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Chronic Blepharitis

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1. Blepharitis

Blepharitis Blepharitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Blepharitis Last reviewed: February 2019 Last updated: October 2018 Summary Significant cause of discomfort, causing foreign body sensation, burning, itching, and crusting around eyelashes. Typical findings include lid erythema, collarettes around eyelashes, and capped meibomian glands. In severe cases, corneal changes, including (...) neovascularisation, scarring, ulceration, and perforation, can lead to visual impairment. Treatment is directed at maintaining eyelid hygiene and may require use of topical corticosteroids and topical or oral antibiotics. Treatment of associated or underlying medical conditions is essential for successful management of blepharitis. Definition Blepharitis refers to a group of disorders characterised by inflammation of the eyelids and associated adnexal structures including skin, lashes, and meibomian glands

2018 BMJ Best Practice

2. Blepharitis

Blepharitis Blepharitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Blepharitis Last reviewed: February 2019 Last updated: October 2018 Summary Significant cause of discomfort, causing foreign body sensation, burning, itching, and crusting around eyelashes. Typical findings include lid erythema, collarettes around eyelashes, and capped meibomian glands. In severe cases, corneal changes, including (...) neovascularisation, scarring, ulceration, and perforation, can lead to visual impairment. Treatment is directed at maintaining eyelid hygiene and may require use of topical corticosteroids and topical or oral antibiotics. Treatment of associated or underlying medical conditions is essential for successful management of blepharitis. Definition Blepharitis refers to a group of disorders characterised by inflammation of the eyelids and associated adnexal structures including skin, lashes, and meibomian glands

2017 BMJ Best Practice

3. Blepharitis (Lid Margin Disease)

of these conditions are typically bilateral, and chronic or relapsing Dry Eye Disease is present in: 50% of people with staphylococcal blepharitis 25-40% of people with seborrhoeic blepharitis Posterior blepharitis is a leading cause of evaporative dry eye A significant association has been found between Demodex infestation and blepharitis (see evidence base), though the role of the mite in the pathogenesis of the condition is unclear Predisposing factors Seborrhoeic blepharitis seborrhoeic dermatitis (...) , Hida RY, Liu Y, Seo KY, Tauber J, Wakamatsu TH, Xu J, Wolffsohn JS, Craig JP. TFOS DEWS II Management and Therapy Report. Ocul Surf. 2017;15(3):575-628 Koo H, Kim TH, Kim KW, Wee SW, Chun YS, Kim JC. Discomfort and Demodex: Effect of Tea Tree Oil Eyelid Scrub in Demodex Blepharitis. J Korean Med Sci 2012;27:1574-9 Lindsley K, Matsumura S, Hatef E, Akpek EK. Interventions for chronic blepharitis. Cochrane Database of Systematic Reviews 2012, 5: CD005556 Preferred Practice Patterns. Blepharitis

2016 College of Optometrists

4. Chronic Blepharitis

Chronic Blepharitis Chronic Blepharitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chronic Blepharitis Chronic Blepharitis Aka (...) : Chronic Blepharitis , Granulated Eyelids , Blepharitis From Related Chapters II. Types Anterior Blepharitis Affects base of eyelashes Associated with staphylococcal infection or Posterior Blepharitis Affects meibomian gland openings Associated with meibomian gland dysfunction III. Symptoms Local irritation and burning IV. Signs Inflammation of margin at the lash follicles Moderate lid swelling along lash line Lower is usually more affected Soft, oily V. Differential Diagnosis See VI. Associated

2018 FP Notebook

5. Quantitative Analysis of the Bacteria in Blepharitis With Demodex Infestation (PubMed)

Quantitative Analysis of the Bacteria in Blepharitis With Demodex Infestation Bacterial infection or Demodex infestation has been reported to contribute to chronic blepharitis. The association between Demodex mites and bacterial flora in this disease remains to be elucidated. Fifty-six consecutive patients diagnosed with chronic blepharitis and 46 healthy volunteers were recruited for this study. Using specimens of three epilated eyelashes and lid margin swabs, Demodex were identified (...) of Propinibacterium acnes and Staphylococcus aureus from patients' eyelashes were significantly higher than that of the controls. Furthermore, bacterial colony counts in blepharitis patients' eyelashes with D. folliculorum were higher than that of controls with D. folliculorum (p < 0.01). Similarly, P. acnes colonies increased significantly in patients' eyelashes with D. folliculorum (p < 0.05). These results suggest that D. folliculorum and P. acnes have a role in the occurrence of the chronic blepharitis

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2018 Frontiers in microbiology

6. Development and evaluation of a measure of patient-reported symptoms of Blepharitis (PubMed)

Development and evaluation of a measure of patient-reported symptoms of Blepharitis Blepharitis is an ocular surface disease and chronic ophthalmic condition. This paper reports on the development of psychometric evaluation of a patient-reported measure of blepharitis symptoms.Self-reports of 13 blepharitis symptoms collected in a Phase 3 multi-site, randomized, double-masked, 4-arm parallel group, clinical trial of 907 individuals with blepharitis (mean age = 62, range: 19-93; 57% female) were (...) of blepharitis. The associations between the self-reports and clinician ratings of 4 symptoms indicate substantial unique information in the new self-reported symptom items.The trial was registered at ClinicalTrials.gov under the registry number NCT01408082 .

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2018 Health and quality of life outcomes

7. To Compare Blephapad Combo vs Standard Treatment for Eyelid Cleansing in Bilateral Posterior Blepharitis

condition in patients seeking an eye examination due to discomfort or eye irritation. Treatment of blepharitis is recommended even in mild cases as chronic inflammation may cause permanent damage to the Meibomian glands. Each eye of each patient represents an experimental unit. Each patient will apply Blephapad Combo to one eye and standard treatment to the other eye in accordance with the randomization procedure. The aim of this randomized, controlled study with a closed sequential design (...) To Compare Blephapad Combo vs Standard Treatment for Eyelid Cleansing in Bilateral Posterior Blepharitis To Compare Blephapad Combo vs Standard Treatment for Eyelid Cleansing in Bilateral Posterior Blepharitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2017 Clinical Trials

8. Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blepharitis

Identifier: NCT03422146 Recruitment Status : Recruiting First Posted : February 5, 2018 Last Update Posted : February 5, 2018 See Sponsor: Ottawa Hospital Research Institute Information provided by (Responsible Party): Ottawa Hospital Research Institute Study Details Study Description Go to Brief Summary: Previous studies have shown the clinical and antimicrobial efficacy of eyelid hygiene with tea tree oil (TTO) in resolving chronic blepharitis. Cliradex® is a novel over-the-counter eyelid wipe which (...) contains the most active ingredient of TTO. The present study is a single-centre, randomized, trial comparing Cliradex® eyelid hygiene and I-Lid 'n Lash® Hygiene, another over-the-counter eyelid wipe, without any medicinal ingredients, in treating chronic blepharitis. The Primary Outcome Measure will be the difference in change in the number of CFU's after 2 weeks treatment, between the groups. The Secondary Outcome Measure will be the difference in change in objective clinical signs and symptoms

2017 Clinical Trials

9. Demodex Blepharitis Treated with a Novel Dilute Povidone-Iodine and DMSO System: A Case Report (PubMed)

with chronic blepharitis involving both the anterior and posterior eyelid margins. The anterior eyelid margins demonstrated pathognomonic features consistent with Demodex infection, and this diagnosis was confirmed with microscopy. Previous traditional therapies had been ineffective at controlling her signs and symptoms.The topical PVP-I/DMSO system was effective at treating the signs and symptoms of Demodex blepharitis. Further investigation of the novel agent is warranted. (...) Demodex Blepharitis Treated with a Novel Dilute Povidone-Iodine and DMSO System: A Case Report Povidone-iodine aqueous solution is an antiseptic commonly used in ophthalmology for treatment of the ocular surface. Dimethylsulfoxide (DMSO) is a well-known skin penetration enhancer that is scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 0.25% PVP-I in a gel containing DMSO for the treatment of Demodex blepharitis.A 95-year-old female presented

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2017 Ophthalmology and therapy

10. Comparative study of the efficacy of different treatment options in patients with chronic blepharitis. (PubMed)

Comparative study of the efficacy of different treatment options in patients with chronic blepharitis. To compare the efficacy of 3 treatment options in patients with chronic blepharitis.An experimental, randomized, controlled study was conducted on 45 patients (female 67%; Mean age: 40.5 years) diagnosed with chronic blepharitis, in order to compare the effectiveness of three treatment options. Group 1: eyelid hygiene with neutral shampoo three times/day; group 2: neutral shampoo eyelid

2015 Archivos de la Sociedad Española de Oftalmología

11. DEBS – a unification theory for dry eye and blepharitis (PubMed)

DEBS – a unification theory for dry eye and blepharitis For many years, blepharitis and dry eye disease have been thought to be two distinct diseases, and evaporative dry eye distinct from aqueous insufficiency. In this treatise, we propose a new way of looking at dry eye, both evaporative and insufficiency, as the natural sequelae of decades of chronic blepharitis. Dry eye is simply the late form and late manifestation of one disease, blepharitis. We suggest the use of a new term (...) in describing this one chronic disease, namely dry eye blepharitis syndrome (DEBS). Bacteria colonize the lid margin within a structure known as a biofilm. The biofilm allows for population densities that initiate quorum-sensing gene activation. These newly activated gene products consist of inflammatory virulence factors, such as exotoxins, cytolytic toxins, and super-antigens, which are then present for the rest of the patient's life. The biofilm never goes away; it only thickens with age, producing

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2016 Clinical ophthalmology (Auckland, N.Z.)

12. Blepharitis

Blepharitis Blepharitis - NICE CKS Clinical Knowledge Summaries Share Blepharitis: Summary Blepharitis describes inflammation of the margin of the eyelids. Chronic blepharitis can be classified according to which part of the margin of the eyelid is affected: Anterior blepharitis — the base of the eyelashes (located on the anterior margin of the eyelid) are inflamed. Posterior blepharitis — the meibomian glands (located on the posterior margin of the eyelid) are inflamed. It can also (...) be classified by its cause, as: Staphylococcal blepharitis. Seborrhoeic blepharitis. Meibomian blepharitis. Blepharitis is common and accounts for about 5% of all ophthalmological problems presenting in primary care. It is more common in older adults but can occur at any age. Blepharitis is a chronic condition. Treatment can control symptoms and prevent complications, however, periodic relapses and exacerbations can occur. Blepharitis should not permanently affect vision, provided that complications

2015 NICE Clinical Knowledge Summaries

13. Cheek and Periorbital Peculiar Discoid Lupus Erythematosus: Rare Clinical Presentation Mimicking Tinea Faciei, Cutaneous Granulomatous Disease or Blepharitis (PubMed)

Cheek and Periorbital Peculiar Discoid Lupus Erythematosus: Rare Clinical Presentation Mimicking Tinea Faciei, Cutaneous Granulomatous Disease or Blepharitis We present clinically peculiar facial discoid lupus erythematosus (DLE) that mimicked tinea faciei. Although DLE is a chronic autoimmune dermatosis, it has a variety of rare clinical presentations, including periorbital DLE, comedonic DLE and hypertrophic DLE recently. In this case, a scaly, erythematous lesion on the eyelid

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2015 Case reports in dermatology

14. Chronic Blepharitis

Chronic Blepharitis Chronic Blepharitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chronic Blepharitis Chronic Blepharitis Aka (...) : Chronic Blepharitis , Granulated Eyelids , Blepharitis From Related Chapters II. Types Anterior Blepharitis Affects base of eyelashes Associated with staphylococcal infection or Posterior Blepharitis Affects meibomian gland openings Associated with meibomian gland dysfunction III. Symptoms Local irritation and burning IV. Signs Inflammation of margin at the lash follicles Moderate lid swelling along lash line Lower is usually more affected Soft, oily V. Differential Diagnosis See VI. Associated

2015 FP Notebook

15. Efficacy of Over the Counter (OTC) Povidone-Ioldine 5% for Treatment of Acute or Chronic Blepharitis

Efficacy of Over the Counter (OTC) Povidone-Ioldine 5% for Treatment of Acute or Chronic Blepharitis Efficacy of Over the Counter (OTC) Povidone-Ioldine 5% for Treatment of Acute or Chronic Blepharitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Efficacy of Over the Counter (OTC) Povidone-Ioldine 5% for Treatment of Acute or Chronic Blepharitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01560962 Recruitment Status : Terminated (research staffs unable to continue.) First Posted : March 22

2012 Clinical Trials

16. Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis. (PubMed)

Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis. To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities.A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 (...) week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up.Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up.

2012 Arquivos brasileiros de oftalmologia

17. Interventions for chronic blepharitis. (PubMed)

Interventions for chronic blepharitis. Blepharitis, an inflammatory condition associated with itchiness, redness, flaking, and crusting of the eyelids, is a common eye condition that affects both children and adults. It is common in all ethnic groups and across all ages. Although infrequent, blepharitis can lead to permanent alterations to the eyelid margin or vision loss from superficial keratopathy (abnormality of the cornea), corneal neovascularization, and ulceration. Most importantly (...) , blepharitis frequently causes significant ocular symptoms such as burning sensation, irritation, tearing, and red eyes as well as visual problems such as photophobia and blurred vision. The exact etiopathogenesis is unknown, but suspected to be multifactorial, including chronic low-grade infections of the ocular surface with bacteria, infestations with certain parasites such as demodex, and inflammatory skin conditions such as atopy and seborrhea. Blepharitis can be categorized in several different ways

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2012 Cochrane database of systematic reviews (Online)

18. Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1%

application have show a good response in lice eradication. In this study , investigators will determinate the security and effectiveness of this compound in the eradication of mites Condition or disease Intervention/treatment Phase Chronic Blepharitis Drug: Ivermectin 0.1% Metronidazole 1% Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking (...) Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1% Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1% - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2014 Clinical Trials

19. Blepharitis, Adult (Follow-up)

examination. Previous References Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea . 2012 May. 31 (5):472-8. . Pinckney J 2nd, Cole P, Vadapalli SP, Rosen T. Phthiriasis palpebrarum: a common culprit with uncommon presentation. Dermatol Online J . 2008 Apr 15. 14(4):7. . Divani S, Barpakis K, Kapsalas D. Chronic blepharitis caused by Demodex folliculorum mites. Cytopathology . 2009 (...) Blepharitis, Adult (Follow-up) Adult Blepharitis Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTIxMTc2My10cmVhdG1lbnQ= processing > Adult

2014 eMedicine.com

20. Blepharitis, Adult (Diagnosis)

to their health and function. Patients with chronic blepharitis experience a considerable amount of discomfort and misery that can greatly reduce their well-being and ability to carry out the daily activities of life and work. Recognition of the waxing and waning course of the disease, and the necessity of management through a prolonged program rather than via an instant cure, helps them to approach the disease in a successful manner. Previous Next: Patient Education For excellent patient education resources (...) . Chronic blepharitis caused by Demodex folliculorum mites. Cytopathology . 2009 Mar 7. . Dhingra KK, Saroha V, Gupta P, Khurana N. Demodex-associated dermatologic conditions - A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma. Pathol Res Pract . 2009 Jan 22. . Jackson WB. Blepharitis: current strategies for diagnosis and management. Can J Ophthalmol . 2008 Apr. 43(2):170-9. . Luchs J. Efficacy of topical azithromycin ophthalmic solution 1

2014 eMedicine.com

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