scanning Technology Briefs

16. EpiFix for chronic wounds

EpiFix for chronic wounds EpiFix for chronic wounds EpiFix for chronic wounds Medtech innovation briefing Published: 30 January 2018 nice.org.uk/guidance/mib139 pathways Summary Summary The technology technology described in this briefing is EpiFix, an amniotic membrane allograft comprised of dehydrated human amniotic membrane. This briefing focuses on its use in treating chronic wounds such as diabetic foot ulcers and venous leg ulcers. The inno innovativ vative aspect e aspect (...) is that it is an allograft of human amniotic membrane. It therefore differs from most wound-care products in being regulated as a human tissue product. The intended place in ther place in therap apy y would be as an alternative to other advanced wound dressings for chronic, difficult-to-heal wounds in addition to standard treatments. The main points from the e main points from the evidence vidence summarised in this briefing are from 5 studies, including 3 studies in people with difficult-to-heal diabetic foot ulcers

2018 National Institute for Health and Clinical Excellence - Advice

17. Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized Wound Care Center. (PubMed)

Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized Wound Care Center. With the dramatic increase in the aging population, the study and care of wounds in the elderly have become priority topics for both researchers and clinicians. The effects of aging on wound healing in humans have remained controversial. The study was a 5-year epidemiological evaluation of standardized data collected regularly during patients' visits at a specialized Wound (...) Care Center with the aim to determine the key factors influencing the healing of chronic lower extremity wounds. In this analysis of 1,158 chronic wounds, the frequency of wound closure was statistically significantly lower in older patients compared with younger patients. The share of closed wounds decreased by nearly 25% in the elderly patients (>or=70 years). The relationship between the patient's age and the proportion of wound closure was nonlinear. The effect of aging on the frequency

2017 Wound Repair and Regeneration

18. Cost-effectiveness analysis of an innovative model of care for chronic wounds patients. (PubMed)

Cost-effectiveness analysis of an innovative model of care for chronic wounds patients. Current provision of services for the care of chronic wounds in Australia is disjointed and costly. There is large variability in the way that services are provided, and little evidence regarding the cost-effectiveness of a specialist model of care for treatment and management. A decision-analytic model to evaluate the cost-effectiveness of a specialist wound care clinic as compared to usual care for chronic (...) wounds is presented. We use retrospective and prospective data from a cohort of patients as well as information from administrative databases and published literature. Our results show specialist wound clinics are cost-effective for the management of chronic wounds. On average, specialist clinics were $3,947 cheaper than usual clinics and resulted in a quality adjusted life year gain of 0.04 per patient, per year. Specialist clinics were the best option under multiple scenarios including a different

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2019 PLoS ONE

19. Lifetime glucocorticoid profiles in baleen of right whale calves: potential relationships to chronic stress of repeated wounding by Kelp Gulls (PubMed)

Lifetime glucocorticoid profiles in baleen of right whale calves: potential relationships to chronic stress of repeated wounding by Kelp Gulls Baleen tissue accumulates stress hormones (glucocorticoids, GC) as it grows, along with other adrenal, gonadal and thyroid hormones. The hormones are deposited in a linear fashion such that a single plate of baleen allows retrospective assessment and evaluation of long-term trends in the whales' physiological condition. In whale calves, a single piece (...) australis) calves that were found dead with varying severity of chronic wounding from Kelp Gull (Larus dominicanus) attacks. In all five calves, prenatally grown baleen exhibited a distinctive profile of elevated glucocorticoids that declined shortly before birth, similar to GC profiles reported from baleen of pregnant females. After birth, GC profiles in calf baleen corresponded with the degree of wounding. The NARW calf and two SRW calves with no or few gull wounds had relatively low and constant GC

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2018 Conservation physiology

20. [CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS]. (PubMed)

[CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS]. To evaluate the effectiveness of liquid wound dressing in the treatment of chronic ulcer wounds.Between January 2014 and October 2015, 84 patients with chronic ulcer wounds were included and divided into 2 groups randomly. The chronic ulcer wounds were covered with liquid wound dressing in the treatment group (n=44) and were managed with iodophor in the control group (n=40). There was no significant difference (...) significantly lower than those in the control group (χ2=12.313, P=0.000; P=0.005), but no significant difference was found at 1 day (χ2=0.066, P=0.797). Side effect was observed in 4 cases of the control group. Vancouver scar scale score was 8.59±1.32 in the treatment group and was 9.85±1.65 in the control group, showing significant difference (t=-3.752, P=0.000).The application of the liquid wound dressing in the treatment of chronic ulcer wound can improve the wound healing rate, shorten the healing time

2018 Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

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