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Chronic Nonallergic Rhinitis

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1. Treatments for Seasonal Allergic Rhinitis

Preventive Services Task Force (USPSTF) Criteria for Randomized Controlled Trials (RCTs) Appendix F. McMaster Quality Assessment Scale of Harms (McHarm)ES-1 Executive Summary Background Seasonal allergic rhinitis (SAR), also known as hay fever, is an allergic reaction in the upper airways that occurs when sensitized individuals encounter airborne allergens (typically tree, grass, and weed pollens and some molds). SAR afflicts approximately 10 percent of the U.S. population, or 30 million individuals. 1,2 (...) Although pollen seasons vary across the United States, generally, tree pollens emerge in the spring, grass pollens in the summer, and weed pollens in the fall. Outdoor molds generally are prevalent in the summer and fall. SAR is distinguished from perennial allergic rhinitis (PAR), which is triggered by continuous exposure to house dust mites, animal dander, and other allergens generally found in an individual’s indoor environment. Patients may have either SAR or PAR or both (i.e., PAR with seasonal

2013 Effective Health Care Program (AHRQ)

2. Non-allergic rhinitis

, cobblestoning of posterior pharynx from chronic post-nasal drainage, and retraction of tympanic membranes indicating congestion. A diagnosis of NAR requires negative specific IgE responses by skin or serological testing. Differentiation between non-allergic rhinitis with eosinophilia syndrome and other sub-types of NAR is determined by the presence or absence of eosinophilia in the nasal passage. Treatment is based on symptoms, and all patients should be counselled on avoidance of triggers. Symptom control (...) and nasal polyposis, or, less commonly, tumour or foreign body. Definition Non-allergic rhinitis (NAR) refers to a group of chronic rhinitis sub-types that are not caused by allergy or infection. At least eight sub-types have been proposed, including vasomotor rhinitis (VMR [also known as 'autonomic rhinitis', 'non-allergic rhinopathy', and 'idiopathic non-allergic rhinitis']), non-allergic rhinitis with eosinophilia syndrome (NARES), atrophic rhinitis, senile rhinitis, gustatory rhinitis, drug-induced

2019 BMJ Best Practice

3. Non-allergic rhinitis

, cobblestoning of posterior pharynx from chronic post-nasal drainage, and retraction of tympanic membranes indicating congestion. A diagnosis of NAR requires negative specific IgE responses by skin or serological testing. Differentiation between non-allergic rhinitis with eosinophilia syndrome and other sub-types of NAR is determined by the presence or absence of eosinophilia in the nasal passage. Treatment is based on symptoms, and all patients should be counselled on avoidance of triggers. Symptom control (...) and nasal polyposis, or, less commonly, tumour or foreign body. Definition Non-allergic rhinitis (NAR) refers to a group of chronic rhinitis sub-types that are not caused by allergy or infection. At least eight sub-types have been proposed, including vasomotor rhinitis (VMR [also known as 'autonomic rhinitis', 'non-allergic rhinopathy', and 'idiopathic non-allergic rhinitis']), non-allergic rhinitis with eosinophilia syndrome (NARES), atrophic rhinitis, senile rhinitis, gustatory rhinitis, drug-induced

2018 BMJ Best Practice

4. Allergic and nonallergic rhinitis. (Abstract)

to vasoconstriction. The diagnosis of rhinitis begins with a directed history, particularly noting pattern, chronicity, and triggers of symptoms. Examination of the nasal cavity with attention to appearance of the septum and inferior turbinates is recommended. Skin testing for aeroallergens is helpful in demonstrating the presence or absence of immunoglobulin E antibodies and to differentiate nonallergic from allergic rhinitis. Treatment includes patient education, irritant or allergen avoidance (...) Allergic and nonallergic rhinitis. Rhinitis is characterized by nasal congestion, rhinorrhea, sneezing, and/or posterior nasal drainage. It affects a significant portion of the population and presents a large burden economically and on quality of life. Rhinitis is broadly characterized as allergic and nonallergic, of which nonallergic rhinitis may be divided into inflammatory and noninflammatory etiologies. The inflammatory causes include nonallergic rhinitis with eosinophilia, postinfectious

2019 Allergy and Asthma Proceedings

5. The association of air pollutants and allergic and nonallergic rhinitis in chronic rhinosinusitis. (Abstract)

The association of air pollutants and allergic and nonallergic rhinitis in chronic rhinosinusitis. There has been little investigation regarding air quality and rhinitis in the pathophysiology of upper airway disease. In this study, we assessed the impact of inhalant pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on allergic rhinitis and chronic rhinosinusitis (CRS) disease severity.CRS patients with nasal polyps (CRSwNP) and without polyps (CRSsNP) were identified. Spatial (...) percent (n = 45) of patients who described rhinitis symptoms demonstrated no reactivity to aeroallergen testing. Sixty-four percent (n = 80) tested positive for at least 1 allergen, with no differences found between CRSsNP and CRSwNP (62.1% vs 67.2%). There were significant differences in air pollutants between patients testing negative and positive for allergies (nonallergic vs allergic: PM2.5 , 11.32 vs 11.07 μg/m3 , p = 0.030; BC, 0.81 vs 0.76 absorbance, p =0.044). Nonallergic CRSwNP demonstrated

2017 International forum of allergy & rhinology

6. Allergic rhinitis

Allergic rhinitis Allergic rhinitis - NICE CKS Share Allergic rhinitis: Summary Allergic rhinitis is an IgE-mediated inflammatory disorder of the nose which occurs when the nasal mucosa becomes exposed and sensitized to allergens, to produce typical symptoms of sneezing, nasal itching, discharge (rhinorrhoea), and congestion. Allergic rhinitis may be classified according to: Seasonal — symptoms occur at the same time each year. If caused by grass and tree pollen allergens, it is also known (...) as 'hay fever'. Perennial — symptoms occur throughout the year, typically due to allergens from house dust mites and animal dander. Intermittent — symptoms occur for less than four days a week, or less than four consecutive weeks. Persistent — symptoms occur for more than four days a week and for more than four consecutive weeks. Occupational — symptoms due to exposure to allergens in the work environment, for example, flour allergy in a baker. Allergic rhinitis is common and its prevalence

2018 NICE Clinical Knowledge Summaries

7. Allergic Rhinitis

surveyed for “hay fever,” “current allergies,” and “current rhinitis” and tested for IgE specific to 19 inhalant allergens. One in 3 participants reported rhinitis symptoms within the last 12 months not associated with an upper respiratory infection. Of those with rhinitis, 52.7% demonstrated at least 1 positive allergy test. By this standard, IgE-mediated AR may affect 1 in 6 persons within the United States. The United States population is most commonly sensitized to grass pollen, dust mites (...) Bloomfield Hospital, 6777 West Maple Rd, West Bloomfield, MI 48322, USA. Email: Abstract Objective Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is estimated to affect nearly 1 in every 6 Americans and generates $2 to $5 billion in direct health expenditures annually. It can impair quality of life and, through loss of work

2015 American Academy of Otolaryngology - Head and Neck Surgery

8. Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis. (Abstract)

Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis. Local allergic rhinitis (LAR) is characterized by chronic rhinitis with localized nasal allergic response to allergens in the absence of systemic immunoglobulin (IgE)-mediated disease assessed by skin prick test (SPT) or specific serum IgE level. Nasal provocation test (NPT) is the gold standard for the diagnosis of LAR. Nasal eosinophilia is a known inflammatory marker in allergic rhinitis. We hypothesized that nasal eosinophilia (...) can be used as a screening tool for LAR.To determine the applicability of nasal eosinophilia as a diagnostic tool for LAR.Forty-eight perennial nonallergic rhinitis (NAR) patients with SPT negative were recruited. Nasal cytology analysis was performed. NPTs with 3 allergens (mixed mites, mixed cockroaches, and Bermuda grass) were performed to diagnose LAR. Nasal symptoms combined with nasal patency were used to determine the results of NPT. The sensitivity, specificity, positive predictive value

2019 American journal of rhinology & allergy

9. Nasal provocation test is useful for discriminating allergic, nonallergic, and local allergic rhinitis. (Abstract)

Nasal provocation test is useful for discriminating allergic, nonallergic, and local allergic rhinitis. No standard study protocol or diagnostic criteria based on nasal provocation test (NPT) and acoustic rhinometry (AR) results are available for allergic rhinitis.We aimed to evaluate the usefulness of NPT plus AR for the differential diagnosis of local allergic rhinitis (LAR), allergic, and nonallergic rhinitis.The medical records and skin-prick test (SPT) and NPT results of 262 patients (...) or equal to 27.6%" had 73.4% sensitivity and 58.1% specificity.NPT with AR could be a useful tool for the differential diagnosis of allergic, nonallergic, and local allergic rhinitis.

2015 American journal of rhinology & allergy

10. Hyeonggaeyeongyo-Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre-Post Study. Full Text available with Trip Pro

Hyeonggaeyeongyo-Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre-Post Study. Hyeonggaeyeongyo-tang (HYT) is an ancient formula of oriental medicine traditionally used to treat rhinitis; however, clinical evidence has not yet been established. The aim of this study was to investigate the short-term and long-term efficacy and safety of HYT for chronic rhinitis. Adult subjects with chronic rhinitis symptoms were recruited. The subjects received HYT for 4 (...) weeks and had follow-up period of 8 weeks. Any medicines used to treat nasal symptoms were not permitted during the study. The skin prick test was performed to distinguish the subjects with allergic rhinitis from those with nonallergic rhinitis. After treatment, the total nasal symptoms score and the Rhinoconjunctivitis Quality of Life Questionnaire score significantly improved in the whole subject group, in the allergic rhinitis group, and in the nonallergic rhinitis group, with no adverse events

2016 Evidence-based Complementary and Alternative Medicine (eCAM)

11. Response to Nonallergenic Irritants in Children With Allergic and Nonallergic Rhinitis Full Text available with Trip Pro

Response to Nonallergenic Irritants in Children With Allergic and Nonallergic Rhinitis Nonallergenic irritants can aggravate the symptoms of rhinitis. We investigated the clinical responses of children with allergic rhinitis (AR) and nonallergic rhinitis (NAR) to nonallergenic irritants, and identified factors associated with these responses.Children with chronic rhinitis (n=208) were classified as having AR or NAR based on the presence of aeroallergen-specific IgE. Healthy controls (n=24) were (...) recruited for comparison. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines were used to classify patients, and their irritant score (0-21 points) and current symptom score (5-35 points) were measured. Subjects with irritant scores ≥3 and <3 were classified as having irritant and nonirritant rhinitis, respectively.The mean age of enrolled subjects was 6.8 years (range: 1.8-16.0 years). The AR and NAR groups had similar irritant scores (P=0.394) and proportions of subjects with irritant

2016 Allergy, asthma & immunology research

12. Natural Course of Allergic and Nonallergic Rhinitis After 2 Years in Korean Children Full Text available with Trip Pro

). Questionnaires regarding chronic rhinitis, a skin prick test (SPT) for 5 inhalent allergens, and specific IgE for 2 dust mites were administered. Children were classified into 4 groups: allergic rhinitis (rhinitis, positive SPT), nonallergic rhinitis (rhinitis, negative SPT), sensitization only (no rhinitis, positive SPT), and control (no rhinitis, negative SPT). We repeated follow them annually, and analyzed the data of first and third year for this study.Finally, the data of 122 children were analyzed (...) Natural Course of Allergic and Nonallergic Rhinitis After 2 Years in Korean Children Allergic and nonallergic rhinitis are very common disease for children, however, little is known about their natural courses in the general population. The purpose is to evaluate the natural course of allergic and nonallergic rhinitis in children.We analyzed data from Snoring Child Cohort of 178 children (107 boys and 71 girls). All children entered the study at the age of 7 years (range, 6.5 to 7.4 years

2016 Clinical and experimental otorhinolaryngology

13. Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis Full Text available with Trip Pro

Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis Allergic rhinitis (AR) is the most common allergic disease but little is known about the difference of local immune responses in children and adults with AR.To compare local immune responses between children and adults with AR and nonallergic rhinitis (NAR), and to investigate whether the association of local and systemic immune responses is different between the two age groups.Fifty-one patients with chronic (...) fluids (r = 0.373, P = 0.061).Elevated local IgE is a common feature of AR in children and adults. Local measures in NAR showed naïve state of immune response which disagree with the hypothesis of local allergic rhinitis. Children showed intense local inflammation and close local-systemic interactions compared to adults supporting pediatric AR as a distinct feature.

2016 PloS one

14. Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis. (Abstract)

Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis. An increased production of several chemoattractants, responsible for guiding the eosinophilic inflammatory process, has been reported in chronic rhinitis. The aim of this study was to evaluate nasal secretion levels of monocyte chemoattractant protein-1 (MCP-1), MCP-3, and regulated on activation normal T cell expressed and secreted (RANTES) and to correlate those levels with nasal (...) symptoms and degree of eosinophilia in patients with nonallergic rhinitis with eosinophilia syndrome (NARES) and perennial allergic rhinitis (PAR).Fourteen patients with PAR and 14 NARES patients were recruited for this cross-sectional study. Fourteen healthy subjects were included as controls. The concentrations of MCP-1, MCP-3, and RANTES in nasal secretions were measured using enzyme-linked immunosorbent assay (ELISA). Eosinophil counts were performed by percentage of differential granulocyte counts

2015 International forum of allergy & rhinology

15. Allergic Rhinitis

the patient’s continuous exposure to the offending allergen (e.g., animal, house dust mites, occupational exposures). Distinguishing prevalence rates of seasonal versus perennial allergic rhinitis is complicated by two factors: first, epidemiologic studies have focused primarily on seasonal allergic rhinitis (e.g., hay fever), and second, the symptom complex of perennial allergic rhinitis overlaps with those of seasonal allergic rhinitis, chronic sinusitis, recurrent upper respiratory infections (...) for corticosteroids. It is most effective when used regularly prior to the onset of allergic symptoms. • Intranasal antihistamines (azelastine), while effective in treating the nasal symptoms associated with seasonal and perennial rhinitis and nonallergic vasomotor rhinitis, offer no therapeutic benefit over conventional treatment and incur additional cost [II A*]. • Ocular preparations should be considered for patients with allergic conjunctivitis who are not adequately controlled with or cannot tolerate an oral

2013 University of Michigan Health System

16. Effects of Fluticasone Furoate Nasal Spray on Parameters of Eosinophilic Inflammation in Patients With Nasal Polyposis and Perennial Allergic Rhinitis. (Abstract)

Effects of Fluticasone Furoate Nasal Spray on Parameters of Eosinophilic Inflammation in Patients With Nasal Polyposis and Perennial Allergic Rhinitis. Regulated on activation normal T cell expressed and secreted (RANTES) and eotaxin-2 have been postulated to be responsible for eosinophilia in chronically inflamed nasal mucosa. This study evaluated mucosal production of RANTES and eotaxin-2 in patients with perennial allergic rhinitis (PAR) and nonallergic and allergic form of chronic (...) rhinosinusitis with nasal polyps (CRSwNP) before and after nasal corticosteroid treatment.Twenty patients with PAR, 20 nonallergic and 20 allergic CRSwNP patients, and 20 healthy controls were included. The RANTES and eotaxin-2 levels were measured in nasal secretion samples. The patients with chronic inflammation were treated with fluticasone furoate nasal spray for 2 weeks. Cytological examination and measurement of RANTES and eotaxin-2 in nasal fluid were performed before and after the treatment.The

2017 Rhinology and Laryngology

17. Chronic Nonallergic Rhinitis

Chronic Nonallergic Rhinitis Aka: Chronic Nonallergic Rhinitis , Nonallergic Rhinitis , Non-allergic Rhinitis , Non-Infective Non-allergic Rhinitis , Atrophic Rhinitis , Hormonal Rhinitis , Occupational Rhinitis From Related Chapters II. Definitions Chronic Nonallergic Rhinitis Chronic (>3 months) without allergic or infectious cause III. Epidemiology : 20-30 Million in U.S. Accounts for 23% of cases in U.S. More common in women (by factor of 2:1 to 3:1) Age >35 years old (contrast with onset <20 (...) ) These images are a random sampling from a Bing search on the term "Chronic Nonallergic Rhinitis." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Non-infective non-allergic rhinitis (C0339804) Concepts Disease or Syndrome ( T047 ) SnomedCT 232345000 English NINA , Non-infect non-allerg rhinitis , NINA - Non-infective non-allergic rhinitis , Non-infective non-allergic rhinitis , Non-infective non-allergic rhinitis

2018 FP Notebook

18. Mediators and Cytokines in Persistent Allergic Rhinitis and Nonallergic Rhinitis with Eosinophilia Syndrome. Full Text available with Trip Pro

Mediators and Cytokines in Persistent Allergic Rhinitis and Nonallergic Rhinitis with Eosinophilia Syndrome. Patients with nonallergic rhinitis with eosinophilia syndrome (NARES) show typical symptoms of persistent allergic rhinitis (PAR). The aim of the present study was to compare nasal cytokine patterns between NARES and PAR.Nasal secretions of 31 patients suffering from NARES, 20 patients with PAR to house dust mite and 21 healthy controls were collected using the cotton wool method (...) -5 and GM-CSF as factors for eosinophil migration and survival. The elevated levels of proinflammatory cytokines in NARES may indicate the chronic, self-perpetuating process of inflammation in NARES which seems to be more pronounced than in PAR. IL-17 might be a factor for neutrophilic infiltration or be responsible for remodeling processes in NARES.Copyright © 2012 S. Karger AG, Basel.

2012 International Archives of Allergy and Immunology

19. An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011. Full Text available with Trip Pro

telephone numbers by random digit dialing. The questions asked during telephone interviews were based on those included in validated questionnaires and focused on topics regarding AR, nonallergic rhinitis (NAR), acute/chronic rhinosinusitis (ARS/CRS), asthma, and atopic dermatitis (AD).During 2011, a total of 47 216 telephone interviews were conducted, and the overall response rate was 77.5%. When compared with the AR prevalence in 11 cities surveyed in 2005, there was a significant increase in self (...) An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011. The prevalence of allergic rhinitis (AR) has increased worldwide in recent decades. This study was conducted to investigate the prevalence of self-reported AR and profiles of AR-related comorbidities in the adult population of China over time.This study surveyed residents of 18 major cities in mainland China. Telephone interviews were conducted with study participants after sampling target

2016 Allergy

20. Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years. (Abstract)

Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years. Allergic rhinitis (AR) is one of the most common chronic diseases, usually starting in the first 2 decades of life. Information on predictors, risk, and protective factors is missing because of a lack of long-term prospective studies.Our aim was to examine early-life environmental and lifestyle determinants for AR up to age 20 years.In 1990, the Multicenter Allergy Study included 1314 newborns in 5 German cities (...) . Children were evaluated at 19 time points. A Cox regression model examined the associations between 41 independent early-life factors and onset of AR (as the primary outcome), including sensitization against aeroallergens and the secondary outcomes of nonallergic rhinitis and AR plus asthma.Two hundred ninety subjects had AR within 13,179 person years observed. The risk of AR was higher with a parental history of AR (adjusted hazard ratio [aHR], 2.49; 95% CI, 1.93-3.21), urticaria (aHR, 1.32; 95% CI

2015 Journal of Allergy and Clinical Immunology

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