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Chronic Cough

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1. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report Chronic Cough Due to Stable Chronic Bronchitis CHEST Expert Panel Report Q43 Mark A. Malesker, PharmD, FCCP Q1 ; Priscilla Callahan-Lyon, MD; J. Mark Madison, MD, FCCP; Belinda Ireland, MD Q2 ; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel * BACKGROUND: Q7 Chronic cough due to chronic bronchitis (CB) causes signi?cant Q8 impairment in quality of life, and effective treatment strategies (...) are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. METHODS: This systematic review asked three questions: (1) What are the clinical features of the history that suggest a patient’s cough-phlegm syndrome is due to CB? (2) Can treatment of stable CB improve or eliminate chronic cough? (3) Can therapy that targets chronic cough due to CB

2020 American College of Chest Physicians

2. Speech and language therapy for management of chronic cough. (Abstract)

Speech and language therapy for management of chronic cough. Cough both protects and clears the airway. Cough has three phases: breathing in (inspiration), closure of the glottis, and a forced expiratory effort. Chronic cough has a negative, far-reaching impact on quality of life. Few effective medical treatments for individuals with unexplained (idiopathic/refractory) chronic cough (UCC) are known. For this group, current guidelines advocate the use of gabapentin. Speech and language therapy (...) is needed to understand which aspects of SLT interventions are most effective in reducing cough (both objective cough frequency and subjective measures of cough) and improving HRQoL. We consider these endpoints to be clinically important. It is also important for future studies to report information on adverse events.Because of the paucity of data, we can draw no robust conclusions regarding the efficacy of SLT interventions for improving outcomes in unexplained chronic cough. Our review identifies

2019 Cochrane

3. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report

Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report Journal Pre-proof Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report Anne B. Chang, PhD, John J. Oppenheimer, MD; FCCP, Richard S. Irwin, MD, Master FCCP, on behalf of the CHEST Expert Cough Panel PII: S0012-3692(20)30325-1 DOI: https://doi.org/10.1016/j.chest.2020.01.042 Reference: CHEST 2916 To appear in: CHEST (...) Received Date: 8 November 2019 Revised Date: 11 December 2019 Accepted Date: 9 January 2020 Please cite this article as: Chang AB, Oppenheimer JJ, Irwin RS, on behalf of the CHEST Expert Cough Panel, Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.01.042. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page

2020 American College of Chest Physicians

4. Assessment of chronic cough

Assessment of chronic cough Assessment of chronic cough - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of chronic cough Last reviewed: February 2019 Last updated: June 2018 Summary Cough is the most common presenting symptom in primary practice. Schappert SM, Burt CW. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001-02. Vital (...) Health Stat 13. 2006 Feb;(159):1-66. http://www.cdc.gov/nchs/data/series/sr_13/sr13_159.pdf http://www.ncbi.nlm.nih.gov/pubmed/16471269?tool=bestpractice.com Sub-acute cough is defined as cough persisting for 3 to 8 weeks, and chronic cough as that persisting for more than 8 weeks. Irwin RS, French CL, Chang AB, et al. Classification of cough as a symptom in adults and management algorithms: CHEST guideline and expert panel report. Chest. 2018 Jan;153(1):196-209. http://journal.chestnet.org/article

2018 BMJ Best Practice

7. A new simple score of chronic cough: cough evaluation test. Full Text available with Trip Pro

A new simple score of chronic cough: cough evaluation test. Chronic cough has an important impact on physical, social and psychological aspects. A simple and effective method to assess different aspects of chronic cough severity is required. We aimed to develop a simple, self-completed test, Cough Evaluation Test (CET), to evaluate cough severity and its impact on health.The items of preliminary CET were generated based on literature review and clinical practice. Items reduction was conducted (...) by modified Delphi method. Patients with chronic cough were recruited to complete CET, Cough Visual Analog Scales (VAS), Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ-MC), and Cough Symptom Score (CSS). Reassessments were performed at 1 week apart before treatment, and after more than 2 weeks treatments. Concurrent validation, internal consistency, repeatability, responsiveness and the minimal important difference (MID) were determined.CET consists of five items with a 5-point Likert

2020 BMC pulmonary medicine

8. Chronic Cough Related to Acute Viral Bronchiolitis in Children

Chronic Cough Related to Acute Viral Bronchiolitis in Children Chronic Cough Related to Acute Viral Bronchiolitis in Children CHEST Expert Panel Report Anne B. Chang, MBBS, PhD, MPH; John J. Oppenheimer, MD; Bruce K. Rubin, MD; Miles Weinberger, MD, FCCP; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic (...) reviews based on key questions (KQs) using the PICO (Population, Intervention, Comparison, Outcome) format. The KQs were: Among children with chronic cough (> 4 weeks) after acute viral bron- chiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta 2 agonist, montelukast); and (3) Inhaled osmotic agents like hypertonic saline? METHODS: We used the CHEST expert cough

2018 American College of Chest Physicians

9. Cough Due to Tuberculous and Other Chronic Infections

Cough Due to Tuberculous and Other Chronic Infections Cough Due to TB and Other Chronic Infections CHEST Guideline and Expert Panel Report Stephen K. Field, MD,CM, FCCP; Patricio Escalante, MD, FCCP; Dina A. Fisher, MD, FCCP; Belinda Ireland, MD; Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Cough is common in pulmonary TB and other chronic respiratory infections. Identifying features that predict whether pulmonary TB is the cause would help target (...) not yet been performed (Ungraded Consensus-Based Statement). 10. For patients with chronic cough in low income countries,wesuggestthatstrategiesforpulmonaryTB diagnosis should focus on improved case detection rather than diagnostic testing (Ungraded Consensus- Based Statement). Approximately 9.6 million people developed active TB worldwide in 2014, and 1.5 million died as a result. 1 The consequences of TB are greatest in the developing world where the prevalence is greatest and resources to diagnose

2018 American College of Chest Physicians

10. [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough]

[Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Virgilio S, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A. [Fractional exhaled nitric oxide measurement in patients with asthma and chronic cough] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rapida No 536. 2017 Authors' conclusions Moderate quality evidence suggests that fractional exhaled

2017 Health Technology Assessment (HTA) Database.

11. Gefapixant in two randomised dose-escalation studies in chronic cough

Gefapixant in two randomised dose-escalation studies in chronic cough Gefapixant in Two Randomised Dose-Escalation Studies in Chronic Cough - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health U.S. National Library of Medicine National Center (...) Mar 20;55(3):1901615. doi: 10.1183/13993003.01615-2019. Print 2020 Mar. Gefapixant in Two Randomised Dose-Escalation Studies in Chronic Cough , , , , , , , , , Affiliations Expand Affiliations 1 University of Manchester and Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK. 2 Merck & Co., Inc., Kenilworth, NJ, USA. 3 Merck & Co., Inc., Kenilworth, NJ, USA jacky.smith@manchester.ac.uk. 4 GetStat Solutions, LLC, Palo Alto, CA, USA. 5 Center

2020 EvidenceUpdates

12. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children Full Text available with Trip Pro

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli such a cold air, perfumes, smoke and bleach. Thus, adults with chronic cough now have a firm physical explanation for their symptoms based on vagal afferent (...) hypersensitivity. Different treatable traits exist with cough variant asthma (CVA)/eosinophilic bronchitis responding to anti-inflammatory treatment and non-acid reflux being treated with promotility agents rather the anti-acid drugs. An alternative antitussive strategy is to reduce hypersensitivity by neuromodulation. Low-dose morphine is highly effective in a subset of patients with cough resistant to other treatments. Gabapentin and pregabalin are also advocated, but in clinical experience they are limited

2020 EvidenceUpdates

13. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report.

Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. | National Guideline Clearinghouse success fail JUN 10 2017 2018 2019 14 Apr 2018 - 13 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective (...) of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Chang AB, Oppenheimer JJ, Weinberger MM, Rubin BK, Grant CC, Weir K, Irwin RS, CHEST Expert Cough Panel. Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and Expert Panel report. Chest. 2017 Apr;151(4):884-90. [33 references] This is the current release of the guideline. This guideline updates a previous version: Chang AB, Glomb WB. Guidelines

2017 National Guideline Clearinghouse (partial archive)

14. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report.

Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. | National Guideline Clearinghouse success fail JUN 09 2017 2018 2019 14 Apr 2018 - 12 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving (...) of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Chang AB, Oppenheimer JJ, Weinberger MM, Rubin BK, Weir K, Grant CC, Irwin RS, CHEST Expert Cough Panel. Use of management pathways or algorithms in children with chronic cough: CHEST guideline and Expert Panel report. Chest. 2017 Apr;151(4):875-83. [48 references] This is the current release of the guideline. This guideline meets NGC's 2013 (revised) inclusion criteria. Age Group UMLS Concepts

2017 National Guideline Clearinghouse (partial archive)

15. Long-term treatment with clarithromycin and carbocisteine improves lung function in chronic cough patients with chronic rhinosinusitis. Full Text available with Trip Pro

Long-term treatment with clarithromycin and carbocisteine improves lung function in chronic cough patients with chronic rhinosinusitis. Chronic cough is a common complaint. Because the pathophysiology of chronic cough is complicated, the management of chronic cough is challenging. To the best of our knowledge, no previous study has examined the effect of macrolide antibiotics in chronic cough patients with chronic rhinosinusitis. The purpose of this study is to determine the changes in lung (...) function for chronic cough patients with chronic rhinosinusitis who are treated by clarithromycin and carbocisteine.Thirty-two chronic cough patients with chronic rhinosinusitis were recruited. Patients using inhaled corticosteroids and/or a bronchodilator, asthmatic patients, and patients with abnormal findings on auscultation and/or chest X-ray examination were excluded from this study. The patients received low-dose clarithromycin treatment for 3 months. Both before and after the treatment

2020 American Journal of Otolaryngology

16. Subfreezing air as a cough trigger and multiple triggers are strongly associated with the presence of asthma in chronic cough. (Abstract)

Subfreezing air as a cough trigger and multiple triggers are strongly associated with the presence of asthma in chronic cough. Management of chronic cough relies on the recognition of cough background disorders. It is not known whether certain cough triggers are associated with specific background disorders.This was an e-mail study to public service employees of two towns in Finland. The questionnaire included twelve triggers. Current asthma was defined as doctor's diagnosis of asthma (...) and current wheezing. Chronic rhinosinusitis was defined as either nasal blockage or nasal discharge and either facial pain/pressure or reduction/loss of smell for more than three months. Gastroesophageal reflux disease was defined as heartburn and/or regurgitation on at least one day a week during the last three months. Idiopathic cough was defined as absence of any of them.There were 421 subjects with current cough that had lasted at least eight weeks. Subfreezing air as a cough trigger was associated

2019 Respiratory medicine

17. Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. Full Text available with Trip Pro

Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly understood. We investigated the phenotypes of cough hypersensitivity by examining transient receptor potential ankyrin 1 (TRPA1)- and transient receptor potential vanilloid 1 (TRPV1 (...) )-mediated cough sensitivity in patients with chronic refractory cough.Using a selective TRPA1 agonist, allyl isothiocyanate (AITC), we established an AITC cough challenge as a measure of TRPA1-mediated cough sensitivity. The AITC cough challenge and the widely used capsaicin (a selective TRPV1 agonist) cough challenge were performed with 250 patients with chronic refractory cough and 56 healthy subjects. The concentration of AITC or capsaicin solution causing at least two (C2) and five coughs (C5

2019 Respiratory research

18. Typical symptoms and not positive reflux-cough correlation predict cure of gastroesophageal reflux disease related chronic cough after laparoscopic fundoplication: a retrospective study. Full Text available with Trip Pro

Typical symptoms and not positive reflux-cough correlation predict cure of gastroesophageal reflux disease related chronic cough after laparoscopic fundoplication: a retrospective study. The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution of reflux-related chronic cough after anti-reflux surgery.A 5 years retrospective review was performed (...) . Logistic regression analysis was used to determine the independent predictors on the cure of chronic cough.Seventy-nine patients were included in this study, among which chronic cough was cured in 47 (59.5%) and significantly improved in 10 (12.7%) patients. Present of typical symptoms (odds ratio = 6.435,95% confidence interval [CI] = 1.427-29.032, p = 0.015) and number of Reflux episodes (impedance) ≥73 (odds ratio = 0.306, 95% confidence interval [CI] = 0.107-0.874, p = 0.027) were significantly

2019 BMC Gastroenterology

19. Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity? (Abstract)

Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity? Objective: To investigate patterns of presentation of cough in primary care and develop an algorithm to identify probable and possible chronic cough (CC). Methods: This retrospective observational study used routine English primary care data and linked hospital data. Patients with ≥1 cough event in the study period (March 2014-February 2015) were selected. Index date (...) %) and 137,718 (91.7%) were classified as having probable CC, possible CC or acute cough, respectively. Compared with probable CC and acute cough, a higher percentage of possible CC cases had a record on or prior to index date indicative of chronic obstructive pulmonary disease (30.6% versus 10.1% and 9.7%), gastro-esophageal reflux disease (32.6% versus 24.9% and 21.1%) or asthma (45.9% versus 27.6% and 27.9%). Prevalences of probable and possible CC were 0.18% and 1.2%, respectively. Conclusions

2019 Current medical research and opinion

20. Impaired cough suppression in chronic refractory cough. (Abstract)

Impaired cough suppression in chronic refractory cough. Functional brain imaging in individuals with chronic cough demonstrates reduced activation in cortical regions associated with voluntary cough suppression. Little is known about the ability of patients with chronic cough to suppress cough. This study aimed to compare the ability to voluntarily suppress cough during inhaled capsaicin challenge in participants with chronic refractory cough with that in healthy controls. This study also aimed (...) to assess the repeatability of capsaicin challenge test with voluntary cough suppression.Participants with chronic refractory cough and healthy controls underwent inhaled capsaicin challenge tests whilst attempting to suppress their cough responses. After 5 days either a conventional capsaicin challenge test with no cough suppression attempt, or a repeat test with an attempt at cough suppression was performed. Threshold capsaicin concentrations required to elicit 1, 2 and 5 coughs were calculated

2019 European Respiratory Journal

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