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Cholesterol Education Resources

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141. A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935

: 11 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Other Official Title: An Open-Label, Positron Emission Tomography, Phase 1 Study With [18F]MNI-792 to Determine Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935 After Single-Dose Oral Administration in Healthy Subjects. Study Start Date : July 2015 Actual Primary Completion Date : December 2015 Actual Study Completion Date : January 2016 Resource links provided by the National Library (...) A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935 A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2015 Clinical Trials

142. HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism

described in FHBL (apolipoprotein B (APOB), Proprotein convertase subtilisin/kexin type 9 (PCSK9)), Microsomal triglyceride transfer protein (MTP or ABL), chylomicron retention disease (CMRD), Secretion associated, Ras related GTPase (SARA2 gene), as well as 6 additional candidate genes in cholesterol metabolism (low density lipoprotein receptor (LDLR), Sortilin (SORT1), Inducible Degrader of the LDL receptor (IDOL), Cholesteryl ester transfer protein (CETP), Apolipoprotein E (ApoE) and Angiopoietin (...) HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2015 Clinical Trials

143. Cellular Effect of Cholesterol-Lowering Prior to Prostate Removal

. Such a trial will require a massive commitment of resources for the large number of patients needing long follow-up. A rational intermediate step is to conduct a presurgical intervention study to lower cholesterol in men undergoing radical prostatectomy. Molecular evidence of treatment effect will provide a sound rationale for definitive clinical trials, and may provide predictive biomarkers that can be validated in these future trials. The investigators propose a prospective trial to assess the effects (...) Cellular Effect of Cholesterol-Lowering Prior to Prostate Removal Cellular Effect of Cholesterol-Lowering Prior to Prostate Removal - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cellular Effect

2015 Clinical Trials

144. The Cholesterol Lowering Effects of Strawberry

Enrollment : 50 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Basic Science Official Title: The Cholesterol Lowering Effects of Strawberry: A Randomized Controlled Trial Establishing Strawberry's Role in Cardiovascular Health Actual Study Start Date : January 4, 2016 Estimated Primary Completion Date : May 4, 2019 Estimated Study Completion Date : May 4, 2019 Resource links (...) The Cholesterol Lowering Effects of Strawberry The Cholesterol Lowering Effects of Strawberry - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Cholesterol Lowering Effects of Strawberry (STR4) The safety

2015 Clinical Trials

145. Effect On Serum Cholesterol Of Dairy Products With Addition Of Esterified Phytosterols

/treatment Phase Dyslipidemias Hypercholesterolemia Dietary Supplement: Phytosterol Dietary Supplement: Placebo Phase 4 Detailed Description: Different protocols have demonstrated that phytosterol intake fluctuates between 1000 to 2000 mg per day decreasing LDL by around 10%, independently of levels of blood triglycerides and HDL (high density lipoproteins) concentrations. In fact, the National Cholesterol Education Program and the American Heart Association recommend the addition of 2 g/day (...) : Effect On Serum Cholesterol Of Dairy Products With Addition Of Esterified Phytosterols In Chilean Subjects With Hypercholesterolemia Study Start Date : October 2015 Actual Primary Completion Date : March 2016 Actual Study Completion Date : May 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Phytosterols Milk powder: subjects will be instructed to consume 22 g/day of the product, with 0.65 g

2015 Clinical Trials

146. Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)

Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C) Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C) (ORION) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02597127 Recruitment Status : Completed First Posted : November 5, 2015 Last Update Posted : November 17

2015 Clinical Trials

147. Effects of Reduction in Saturated Fat on Cholesterol and Lipoproteins in Lean and Obese Persons

: None (Open Label) Primary Purpose: Prevention Official Title: Effects of Reduction in Saturated Fat on Cholesterol and Lipoproteins in Lean and Obese Persons Study Start Date : September 2016 Actual Primary Completion Date : February 2018 Actual Study Completion Date : February 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: unsaturated fat an intervention diet substituting unsaturated fats from (...) Effects of Reduction in Saturated Fat on Cholesterol and Lipoproteins in Lean and Obese Persons Effects of Reduction in Saturated Fat on Cholesterol and Lipoproteins in Lean and Obese Persons - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2015 Clinical Trials

148. Evaluation of ARI-3037MO, to Suppress LDL Cholesterol in Patients With Dyslipidemia

Evaluation of ARI-3037MO, to Suppress LDL Cholesterol in Patients With Dyslipidemia Evaluation of ARI-3037MO, to Suppress LDL Cholesterol in Patients With Dyslipidemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Evaluation of ARI-3037MO, to Suppress LDL Cholesterol in Patients With Dyslipidemia (REASCEND) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02532218 Recruitment Status : Unknown Verified September 2015 by Arisaph Pharmaceuticals Inc. Recruitment status was: Active, not recruiting First

2015 Clinical Trials

149. Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects

and Function in Healthy Subjects Study Start Date : December 2015 Estimated Primary Completion Date : February 2016 Estimated Study Completion Date : April 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Low versus high fat/cholesterol diet The first day of the study protocol a low-fat/low-cholesterol (LFLC) normocaloric diet for 14 days was prescribed to the participants followed by a high-fat/high (...) -cholesterol (HFHC) normocaloric diet for further 14 days. Dietary Supplement: Low versus high fat/cholesterol diet The low fat/cholesterol diet had 10% calories from fat and 150-200 mg of cholesterol per day.The high fat/cholesterol diet had 40% calories from fat and 250-300 mg of cholesterol per day. Outcome Measures Go to Primary Outcome Measures : Dichlorofluorescein fluorescence slope [ Time Frame: 14 days ] Secondary Outcome Measures : hydroxyeicosatetraenoic acid [ Time Frame: 14 days

2015 Clinical Trials

150. Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease: a Randomized Comparison Trial

Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease: a Randomized Comparison Trial Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease: a Randomized Comparison Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information (...) . Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease: a Randomized Comparison Trial (LODESTAR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study

2015 Clinical Trials

151. An Observational Study Evaluating Cholesterol Levels in Patients on Cholesterol Lowering Drugs in Jordan and Lebanon

An Observational Study Evaluating Cholesterol Levels in Patients on Cholesterol Lowering Drugs in Jordan and Lebanon An Observational Study Evaluating Cholesterol Levels in Patients on Cholesterol Lowering Drugs in Jordan and Lebanon - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. An Observational Study Evaluating Cholesterol Levels in Patients on Cholesterol Lowering Drugs in Jordan and Lebanon (CEPHEUS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01614561 Recruitment Status : Completed First

2012 Clinical Trials

152. Diabetes Screening & Prevention for People With Learning (Intellectual) Disabilities:STOP Diabetes Study

with impaired glucose regulation make changes to their lifestyle (diet and exercise) they can prevent or delay getting diabetes. The aim of this study is to screen people with learning disabilities for diabetes and impaired glucose regulation. The investigators also want to find out the best way to give people with learning disabilities some education around healthy lifestyles (for example, eating and exercise) to help with prevention of diabetes and cardiovascular disease. Therefore, the investigators also (...) Programme for Prevention of Type 2 Diabetes in a Population With Learning Disabilities Study Start Date : February 2013 Actual Primary Completion Date : September 2015 Actual Study Completion Date : September 2015 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Glycosylated haemoglobin (HbA1c) [ Time Frame: Baseline screening appointment ] Identification of type 2 diabetes, impaired glucose regulation

2015 Clinical Trials

153. Evaluating System Change to Advance Learning and Take Evidence to Scale (ESCALATES)

with substantial resources, large quality improvement campaigns have been shown to increase adherence to guidelines by creating communities of learning that change behavior on a large scale. Agency for Healthcare Research and Quality (AHRQ) and the Patient Centered Outcomes Research Institute (PCORI) are partnering to launch a campaign to promote the improvement of guideline-based CVD preventive care in small primary care practices with limited resources and experience with quality improvement ("Implementation (...) Evaluating System Change to Advance Learning and Take Evidence to Scale (ESCALATES) Evaluating System Change to Advance Learning and Take Evidence to Scale (ESCALATES) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2015 Clinical Trials

154. Model-based simulation to explore the cost-effectiveness of following practice guidelines for triglyceride and low-density lipoprotein cholesterol control among patients with diabetes mellitus and mixed dyslipidemia

of economic evaluation Cost-effectiveness analysis, cost-utility analysis Study objective This study assessed the cost-effectiveness of guidelines for the prevention of coronary heart disease (CHD) by reducing cholesterol and triglycerides in a typical 60-year-old patient with diabetes mellitus and mixed dyslipidaemia. Interventions The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines were compared with the usual care. These guidelines had the following target (...) Model-based simulation to explore the cost-effectiveness of following practice guidelines for triglyceride and low-density lipoprotein cholesterol control among patients with diabetes mellitus and mixed dyslipidemia Model-based simulation to explore the cost-effectiveness of following practice guidelines for triglyceride and low-density lipoprotein cholesterol control among patients with diabetes mellitus and mixed dyslipidemia Model-based simulation to explore the cost-effectiveness

2009 NHS Economic Evaluation Database.

155. LDL – Lion King of Surrogate Endpoints – key cholesterol issue this week

if it turns out insurers really can’t prevent statin intolerant patients from getting the medicines. In the vast heart disease empire (market), LDL, Lion King of the surrogates, still rules. Boilerplate caveat: an FDA advisory committee’s advice is not binding on the FDA. What’s recommended is not always the same as the final FDA action. Note: If you don’t know much about surrogate markers, you might learn from reading our primer, “ ,” and its collection of links to other resources on the topic. Addendum (...) LDL – Lion King of Surrogate Endpoints – key cholesterol issue this week LDL - Lion King of surrogate endpoints, key cholesterol issue Note to our followers: Our nearly 13-year run of daily publication of new content on HealthNewsReview.org came to a close at the end of 2018. Publisher Gary Schwitzer and other contributors may post new articles periodically. But all of the 6,000+ articles we have published contain lessons to help you improve your critical thinking about health care

2015 HealthNewsReview

156. The Effect of Statin Treatment on Trained Innate Immunity

The Effect of Statin Treatment on Trained Innate Immunity The Effect of Statin Treatment on Trained Innate Immunity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effect of Statin Treatment on Trained (...) by (Responsible Party): Radboud University Study Details Study Description Go to Brief Summary: The innate immune system plays a pivotal role in the development and progression of atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting immunological memory after stimulation with various microorganisms, which has been termed 'trained innate immunity'. This memory is induced by epigenetic reprogramming, in particular trimethylation of lysine 4 at histone 3 (H3K4me3). In this study

2016 Clinical Trials

157. A Randomized Controlled Trial in Women With Coronary Artery Disease Investigating the Effects of Aerobic Interval Training Versus Moderate Intensity Continuous Exercise

A Randomized Controlled Trial in Women With Coronary Artery Disease Investigating the Effects of Aerobic Interval Training Versus Moderate Intensity Continuous Exercise A Randomized Controlled Trial in Women With Coronary Artery Disease Investigating the Effects of Aerobic Interval Training Versus Moderate Intensity Continuous Exercise - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search (...) for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Randomized Controlled Trial in Women With Coronary Artery Disease Investigating the Effects of Aerobic Interval Training Versus Moderate Intensity Continuous Exercise (CAT vs MICE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does

2016 Clinical Trials

158. High Intensity Aerobic Interval Training With Mediterranean Diet Recommendations in Post-Myocardial Infarct Patients

High Intensity Aerobic Interval Training With Mediterranean Diet Recommendations in Post-Myocardial Infarct Patients High Intensity Aerobic Interval Training With Mediterranean Diet Recommendations in Post-Myocardial Infarct Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. High Intensity Aerobic Interval Training With Mediterranean Diet Recommendations in Post-Myocardial Infarct Patients (INTERFARCT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2016 Clinical Trials

159. The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis.

(Clinical Trial) Actual Enrollment : 12 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis. Actual Study Start Date : January 2017 Actual Primary Completion Date : September 2017 Actual Study Completion Date : September 2017 Resource links provided by the National Library of Medicine related (...) The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis. The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2016 Clinical Trials

160. Anabolic Effects of Whey and Casein After Strength Training in Young and Elderly

Intervention Model: Crossover Assignment Masking: Triple (Participant, Care Provider, Outcomes Assessor) Primary Purpose: Basic Science Official Title: Effects of Whey and Casein Supplementation on Acute Anabolic Responses in Muscle After Strength Training in Young and Elderly Study Start Date : August 2014 Actual Primary Completion Date : April 2015 Actual Study Completion Date : May 2017 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm (...) baseline [ Time Frame: 30 min before, 1, 2.5 and 5 hours after training and protein intake ] Biopsies from m. Vastus Lateralis was analyzed by western blot Ubiquitin [ Time Frame: 30 min before, 1, 2.5 and 5 hours after training and protein intake ] Biopsies from m. Vastus Lateralis was analyzed by western blot Plasma amino acid concentration [ Time Frame: 180 and 60 min before, and 45, 60, 75, 120, 160, 180, 200, 220 and 300 min after training and protein intake ] Muscle force generating capacity

2016 Clinical Trials

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