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81. Acute Kidney Injury (AKI)

in the delivery of this care as well as relevant patient groups. It excludes the neonatal population and adults at risk of contrast nephropathy, for whom joint guidance already exists [1]. In the context of UK practice, our document joins Clinical Guidelines from the National Institute for Health and Care Excellence (NICE CG 169) [2] and the extensive resources of the Think Kidneys programme (https://www.thinkkidneys.nhs.uk/) . The view of the guideline development group was that the present work should (...) -requiring) at hospital discharge ? within 30 days for those with ongoing dialysis requirements at the time of hospital discharge Renal Association Clinical Practice Guideline Acute Kidney Injury (AKI) - August 2019 13 11. Education Guideline 11.1 – Adults and Paediatrics We recommend that undergraduate and postgraduate medical trainees should be taught the principles of prevention, detection and treatment of AKI. (1C) Renal Association Clinical Practice Guideline Acute Kidney Injury (AKI) - August 2019

2019 Renal Association

82. Population-level strategies to support healthy weight

, the greater the degree of individual agency required for an intervention to be effective, the more likely it is that the intervention will preferentially benefit people with a higher POPULATION-LEVEL STRATEGIES TO SUPPORT HEALTHY WEIGHT | SAX INSTITUTE 7 socioeconomic position compared with those with more limited social and economic resources. Accordingly, interventions focused on education and behaviour change are likely to have a negative overall impact on equity. In contrast, interventions that change (...) instruments (such as regulations, support for community action, and behav- iour change and education-based initiatives) have shown evidence of effectiveness and cost-effective- ness. • In community settings (such as schools, supermarkets, restaurants and workplaces) effective interven- tions are typically multi-component in nature, involving changes to the environment, behaviour change components and capacity building. • Due to the complex determinants of obesity, interventions are likely to have

2019 Sax Institute Evidence Check

83. Delivering novel therapies in the 21st century

antibody-drug conjugates, protein scaffolds and peptide fusions that combine functionality. These enable specificity to the drug target and bring benefits to particular disease settings. CASE STUDY 1 Antibody-peptide bispecific fusion A new antibody-peptide bispecific fusion combines different functionalities in one molecule. The monoclonal antibody a-PCSK9 lowers low density lipoprotein (so-called ‘bad’ cholesterol) in patients with cardiovascular disease. When bound to the peptide GLP-1R, which (...) the liver to restore function: while AAV alone repairs only 0.4% of cells, using AAV and CRISPR-Cas9 together repairs 6% of the liver. Fully synthetic systems are now being developed that do not require viruses for in vivo genome editing, by chemically modifying guide mRNA. This is being applied to create a single-administration treatment to lower cholesterol by deactivating the gene PCSK9. “I think that nanoparticles will be key to deliver genome editing tools, making drugs that repair your DNA while

2019 Academy of Medical Sciences

84. National Adult Diabetes Clinician Guide

depending on baseline HbA1C, baseline BMI (> 30 vs. 9 lbs., a diagnosis of GDM or polycystic ovary syndrome (PCOS) ? hypertension (= 140/90 mmHg or on therapy for hypertension) ? high-density lipoprotein cholesterol (HDL-C) level 250 mg/dl (2.82 mmol/l), or both ? HbA1c = 5.7%, IGT, or IFG on previous testing ? other clinical conditions associated with insulin resistance (e.g., severe obesity [defined as BMI = 40 kp/m 2 ], acanthosis nigricans) CLINICAL PRACTICE GUIDELINES | NATL February 2019 BLOOD (...) • Simultaneous use of an ACEI, ARB, and/or renin inhibitor is potentially harmful and is not recommended. • Do not prescribe ACEIs/ARBs, to women of childbearing potential, unless there is a compelling indication. Additional Details CLINICAL PRACTICE GUIDELINES | NATL February 2019 • For additional details, see KP Blood Pressure guideline. CHOLESTEROL THERAPY • See Cholesterol and Cardiovascular Risk guideline. ASPIRIN THERAPY • See Integrated Cardiovascular Health Clinical Leads interim guidance on aspirin

2019 Kaiser Permanente National Guideline Program

85. Productive healthy ageing: interventions for quality of life

for Productive Healthy Ageing 5 changing them, if appropriate) or by encouraging older people to increase their physical activity, reduce alcohol intake, maintain a healthy weight and balanced diet. The Centre for Pharmacy Postgraduate Education (CPPE), funded by Health Education England (HEE), provides a range of e-learning resources on topics such as Dementia and Older people. Pharmacy staff may want to use these learning materials to better support older people to live healthier lives to support (...) isolation and loneliness 16 Malnutrition 18 Improving public mental health 21 Further information, tools and resources 23 References 25 A Menu of Interventions for Productive Healthy Ageing 4 Introduction The Menu of Interventions (MOIs) for productive health ageing is a guide that pharmacy teams working in different healthcare settings can use to support older people to improve the quality of their lives. It suggests opportunistic, evidence-based interventions that can help provide benefits for healthy

2019 Public Health England

86. Oral care and people with learning disabilities

people. This might include making practical adjustments to the environment or changes in the process. This guidance signposts resources that can be used to support people with learning disabilities with their oral care. There are strategies that can be used to help reduce anxiety and better prepare people for dental treatment, such as desensitisation. There is a need for training and education for people with learning disabilities, their family carers and supporters and dental professionals (...) (an update from one on the same topic published in 2012) is one in a looking at reasonable adjustments in a specific service area. The aim is to share information, ideas and good practice in relation to the provision of reasonable adjustments. We searched for policy, guidelines, research and resources that relate to people with learning disabilities and oral care and dental services. We put a request out through a range of networks for people interested in services and care for people with learning

2019 Public Health England

87. Community Health Workers for Patients with Chronic Disease

(The Community Guide, n.d.). The CPSTF defines CHWs as frontline public health workers who serve as a bridge between underserved communities and health care systems. CHWs can be from or have a unique understanding of the community being served. Cardiovascular Disease Prevention Strong evidence was found on effectiveness in improving blood pressure and cholesterol when CHWs are engaged in a team-based care model. Sufficient evidence was found for the effectiveness of CHW interventions for health education (...) of Population Health Effect Evidence Type Resource Allocation Values and Preferences Other Considerations Disease-specific morbidity measures (Critical outcome) The preponderance of evidence supports the effectiveness of CHW interventions to improve disease-specific morbidity measures such as HbA1c, blood pressure, and asthma symptom-free days. Evidence type: Systematic reviews of RCTs, observational studies, and quasi-experimental studies Paying CHWs to engage in long duration, high- intensity

2019 Oregon Health Evidence Review Commission

88. Management of Dyslipidaemias (Full text)

and are regularly updated. The ESC carries out a number of registries which are essential to assess diagnostic/therapeutic processes, use of resources and adherence to Guidelines. These registries aim at providing a better understanding of medical practice in Europe and around the world, based on data collected during routine clinical practice. The guidelines are developed together with derivative educational material addressing the cultural and professional needs for cardiologists and allied professionals (...) and lipoproteins in the pathophysiology of atherosclerosis 17 5.3 Evidence for the causal effects of lipids and lipoproteins on the risk of atherosclerotic cardiovascular disease 18 5.3.1 Low-density lipoprotein cholesterol and risk of atherosclerosis 18 5.3.2 Triglyceride-rich lipoproteins and risk of atherosclerosis 18 5.3.3 High-density lipoprotein cholesterol and risk of atherosclerosis 19 5.3.4 Lipoprotein(a) and risk of atherosclerosis 19 5.4 Laboratory measurement of lipids and lipoproteins 19 5.4.1

2019 European Society of Cardiology PubMed abstract

89. Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases developed in collaboration with the EASD (Full text)

are essential to assess, diagnostic/therapeutic processes, use of resources and adherence to Guidelines. These registries aim at providing a better understanding of medical practice in Europe and around the world, based on data collected during routine clinical practice. The guidelines are developed together with derivative educational material addressing the cultural and professional needs for cardiologists and allied professionals. Collecting high-quality observational data, at appropriate time interval (...) disease HAS-BLED Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (>65 years), Drugs/alcohol concomitantly HbA1c Haemoglobin A1c HEART2D Hyperglycemia and Its Effect After Acute Myocardial Infarction on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus HDL-C High-density lipoprotein cholesterol HF Heart failure HFmrEF Heart failure with mid-range ejection fraction HFpEF Heart failure with preserved

2019 European Society of Cardiology PubMed abstract

90. Guidelines on Chronic Coronary Syndromes (Full text)

IMT Intima−media thickness IONA Impact Of Nicorandil in Angina iwFR Instantaneous wave-free ratio (instant flow reserve) LAD Left anterior descending LBBB Left bundle branch block LDL-C Low-density lipoprotein cholesterol LM Left main (coronary artery) LV Left ventricular LVEF Left ventricular ejection fraction MI Myocardial infarction MRA Mineralocorticoid receptor antagonist NOAC Non-vitamin K antagonist oral anticoagulant NT-proBNP N-terminal pro-B-type natriuretic peptide OAC Oral (...) on the ESC website ( ). The ESC Guidelines represent the official position of the ESC on a given topic and are regularly updated. The ESC carries out a number of registries which are essential to assess, diagnostic/therapeutic processes, use of resources and adherence to Guidelines. These registries aim at providing a better understanding of medical practice in Europe and around the world, based on data collected during routine clinical practice. The guidelines are developed together with derivative

2019 European Society of Cardiology PubMed abstract

91. Telehealth and the use of video conferences: A Rapid Review

disease. Nor were there any reviews that focused on appointment attendance as an outcome measure. Figure 1. PRISMA flowchart of included studies Skype video conferencing 2 One review 2 looked specifically at the use of Skype, a low-cost or no-cost video conferencing tool in healthcare settings. They found that the use of Skype was most prevalent in the management of chronic diseases such as cardiovascular diseases and diabetes, followed by educational and speech and language pathology applications (...) significant reductions in HbA1c and LDL-cholesterol. These results are comparable to patient results from face-to-face visits with clinical pharmacists. There were no significant changes in the number of patients attaining their HbA1c or LDL- cholesterol goals after video conference intervention. 8 Paediatrics Patient satisfaction has been reported to be high for paediatric video conferencing, with reports of cost and time savings for patients. Patient comfort with the consultation was reported in 77

2019 Monash Health Evidence Reviews

92. Canadian stroke best practice recommendations: secondary prevention of stroke, sixth edition practice guidelines

, atrial fibrillation, and other cardiac conditions. Notable changes in this sixth edition include the development of core elements for delivering secondary stroke prevention services, the addition of a section on cervical artery dissection, new rec- ommendations regarding the management of patent foramen ovale, and the removal of the recommendations on man- agement of sleep apnea. The Canadian Stroke Best Practice Recommendations include a range of supporting materials such as implementation resources (...) , and those who are hospitalized because of stroke or transient ischemic attack. Each section of these recommendations is supported by detailedevidencetablesandasummaryoftheevidence, a rationale for the importance of the topic, system implications to facilitate timely and e?cient implemen- tation, key quality indicators for measuring perform- ance and resources to support implementation and uptake for health care professionals and for patients. These are available at www.strokebestpractices.ca. Section 1

2018 CPG Infobase

93. Assessment of elevated creatinine

creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18. http://www.clinchem.org/cgi/content/full/52/1/5 http://www.ncbi.nlm.nih.gov/pubmed/16332993?tool=bestpractice.com Combining HPLC with IDMS provides highly accurate results, but is not available in most centres. POCT-based serum creatinine measurement appears to be sufficiently accurate for clinical use. Calzavacca P, Tee A, Licari E, et al. Point-of-care (...) with the Jaffe method by 20% or more in conditions such as diabetic ketoacidosis. The non-creatinine chromogens do not significantly affect urine creatinine levels, and have a smaller effect on the total reaction in advanced renal dysfunction than in normal renal function. Myers GL, Miller WG, Coresh J, et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18. http

2018 BMJ Best Practice

94. Assessment of elevated creatinine

creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18. http://www.clinchem.org/cgi/content/full/52/1/5 http://www.ncbi.nlm.nih.gov/pubmed/16332993?tool=bestpractice.com Combining HPLC with IDMS provides highly accurate results, but is not available in most centres. POCT-based serum creatinine measurement appears to be sufficiently accurate for clinical use. Calzavacca P, Tee A, Licari E, et al. Point-of-care (...) with the Jaffe method by 20% or more in conditions such as diabetic ketoacidosis. The non-creatinine chromogens do not significantly affect urine creatinine levels, and have a smaller effect on the total reaction in advanced renal dysfunction than in normal renal function. Myers GL, Miller WG, Coresh J, et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18. http

2018 BMJ Best Practice

95. Obese, overweight with risk factors: liraglutide (Saxenda)

have lost at least 5% of their initial body weight after 12 weeks treatment. There were high dropout rates in all of the studies so continuation with treatment may be a problem in practice. A summary to inform local decision-making is shown in table 1. T T able able 1 Summary of the e 1 Summary of the evidence on effectiv vidence on effectiveness, safety eness, safety, patient factors and resource implications , patient factors and resource implications Obese, overweight with risk factors (...) 3.0 mg compared with 3.3% to 6.0% with placebo across the 4 studies discussed in the evidence summary). Gastrointestinal disorders were the most common adverse events reported in the studies. Across the studies in the clinical development programme, nausea was reported in 39.3% of participants taking liraglutide 3.0 mg daily compared with 13.8% taking placebo (EPAR: Saxenda). Resource implications Resource implications Liraglutide (Saxenda) costs £196.20 for 30 days' supply at the maintenance dose

2017 National Institute for Health and Clinical Excellence - Advice

96. Management of stable angina

Perioperative revascularisation 33 6.3 Drug therapy in patients undergoing non-cardiac surgery 34 7 Psychological health 38 7.1 How does angina affect quality of life? 38 7.2 Improving symptom control with behavioural interventions 39 7.3 The effect of health beliefs on symptoms and functional status 40 8 Provision of information 41 8.1 Information and education about surgery and other interventions 41 8.2 Cardiac waiting times 42 8.3 Follow up in patients with angina 42 8.4 Checklist for provision (...) of information 43 8.5 Publications from SIGN 44 Management of stable angina Contents8.6 Sources of further information 44 9 Implementing the guideline 46 9.1 Implementation strategy 46 9.2 Resource implications of key recommendations 46 9.3 Auditing current practice 46 9.4 Health technology assessment advice for NHSScotland 47 10 The evidence base 48 10.1 Systematic literature review 48 10.2 Recommendations for research 48 10.3 Review and updating 49 11 Development of the guideline 50 11.1 Introduction 50

2018 SIGN

97. Public health service provision by community pharmacies: a systematic map of evidence

; Fajemisin 2013) and might be a person's only point of contact with a healthcare professional (LGA 2013). The range of services provided in community pharmacies are broad and varied, ranging from long- established services such as prescription services and sale of over the counter medicines, to health advice, education, distribution and advice around emergency hormonal contraception (EHC) and condoms and information or testing for specific conditions such as cholesterol testing. Further services (...) : This report should be cited as: Stokes G, Rees R, Khatwa M, Stansfield C, Burchett H, Dickson, K, Brunton G, Thomas J (2019) Public health service provision by community pharmacies: a systematic map of evidence. London: EPPI-Centre, Social Science Research Unit, Institute of Education, University College London. Funding This report is independent research commissioned by the National Institute for Health Research (NIHR) Policy Research Programme (PRP) for the Department of Health and Social Care (DHSC

2019 EPPI Centre

98. A systematic review of the effectiveness of primary health education or intervention programs in improving rural women's knowledge of heart disease risk factors and changing lifestyle behaviours. (Abstract)

A systematic review of the effectiveness of primary health education or intervention programs in improving rural women's knowledge of heart disease risk factors and changing lifestyle behaviours. Cardiovascular disease is the leading cause of death and disability for women in Australia. Women living in rural areas are at greater risk of heart disease, because of limited access and availability of healthcare in rural areas. Lifestyle is a major determinant to the risk of heart disease. Risk (...) factors such as smoking, hypertension, diet, physical activity and alcohol intake can be controlled or modified by lifestyle changes. As heart disease develops over many years, women need to be following healthy lifestyle practices and reduce their chance of a first or recurrent heart attack.To determine the effectiveness of primary health education or intervention programs for cardiac risk reduction in healthy women living in rural areas.Types of participants. Women aged 16-65 years, living in rural

2011 International journal of evidence-based healthcare

99. Stroke Health and Risk Education (SHARE)

: Prevention Official Title: Stroke Health and Risk Education (SHARE) Study Start Date : May 2011 Actual Primary Completion Date : December 2013 Actual Study Completion Date : December 2013 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Intervention for diet, exercise This group will receive the educational intervention for healthy diet and increased physical activity Behavioral (...) Stroke Health and Risk Education (SHARE) Stroke Health and Risk Education (SHARE) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Stroke Health and Risk Education (SHARE) (SHARE) The safety and scientific

2011 Clinical Trials

100. Two Years Maintenance of Structured Group Self-management Education in Type 2 Diabetes : a Randomized Controlled Trial

Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Prevention Official Title: Multicenter Randomized Trial of Structured Educational Intervention at the Community Level in Insufficiently Controlled Patients With Type 2 Diabetes in Reunion Island Actual Study Start Date : October 2011 Actual Primary Completion Date : September 2016 Actual Study Completion Date : September 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go (...) Two Years Maintenance of Structured Group Self-management Education in Type 2 Diabetes : a Randomized Controlled Trial Two Years Maintenance of Structured Group Self-management Education in Type 2 Diabetes : a Randomized Controlled Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2011 Clinical Trials

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