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Chronic Cough Causes

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1. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report Chronic Cough Due to Stable Chronic Bronchitis CHEST Expert Panel Report Q43 Mark A. Malesker, PharmD, FCCP Q1 ; Priscilla Callahan-Lyon, MD; J. Mark Madison, MD, FCCP; Belinda Ireland, MD Q2 ; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel * BACKGROUND: Q7 Chronic cough due to chronic bronchitis (CB) causes signi?cant Q8 impairment in quality of life, and effective treatment strategies (...) at making cough less severe or resolve sooner (Ungraded Consensus-Based Statement). Q12 Chronic bronchitis (CB) is a medical condition de?ned by the presence of cough with sputum production for at least 3 months per year during 2 consecutive years when other respiratory or cardiac causes for the chronic, productive cough have been excluded. 1 Development of CB is frequently associated with and aggravated by exposure to irritating inhaled agents. Cigarette smoking is a major contributor to development

2020 American College of Chest Physicians

2. Speech and language therapy for management of chronic cough. (Abstract)

Speech and language therapy for management of chronic cough. Cough both protects and clears the airway. Cough has three phases: breathing in (inspiration), closure of the glottis, and a forced expiratory effort. Chronic cough has a negative, far-reaching impact on quality of life. Few effective medical treatments for individuals with unexplained (idiopathic/refractory) chronic cough (UCC) are known. For this group, current guidelines advocate the use of gabapentin. Speech and language therapy (...) is needed to understand which aspects of SLT interventions are most effective in reducing cough (both objective cough frequency and subjective measures of cough) and improving HRQoL. We consider these endpoints to be clinically important. It is also important for future studies to report information on adverse events.Because of the paucity of data, we can draw no robust conclusions regarding the efficacy of SLT interventions for improving outcomes in unexplained chronic cough. Our review identifies

2019 Cochrane

3. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report

are not presumed to be common causes in children and (b) their age and 88 the clinical settings (e.g. country and region) are taken into consideration when 89 evaluating and managing their chronic cough (Grade 1B). 2 90 3. For children aged =14-years with chronic cough, we recommend using pediatric-specific 91 cough management protocols or algorithms (Grade 1B). 1 92 4. For children aged =14-years with chronic cough, we recommend taking a systematic 93 approach (such as using a validated guideline (...) ) to determine the cause of the cough (Grade 94 1A). 1 95 5. For children aged =14-years with chronic cough, we recommend basing the management 96 or testing algorithm on cough characteristics and the associated clinical history such as 97 using specific cough pointers like presence of productive/wet cough (Grade 1A). 1 98 6. For children aged =14-years with chronic cough, we recommend that a chest radiograph 99 and, when age appropriate, spirometry (pre and post ß 2 agonist) be undertaken (Grade 100 1B). 1

2020 American College of Chest Physicians

4. Assessment of chronic cough

/S0012-3692(17)32918-5/fulltext http://www.ncbi.nlm.nih.gov/pubmed/29080708?tool=bestpractice.com Sub-acute cough is most often self-limiting, but chronic cough may provide significant challenges for effective evaluation and management. Non-targeted cough suppressant therapy is rarely effective for chronic cough. However, the difficulty is in determining the cause of cough, because some 'aetiologies' are syndromes without accurate diagnostic tests. The cause is determined instead by typical (...) historical features, elimination of alternative causes, and response to targeted therapies (therapeutic trials serve as tests). Nonetheless, a careful history, along with selected therapeutic trials and/or diagnostic evaluations performed in a systematic and informed way, may satisfactorily resolve cough in over 90% of cases. Differentials Upper airway cough syndrome (UACS; postnasal drip) Asthma Gastro-oesophageal reflux disease (GORD) Non-asthmatic eosinophilic bronchitis (NAEB) Chronic bronchitis/COPD

2018 BMJ Best Practice

5. A foreign body in the mediastinum as a cause of chronic cough in a 10-year-old child with asthma. (Abstract)

A foreign body in the mediastinum as a cause of chronic cough in a 10-year-old child with asthma. Introduction: Chronic cough is a common problem faced by pediatricians, with a reported prevalence of 20% among preschoolers. It is also the most frequent symptom of asthma. Many causes of chronic cough may also be possible causes of asthma exacerbations.Case study: We describe a 10-year-old boy with asthma, which was admitted to the hospital with a persistent dry cough for five months. Initially (...) diagnosis. Our findings demonstrate that chronic cough in children with asthma is not always a result of exacerbation. Precise interviewing and correct interpretation of basic diagnostic testing may be key for setting an accurate diagnosis.

2019 Journal of Asthma

6. Cough Due to Tuberculous and Other Chronic Infections

Cough Due to Tuberculous and Other Chronic Infections Cough Due to TB and Other Chronic Infections CHEST Guideline and Expert Panel Report Stephen K. Field, MD,CM, FCCP; Patricio Escalante, MD, FCCP; Dina A. Fisher, MD, FCCP; Belinda Ireland, MD; Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Cough is common in pulmonary TB and other chronic respiratory infections. Identifying features that predict whether pulmonary TB is the cause would help target (...) - resistant Mycobacterium tuberculosis strains, a surrogate marker for multidrug-resistant TB (MDR- TB). 6,7 Rapid and accurate identi?cation of MDR-TB cases is critical in many areas in the world where MDR-TB is highly prevalent. 6,8 Conversely, the prevalence of cough is greatest in those with smear- positive sputum. However, even in areas with a high TB prevalence, the majority of coughs are due to another cause. 9,10 Common causes include acute viral bronchitis, chronic bronchitis, respiratory

2018 American College of Chest Physicians

7. A Rare Case of Isolated Chronic Cough Caused by Pulmonary Lymphangitic Carcinomatosis as a Primary Manifestation of Rectum Carcinoma Full Text available with Trip Pro

A Rare Case of Isolated Chronic Cough Caused by Pulmonary Lymphangitic Carcinomatosis as a Primary Manifestation of Rectum Carcinoma A 36-year old man was referred to our hospital due to isolated chronic cough that was refractory to anti-asthma medications, including inhaled corticosteroids/long-acting β2 agonists. Chest X-ray showed diffuse nodular and enhanced vascular shadows with Kerley lines in both lungs. A blood analysis showed elevated serum carcinoembryonic antigen (CEA) and CA19-9 (...) levels. A transbronchial biopsy revealed well to moderately differentiated adenocarcinoma, the origin of which was immunohistochemically suspected to be the gastrointestinal tract. Colonoscopy confirmed the diagnosis of primary rectum carcinoma. Pulmonary lymphangitic carcinomatosis was therefore regarded as the origin of the cough. Lymphangitic carcinomatosis is an uncommon diagnosis but important to consider in patients with persistent cough.

2018 Internal Medicine

8. An unexpected cause of chronic cough in a young woman: Tachycardia-induced cardiomyopathy. (Abstract)

An unexpected cause of chronic cough in a young woman: Tachycardia-induced cardiomyopathy. Heart failure typically manifests with exertional dyspnea or limb edema. Old age, underlying heart disease, and coronary risk factors are known risk factors for heart failure. Thus, congestive heart failure is rarely considered as a differential diagnosis of chronic cough in a previously healthy young person. However, tachycardia-induced cardiomyopathy (TIC) can result in such a situation. A case (...) of a previously healthy 27-year-old woman with TIC is described herein. On the first examination, the patient presented with left ventricular (LV) dysfunction caused by persistent tachyarrhythmia. Cardiomyopathy subsided with only heart rate control; therefore, the patient was diagnosed as having TIC. TIC can develop irrespective of age and underlying heart disease. The long-term outcome may be good, and LV systolic function recovers in most patients following resolution of arrhythmia. Physicians need

2018 American Journal of Emergency Medicine

9. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children Full Text available with Trip Pro

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli such a cold air, perfumes, smoke and bleach. Thus, adults with chronic cough now have a firm physical explanation for their symptoms based on vagal afferent (...) by adverse events. Perhaps the most promising future developments in pharmacotherapy are drugs which tackle neuronal hypersensitivity by blocking excitability of afferent nerves by inhibiting targets such as the ATP receptor (P2X3). Finally, cough suppression therapy when performed by competent practitioners can be highly effective. Children are not small adults and a pursuit of an underlying cause for cough is advocated. Thus, in toddlers, inhalation of a foreign body is common. Persistent bacterial

2020 EvidenceUpdates

10. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report.

a validated guideline) to determine the cause of the cough ( Grade 1A ). For children aged ≤14 years with chronic cough, the Expert Panel recommends basing the management or testing algorithm on cough characteristics and the associated clinical history, such as using specific cough pointers like presence of productive/wet cough ( Grade 1A ). For children aged ≤14 years with chronic cough, the Expert Panel recommends basing the management on the etiology of the cough. An empirical approach aimed (...) ., foreign body) may cause chronic respiratory morbidity, whereas early diagnosis of chronic disease leads to appropriate management and subsequent resolution of cough and improved quality of life (QoL). Use of cough algorithms or pathways can potentially lead to earlier diagnosis and reduce morbidity, unnecessary costs, and medication use associated with chronic cough. The variations in algorithms raise the question of whether algorithms that are specific to the clinical setting should be used

2017 National Guideline Clearinghouse (partial archive)

11. Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. Full Text available with Trip Pro

)-mediated cough sensitivity in patients with chronic refractory cough.Using a selective TRPA1 agonist, allyl isothiocyanate (AITC), we established an AITC cough challenge as a measure of TRPA1-mediated cough sensitivity. The AITC cough challenge and the widely used capsaicin (a selective TRPV1 agonist) cough challenge were performed with 250 patients with chronic refractory cough and 56 healthy subjects. The concentration of AITC or capsaicin solution causing at least two (C2) and five coughs (C5 (...) Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly understood. We investigated the phenotypes of cough hypersensitivity by examining transient receptor potential ankyrin 1 (TRPA1)- and transient receptor potential vanilloid 1 (TRPV1

2019 Respiratory research

12. Cough (acute): antimicrobial prescribing

are viral infections. It can also be caused by acute bronchitis, a lower respiratory tract infection, which is usually a viral infection but can be bacterial. Other infective causes of cough include pneumonia, acute exacerbations of asthma, chronic obstructive pulmonary disease or bronchiectasis (which may also be non-infective exacerbations), and viral-induced wheeze, bronchiolitis, croup or whooping cough. Non-infective causes may include lung cancer, a foreign body, interstitial lung disease (...) of 36Recommendations Recommendations 1.1 Managing acute cough 1.1.1 Be aware that an acute cough: is usually self-limiting and gets better within 3 to 4 weeks without antibiotics is most commonly caused by a viral upper respiratory tract infection, such as a cold or flu can also be caused by acute bronchitis, a lower respiratory tract infection, which is usually a viral infection but can be bacterial can also have other infective or non-infective causes. 1.1.2 For children under 5 with an acute cough and fever

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

13. Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report Full Text available with Trip Pro

Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report Whether gastroesophageal reflux (GER) or GER disease (GERD) causes chronic cough in children is controversial. Using the Population, Intervention, Comparison, Outcome (PICO) format, we undertook four systematic reviews. For children with chronic cough (> 4-weeks duration) and without underlying lung disease: (1) who do not have gastrointestinal GER symptoms, should empirical treatment for GERD be used (...) ? (2) with gastrointestinal GER symptoms, does treatment for GERD resolve the cough? (3) with or without gastrointestinal GER symptoms, what GER-based therapies should be used and for how long? (4) if GERD is suspected as the cause, what investigations and diagnostic criteria best determine GERD as the cause of the cough?We used the CHEST Expert Cough Panel's protocol and American College of Chest Physicians (CHEST) methodological guidelines and GRADE (Grading of Recommendations Assessment

2019 EvidenceUpdates

14. Endobronchial hamartoma; a rare structural cause of chronic cough Full Text available with Trip Pro

Endobronchial hamartoma; a rare structural cause of chronic cough Pulmonary hamartomas are rare benign tumors consisting of multiple mesenchymal cell lines like cartilage, bone and fat. We discuss an interesting case of a 53-year-old male patient, who was referred to our clinic for persistent cough. Chest X-ray revealed a left suprahilar density associated with plate like atelectasis, which on chest CT was found to be a densely calcified nodule, causing narrowing of the left upper lobe (LUL

2017 Respiratory Medicine Case Reports

15. Somatic Cough Syndrome (Previously Referred to as Psychogenic Cough) and Tic Cough (Previously Referred to as Habit Cough) in Adults and Children

of somatic cough disorder can only be made aft er an extensive evaluation has been performed that includes ruling out tic disorders and uncommon causes and the patient meets the DSM-5 criteria (see Table 1) for a somatic symptom disorder (Grade 2C) . 10. In children with chronic cough diagnosed with somatic cough disorder (previously referred to as psychogenic cough), we suggest non-pharmacological trials of hypnosis or suggestion therapy or combina- tions of reassurance, counseling, or referral (...) - 486 . 9. C h a n g A B , G a ff n e y J T , E a s t b u r n M M , F a o a g a l i J , Co x N C , M a s t e r s I B . Cough quality in children: a comparison of subjective vs. broncho- scopic fi ndings . Respir Res . 2005 ; 6 : 3 . 10. M e llo CJ , I r win RS , C u rle y FJ . P r edic ti v e val ues o f t h e c h a rac t e r , timing, and complications of chronic cough in diagnosing its cause . Arch Intern Med . 1996 ; 156 ( 9 ): 997 - 1003 . 11. P o w er JT , S t e wa r t I C , C o nna ug h t o n

2015 American College of Chest Physicians

16. Health seeking behavior among individuals presenting with chronic cough at referral hospitals in Uganda; Missed opportunity for early tuberculosis diagnosis. Full Text available with Trip Pro

Health seeking behavior among individuals presenting with chronic cough at referral hospitals in Uganda; Missed opportunity for early tuberculosis diagnosis. Tuberculosis (TB) is the 9th leading cause of death from a single infectious agent. Patients live in a complex health care system with both formal and informal providers, and it is important that a TB diagnosis is not missed at the first interaction with the health care system. In this study, we highlight the health seeking behavior (...) of patients and missed opportunities for early TB diagnosis for which interventions could be instituted to ensure early TB diagnosis and prompt TB treatment initiation.This study was nested in a cross-sectional study that assessed the accuracy of different Xpert MTB/Rif implementation strategies in programmatic settings at the referral hospitals in Uganda. We documented the symptom profile of presumptive TB patients and assessed the health seeking behavior of those with chronic cough by calculating

2019 PLoS ONE

17. Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report Full Text available with Trip Pro

Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report Cough is common in pulmonary TB and other chronic respiratory infections. Identifying features that predict whether pulmonary TB is the cause would help target appropriate individuals for rapid and cost-effective screening, potentially limiting disease progression and preventing transmission to others.A systematic literature search for individual studies to answer eight key questions (KQs) was conducted (...) according to established Chest Organization methods by using the following databases: MEDLINE via PubMed, Embase, Scopus, and the Cochrane Database of Systematic Reviews from January 1, 1984, to April 2014. Searches for KQ 1 and KQ 3 were updated in February 2016. An updated KQ 2 search was undertaken in March 2017.Even where TB prevalence is greatest, most individuals with cough do not have pulmonary TB. There was no evidence that 1, 3, or 4 weeks' duration were better predictors than cough lasting ≥ 2

2018 EvidenceUpdates

18. Chronic Cough Causes in Children

Chronic Cough Causes in Children Chronic Cough Causes in Children Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chronic Cough Causes (...) in Children Chronic Cough Causes in Children Aka: Chronic Cough Causes in Children From Related Chapters II. Causes: Chronic Cough in Infancy Airway malformation Tracheoesophageal fistula Primary ciliary Immune deficiency Infection (RSV) (CMV) III. Causes: Chronic Cough in preschool children Reactive changes Postnasal discharge ( ) Passive smoke Infection Viral causes Primary ciliary Immune deficiency IV. Causes: Chronic Cough in school age children (ages 6 to 15 years old) Reactive changes Environmental

2018 FP Notebook

19. Chronic Cough Causes

Chronic Cough Causes Chronic Cough Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chronic Cough Causes Chronic Cough Causes (...) Aka: Chronic Cough Causes , Chronic Cough Causes in Adults From Related Chapters II. Causes: Common (represents 90% of Chronic Cough Causes) or post nasal drainage (40%) (24%) (15%) or post- tic (11%) abuse Transient airway hyperresponsiveness Post-viral cough Post- tic cough infection is responsible for 20% of severe cough in adults and teens >2 weeks presenting to ED Medication related s (5-20% of patients) s (less common) III. Causes: Less Common Causes of Chronic Cough Cancer disease (4

2018 FP Notebook

20. A Surprising Cause of Chronic Cough. (Abstract)

A Surprising Cause of Chronic Cough. 26244310 2015 08 13 2015 08 06 1533-4406 373 6 2015 Aug 06 The New England journal of medicine N. Engl. J. Med. CLINICAL PROBLEM-SOLVING. A Surprising Cause of Chronic Cough. 561-6 10.1056/NEJMcps1303787 Damaraju Deepti D Steiner Ted T Wade John J Gin Kenneth K FitzGerald J Mark JM eng Case Reports Clinical Conference Journal Article United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents AIM IM Anti-Bacterial Agents therapeutic use Arthritis (...) etiology Asthma diagnosis Chronic Disease Cough etiology Delayed Diagnosis Diagnosis, Differential Endocarditis, Bacterial microbiology Gastroesophageal Reflux diagnosis Humans Lymph Nodes microbiology pathology Male Middle Aged Radiography, Abdominal Tropheryma isolation & purification Whipple Disease complications diagnosis drug therapy 2015 8 6 6 0 2015 8 6 6 0 2015 8 14 6 0 ppublish 26244310 10.1056/NEJMcps1303787

2015 NEJM

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