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Chronic Nonallergic Rhinitis

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1. The association of air pollutants and allergic and nonallergic rhinitis in chronic rhinosinusitis. (PubMed)

The association of air pollutants and allergic and nonallergic rhinitis in chronic rhinosinusitis. There has been little investigation regarding air quality and rhinitis in the pathophysiology of upper airway disease. In this study, we assessed the impact of inhalant pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on allergic rhinitis and chronic rhinosinusitis (CRS) disease severity.CRS patients with nasal polyps (CRSwNP) and without polyps (CRSsNP) were identified. Spatial (...) percent (n = 45) of patients who described rhinitis symptoms demonstrated no reactivity to aeroallergen testing. Sixty-four percent (n = 80) tested positive for at least 1 allergen, with no differences found between CRSsNP and CRSwNP (62.1% vs 67.2%). There were significant differences in air pollutants between patients testing negative and positive for allergies (nonallergic vs allergic: PM2.5 , 11.32 vs 11.07 μg/m3 , p = 0.030; BC, 0.81 vs 0.76 absorbance, p =0.044). Nonallergic CRSwNP demonstrated

2017 International forum of allergy & rhinology

2. Chronic Nonallergic Rhinitis

Chronic Nonallergic Rhinitis Chronic Nonallergic Rhinitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chronic Nonallergic Rhinitis (...) Chronic Nonallergic Rhinitis Aka: Chronic Nonallergic Rhinitis , Nonallergic Rhinitis , Non-allergic Rhinitis , Non-Infective Non-allergic Rhinitis , Atrophic Rhinitis , Hormonal Rhinitis , Occupational Rhinitis From Related Chapters II. Definitions Chronic Nonallergic Rhinitis Chronic (>3 months) without allergic or infectious cause III. Epidemiology : 20-30 Million in U.S. Accounts for 23% of cases in U.S. More common in women (by factor of 2:1 to 3:1) Age >35 years old (contrast with onset <20

2018 FP Notebook

3. Nonallergic rhinitis and its association with smoking and lower airway disease: A general population study. (PubMed)

Nonallergic rhinitis and its association with smoking and lower airway disease: A general population study. The cause of nonallergic rhinitis (NAR) and its relation to lower airway disease remains unclear. The purpose of this study was to perform a descriptive analysis of the occurrence of rhinitis in a Danish general population with focus on NAR and its association with smoking and lower airway disease.A population-based, cross-sectional study conducted in Copenhagen, Denmark was performed (...) specific IgE but no rhinitis (sensitized).We found that NAR was associated with asthma (odds ratio [OR] = 2.51 [1.87-3.37]); chronic bronchitis (OR = 2.27 [1.85-2.79]); current smoking (>15 g/day; OR = 1.57 [1.18-2.08]); lower forced expiratory volume in 1 second/forced vital capacity (FEV(1)/FVC) ratios and reduced FEV(1) values. The association with chronic bronchitis was stronger in NAR than in AR, whereas the opposite was true for asthma. FEV(1)/FVC of <70% was not significantly associated to any

2017 American journal of rhinology & allergy

4. Chapter 14: Nonallergic rhinitis. (PubMed)

the nonallergic rhinitis syndromes include gustatory rhinitis, nonallergic rhinitis with eosinophilia syndrome (NARES), atrophic, drug-induced (rhinitis medicamentosa), hormone induced, senile rhinitis (of the elderly), rhinitis associated with chronic rhinosinusitis with or without nasal polyps, and the idiopathic variant formerly known as vasomotor rhinitis but more accurately denoted as nonallergic rhinopathy (NAR). The prevalence of nonallergic rhinitis has been observed to be one-third that of allergic (...) Chapter 14: Nonallergic rhinitis. Rhinitis is characterized by one or more of the following nasal symptoms: congestion, rhinorrhea (anterior and posterior), sneezing, and itching. It is classified as allergic or nonallergic, the latter being a diverse syndrome that is characterized by symptoms of rhinitis that are not the result of IgE-mediated events. Excluding infectious rhinitis and underlying systemic diseases, clinical entities that can be classified among the disorders that make up

2017 American journal of rhinology & allergy

5. Physician perceptions of the treatment and management of allergic and nonallergic rhinitis. (PubMed)

Physician perceptions of the treatment and management of allergic and nonallergic rhinitis. Historically, rhinitis has been perceived by many clinicians in respiratory medicine as an unimportant condition. The purpose of this study was to evaluate physicians' perceptions of the impact of allergic rhinitis and chronic or nonallergic rhinitis on patients' health. This cross-sectional survey involved U.S. physicians identified from a claims database as treating patients with allergic rhinitis (...) or chronic rhinitis during a 13-month period. Responses were stratified by physicians' overall assessment of their patients' rhinitis severity, presence or absence of an allergy specialist at the practice, and agreement or disagreement that allergic rhinitis and nonallergic rhinitis should be managed similarly. Of 2614 physicians invited to participate, 766 responded. Physicians who perceived the majority of their patients as having moderate-to-severe symptoms were more likely to be prescribed more than

2017 Allergy and Asthma Proceedings

6. Natural Course of Allergic and Nonallergic Rhinitis After 2 Years in Korean Children (PubMed)

). Questionnaires regarding chronic rhinitis, a skin prick test (SPT) for 5 inhalent allergens, and specific IgE for 2 dust mites were administered. Children were classified into 4 groups: allergic rhinitis (rhinitis, positive SPT), nonallergic rhinitis (rhinitis, negative SPT), sensitization only (no rhinitis, positive SPT), and control (no rhinitis, negative SPT). We repeated follow them annually, and analyzed the data of first and third year for this study.Finally, the data of 122 children were analyzed (...) Natural Course of Allergic and Nonallergic Rhinitis After 2 Years in Korean Children Allergic and nonallergic rhinitis are very common disease for children, however, little is known about their natural courses in the general population. The purpose is to evaluate the natural course of allergic and nonallergic rhinitis in children.We analyzed data from Snoring Child Cohort of 178 children (107 boys and 71 girls). All children entered the study at the age of 7 years (range, 6.5 to 7.4 years

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2016 Clinical and experimental otorhinolaryngology

7. Hyeonggaeyeongyo-Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre-Post Study. (PubMed)

Hyeonggaeyeongyo-Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre-Post Study. Hyeonggaeyeongyo-tang (HYT) is an ancient formula of oriental medicine traditionally used to treat rhinitis; however, clinical evidence has not yet been established. The aim of this study was to investigate the short-term and long-term efficacy and safety of HYT for chronic rhinitis. Adult subjects with chronic rhinitis symptoms were recruited. The subjects received HYT for 4 (...) weeks and had follow-up period of 8 weeks. Any medicines used to treat nasal symptoms were not permitted during the study. The skin prick test was performed to distinguish the subjects with allergic rhinitis from those with nonallergic rhinitis. After treatment, the total nasal symptoms score and the Rhinoconjunctivitis Quality of Life Questionnaire score significantly improved in the whole subject group, in the allergic rhinitis group, and in the nonallergic rhinitis group, with no adverse events

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2016 Evidence-based Complementary and Alternative Medicine (eCAM)

8. Response to Nonallergenic Irritants in Children With Allergic and Nonallergic Rhinitis (PubMed)

Response to Nonallergenic Irritants in Children With Allergic and Nonallergic Rhinitis Nonallergenic irritants can aggravate the symptoms of rhinitis. We investigated the clinical responses of children with allergic rhinitis (AR) and nonallergic rhinitis (NAR) to nonallergenic irritants, and identified factors associated with these responses.Children with chronic rhinitis (n=208) were classified as having AR or NAR based on the presence of aeroallergen-specific IgE. Healthy controls (n=24) were (...) recruited for comparison. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines were used to classify patients, and their irritant score (0-21 points) and current symptom score (5-35 points) were measured. Subjects with irritant scores ≥3 and <3 were classified as having irritant and nonirritant rhinitis, respectively.The mean age of enrolled subjects was 6.8 years (range: 1.8-16.0 years). The AR and NAR groups had similar irritant scores (P=0.394) and proportions of subjects with irritant

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2016 Allergy, asthma & immunology research

9. Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis (PubMed)

Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis Allergic rhinitis (AR) is the most common allergic disease but little is known about the difference of local immune responses in children and adults with AR.To compare local immune responses between children and adults with AR and nonallergic rhinitis (NAR), and to investigate whether the association of local and systemic immune responses is different between the two age groups.Fifty-one patients with chronic (...) rhinitis were enrolled and grouped into children (N = 27, mean age 7.2 years) and adults (N = 24, mean age 29.9 years). Diagnosis of AR was based on symptoms, skin prick tests and serum specific IgEs. Nasal lavage (NAL) fluids were collected from all subjects and used to measure the levels of total IgE, specific IgEs to house dust mites (Dp and Df), and cytokines (TNF-α, IL-4, IL-10, IL-17A and IFN-γ). Flow cytometry was used to measure inflammatory cell types in NAL fluids.AR had significantly

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2016 PloS one

10. Non-allergic rhinitis

rhinitis, hormonal rhinitis, and occupational rhinitis. VMR is the most common sub-type. Kaliner MA, Baraniuk JN, Benninger M, et al. Consensus definition of nonallergic rhinopathy, previously referred to as vasomotor rhinitis, nonallergic rhinitis, and/or idiopathic rhinitis. World Allergy Organ J. 2009 Jun 15;2(6):119-20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650969/ http://www.ncbi.nlm.nih.gov/pubmed/24229320?tool=bestpractice.com To establish a definitive diagnosis of NAR, all other chronic (...) , cobblestoning of posterior pharynx from chronic post-nasal drainage, and retraction of tympanic membranes indicating congestion. A diagnosis of NAR requires negative specific IgE responses by skin or serological testing. Differentiation between non-allergic rhinitis with eosinophilia syndrome and other sub-types of NAR is determined by the presence or absence of eosinophilia in the nasal passage. Treatment is based on symptoms, and all patients should be counselled on avoidance of triggers. Symptom control

2019 BMJ Best Practice

11. Non-allergic rhinitis

rhinitis, hormonal rhinitis, and occupational rhinitis. VMR is the most common sub-type. Kaliner MA, Baraniuk JN, Benninger M, et al. Consensus definition of nonallergic rhinopathy, previously referred to as vasomotor rhinitis, nonallergic rhinitis, and/or idiopathic rhinitis. World Allergy Organ J. 2009 Jun 15;2(6):119-20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650969/ http://www.ncbi.nlm.nih.gov/pubmed/24229320?tool=bestpractice.com To establish a definitive diagnosis of NAR, all other chronic (...) , cobblestoning of posterior pharynx from chronic post-nasal drainage, and retraction of tympanic membranes indicating congestion. A diagnosis of NAR requires negative specific IgE responses by skin or serological testing. Differentiation between non-allergic rhinitis with eosinophilia syndrome and other sub-types of NAR is determined by the presence or absence of eosinophilia in the nasal passage. Treatment is based on symptoms, and all patients should be counselled on avoidance of triggers. Symptom control

2018 BMJ Best Practice

12. Endotypes of chronic rhinitis: a cluster analysis study. (PubMed)

Endotypes of chronic rhinitis: a cluster analysis study. Chronic rhinitis (CR) is currently regarded as a syndrome, which presents as several endotypes. The aim of this study was to identify the CR endotype clusters and investigate the inflammatory patterns associated with the different endotypes.A total of 259 CR patients and 20 control subjects were enrolled in this prospective study. Twelve clinical variables were analyzed using cluster analysis and five inflammatory variables were measured (...) to investigate the inflammatory patterns associated with the different clusters.Six endotype clusters of CR were defined in the Chinese CR patients. Patients in cluster 1 (38.6%) were diagnosed as allergic rhinitis (AR) without asthma, and in cluster 2 (13.5%) as AR with asthma, with all demonstrating positive results for local eosinophils and high levels of local and serum IgE. Similarly, patients in cluster 3 (18.6%) were diagnosed as nonallergic rhinitis with eosinophilia syndrome (NARES) without asthma

2018 Allergy

13. Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. (PubMed)

identify the safety, efficacy, and durability of treatment response of cryotherapy in treating chronic rhinitis.A systematic literature review was performed to identify studies that investigated the utility of cryotherapy in chronic rhinitis. Only studies with the primary objective of assessing the efficacy of cryotherapy on chronic rhinitis were included. Patients were classified as allergic rhinitis, nonallergic rhinitis (vasomotor rhinitis), or mixed rhinitis using the original author's criteria (...) Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. Chronic rhinitis impacts 60 million Americans and is associated with significant costs for patients. Although medical treatments are first line, some patients require surgical intervention such as vidian or posterial nasal neurectomy. Previous reviews have investigated the role of surgical management in chronic rhinitis, but none have investigated a longstanding treatment with recent interest: cryotherapy.To

2018 American journal of rhinology & allergy

14. 6 endotypes of chronic rhinitis

6 endotypes of chronic rhinitis Allergy Notes: 6 endotypes of chronic rhinitis Allergy, Asthma and Immunology News Updated Daily by Board-certified Allergist at Cleveland Clinic Florida Pages 6 endotypes of chronic rhinitis 6 endotypes of chronic rhinitis with different inflammatory patterns, which may help in delivering individualized treatment: 1. 38.6% were diagnosed as allergic rhinitis (AR) without asthma , with positive results for local eosinophils and high levels of local and serum IgE (...) . 2. 13.5% as AR with asthma , with positive results for local eosinophils and high levels of local and serum IgE. 3. 18.6% were diagnosed as nonallergic rhinitis with eosinophilia syndrome (NARES) without asthma , with positive result for local eosinophils, and negative results for both local and serum IgE. 4. 4.6% were diagnosed as local allergic rhinitis (LAR) and showed positive results for local eosinophils and local IgE, but negative results for serum IgE 5. 5.0% as NARES with asthma

2018 Allergy Notes blog

15. Nonallergic Rhinitis in the Elderly: A Reliable and Safe Therapeutic Approach. (PubMed)

Nonallergic Rhinitis in the Elderly: A Reliable and Safe Therapeutic Approach. Nonallergic rhinitis (NAR) causes significant functional and emotional impairment, affecting the quality of life (QoL) of elderly patients often suffering from other chronic diseases that require additional therapies to be added to the numerous daily medications. This study aimed to evaluate the effectiveness of crenotherapy with sodium chloride sulfate hyperthermal water rich in mineral salts on the QoL of elderly

2015 ORL; journal for oto-rhino-laryngology and its related specialties

16. Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis. (PubMed)

Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis. An increased production of several chemoattractants, responsible for guiding the eosinophilic inflammatory process, has been reported in chronic rhinitis. The aim of this study was to evaluate nasal secretion levels of monocyte chemoattractant protein-1 (MCP-1), MCP-3, and regulated on activation normal T cell expressed and secreted (RANTES) and to correlate those levels with nasal (...) symptoms and degree of eosinophilia in patients with nonallergic rhinitis with eosinophilia syndrome (NARES) and perennial allergic rhinitis (PAR).Fourteen patients with PAR and 14 NARES patients were recruited for this cross-sectional study. Fourteen healthy subjects were included as controls. The concentrations of MCP-1, MCP-3, and RANTES in nasal secretions were measured using enzyme-linked immunosorbent assay (ELISA). Eosinophil counts were performed by percentage of differential granulocyte counts

2015 International forum of allergy & rhinology

17. Nasal provocation test is useful for discriminating allergic, nonallergic, and local allergic rhinitis. (PubMed)

Nasal provocation test is useful for discriminating allergic, nonallergic, and local allergic rhinitis. No standard study protocol or diagnostic criteria based on nasal provocation test (NPT) and acoustic rhinometry (AR) results are available for allergic rhinitis.We aimed to evaluate the usefulness of NPT plus AR for the differential diagnosis of local allergic rhinitis (LAR), allergic, and nonallergic rhinitis.The medical records and skin-prick test (SPT) and NPT results of 262 patients (...) with symptoms of chronic rhinitis were reviewed. Patients were allocated to one of three groups, that is, group A [n = 110, negative SPT result for Dermatophagoides pteronyssinus (DP)], group B (n = 53, weakly positive result), or group C (n = 99, strongly positive result).Twelve patients had a negative SPT result and provoked response in NPT [≥29% decrease of minimal cross-sectional area (MCA) after DP challenge] were diagnosed to have LAR. After DP challenge, group C showed significant aggravation

2015 American journal of rhinology & allergy

18. Relationships among rhinitis, fibromyalgia, and chronic fatigue. (PubMed)

Relationships among rhinitis, fibromyalgia, and chronic fatigue. New information about the pathophysiology of idiopathic nonallergic rhinopathy indicates a high prevalence in chronic fatigue syndrome (CFS). This article shows the relevance of CFS and allied disorders to allergy practice. CFS has significant overlap with systemic hyperalgesia (fibromyalgia), autonomic dysfunction (irritable bowel syndrome and migraine headaches), sensory hypersensitivity (dyspnea; congestion; rhinorrhea (...) ; and appreciation of visceral nociception in the esophagus, gastrointestinal tract, bladder, and other organs), and central nervous system maladaptations (central sensitization) recorded by functional magnetic resonance imaging (fMRI). Neurological dysfunction may account for the overlap of CFS with idiopathic nonallergic rhinopathy. Scientific advances are in fMRI, nociceptive sensor expression, and, potentially, infection with xenotropic murine leukemia-related virus provide additional insights to novel

2017 Allergy and Asthma Proceedings

19. Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. (PubMed)

Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. No diagnostic test had been specifically developed to diagnose nonallergic rhinitis (NAR). Also a negative nasal smear for eosinophils does not rule out the diagnosis. There is a significant diagnostic problem in patients with NAR. How can we solve this problem?Assessment of other cells than eosinophils present in the cytogram such as basophils, neutrophils, and goblet cells may help us to classify and management (...) , neutrophilic, eosinophilic, mixed, and nonallergic noninfectious type. So the frequency rates of the subgroups were calculated and also smear cytologic results were compared.Frequency of AR was approximately equal to NAR in subjects with chronic rhinitis. Neutrophilic, eosinophilic, mixed, and nonallergic noninfectious types were the common types of NAR. An evident nasal eosinophilia was found in AR and eosinophilic NAR, whereas a higher percentage of goblet cells were determined in nonallergic

2017 American Journal of Otolaryngology

20. Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins. (PubMed)

Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins. Chronic rhinitis (CR) is characteristically divided into several major clinical phenotypes: allergic rhinitis (AR); nonallergic, noninfectious rhinopathy (NAR); and chronic rhinosinusitis (CRS). CRS has two phenotypic variants: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). An area of growing interest is to identify biologic markers that could assess

2016 Allergy and Asthma Proceedings

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