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Chronic Osteomyelitis

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1. Antibiotics for treating osteomyelitis in people with sickle cell disease. (Abstract)

Antibiotics for treating osteomyelitis in people with sickle cell disease. Osteomyelitis (both acute and chronic) is one of the most common infectious complications in people with sickle cell disease. There is no standardized approach to antibiotic therapy and treatment is likely to vary from country to country. Thus, there is a need to identify the efficacy and safety of different antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis (...) to independently extract data and assess trial quality by standard Cochrane methodologies, but no eligible randomised controlled trials were identified.This update was unable to find any randomised or quasi-randomised controlled trials on antibiotic treatment approaches for osteomyelitis in people with sickle cell disease.We were unable to identify any relevant trials on the efficacy and safety of the antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis. Randomised

2019 Cochrane

2. Osteomyelitis

Osteomyelitis Osteomyelitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Osteomyelitis Last reviewed: February 2019 Last updated: May 2018 Summary Suspect osteomyelitis in those with a history of open fracture, recent orthopaedic surgery, or a discharging sinus; in the immunocompromised patient; or in the unwell child. Plain radiographs provide a good initial imaging modality for screening acute and chronic (...) osteomyelitis. Magnetic resonance imaging and computed tomography (CT) may be used to determine diagnosis and treatment decisions. In some cases positron emission tomography/CT or single-photon emission computed tomography/CT may have a role. Diagnosis must be confirmed using deep microbiological samples via radiological guided biopsy or open surgery. In chronic osteomyelitis, surgery to remove the dead bone is the primary treatment modality. Antibiotics alone cannot achieve a cure. Giving empirical

2018 BMJ Best Practice

3. Response to Early-onset Pamidronate Treatment in Chronic Non-Bacterial Osteomyelitis: A Retrospective Single Center Study. (Abstract)

Response to Early-onset Pamidronate Treatment in Chronic Non-Bacterial Osteomyelitis: A Retrospective Single Center Study. Chronic non-bacterial osteomyelitis (CNO) is a sterile inflammatory bone disorder with an unpredictable course of disease. The aim of the present study was to assess clinical and radiological disease activity in children with CNO including response to early-onset pamidronate treatment in CNO.We conducted a single center retrospective study of children fulfilling the Bristol

2019 Journal of Rheumatology

4. Total clavicle reconstruction with free peroneal graft for the surgical management of chronic nonbacterial osteomyelitis of the clavicle: a case report. Full Text available with Trip Pro

Total clavicle reconstruction with free peroneal graft for the surgical management of chronic nonbacterial osteomyelitis of the clavicle: a case report. Chronic nonbacterial osteomyelitis (CNO) is a rare chronic autoinflammatory syndrome affecting mainly children and young adults. The natural history of the disease is marked by recurrent pain as the mainstay of inflammatory outbreaks. Typical radiographic findings are osteosclerosis and hyperostosis of the medial clavicle, sternum and first rib (...) plexus and subclavian vessels. Following surgical biopsy for diagnosis confirmation, she further developed a chronic cutaneous fistula. Therefore, a two-stage total clavicle reconstruction using a vascularized peroneal graft stabilized by ligamentous reconstruction was performed. At two-year follow-up, complete pain relief and improvement of her left shoulder Constant-Murley score were observed, along with satisfactory cosmetic outcome.This case illustrates a rarely described complication of CNO

2019 BMC Musculoskeletal Disorders

5. Newer perspectives in the treatment of chronic osteomyelitis: A preliminary outcome report. (Abstract)

Newer perspectives in the treatment of chronic osteomyelitis: A preliminary outcome report. The prevalence of chronic osteomyelitis due to trauma and surgical complications does not seem to be diminishing in our society. In many African Nations, with the urbanization and shift to the larger cities that has been occurring, Trauma has been classified as the number one disease problem plaguing such societies. This brings along with it the ensuing infections. With our better understanding of how (...) microbes gain attachment to sites in our body and morph from a planktonic state to the slow growing sessile phase of growth, combined with their formation of a highly structured biofilm colony, we have come to realize that we must resort to other forms of treatment. This means changing our philosophical approach to treatment utilized over the past nearly 70 years involving complete reliance on chemotherapeutic agents with their resultant questionable efficacy in the treatment of chronic osteomyelitis

2019 Injury

6. Bacterial resistance trends among intraoperative bone culture of chronic osteomyelitis in an affiliated hospital of South China for twelve years. Full Text available with Trip Pro

Bacterial resistance trends among intraoperative bone culture of chronic osteomyelitis in an affiliated hospital of South China for twelve years. The purpose of this study was to gather temporal trends on bacteria epidemiology and resistance of intraoperative bone culture from chronic ostemyelitis at an affiliated hospital in South China.Records of patients with chronic osteomyelitis from 2003 to 2014 were retrospectively reviewed. The medical data were extracted using a unified protocol (...) to Cefotaxime and Ceftazidime were decreased from 83.3 to 36.4%.From 2003 to 2014, positive rate of intraoperative bone culture of chronic osteomyelitis was decreased; the proportion of Staphylococcus aureus was decreased gradually, and our results indicate the importance of bacterial surveilance studies about chronic osteomyelitis.

2019 BMC Infectious Diseases

7. Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis. Full Text available with Trip Pro

Physical activity and health-related quality of life in chronic non-bacterial osteomyelitis. Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often suffer from functional impairment with significant disabilities of daily life. The objective of this study was to assess physical activity, fitness and health-related quality of life (HRQOL

2019 Pediatric Rheumatology

8. Chronic non-bacterial osteomyelitis: a comparative study between children and adults. Full Text available with Trip Pro

Chronic non-bacterial osteomyelitis: a comparative study between children and adults. To compare clinical presentation, diagnostic and treatment strategies, and outcome between pediatric and adult patients with chronic non-bacterial osteomyelitis (CNO).Retrospective single-centre comparative study of pediatric and adult patients diagnosed with chronic recurrent multifocal osteomyelitis (CRMO)/CNO or synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome treated at the Medical

2019 Pediatric Rheumatology

9. The microbiology of chronic osteomyelitis: Changes over ten years. (Abstract)

The microbiology of chronic osteomyelitis: Changes over ten years. This study quantified changes in the microbiology of osteomyelitis over a ten year period from a single centre within the UK with regard to infection with multi-drug resistant (MDR) bacteria and susceptibility of antimicrobial regimens.Patients with chronic osteomyelitis undergoing definitive surgery from 2013-2017 were inluded (n = 223). Microbiology was compared to patients in a cohort from 2001-2004, using the same diagnostic (...) in both cohorts (15.2% versus 17.2%). Metalwork was associated with MDR infection (unadjusted OR 5.0; 95% CI: 1.15 to 22.0). There was no change in resistance to glycopeptide / meropenem combination treatment (2.2% vs 2.5%, p > 0.9).In this centre, rates of MRSA osteomyelitis have fallen by two thirds, over the past 10 years, in line with the reducing rate of MRSA bacteraemia nationally. A history of metalwork may predict MDR infection. A glycopeptide with an anti-pseudomonal carbapenem remains

2019 Journal of Infection

10. Current Health and Economic Burden of Chronic Diabetic Osteomyelitis. (Abstract)

Current Health and Economic Burden of Chronic Diabetic Osteomyelitis. Diabetic foot ulcer (DFU) prevalence is as high as 25% and 40-80% of DFUs become infected (DFI). About 20% of infected ulcers will spread to bone causing diabetic foot osteomyelitis (DFO). DFU costs Medicare $9-13 billion/year. The most expensive costs associated with DFU are inpatient costs and hospital admissions. DFO costs are driven mostly by surgical procedures. DFU patients have a 3-year cumulative mortality rate of 28 (...) % and rates approaching 50% in amputated patients. Areas covered: This review will summarize the current health and economic burden of DFO covering management, epidemiology, and copious costs associated with DFO. The review began by searching PubMed and Cochrane databases for various terms including, 'diabetic osteomyelitis costs,' 'diabetic foot infection,' and 'diabetes and antibiotics.' Additionally, references from retrieved publications were reviewed. The global burden of DFU calls for investigating

2019 Expert review of pharmacoeconomics & outcomes research

11. Chronic Mycobacterium avium skin and soft tissue infection complicated with scalp osteomyelitis possibly secondary to anti-interferon-γ autoantibody formation. Full Text available with Trip Pro

Chronic Mycobacterium avium skin and soft tissue infection complicated with scalp osteomyelitis possibly secondary to anti-interferon-γ autoantibody formation. Nontuberculous mycobacterial (NTM) disease is commonly an opportunistic infection frequently found in immunocompromised individuals, but sometimes can also be found in the immunocompetent hosts, especially in East Asians. The NTM separation rate in China is increasing, which reminds us to focus on NTM infections in immunocompromised (...) ) and OM (osteomyelitis) with possible secondary immunodeficiency syndrome induced by anti-interferon-γ autoantibody".

2019 BMC Infectious Diseases

12. Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus.

scintigraphy for the diagnosis of chronic osteomyelitis in patients with grade IV pressure ulcers, as compared with a standard diagnostic protocol. Ann Plast Surg. 2005;54(6):633-636. 13. Vesco L, Boulahdour H, Hamissa S, et al. The value of combined radionuclide and magnetic resonance imaging in the diagnosis and conservative management of minimal or localized osteomyelitis of the foot in diabetic patients. Metabolism. 1999;48(7):922-927. ACR Appropriateness Criteria ® 8 Suspected Osteomyelitis-Diabetic (...) , Raijmakers PG, Scholten HJ, Bakker FC, Patka P, Haarman HJ. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. J Bone Joint Surg Am. 2005;87(11):2464-2471. 29. Capriotti G, Chianelli M, Signore A. Nuclear medicine imaging of diabetic foot infection: results of meta- analysis. Nucl Med Commun. 2006;27(10):757-764. 30. Ertugrul MB, Baktiroglu S, Salman S, et al. The diagnosis of osteomyelitis of the foot in diabetes: microbiological

2019 American College of Radiology

13. Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults

Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults Quality Department Guidelines for Clinical Care Inpatient Vertebral Osteomyelitis Guideline Team Team Leader Carol E. Chenoweth, MD Infectious Diseases Team Members Benjamin S. Bassin, MD Emergency Medicine Megan R. Mack, MD Internal Medicine Mark E. Oppenlander, MD Neurosurgery Douglas J. Quint, MD Radiology F. Jacob Seagull, PhD Medical Education Consultant Rakesh D. Patel, MD Orthopaedic Surgery Initial Release August (...) results. The ultimate judgment regarding any specific clinical procedure or treatment must be made by the physician in light of the circumstances presented by the patient. Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults Patient Population: Adult patients with suspected or confirmed vertebral osteomyelitis, discitis, paravertebral abscess, or spinal epidural abscess. (This guideline does not address vertebral osteomyelitis associated with hardware placed at a previous surgery

2018 University of Michigan Health System

14. Application of antibiotic impregnated beads on the patients with tibial chronic osteomyelitis. (Abstract)

Application of antibiotic impregnated beads on the patients with tibial chronic osteomyelitis. To investigate the clinical efficacy of antibiotic impregnated beads on the tibial chronic osteomyelitis, so as to search for a more applicable method for the treatment. Through comparative analysis, we divided 72 patients with chronic tibial osteomyelitis who received treatment in hospital between January 2016 and December 2016 randomly into two groups: Control group (n=36) and the experiment group (...) % and elimination rate of bacteria was 88.0%; in the experiment group, average length of stay in hospital was ((2.2±1.3) months, average time of surgery was (2.4±1.0) times, cure rate was 47.2%, and elimination rate of bacteria was 93.8%. Differences in the average length of stay in hospital, the cure rate and elimination rate of bacteria between two groups showed statistical significance (p<0.05). For tibial chronic osteomyelitis, antibiotic impregnated bead implantation can reduce the chance of secondary

2018 Pakistan journal of pharmaceutical sciences Controlled trial quality: uncertain

15. Research on the clinical efficacy of the combination of Chinese traditional medicine and western medicine on the chronic traumatic tibial osteomyelitis. (Abstract)

Research on the clinical efficacy of the combination of Chinese traditional medicine and western medicine on the chronic traumatic tibial osteomyelitis. The research investigation is carried to observe the clinical efficacy of the combination of Chinese traditional medicine (TCM) and Western medicine on the traumatic chronic tibial osteomyelitis (CO). A total of 80 patients who were admitted to this hospital between January 2012 and January 2017 were randomly divided into two groups, i.e

2018 Pakistan journal of pharmaceutical sciences Controlled trial quality: uncertain

16. ASSESSMENT OF EFFICACY OF THE METHOD OF PROGRAMMED IRRIGATION ASPIRATION SANATION IN COMPLEX TREATMENT OF PATIENTS WITH CHRONIC POSTTRAUMATIC OSTEOMYELITIS OF THE LONG BONES. (Abstract)

ASSESSMENT OF EFFICACY OF THE METHOD OF PROGRAMMED IRRIGATION ASPIRATION SANATION IN COMPLEX TREATMENT OF PATIENTS WITH CHRONIC POSTTRAUMATIC OSTEOMYELITIS OF THE LONG BONES. The analysis of treatment results of 128 patients aged from 21 to 62 years old with chronic posttraumatic osteomyelitis of the long bones was made at the period from 2006 to 2013. The main group included 67 patients and the method of programmed irrigation aspiration sanation was applied for them. The comparison group

2018 Vestnik khirurgii imeni I. I. Grekova Controlled trial quality: uncertain

17. The Role of Free Tissue Transfer in the Management of Chronic Frontal Sinus Osteomyelitis. Full Text available with Trip Pro

The Role of Free Tissue Transfer in the Management of Chronic Frontal Sinus Osteomyelitis. Chronic frontal sinus infection is managed with a combination of medical and surgical interventions. Frontal bone osteomyelitis due to recurrent infection following trauma or prior open surgery may require more significant debridement. Free tissue transfer may allow for extensive debridement with replacement of tissue, and definitive eradication of osteomyelitis.Retrospective chart review.Patients (...) undergoing free flap obliteration of the frontal sinus for frontal bone osteomyelitis at a single institution were included in the study. Clinical, radiologic, and surgical data were collected. Surgeries before and after free flap obliteration were compared by Wilcoxon signed rank test.Fifteen patients were identified; however, one patient had less than 6 months of follow-up and was excluded from analysis. Of the remaining 14 patients, mean follow-up duration was 26 months (range, 6-120 months). Mean

2018 Laryngoscope

18. Orbital dermoid cyst presenting as chronic osteomyelitis. (Abstract)

Orbital dermoid cyst presenting as chronic osteomyelitis. A dermoid cyst is a choristoma that arises from the displacement of ectoderm to a subcutaneous location along embryonic closure lines. Rarely dermoids have a deep intraorbital component that is connected to a superficial component through a defect in bone, also known as dumbbell dermoid. We report the case of a young boy who was misdiagnosed having chronic osteomyelitis of the zygoma, based on the clinical and radiological features (...) . On surgical exploration he was found to have a dumbbell-shaped dermoid with a bony defect. Histopathological features were consistent with a diagnosis of dermoid cyst with chronic inflammation.Copyright © 2018 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

2018 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

19. Case series of psoriasis associated with tumor necrosis factor-α inhibitors in children with chronic recurrent multifocal osteomyelitis Full Text available with Trip Pro

Case series of psoriasis associated with tumor necrosis factor-α inhibitors in children with chronic recurrent multifocal osteomyelitis 30246121 2019 02 26 2352-5126 4 8 2018 Sep JAAD case reports JAAD Case Rep Case series of psoriasis associated with tumor necrosis factor-α inhibitors in children with chronic recurrent multifocal osteomyelitis. 767-771 10.1016/j.jdcr.2018.06.008 Campbell Julie Ann JA Seattle Children's Hospital, Department of Pediatrics, University of Washington, Seattle (...) , Washington. eng Case Reports 2018 09 14 United States JAAD Case Rep 101665210 2352-5126 BSA, body surface area CRMO, chronic recurrent multifocal osteomyelitis Chronic recurrent multifocal osteomyelitis HLA, human leukocyte antigen IBD, inflammatory bowel disease MRI, magnetic resonance imaging TNFi, tumor necrosis factor-α inhibitor psoriasis tumor necrosis factor inhibitor 2018 9 25 6 0 2018 9 25 6 0 2018 9 25 6 1 epublish 30246121 10.1016/j.jdcr.2018.06.008 S2352-5126(18)30158-9 PMC6141644 J Rheumatol

2018 JAAD Case Reports

20. Presurgical localization of infected avascular bone segments in chronic complicated posttraumatic osteomyelitis in the lower extremity using dual-tracer PET/CT Full Text available with Trip Pro

Presurgical localization of infected avascular bone segments in chronic complicated posttraumatic osteomyelitis in the lower extremity using dual-tracer PET/CT Localizing and removing the infected sequestrum in long-standing trauma-related chronic osteomyelitis remains a clinical challenge. PET/CT with 18F-fluorodeoxyglucose (FDG-PET) has a high sensitivity for chronic osteomyelitis and 18F-sodium-fluoride PET/CT (NaF-PET) has a high specificity for identifying non-viable bone. Combining both (...) , high signal on FDG-PET in the bone without signal on NaF-PET could potentially guide surgery to become more precise with curative intent. Eight patients with long-standing (average 22 years) posttraumatic (n = 7) or postoperative (n = 1) chronic osteomyelitis in the lower extremity and with multiple futile attempts for curative surgery were recruited in this prospective pilot study. FDG-PET and NaF-PET were performed within a week in between using standard scanning protocols. The most likely

2018 EJNMMI research

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