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81. Efficacy and Safety of Extended Release (ER) Niacin/Laropiprant When Added to Ongoing Lipid-Modifying Therapy in Patients With High Cholesterol or Abnormal Lipid Levels (MK-0524A-133)

at Week 4 [ Time Frame: Baseline and Week 4 ] Percent Change From Baseline in Lp(a) at Week 4 [ Time Frame: Baseline and Week 4 ] Percent Change From Baseline in Apo A-I at Week 4 [ Time Frame: Baseline and Week 4 ] Percent Change From Baseline in TC at Week 4 [ Time Frame: Baseline and Week 4 ] Number of Participants Who Achieve LDL-C Target Levels at Week 12 of Treatment [ Time Frame: Baseline and 12 weeks ] assessed as per National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP (...) Efficacy and Safety of Extended Release (ER) Niacin/Laropiprant When Added to Ongoing Lipid-Modifying Therapy in Patients With High Cholesterol or Abnormal Lipid Levels (MK-0524A-133) Efficacy and Safety of Extended Release (ER) Niacin/Laropiprant When Added to Ongoing Lipid-Modifying Therapy in Patients With High Cholesterol or Abnormal Lipid Levels (MK-0524A-133) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration

2010 Clinical Trials

82. Translating ATP III Cholesterol Management Guidelines Into Primary Care Practice

room with HeartAge risk calculator, PDA based decision support tool regarding hyperlipidemia management, website and tool box with coronary risk reduction tools for smoking cessation, diet and exercise, medication adherence Other Name: Cholesterol Education and Research Trial Usual care 15 practices receive academic detailing reviewing the ATP III cholesterol management guidelines Outcome Measures Go to Primary Outcome Measures : %patients at ATP III goals [ Time Frame: one year after intervention (...) Translating ATP III Cholesterol Management Guidelines Into Primary Care Practice Translating ATP III Cholesterol Management Guidelines Into Primary Care Practice - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2010 Clinical Trials

83. Pilot Program to Improve Statin Adherence and Lower Cholesterol in Older Adults

and Lower Cholesterol in Older Adults Study Start Date : October 2010 Actual Primary Completion Date : December 2013 Actual Study Completion Date : February 2014 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Medication adherence intervention Receives 12-week behavioral feedback intervention to improve adherence to statin medication Behavioral: Medication adherence intervention 12-week behavioral feedback (...) intervention to improve adherence to statin medication No Intervention: Control No intervention Active Comparator: Attention-control Receives visits on the same schedule as the intervention group, with health education that is unrelated to medications or cholesterol Behavioral: Attention-control Health education visits that are unrelated to medications or cholesterol, provided on the same visit schedule as the intervention group Outcome Measures Go to Primary Outcome Measures : Medication adherence [ Time

2010 Clinical Trials

84. Controlled trial of an intervention to improve cholesterol management in diabetes patients in remote Aboriginal communities. (PubMed)

Controlled trial of an intervention to improve cholesterol management in diabetes patients in remote Aboriginal communities. Aboriginal communities have a high prevalence of diabetes and heart disease, and limited resources to address them. The objective of this study was to test the effectiveness of prioritizing care with audit and feedback on cholesterol management of diabetic patients.A controlled before-after intervention trial was conducted among health care providers in Oji-Cree reserves (...) in Sioux Lookout Zone, Ontario. Two communities were randomized to receive an interactive educational workshop and chart audit with feedback on cholesterol management; 2 control communities received usual care.The primary outcome measure used was the proportion of patients on statins, and the secondary outcome measure was the proportion of patients with LDL>2.5 mmol/L or TC/HDL>4.0 on statins. Outcomes were assessed by chart review at baseline and 10 months post-intervention.Patients in the 2

2010 International journal of circumpolar health

85. Telehealth and the use of video conferences: A Rapid Review

disease. Nor were there any reviews that focused on appointment attendance as an outcome measure. Figure 1. PRISMA flowchart of included studies Skype video conferencing 2 One review 2 looked specifically at the use of Skype, a low-cost or no-cost video conferencing tool in healthcare settings. They found that the use of Skype was most prevalent in the management of chronic diseases such as cardiovascular diseases and diabetes, followed by educational and speech and language pathology applications (...) significant reductions in HbA1c and LDL-cholesterol. These results are comparable to patient results from face-to-face visits with clinical pharmacists. There were no significant changes in the number of patients attaining their HbA1c or LDL- cholesterol goals after video conference intervention. 8 Paediatrics Patient satisfaction has been reported to be high for paediatric video conferencing, with reports of cost and time savings for patients. Patient comfort with the consultation was reported in 77

2019 Monash Health Evidence Reviews

86. Delivering novel therapies in the 21st century

antibody-drug conjugates, protein scaffolds and peptide fusions that combine functionality. These enable specificity to the drug target and bring benefits to particular disease settings. CASE STUDY 1 Antibody-peptide bispecific fusion A new antibody-peptide bispecific fusion combines different functionalities in one molecule. The monoclonal antibody a-PCSK9 lowers low density lipoprotein (so-called ‘bad’ cholesterol) in patients with cardiovascular disease. When bound to the peptide GLP-1R, which (...) the liver to restore function: while AAV alone repairs only 0.4% of cells, using AAV and CRISPR-Cas9 together repairs 6% of the liver. Fully synthetic systems are now being developed that do not require viruses for in vivo genome editing, by chemically modifying guide mRNA. This is being applied to create a single-administration treatment to lower cholesterol by deactivating the gene PCSK9. “I think that nanoparticles will be key to deliver genome editing tools, making drugs that repair your DNA while

2019 Academy of Medical Sciences

87. Productive healthy ageing: interventions for quality of life

for Productive Healthy Ageing 5 changing them, if appropriate) or by encouraging older people to increase their physical activity, reduce alcohol intake, maintain a healthy weight and balanced diet. The Centre for Pharmacy Postgraduate Education (CPPE), funded by Health Education England (HEE), provides a range of e-learning resources on topics such as Dementia and Older people. Pharmacy staff may want to use these learning materials to better support older people to live healthier lives to support (...) isolation and loneliness 16 Malnutrition 18 Improving public mental health 21 Further information, tools and resources 23 References 25 A Menu of Interventions for Productive Healthy Ageing 4 Introduction The Menu of Interventions (MOIs) for productive health ageing is a guide that pharmacy teams working in different healthcare settings can use to support older people to improve the quality of their lives. It suggests opportunistic, evidence-based interventions that can help provide benefits for healthy

2019 Public Health England

88. Oral care and people with learning disabilities

people. This might include making practical adjustments to the environment or changes in the process. This guidance signposts resources that can be used to support people with learning disabilities with their oral care. There are strategies that can be used to help reduce anxiety and better prepare people for dental treatment, such as desensitisation. There is a need for training and education for people with learning disabilities, their family carers and supporters and dental professionals (...) (an update from one on the same topic published in 2012) is one in a looking at reasonable adjustments in a specific service area. The aim is to share information, ideas and good practice in relation to the provision of reasonable adjustments. We searched for policy, guidelines, research and resources that relate to people with learning disabilities and oral care and dental services. We put a request out through a range of networks for people interested in services and care for people with learning

2019 Public Health England

89. National Adult Diabetes Clinician Guide

depending on baseline HbA1C, baseline BMI (> 30 vs. 9 lbs., a diagnosis of GDM or polycystic ovary syndrome (PCOS) ? hypertension (= 140/90 mmHg or on therapy for hypertension) ? high-density lipoprotein cholesterol (HDL-C) level 250 mg/dl (2.82 mmol/l), or both ? HbA1c = 5.7%, IGT, or IFG on previous testing ? other clinical conditions associated with insulin resistance (e.g., severe obesity [defined as BMI = 40 kp/m 2 ], acanthosis nigricans) CLINICAL PRACTICE GUIDELINES | NATL February 2019 BLOOD (...) • Simultaneous use of an ACEI, ARB, and/or renin inhibitor is potentially harmful and is not recommended. • Do not prescribe ACEIs/ARBs, to women of childbearing potential, unless there is a compelling indication. Additional Details CLINICAL PRACTICE GUIDELINES | NATL February 2019 • For additional details, see KP Blood Pressure guideline. CHOLESTEROL THERAPY • See Cholesterol and Cardiovascular Risk guideline. ASPIRIN THERAPY • See Integrated Cardiovascular Health Clinical Leads interim guidance on aspirin

2019 Kaiser Permanente National Guideline Program

90. Management of stable angina

Perioperative revascularisation 33 6.3 Drug therapy in patients undergoing non-cardiac surgery 34 7 Psychological health 38 7.1 How does angina affect quality of life? 38 7.2 Improving symptom control with behavioural interventions 39 7.3 The effect of health beliefs on symptoms and functional status 40 8 Provision of information 41 8.1 Information and education about surgery and other interventions 41 8.2 Cardiac waiting times 42 8.3 Follow up in patients with angina 42 8.4 Checklist for provision (...) of information 43 8.5 Publications from SIGN 44 Management of stable angina Contents8.6 Sources of further information 44 9 Implementing the guideline 46 9.1 Implementation strategy 46 9.2 Resource implications of key recommendations 46 9.3 Auditing current practice 46 9.4 Health technology assessment advice for NHSScotland 47 10 The evidence base 48 10.1 Systematic literature review 48 10.2 Recommendations for research 48 10.3 Review and updating 49 11 Development of the guideline 50 11.1 Introduction 50

2018 SIGN

91. Canadian stroke best practice recommendations: secondary prevention of stroke, sixth edition practice guidelines

, atrial fibrillation, and other cardiac conditions. Notable changes in this sixth edition include the development of core elements for delivering secondary stroke prevention services, the addition of a section on cervical artery dissection, new rec- ommendations regarding the management of patent foramen ovale, and the removal of the recommendations on man- agement of sleep apnea. The Canadian Stroke Best Practice Recommendations include a range of supporting materials such as implementation resources (...) , and those who are hospitalized because of stroke or transient ischemic attack. Each section of these recommendations is supported by detailedevidencetablesandasummaryoftheevidence, a rationale for the importance of the topic, system implications to facilitate timely and e?cient implemen- tation, key quality indicators for measuring perform- ance and resources to support implementation and uptake for health care professionals and for patients. These are available at www.strokebestpractices.ca. Section 1

2018 CPG Infobase

92. Assessment of elevated creatinine

creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18. http://www.clinchem.org/cgi/content/full/52/1/5 http://www.ncbi.nlm.nih.gov/pubmed/16332993?tool=bestpractice.com Combining HPLC with IDMS provides highly accurate results, but is not available in most centres. POCT-based serum creatinine measurement appears to be sufficiently accurate for clinical use. Calzavacca P, Tee A, Licari E, et al. Point-of-care (...) with the Jaffe method by 20% or more in conditions such as diabetic ketoacidosis. The non-creatinine chromogens do not significantly affect urine creatinine levels, and have a smaller effect on the total reaction in advanced renal dysfunction than in normal renal function. Myers GL, Miller WG, Coresh J, et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18. http

2018 BMJ Best Practice

93. Assessment of elevated creatinine

creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18. http://www.clinchem.org/cgi/content/full/52/1/5 http://www.ncbi.nlm.nih.gov/pubmed/16332993?tool=bestpractice.com Combining HPLC with IDMS provides highly accurate results, but is not available in most centres. POCT-based serum creatinine measurement appears to be sufficiently accurate for clinical use. Calzavacca P, Tee A, Licari E, et al. Point-of-care (...) with the Jaffe method by 20% or more in conditions such as diabetic ketoacidosis. The non-creatinine chromogens do not significantly affect urine creatinine levels, and have a smaller effect on the total reaction in advanced renal dysfunction than in normal renal function. Myers GL, Miller WG, Coresh J, et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006 Jan;52(1):5-18. http

2018 BMJ Best Practice

94. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

the presence of (pre- )diabetes, hypertension, a low HDL-cholesterol, high triglycerides, and/or a high waist-circumference might indicate a higher associated risk, as is also the presence of non-alcoholic steato-hepatitis. Insulin resistance and metabolic syndrome are more prevalent in people with visceral adiposity. Obesity clearly does imply risks, may lead to physical and psychological symptoms, can cause functional limitation, the development of co- morbidities and complications, and cause psycho (...) characteristics, like e.g. the diabetes duration at moment of surgery. 39 Whether bariatric surgery is associated with a long-term reduction in complications from diabetes when compared with modern-day diabetes therapy is unknown. 39 The impact of surgery on serum lipids most often is a secondary study outcome. A pooled analysis of RCT data at 3 years showed a significant improvement (increase) in HDL cholesterol after surgery, but no statistically significant difference in serum triglycerides nor in total

2019 Belgian Health Care Knowledge Centre

95. Chronic kidney disease

, and providing the decrease in eGFR is 40% reduction in non-HDL cholesterol is not achieved. A renal specialist should be consulted if higher doses are required for patients with a eGFR 20%), increased length of hospital stay, and incomplete recovery of kidney function (many patients will be left with CKD). AKI and CKD are complex interconnected syndromes; CKD increases the risk of AKI and an episode of AKI increases the likelihood of subsequent development of CKD. Although AKI is common in hospitalised (...) for developing CKD after AKI is long-term and increases with increasing severity of AKI. 16 It is important to ensure appropriate follow-up and patient education. Patients should be monitored for the development or progression of CKD for at least two to three years after AKI, even if serum creatinine has returned to baseline. 2 A plan to carefully re-introduce or re-titrate necessary medicines that were withheld during the acute illness should be discussed with the patient together with the risk of recurrent

2018 WeMeReC

96. Menopause

Menopause CLINICAL PROFESSIONAL RESOURCE Menopause RCN guidance for nurses, midwives and health visitors Endorsed by This publication is supported by industryMENOPAUSE 2 This publication is due for review in November 2020. To provide feedback on its contents or on your experience of using the publication, please email publications.feedback@rcn.org.uk Acknowledgements This new publication is based on, and replaces, previous RCN publications – Women’s Health and the Menopause: RCN Guidance (...) 12 Screening 14 Hormone replacement therapy (HRT) 15 Prescribed alternatives to HRT 18 The therapeutic approach 19 Complementary approaches 19 6. Conclusion 24 References and further reading 25 Useful contacts and resources 26 ContentsMENOPAUSE 4 To provide support and advice to women it is important that all health care professionals understand the changes that women face at the time of their menopause and the issues related to improving health after menopause. Those working specifically

2018 Royal College of Nursing

97. Dietary patterns and cardiovascular disease outcomes

are based predominantly on single nutrients or foods. Recommendations include decreasing consumption of total fat, saturated fatty acids, cholesterol, salt and/or increasing consumption of fruit, vegetables, polyunsaturated fatty acids, monounsaturated fatty acids, fish, fibre and potassium. 4 Increasingly, literature has emerged that explores whole dietary patterns, rather than single nutrients or foods. Analysing food consumption in the form of dietary patterns offers a perspective different from (...) were determined to improve blood lipids, specifically total cholesterol and low-density cholesterol, while Low GI/GL was found to gain improvement in fat-free mass. Ten of the reviews for primary prevention included a meta-analysis, which compared a dietary pattern to another dietary approach. The comparator group varied across each of the meta-analysis and a detailed table of the comparators can be found in Appendix 7. The comparator diet was described as a ‘Western’ diet in n= 4 reviews, DASH

2018 Sax Institute Evidence Check

98. Multimorbidity: a priority for global health research

strategies for multimorbidity 60 5.3 Better models of healthcare for treating patients with multimorbidity 63 Acronyms 72 Glossary of terms 73 Annex 1: Project conduct and timeline 75 Annex 2: Membership of the working group, secretariat, and review group 76 Annex 3: Helpful resources 81 Annex 4: Clustering of conditions 82 Annex 5: Clustering of mental and physical health conditions 83 Annex 6: Sex as a determinant of multimorbidity 85 Annex 7: Ethnicity as a determinant of multimorbidity 87 Annex 8 (...) , and resource utilisation. 42,43 Many different weighted measures have been developed, including the Charlson Index, 44 the Chronic Disease Score, 45 the Adjusted Clinical Groups (ACG) System, 46 the Cumulative Illness Rating Scale (CIRS), 47 and the Functional Comorbidity Index (FCI). 48 A detailed description and appraisal of such measures is beyond the scope of this report, but each differ with respect to the study population and setting in which they have been most robustly validated (e.g. primary

2018 Academy of Medical Sciences

99. Accountable care organisations

a specified population for which providers are jointly accountable • Performance — determining target outcomes for the specified population, including resource use • Metrics and learning — developing and refining metrics to help determine whether outcomes are improving and to learn from these measurements and variations in results • Payment and incentives — restructuring payments and other incentives to align with the target outcomes, including details of risk-sharing arrangements • Coordinated delivery

2018 Sax Institute Evidence Check

100. The Patient Centred Medical Home: barriers and enablers to implementation

to specific populations 59 Additional enablers supporting the implementation of the PCMH 66 General 66 Education programs 67 Practice facilitation/ coaching 68 Learning collaboratives 69 Learning resources/ ‘toolkits’ 70 Performance measurement and feedback 70 Roles incorporated into primary care to support PCMH functions 71 Enablers for Indigenous populations 74 Gaps in the evidence 74 Discussion of findings 76 Applicability 78 Conclusion 79 References 80 Appendix 1: Literature selection process 88 (...) of care General strategies: Education programs Practice facilitation/coaching Learning communities/collaboratives Learning resources/’toolkits’ New/ enhanced roles: Medical practice assistant Community health workers Embedded pharmacists Integrated community specialists 3. Care coordination beyond the practice 3. Care coordination beyond the practice • Partnerships with community providers • Linkages with specialty and hospital care • Information sharing and continuity of care 4. Health information

2018 Sax Institute Evidence Check

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