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Chronic Sialoadenitis

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1. Clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis: a review. (PubMed)

Clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis: a review. Immunoglobulin G4-related disease (IgG4-RD), recognized only recently as a single diagnostic entity, is a chronic inflammatory condition of unknown etiology. The diagnosis of IgG4-RD relies heavily on histopathological analysis and the correlation of histology findings with clinical, serological, and radiological data. CD4+ T and B cells, including IgG4-expressing plasmablasts (...) of the interactions between these CD4+ T cells and cells of the B lymphocyte lineage is critical to understanding the pathophysiology of IgG4-RD. The establishment of pathogenic T cell clones and the identification of antigens specific to these clones constitute the first steps in determining the pathogenesis of this disease. This review focuses on clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis, from a perspective suitable for oral and maxillofacial

2019 International Journal of Oral and Maxillofacial Surgery

2. Chronic Sialoadenitis

Chronic Sialoadenitis Chronic Sialoadenitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chronic Sialoadenitis Chronic (...) Sialoadenitis Aka: Chronic Sialoadenitis , Chronic Sialadenitis , Recurrent Parotitis , Chronic Bacterial Sialadenitis , Chronic Bacterial Parotitis , Chronic Suppurative Sialadenitis From Related Chapters II. Pathophysiology Repeated episodes of (typically ) pain and inflammation Secondary to (due to stone, stricture, scarring or external compression) stasis and acini replaced with cysts Chronic, low-grade ry gland Mixed Ultimately results in destruction Progressive ry acini destruction and fibrosis

2018 FP Notebook

3. Sialoadenitis

, Sialadenitis , Salivary Gland Infection From Related Chapters II. Definition Inflammation or infection of or duct III. Causes (Viral) ( l) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Sialoadenitis." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Sialadenitis (C0037023) Definition (NCI) An acute or chronic inflammatory process affecting a salivary (...) Adenitides , Salivary Gland Adenitis , Salivary Gland Inflammation , Inflammation, Salivary Gland , Sialadenitis, Chronic , Salivary Gland Inflammations , Chronic Sialadenitides , Sialadenitides, Chronic , Inflammations, Salivary Gland , Sialoadenitis , Adenitis, Salivary Gland , Chronic Sialadenitis , Adenitides, Salivary Gland , sialadenitis , Sialoadenitis, unspecified , Sialoadenitis NOS (disorder) , Sialoadenitis (disorder) , adenitis; salivary gland , salivary gland; adenitis , salivary gland

2018 FP Notebook

4. Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. (Full text)

Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. IgG4-related disease (IgG4-RD) is a chronic, systemic, inflammatory condition of unknown aetiology. We have recently described clonally expanded circulating CD4+ cytotoxic T lymphocytes (CTLs) in IgG4-RD that infiltrate affected tissues where they secrete interleukin (IL)-1β and transforming growth factor -β1 (TGF-β1). In this study, we sought to examine the role of CD4+ CTLs in the pathogenesis (...) of IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) and to determine whether these cells secrete interferon-gamma (IFN-γ) at lesional sites.Salivary glands of 25 patients with IgG4-DS, 22 patients with Sjögren's syndrome (SS), 12 patients with chronic sialoadenitis (CS) and 12 healthy controls were analysed in this study. Gene expression analysis was performed on submandibular glands (SMGs) from five patients with IgG4-DS, three with CS and three healthy controls. Infiltrating CD4+ CTLs were

2016 Annals of the Rheumatic Diseases PubMed

5. Chronic Sialoadenitis

Chronic Sialoadenitis Chronic Sialoadenitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chronic Sialoadenitis Chronic (...) Sialoadenitis Aka: Chronic Sialoadenitis , Chronic Sialadenitis , Recurrent Parotitis , Chronic Bacterial Sialadenitis , Chronic Bacterial Parotitis , Chronic Suppurative Sialadenitis From Related Chapters II. Pathophysiology Repeated episodes of (typically ) pain and inflammation Secondary to (due to stone, stricture, scarring or external compression) stasis and acini replaced with cysts Chronic, low-grade ry gland Mixed Ultimately results in destruction Progressive ry acini destruction and fibrosis

2015 FP Notebook

6. Sialoadenitis

, Sialadenitis , Salivary Gland Infection From Related Chapters II. Definition Inflammation or infection of or duct III. Causes (Viral) ( l) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Sialoadenitis." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Sialadenitis (C0037023) Definition (NCI) An acute or chronic inflammatory process affecting a salivary (...) Adenitides , Salivary Gland Adenitis , Salivary Gland Inflammation , Inflammation, Salivary Gland , Sialadenitis, Chronic , Salivary Gland Inflammations , Chronic Sialadenitides , Sialadenitides, Chronic , Inflammations, Salivary Gland , Sialoadenitis , Adenitis, Salivary Gland , Chronic Sialadenitis , Adenitides, Salivary Gland , sialadenitis , Sialoadenitis, unspecified , Sialoadenitis NOS (disorder) , Sialoadenitis (disorder) , adenitis; salivary gland , salivary gland; adenitis , salivary gland

2015 FP Notebook

7. Chronic cutaneous graft-versus-host disease in man. (Full text)

Chronic cutaneous graft-versus-host disease in man. This clinicopathologic study of patients with chronic graft-versus-host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoadenitis and the neurologic findings. Chronic cutaneous GVHD affected 19 of 92 recipients surviving 150 days or more. In 6 patients chronic GVHD presented as a continuation of acute (...) variable picture of poikiloderma, dermal sclerosis, and contractures. Microscopically, it resembled lupus of erythematosus profundus and scleroderma. Guidelines for defining and subclassifying chronic cutaneous GVHD are proposed.

1978 The American journal of pathology PubMed

8. [Sialendoscopy for the management of obstructive salivary gland disease]

effectiveness when it comes to resolving the salivary obstruction, namely, 74% when used alone or 93% when used on a multimodal basis. Furthermore, sialoendoscopy substantially reduces the number of sialoadenectomies performed, and its adverse effects are infrequent and mild. Its principal indications are chronic recurrent sialolithiasis, juvenile recurrent parotid sialoadenitis, radioactive iodine induced sialoadenitis and stenosis due to Sjögren's syndrome Final publication URL Indexing Status Subject

2014 Health Technology Assessment (HTA) Database.

9. Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome. (PubMed)

Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome. Sjögren syndrome (SS), a chronic autoimmune disorder causing dry mouth, adversely affects the overall oral health in patients. Activation of innate immune responses and excessive production of type I interferons (IFNs) play a critical role in the pathogenesis of this disorder. Recognition of nucleic acids by cytosolic nucleic acid sensors is a major trigger for the induction of type I IFNs. Upon activation, cytosolic DNA (...) of IFN-γ, and their numbers increased significantly within 3 d of treatment. STING expression in SGs was mainly observed in ductal and interstitial cells. In primary SG cells, DMXAA activated STING and induced IFN-β production. The DMXAA-treated mice developed autoantibodies, sialoadenitis, and glandular hypofunction. Our study demonstrates that activation of the STING pathway holds the potential to initiate SS. Thus, apart from viral infections, conditions that cause cellular perturbations

2018 Journal of Dental Research

10. Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome. (Full text)

Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome. The phosphatidylinositol 3-kinase delta isoform (PI3Kδ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism, survival, proliferation, apoptosis and migration and has been successfully targeted in B-cell malignancies. Primary Sjögren's syndrome (pSS) is a chronic immune-mediated inflammatory disease characterised by exocrine gland lymphocytic infiltration and B-cell (...) hyperactivation which results in systemic manifestations, autoantibody production and loss of glandular function. Given the central role of B cells in pSS pathogenesis, we investigated PI3Kδ pathway activation in pSS and the functional consequences of blocking PI3Kδ in a murine model of focal sialoadenitis that mimics some features of pSS.Target validation assays showed significant expression of phosphorylated ribosomal protein S6 (pS6), a downstream mediator of the phosphatidylinositol 3-kinase delta (PI3Kδ

2018 Annals of the rheumatic diseases PubMed

11. Fine needle aspiration cytology for parotid lesions, can we avoid surgery? (PubMed)

conservatively.Retrospective case series with chart review.Tertiary medical centre.From 1991 to 2014, all patients 18 or older with both preoperative FNAC and postoperative pathology report were included. Patients with a history of head and neck malignancy or chronic sialoadenitis and patients who had undergone prior oncological treatment were excluded.470 patients were available for analysis. Overall accuracy was 82.6%. Positive predictive value (PPV) varied between 88.6% and 94.3% for pleomorphic adenoma and 77.1%-100

2017 Clinical Otolaryngology

12. CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity (Full text)

were recruited together with 20 patients affected by sicca syndrome and/or chronic sialoadenitis and 30 healthy controls. Disease activity and damage were evaluated according to SS disease activity index, EULAR SS disease activity index, and SS disease damage index. T lymphocytes were analyzed for the expression of autophagy-specific markers by biochemical, molecular, and histological assays in peripheral blood and labial gland biopsies. Serum interleukin (IL)-23 and IL-21 levels were quantified (...) CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. In the current study, we aimed to investigate the possible pathogenic implication of autophagy in T lymphocytes in patients with pSS.Thirty consecutive pSS patients

2017 Arthritis research & therapy PubMed

13. Neonatal Sialadenitis

or chronic inflammatory process affecting a salivary gland. Signs and symptoms include pain and tenderness in the affected area. Definition (MSH) INFLAMMATION of salivary tissue (SALIVARY GLANDS), usually due to INFECTION or injuries. Concepts Disease or Syndrome ( T047 ) MSH ICD9 527.2 ICD10 , SnomedCT 196481002 , 196490009 , 266494007 , 155655005 , 42982001 English Sialadenitides , SIALOADENITIS , Sialoadenitis NOS , Sialadenitis , sialoadenitis , sialoadenitis (diagnosis) , Sialadenitis [Disease (...) /Finding] , Sialoadenitides , Salivary Gland Adenitides , Salivary Gland Adenitis , Salivary Gland Inflammation , Inflammation, Salivary Gland , Sialadenitis, Chronic , Salivary Gland Inflammations , Chronic Sialadenitides , Sialadenitides, Chronic , Inflammations, Salivary Gland , Sialoadenitis , Adenitis, Salivary Gland , Chronic Sialadenitis , Adenitides, Salivary Gland , sialadenitis , Sialoadenitis, unspecified , Sialoadenitis NOS (disorder) , Sialoadenitis (disorder) , adenitis; salivary gland

2018 FP Notebook

14. DNA Microarray Analysis of Submandibular Glands in IgG4-Related Disease Indicates a Role for MARCO and Other Innate Immune-Related Proteins. (Full text)

mechanism remains unclear. In this study, we sought to identify the disease-associated genes, especially innate immune molecules. Gene expression was analyzed by DNA microarray in submandibular glands (SMGs) from patients with IgG4-RD (n = 5), chronic sialoadenitis (CS) (n = 3), and controls (n = 3). Differentially expressed genes (DEGs) were validated by real-time polymerase chain reaction (PCR) and immunohistochemical staining in IgG4-RD (n = 18), CS (n = 4), Sjögren syndrome (n = 11), and controls (n

2016 Medicine PubMed

15. Xeljanz - tofacitinib citrate

Blood urea nitrogen CFB Change from baseline CHF Congestive heart failure CHOP Cyclophosphamide-hydroxydaunorubicin-oncovin-prednisone CI Confidence interval CIOMS Council for International Organization of Medical Sciences CK Creatine kinase CLt Total clearance Cmax Maximum plasma concentration Cmin Minimum plasma concentration CMV Cytomegalovirus COPD Chronic obstructive pulmonary disease CORRONA Consortium of Rheumatology Researchers of North America COX Cyclooxygenase CrI Credible intervals CRP C (...) data available and the scientific discussion within the Committee, the CHMP re-examined its initial opinion and in its final opinion concluded that the application did not satisfy the criteria for authorisation and did not recommend the granting of the marketing authorisation. 2. Scientific discussion 2.1. Introduction Problem statement Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease characterized by synovial inflammation, cartilage and bone destructions with joints

2013 European Medicines Agency - EPARs

16. Submandibular Sialadenitis/Sialadenosis

, superficial to both the hypoglossal and the lingual nerves, the latter supplying parasympathetic innervation by way of the chorda tympani nerve (from cranial nerve VII) and the submandibular ganglion. The duct of the submandibular gland, also known as the Wharton duct, exits the gland from the deep lobe, passing through the floor of the mouth, and opening in close proximity to the lingual frenulum. See the image below. Sialogram with stenosis secondary to chronic sialadenosis. Diagnosis and management (...) -0.002%, but this is unconfirmed. Race No race predilection per se exists. Sex No sex predilection per se exists. Age Although no obvious age predilection exists, per se, sialadenitis as a whole tends to occur in the older, debilitated, or dehydrated patient. [ ] Previous References Chandak R, Degwekar S, Chandak M, Rawlani S. Acute submandibular sialadenitis-a case report. Case Rep Dent . 2012. 2012:615375. . . Isacsson G, Isberg A, Haverling M, Lundquist PG. Salivary calculi and chronic

2014 eMedicine Surgery

17. Salivary Gland Tumors, Major, Benign (Overview)

peripheral enhancement consistent with Warthin tumor. In this patient with infectious sialoadenitis, note inhomogeneous, enlarged left submandibular gland with mild thickening of adjacent platysma. After radiation treatment of right parotid sialoadenitis. After radiation treatment of right sialoadenitis. Nodular and cystic changes in both parotid glands. These changes are stable in this patient with history of chronic sialoadenitis. Dense, small, solid lesions in parotid glands (more on left side than

2014 eMedicine Surgery

18. Salivary Gland Tumors, Major, Benign (Diagnosis)

peripheral enhancement consistent with Warthin tumor. In this patient with infectious sialoadenitis, note inhomogeneous, enlarged left submandibular gland with mild thickening of adjacent platysma. After radiation treatment of right parotid sialoadenitis. After radiation treatment of right sialoadenitis. Nodular and cystic changes in both parotid glands. These changes are stable in this patient with history of chronic sialoadenitis. Dense, small, solid lesions in parotid glands (more on left side than

2014 eMedicine Surgery

19. Parotid Tumors, Malignant

patients with high-grade tumors with lymph node metastasis at the time of diagnosis have a 5-year survival of only 5%. Overall 10-year survival is 50%. Differential diagnosis includes chronic sialoadenitis, , and other carcinomas. An association has been reported between mucoepidermoid carcinoma and . [ ] Adenoid cystic carcinoma The adenoid cystic carcinoma is characterized by its unpredictable behavior and propensity to spread along nerves. It possesses a highly invasive quality but may remain

2014 eMedicine Surgery

20. Sarcoidosis, Thoracic

-limiting subclinical process in 60-70% of cases. About 20-30% of patients are left with a variable degree of permanent lung damage. In 10-15% of the patients, sarcoidosis can become chronic. The incidence of ocular involvement is about 20-30%. Bilateral hilar lymphadenopathy is the most common radiographic finding. Other radiographic findings include interstitial lung disease; occasional calcification of affected lymph nodes; and rarely, pleural effusions and thickening. Because the disease so often (...) of noncaseating granulomas in biopsy specimens, and it may be useful in differentiating chronic hypersensitivity pneumonitis from sarcoidosis. [ , , , , , , , , , ] No large imaging studies are available to assess sarcoid cardiac involvement. Some have suggested a combined use of 67 Ga and thallium scans. However, the number of studies that have reported on this technique have been small and subject to significant bias. Moreover, because of patchy sarcoid cardiac involvement, endomyocardial biopsy, which

2014 eMedicine Radiology

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