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Chorionic Villus Sampling

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1. Amniocentesis and chorionic villus sampling for prenatal diagnosis. (PubMed)

Amniocentesis and chorionic villus sampling for prenatal diagnosis. During pregnancy, fetal cells suitable for genetic testing can be obtained from amniotic fluid by amniocentesis (AC), placental tissue by chorionic villus sampling (CVS), or fetal blood. A major disadvantage of second trimester amniocentesis is that the results are available relatively late in pregnancy (after 16 weeks' gestation). Earlier alternatives are chorionic villus sampling (CVS) and early amniocentesis, which can (...) of ultrasound-assisted procedure that is now considered obsolete.Second trimester amniocentesis increased the risk of pregnancy loss, but it was not possible to quantify this increase precisely from only one study, carried out more than 30 years ago.Early amniocentesis was not as safe as second trimester amniocentesis, illustrated by increased pregnancy loss and congenital anomalies (talipes). Transcervical chorionic villus sampling compared with second trimester amniocentesis may be associated

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2017 Cochrane

2. Risk of miscarriage following amniocentesis and chorionic villus sampling - systematic review of the literature and meta-analysis

Risk of miscarriage following amniocentesis and chorionic villus sampling - systematic review of the literature and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record (...) . ">Planned approach If a meta-analysis is planned , please specify the following:"> Example: number of metastases: standardized mean difference; incidence of metastasis: risk ratio. ">Effect measure The random-effects model is the typical model of choice for pre-clinical meta-analyses. This is because in the fixed-effect model, it is assumed that the differences in observed effect between studies is solely due to sampling error (i.e. differences in sample size), and that the true effect is the same

2019 PROSPERO

3. Procedure related risk of miscarriage from chorionic villus sampling and amniocentesis. (PubMed)

Procedure related risk of miscarriage from chorionic villus sampling and amniocentesis. The objective of our study was to estimate the procedure-related risks of miscarriage following CVS and amniocentesis in a large unselected screened and to determine whether these risks are consistent with those reported in systematic reviews and meta-analysis.This was a retrospective cohort study undertaken at a large Fetal Medicine Unit in the United Kingdom during the period of January 2009 to May 2018

2019 Ultrasound in Obstetrics and Gynecology

4. Trials and tribulations of meta-analysing procedure-related risks of amniocentesis and chorionic villus sampling. (PubMed)

Trials and tribulations of meta-analysing procedure-related risks of amniocentesis and chorionic villus sampling. Evidence-based guidelines have previously quoted relatively high procedure-related risks of miscarriage with chorionic villus sampling and amniocentesis of 2% and 1%, respectively. Randomised controlled trials in this area are unlikely to be repeated, but contemporaneous observational data suggest much lower procedure-related risks. We were asked to update the evidence for the new

2019 Ultrasound in Obstetrics and Gynecology

5. Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of the literature and updated meta-analysis. (PubMed)

Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of the literature and updated meta-analysis. To estimate the procedure-related risks of miscarriage after amniocentesis and after transabdominal chorionic villus sampling (CVS), based on a systematic review of the literature and an updated meta-analysis.A search of MEDLINE, EMBASE, and The Cochrane Library was carried out to identify studies reporting complications following CVS or amniocentesis

2019 Ultrasound in Obstetrics and Gynecology

6. Rare autosomal trisomies (RATs): a comparison of the detection through cell-free DNA and chorionic villus sampling. (PubMed)

Rare autosomal trisomies (RATs): a comparison of the detection through cell-free DNA and chorionic villus sampling. Direct chromosome preparations of chorionic villus samples (CVS) and cell-free (cf) DNA testing both involve analysis of the trophoblastic cell lineage. We compared the spectrum of rare autosomal trisomies (RATs) detected by these two approaches and assessed the available information on their clinical significance.Data from 10 reports on genome-wide cfDNA testing were pooled (...) to those present in spontaneous abortions.RATs were present in 634 of 196,662 (0.32%) cfDNA samples and 237 of 57,539 (0.41% CVS trophoblast samples (P<0.01). Rates for cfDNA varied over 8-fold between reports. Confirmation of abnormality through amniocentesis was more likely when RATs were ascertained through cfDNA (15 of 237, 9.8%) compared to CVS trophoblasts (7 of 237, 3%) (P<0.01). cfDNA ascertained cases contained proportionately more trisomy 16, 15 and 22 which are associated with fetal loss

2019 Ultrasound in Obstetrics and Gynecology

7. Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing. (PubMed)

Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing. To evaluate the risk of inducing RhD immunisation in pregnancies of RhD-negative mothers with an RhD-positive fetus undergoing chorionic villus samplings (CVS) or amniocenteses (AC).Registry-based study in a Danish cohort which has not been given rhesus prophylaxis.Data were retrieved from

2019 BJOG

8. Prenatal enzymatic diagnosis of lysosomal storage diseases using cultured amniotic cells, uncultured chorionic villus samples, and fetal blood cells: Hacettepe experience. (PubMed)

Prenatal enzymatic diagnosis of lysosomal storage diseases using cultured amniotic cells, uncultured chorionic villus samples, and fetal blood cells: Hacettepe experience. 31411753 2019 08 23 1097-0223 2019 Aug 14 Prenatal diagnosis Prenat. Diagn. Prenatal enzymatic diagnosis of lysosomal storage diseases using cultured amniotic cells, uncultured chorionic villus samples, and fetal blood cells: Hacettepe experience. 10.1002/pd.5547 Unal Canan C https://orcid.org/0000-0003-0881-2831 Division (...) of prenatal enzymatic diagnostic studies for detecting lysosomal storage diseases (LSDs) during 1992 to 2018. Pregnancies subjected to “prenatal enzymatic diagnosis of LSDs” during 1992 to 2018 were retrospectively evaluated in terms of invasive prenatal tests, type of LSDs, and obstetric outcomes. A total of 142 pregnancies were evaluated for various types of LSDs of which 30, 103, and 9 cases were subjected to amniocentesis, chorionic villus sampling, and fetal blood sampling, respectively

2019 Prenatal diagnosis

9. The Spectrum of Beta-thalassemia Mutations in Couples Referred for Chorionic Villus Sampling at Bahawal Victoria Hospital, Bahawalpur (PubMed)

The Spectrum of Beta-thalassemia Mutations in Couples Referred for Chorionic Villus Sampling at Bahawal Victoria Hospital, Bahawalpur Introduction The prevalence of beta-thalassemia mutations is different in various castes, regions, and ethnic groups. By knowing this prevalence, we can conduct a targeted screening of only the high-risk population and only for the specific mutations that are prevalent in each group. Objective The purpose of this study was to determine the regional, caste-wise (...) , and ethnic spectrum of beta-thalassemia mutations in couples referred for a prenatal diagnosis. Methods A cross-sectional analytical study was conducted at the thalassemia unit, Bahawal Victoria Hospital, Bahawalpur, from October 1, 2015, to May 15, 2018. After obtaining informed consent, chorionic villus sampling (CVS) was performed in 144 women having a gestational age of 12 to 16 weeks. We took blood samples of the couples. A chromosomal analysis for 13 mutations was done at Punjab Thalassaemia

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2018 Cureus

10. Managing pain and anxiety during transabdominal chorionic villus sampling. A noninferiority randomized trial of nitrous oxide vs local anesthesia. (PubMed)

Managing pain and anxiety during transabdominal chorionic villus sampling. A noninferiority randomized trial of nitrous oxide vs local anesthesia. Transabdominal chorionic villus sampling (CVS) is an invasive procedure for prenatal diagnosis reported to be associated with anxiety and pain. In this context, the need for analgesia during CVS has been considered useful. Even though several authors have been interested in pain management during amniocentesis, no study has been published on pain (...)  minutes) and 30-60 minutes after CVS. With a statistical power of 90%, type I error of 5% and two-sided test and potential exclusions, a sample size of 96 patients per group was enrolled and randomized. No patient was enrolled before the trial registration date.From 13 March 2013 through 10 February 2015, 192 patients (96 per group) were screened and randomized. Most characteristics were similar across groups. Pain in the N2 O group was 2.65 ± 0.22 vs 3.32 ± 0.26 in local anesthesia group [mean

2018 Acta Obstetricia et Gynecologica Scandinavica Controlled trial quality: uncertain

11. Analgesia for amniocentesis or chorionic villus sampling. (PubMed)

Analgesia for amniocentesis or chorionic villus sampling. Besides risks of miscarriage, pregnant women undergoing amniocentesis or chorionic villus sampling (CVS) are also concerned about pain associated with these procedures. Currently, approaches to analgesia can be categorised in two broad categories - non-pharmacological and pharmacological agents.To evaluate whether different methods of analgesia have any impact on pain reduction during amniocentesis or chorionic villus sampling (CVS).We

2011 Cochrane

12. Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. (PubMed)

Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature. The aim of this paper was to estimate the risk of miscarriage after amniocentesis or chorionic villus sampling (CVS) based on a systematic review of the literature.A search of Medline, Embase, and The Cochrane Library (2000-2017) was carried out to identify studies reporting complications following CVS or amniocentesis. The inclusion criteria for the systematic review were studies

2017 Minerva ginecologica

13. Chorionic villus sampling in the cell-free DNA aneuploidy screening era: careful selection criteria can maximise the clinical utility of screening and invasive testing. (PubMed)

Chorionic villus sampling in the cell-free DNA aneuploidy screening era: careful selection criteria can maximise the clinical utility of screening and invasive testing. To quantify the impact of cell-free DNA (cfDNA) screening on chorionic villus sampling (CVS) test indications and outcomes in a tertiary maternity service.Retrospective cohort study of all CVS procedures performed for any indication on singleton pregnancies at The Royal Women's Hospital, Melbourne, and at Women's Ultrasound

2017 Prenatal diagnosis

14. Pain Perception During Chorionic Villus Sampling

Pain Perception During Chorionic Villus Sampling Pain Perception During Chorionic Villus Sampling - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pain Perception During Chorionic Villus Sampling The safety (...) Enrollment : 120 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Randomized Trial to Determine if Local Anesthesia Decreases Pain Perception in Women Undergoing Chorionic Villus Sampling Actual Study Start Date : September 2016 Actual Primary Completion Date : May 23, 2017 Actual Study Completion Date : May 23, 2017 Resource links provided by the National Library of Medicine available for: Arms

2017 Clinical Trials

15. Maternal anxiety and its correlation with pain experience during chorion villus sampling and amniocentesis (PubMed)

Maternal anxiety and its correlation with pain experience during chorion villus sampling and amniocentesis Invasive prenatal diagnostic procedures, such as chorion villus sampling (CVS) and amniocentesis (AC), are routinely performed to exclude or diagnose fetal chromosomal abnormalities. The aim of this study was to investigate anxiety-dependent pain experience during CVS and AC and the potential factors that increase anxiety and pain levels.During a 2-year period, women undergoing invasive

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2017 Journal of pain research

16. Chorionic villus sampling as a source of trophoblasts. (PubMed)

Chorionic villus sampling as a source of trophoblasts. Unlike trophoblasts obtained from pregnancy termination material, trophoblasts grown from explanted chorionic villus samples (CVS) from 11-14 weeks of gestation potentially enable investigation of pre-eclampsia and other pregnancy disorders as the pregnancy outcome will later be known. CVS surplus to diagnostic needs were cultured as explants on either Matrigel or gelatin and the outgrowing cells characterised. Cell morphology was examined

2017 Placenta

17. Optimization of techniques for multiple platform testing in small, precious samples such as Human Chorionic Villus Sampling. (PubMed)

Optimization of techniques for multiple platform testing in small, precious samples such as Human Chorionic Villus Sampling. Multiple testing to understand global changes in gene expression based on genetic and epigenetic modifications is evolving. Chorionic villi, obtained for prenatal testing, is limited, but can be used to understand ongoing human pregnancies. However, optimal storage, processing and utilization of CVS for multiple platform testing have not been established.Leftover CVS (...) buffer to 70 °C. Purification of DNA was not necessary for bisulfite-conversion and genome-wide methylation profiling. CVS cells were propagated and continue to express genes found in freshly isolated chorionic villi.CVS samples preserved in RNAlater are superior. Our optimized techniques provide specimens for genetic, epigenetic and gene expression studies from a single small sample which can be used to develop diagnostics and treatments using a systems biology approach in the prenatal period. ©

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2016 Prenatal diagnosis

18. Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series. (PubMed)

Amniocentesis and chorionic villus sampling in HIV-infected pregnant women: a multicentre case series. To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures.Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used.University and hospital clinics.Pregnant women with HIV.Temporal trends were analysed by analysis of variance

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2016 BJOG

19. Total pregnancy loss after chorionic villus sampling and amniocentesis - A cohort study. (PubMed)

Total pregnancy loss after chorionic villus sampling and amniocentesis - A cohort study. To identify maternal-, operator- and procedure-related variables that affect procedure-related pregnancy loss after transcervical (TC) and transabdominal (TA) chorionic villus sampling (CVS) and amniocentesis and to estimate the rates of spontaneous and procedure-related loss in comparable subgroups of women.This was a retrospective cohort study conducted at the University Medical Center Groningen

2016 Ultrasound in Obstetrics and Gynecology

20. Chromosomal copy number analysis on chorionic villus samples from early spontaneous miscarriages by high throughput genetic technology (PubMed)

Chromosomal copy number analysis on chorionic villus samples from early spontaneous miscarriages by high throughput genetic technology About 10 -15 % of all clinically recognized pregnancies result in spontaneous miscarriages, and chromosomal abnormalities are the most common reason. The conventional karyotyping on chorionic villus samples (CVSs) is limited by cell culture and its resolution. This study aimed at evaluating the efficiency of the application of high throughput genetic technology (...) , including array comparative genomic hybridization (array CGH) and next generation sequencing (NGS) on the chromosomal copy number analysis of CVSs from early spontaneous miscarriages.Four hundred and thirty-six CVSs from early spontaneous abortion were collected. Genomic DNA was extracted using a routine method, and the chromosomal copy number variants (CNVs) were analyzed by array CGH and NGS. Two hundred and twenty-five samples (51.6 %) with abnormal chromosomes were identified among 436 samples

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2016 Molecular cytogenetics

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