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Chorionic Villus Sampling

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1. Amniocentesis and chorionic villus sampling for prenatal diagnosis. (PubMed)

Amniocentesis and chorionic villus sampling for prenatal diagnosis. During pregnancy, fetal cells suitable for genetic testing can be obtained from amniotic fluid by amniocentesis (AC), placental tissue by chorionic villus sampling (CVS), or fetal blood. A major disadvantage of second trimester amniocentesis is that the results are available relatively late in pregnancy (after 16 weeks' gestation). Earlier alternatives are chorionic villus sampling (CVS) and early amniocentesis, which can (...) of ultrasound-assisted procedure that is now considered obsolete.Second trimester amniocentesis increased the risk of pregnancy loss, but it was not possible to quantify this increase precisely from only one study, carried out more than 30 years ago.Early amniocentesis was not as safe as second trimester amniocentesis, illustrated by increased pregnancy loss and congenital anomalies (talipes). Transcervical chorionic villus sampling compared with second trimester amniocentesis may be associated

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2017 Cochrane

2. Risk of miscarriage following amniocentesis and chorionic villus sampling - systematic review of the literature and meta-analysis

Risk of miscarriage following amniocentesis and chorionic villus sampling - systematic review of the literature and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record (...) . ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e. differences in sample size), and that the true effect is the same

2019 PROSPERO

3. Procedure related risk of miscarriage from chorionic villus sampling and amniocentesis. (PubMed)

Procedure related risk of miscarriage from chorionic villus sampling and amniocentesis. The objective of our study was to estimate the procedure-related risks of miscarriage following CVS and amniocentesis in a large unselected screened and to determine whether these risks are consistent with those reported in systematic reviews and meta-analysis.This was a retrospective cohort study undertaken at a large Fetal Medicine Unit in the United Kingdom during the period of January 2009 to May 2018

2019 Ultrasound in Obstetrics and Gynecology

4. The Spectrum of Beta-thalassemia Mutations in Couples Referred for Chorionic Villus Sampling at Bahawal Victoria Hospital, Bahawalpur (PubMed)

The Spectrum of Beta-thalassemia Mutations in Couples Referred for Chorionic Villus Sampling at Bahawal Victoria Hospital, Bahawalpur Introduction The prevalence of beta-thalassemia mutations is different in various castes, regions, and ethnic groups. By knowing this prevalence, we can conduct a targeted screening of only the high-risk population and only for the specific mutations that are prevalent in each group. Objective The purpose of this study was to determine the regional, caste-wise (...) , and ethnic spectrum of beta-thalassemia mutations in couples referred for a prenatal diagnosis. Methods A cross-sectional analytical study was conducted at the thalassemia unit, Bahawal Victoria Hospital, Bahawalpur, from October 1, 2015, to May 15, 2018. After obtaining informed consent, chorionic villus sampling (CVS) was performed in 144 women having a gestational age of 12 to 16 weeks. We took blood samples of the couples. A chromosomal analysis for 13 mutations was done at Punjab Thalassaemia

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2018 Cureus

5. Managing pain and anxiety during transabdominal chorionic villus sampling. A noninferiority randomized trial of nitrous oxide vs local anesthesia. (PubMed)

Managing pain and anxiety during transabdominal chorionic villus sampling. A noninferiority randomized trial of nitrous oxide vs local anesthesia. Transabdominal chorionic villus sampling (CVS) is an invasive procedure for prenatal diagnosis reported to be associated with anxiety and pain. In this context, the need for analgesia during CVS has been considered useful. Even though several authors have been interested in pain management during amniocentesis, no study has been published on pain (...)  minutes) and 30-60 minutes after CVS. With a statistical power of 90%, type I error of 5% and two-sided test and potential exclusions, a sample size of 96 patients per group was enrolled and randomized. No patient was enrolled before the trial registration date.From 13 March 2013 through 10 February 2015, 192 patients (96 per group) were screened and randomized. Most characteristics were similar across groups. Pain in the N2 O group was 2.65 ± 0.22 vs 3.32 ± 0.26 in local anesthesia group [mean

2018 Acta Obstetricia et Gynecologica Scandinavica

6. Analgesia for amniocentesis or chorionic villus sampling. (PubMed)

Analgesia for amniocentesis or chorionic villus sampling. Besides risks of miscarriage, pregnant women undergoing amniocentesis or chorionic villus sampling (CVS) are also concerned about pain associated with these procedures. Currently, approaches to analgesia can be categorised in two broad categories - non-pharmacological and pharmacological agents.To evaluate whether different methods of analgesia have any impact on pain reduction during amniocentesis or chorionic villus sampling (CVS).We

2011 Cochrane

7. Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. (PubMed)

Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. The aim of this paper was to estimate the risk of miscarriage after amniocentesis or chorionic villus sampling (CVS) based on a systematic review of the literature.A search of Medline, Embase, and The Cochrane Library (2000-2017) was carried out to identify studies reporting complications following CVS or amniocentesis. The inclusion criteria for the systematic review were studies

2017 Minerva ginecologica

8. Chorionic villus sampling in the cell-free DNA aneuploidy screening era: careful selection criteria can maximise the clinical utility of screening and invasive testing. (PubMed)

Chorionic villus sampling in the cell-free DNA aneuploidy screening era: careful selection criteria can maximise the clinical utility of screening and invasive testing. To quantify the impact of cell-free DNA (cfDNA) screening on chorionic villus sampling (CVS) test indications and outcomes in a tertiary maternity service.Retrospective cohort study of all CVS procedures performed for any indication on singleton pregnancies at The Royal Women's Hospital, Melbourne, and at Women's Ultrasound

2017 Prenatal diagnosis

9. Pain Perception During Chorionic Villus Sampling

Pain Perception During Chorionic Villus Sampling Pain Perception During Chorionic Villus Sampling - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pain Perception During Chorionic Villus Sampling The safety (...) Enrollment : 120 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Randomized Trial to Determine if Local Anesthesia Decreases Pain Perception in Women Undergoing Chorionic Villus Sampling Actual Study Start Date : September 2016 Actual Primary Completion Date : May 23, 2017 Actual Study Completion Date : May 23, 2017 Resource links provided by the National Library of Medicine available for: Arms

2017 Clinical Trials

10. Maternal anxiety and its correlation with pain experience during chorion villus sampling and amniocentesis (PubMed)

Maternal anxiety and its correlation with pain experience during chorion villus sampling and amniocentesis Invasive prenatal diagnostic procedures, such as chorion villus sampling (CVS) and amniocentesis (AC), are routinely performed to exclude or diagnose fetal chromosomal abnormalities. The aim of this study was to investigate anxiety-dependent pain experience during CVS and AC and the potential factors that increase anxiety and pain levels.During a 2-year period, women undergoing invasive

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2017 Journal of pain research

11. Chorionic villus sampling as a source of trophoblasts. (PubMed)

Chorionic villus sampling as a source of trophoblasts. Unlike trophoblasts obtained from pregnancy termination material, trophoblasts grown from explanted chorionic villus samples (CVS) from 11-14 weeks of gestation potentially enable investigation of pre-eclampsia and other pregnancy disorders as the pregnancy outcome will later be known. CVS surplus to diagnostic needs were cultured as explants on either Matrigel or gelatin and the outgrowing cells characterised. Cell morphology was examined

2017 Placenta

12. Optimization of techniques for multiple platform testing in small, precious samples such as Human Chorionic Villus Sampling. (PubMed)

Optimization of techniques for multiple platform testing in small, precious samples such as Human Chorionic Villus Sampling. Multiple testing to understand global changes in gene expression based on genetic and epigenetic modifications is evolving. Chorionic villi, obtained for prenatal testing, is limited, but can be used to understand ongoing human pregnancies. However, optimal storage, processing and utilization of CVS for multiple platform testing have not been established.Leftover CVS (...) buffer to 70 °C. Purification of DNA was not necessary for bisulfite-conversion and genome-wide methylation profiling. CVS cells were propagated and continue to express genes found in freshly isolated chorionic villi.CVS samples preserved in RNAlater are superior. Our optimized techniques provide specimens for genetic, epigenetic and gene expression studies from a single small sample which can be used to develop diagnostics and treatments using a systems biology approach in the prenatal period. ©

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2016 Prenatal diagnosis

13. Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series. (PubMed)

Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series. To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.University and hospital clinics.Pregnant women with HIV.Temporal trends were analysed by analysis of variance

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2016 BJOG

14. Total pregnancy loss after chorionic villus sampling and amniocentesis - A cohort study. (PubMed)

Total pregnancy loss after chorionic villus sampling and amniocentesis - A cohort study. To identify maternal-, operator- and procedure-related variables that affect procedure-related pregnancy loss after transcervical (TC) and transabdominal (TA) chorionic villus sampling (CVS) and amniocentesis and to estimate the rates of spontaneous and procedure-related loss in comparable subgroups of women.This was a retrospective cohort study conducted at the University Medical Center Groningen

2016 Ultrasound in Obstetrics and Gynecology

15. Chromosomal copy number analysis on chorionic villus samples from early spontaneous miscarriages by high throughput genetic technology (PubMed)

Chromosomal copy number analysis on chorionic villus samples from early spontaneous miscarriages by high throughput genetic technology About 10 -15 % of all clinically recognized pregnancies result in spontaneous miscarriages, and chromosomal abnormalities are the most common reason. The conventional karyotyping on chorionic villus samples (CVSs) is limited by cell culture and its resolution. This study aimed at evaluating the efficiency of the application of high throughput genetic technology (...) , including array comparative genomic hybridization (array CGH) and next generation sequencing (NGS) on the chromosomal copy number analysis of CVSs from early spontaneous miscarriages.Four hundred and thirty-six CVSs from early spontaneous abortion were collected. Genomic DNA was extracted using a routine method, and the chromosomal copy number variants (CNVs) were analyzed by array CGH and NGS. Two hundred and twenty-five samples (51.6 %) with abnormal chromosomes were identified among 436 samples

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2016 Molecular cytogenetics

16. Chorionic Villus Sampling

Chorionic Villus Sampling Chorionic Villus Sampling Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chorionic Villus Sampling (...) Chorionic Villus Sampling Aka: Chorionic Villus Sampling II. Definition Definitive, first trimester for fetal chromosomal abnormalities III. Indications for fetal chromosomal abnormalities for high risk pregnancies IV. Protocol Performed between 10-13 weeks gestation Placental tissue sampling techniques Transabdominal sampling Transcervical sampling Higher of pregnancy loss than with abdominal sampling Indicated if placenta posterior or bowel blocks abdominal sampling V. Adverse Effects Pregnancy loss

2018 FP Notebook

17. Revisiting the challenges of training Maternal Fetal Medicine fellows in chorionic villus sampling. (PubMed)

Revisiting the challenges of training Maternal Fetal Medicine fellows in chorionic villus sampling. More than a decade ago, researchers described a survey of Maternal Fetal Medicine fellows that showed that chorionic villus sampling training was limited for Maternal Fetal Medicine fellows in the United States. Prenatal screening and diagnosis have rapidly evolved since then and include the introduction of noninvasive aneuploidy screening that uses cell-free fetal DNA. Yet, chorionic villus (...) sampling remains the only method available for first-trimester genetic diagnosis.This study evaluated the chorionic villus sampling training of Maternal Fetal Medicine fellows with respect to availability, competency standards, and education methods.In November 2015, an electronic survey was sent to Maternal Fetal Medicine fellows and fellowship directors of accredited Maternal Fetal Medicine fellowship programs in the United States.Fifty-eight percent of fellows (179/310) and 46% of program directors

2016 American Journal of Obstetrics and Gynecology

18. Effect of chorionic villus sampling on the occurrence of preeclampsia and gestational hypertension: An updated systematic review and meta-analysis. (PubMed)

Effect of chorionic villus sampling on the occurrence of preeclampsia and gestational hypertension: An updated systematic review and meta-analysis. To perform a meta-analysis for an assessment of the risk of preeclampsia or gestational hypertension following chorionic villus sampling (CVS).PubMed was systematically searched from its inception through January 2016.Nine reports were identified. A pre-specified scale was used to assess their quality.We performed pooling into three subgroups

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2016 Journal of the Turkish German Gynecological Association

19. Quantitative fluorescent polymerase chain reaction for rapid prenatal diagnosis of fetal aneuploidies in chorionic villus sampling in a single institution (PubMed)

Quantitative fluorescent polymerase chain reaction for rapid prenatal diagnosis of fetal aneuploidies in chorionic villus sampling in a single institution To validate quantitative fluorescent polymerase chain reaction (QF-PCR) via chorionic villus sampling (CVS) for the diagnosis of fetal aneuploidies.We retrospectively reviewed the medical records of consecutive pregnant women who had undergone CVS at Cheil General Hospital between December 2009 and June 2014. Only cases with reported QF-PCR

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2016 Obstetrics & gynecology science

20. Amniocentesis and Chorionic Villus Sampling

Amniocentesis and Chorionic Villus Sampling Amniocentesis and Chorionic Villus Sampling Green–top Guideline No. 8 June 2010RCOG Green-top Guideline No. 8 2of 13 © Royal College of Obstetricians and Gynaecologists Amniocentesis and Chorionic Villus Sampling This is the fourth edition of this guideline, which was previously published in October 1996, February 2000 and January 2005. 1. Aim It is estimated that around 5% of the pregnant population (approximately 30 000 women per annum in the UK (...) ) are offered a choice of invasive prenatal diagnostic tests (most commonly amniocentesis or chorionic villus sampling). The type of diagnostic test available and offered is likely to vary depending upon the timing of any initial screening test that is performed. The aim of this guideline is to set a series of evidence-based standards to ensure a high level and consistency of practice in the provision and performance of amniocentesis and chorionic villus sampling. 2. Background and introduction

2010 Royal College of Obstetricians and Gynaecologists

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