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301. Niacin/Laropiprant Tablet for South and Southeast Asians With Low High-Density Lipoprotein Cholesterol (LDL-C) at Risk for Cardiovascular Disease (MK-0524A-108)

and Safety of Extended Release Niacin/Laropiprant in South and Southeast Asians Not on a Lipid Modulating Agent, With Decreased High-Density Lipoprotein Cholesterol and Low- Density Lipoprotein Cholesterol at or Below NCEP ATP III Goal Study Start Date : September 2011 Actual Primary Completion Date : February 2013 Actual Study Completion Date : February 2013 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment (...) about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion criteria: LMT ineligible Participants must meet the lipid criteria of "low to moderate CHD risk" as defined by National Cholesterol Education Program Adult Treatment Panel III

2011 Clinical Trials

302. Effect of Beta-Glucan on Cholesterol Lowering

Effect of Beta-Glucan on Cholesterol Lowering Effect of Beta-Glucan on Cholesterol Lowering - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Beta-Glucan on Cholesterol Lowering The safety (...) . Nancy Ames, University of Manitoba Study Details Study Description Go to Brief Summary: The primary aim of this study is to determine whether the cholesterol-lowering efficacy of barley b- glucan varied as function of molecular weight (MW) and the total daily amount consumed. Our second aim is to investigate the mechanism responsible for the action, specifically, whether β-glucan lowers circulating cholesterol concentration via inhibiting cholesterol absorption and synthesis. Thirdly, we aim

2011 Clinical Trials

303. Tomato Consumption and High Density Lipoprotein-cholesterol

Tomato Consumption and High Density Lipoprotein-cholesterol Tomato Consumption and High Density Lipoprotein-cholesterol - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tomato Consumption and High Density (...) Lipoprotein-cholesterol The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01342666 Recruitment Status : Completed First Posted : April 27, 2011 Results First Posted : February 12, 2013 Last Update Posted : February 28, 2013 Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

2011 Clinical Trials

304. Cholesterol Goal Attainment Rate and Its Associated Factors Among Dyslipidemic Patients on Lipid-lowering Drug Therapy in Korea

Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 4950 participants Observational Model: Case-Only Time Perspective: Retrospective Official Title: Cholesterol Goal Attainment Rate and Its Associated Factors Among Dyslipidemic Patients on Lipid-lowering Drug Therapy in Korea (CRESCENDO) Study Start Date : August 2011 Actual Primary Completion Date : October 2011 Actual Study Completion Date : October 2011 Resource links provided by the National (...) Cholesterol Goal Attainment Rate and Its Associated Factors Among Dyslipidemic Patients on Lipid-lowering Drug Therapy in Korea Cholesterol Goal Attainment Rate and Its Associated Factors Among Dyslipidemic Patients on Lipid-lowering Drug Therapy in Korea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2011 Clinical Trials

305. Cholesterol Metabolites as Markers for CYP3A Induction

Cholesterol Metabolites as Markers for CYP3A Induction Cholesterol Metabolites as Markers for CYP3A Induction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cholesterol Metabolites as Markers for CYP3A (...) Description Go to Brief Summary: The objectives of this study are: To investigate if the endogenous cholesterol metabolite, 4beta-OHcholesterol could be used as a marker for induction of cytochrome P450 (CYP) 3A4. To compare 4beta-OHcholesterol with midazolam as a marker for induction of CYP3A4. Condition or disease Intervention/treatment Phase CYP3A4 Induction Drug: Rifampicin treatment Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial

2011 Clinical Trials

306. Study Into Genetic Influence on Cholesterol Response to Dietary Fat

PCA2 Machine (Micromedical, UK) Change in fasting glucose [ Time Frame: 0, 8, 16, 24 weeks ] Change in fasting insulin [ Time Frame: 0, 8, 16, 24 weeks ] Change in fasting triglycerides (TAG) [ Time Frame: 0, 8, 16, 24 weeks ] Change in C-reactive protein (CRP) [ Time Frame: 0, 8, 16, 24 weeks ] Change in blood pressure [ Time Frame: 0, 8, 16, 24 weeks ] Change in body weight [ Time Frame: 0, 8, 16, 24 weeks ] Change in plasma phospholipid fatty acids [ Time Frame: 0, 8, 16, 24 weeks ] Change (...) Study Into Genetic Influence on Cholesterol Response to Dietary Fat Study Into Genetic Influence on Cholesterol Response to Dietary Fat - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study Into Genetic

2011 Clinical Trials

307. Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL Cholesterol

: Cardiovascular Fixed Combination Pill ASR: Pharmacodynamic Clinical Trial of a Fixed Dose Combination of Acetylsalicylic Acid, Simvastatin, and Ramipril (Cardiovascular Polypill); LDL Cholesterol Study Start Date : October 2010 Actual Primary Completion Date : April 2012 Actual Study Completion Date : April 2012 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Fixed Dose Combination Pill A fixed (...) by (Responsible Party): Ferrer Internacional S.A. Study Details Study Description Go to Brief Summary: This study evaluates the effect on LDL cholesterol of the 3 drugs given together in the cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin, and ramipril) as compared to the effect on LDL cholesterol of the reference products (simvastatin, ramipril, acetylsalicylic acid) Approximately 350 subjects will be screened, 266 randomized in order about 238 subjects to finish the study

2011 Clinical Trials

308. RT300 for spinal cord injury rehabilitation

to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 12(exclusive of VAT) plus an annual service charge of £495. An extra 6-channel stimulation unit costs £6,995. The resource impact resource impact is unclear because of a lack of evidence and uncertainty in the standard care pathway and which people may benefit. The technology The technology The RT300 combines functional electrical stimulation (FES) with a motorised ergometer that allows repetitive cycling (...) . Training plans vary in clinical practice. The typical training session can range from 15 to 60 minutes per session, 3 to 4 times per week. The training can last from 6 weeks up to lifetime use depending on the severity of spinal injuries. RT300 has systems configurable for different muscle groups (arms, legs) and can be used while in a wheelchair, chair or bed. It can be used by children. During a therapy session, the technology starts by passively cycling muscles and prepares them for exercise

2019 National Institute for Health and Clinical Excellence - Advice

309. Therapeutic guidelines for antiretroviral (ARV) treatment of adult HIV infection

Director & Director of Epidemiology & Population Health and Drug Treatment Program, BC Centre for Excellence in HIV/AIDS; Clinical Assistant Professor, School of Population and Public Health, University of British Columbia; Associate Member, Division of AIDS, Department of Medicine, University of British Columbia Silvia Guillemi, MD, MCFP Clinical Professor, Department of Family Practice, Faculty of Medicine, University of British Columbia; Director of Clinical Education, BC Centre for Excellence (...) of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10): e1003691. THERAPEUTIC GUIDELINES FOR ANTIRETROVIRAL TREATMENT OF ADULT HIV INFECTION 11 VERSION: DEC 2019 RETURN TO TABLE OF CONTENTS 19. British Columbia Guidelines for the care of HIV-positive pregnant individuals and interventions to reduce perinatal transmission and Dolutegravir prescribing guidelines for pregnancy and women of reproductive potential. Available at: http://www.bcwomens.ca/Professional-Resources- site/Documents/Oak

2020 CPG Infobase

310. Brain tumours (primary) and brain metastases in adults

-up for meningioma 51 Investigation of suspected brain metastases 52 Management of confirmed brain metastases 53 Follow-up for brain metastases 54 Care needs of people brain tumours 55 Neurorehabilitation needs of people with brain tumours 56 Surveillance for the late-onset side effects of treatment 57 Context 58 Finding more information and resources 60 Brain tumours (primary) and brain metastases in adults (NG99) © NICE 2019. All rights reserved. Subject to Notice of rights (https (...) glioma) and how they might affect practice, see rationale and impact. T T echniques for resection of glioma echniques for resection of glioma 1.2.36 If a person has a radiologically enhancing suspected high-grade glioma and the multidisciplinary team thinks that surgical resection of all enhancing tumour is possible, offer 5-aminolevulinic acid (5-ALA)-guided resection as an adjunct to maximise resection at initial surgery. Brain tumours (primary) and brain metastases in adults (NG99) © NICE 2019

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

311. Examining the Role of Coaching in Health-system Transformations

of the Interactive Systems Framework for Dissemination and Implementation, which consists of a support system working with the delivery system to enhance implementation capacity.(2) The framework includes four components that should be put in place: 1) tools (e.g., informational resources designed to organize, summarize and communicate knowledge to those driving change); 2) training (e.g., instructional activity that promotes the acquisition of knowledge such as how to do a needs assessment); 3) technical (...) to refer individuals and organizations to appropriate trusted resources. Finally, organizational leaders may have more trust in coaches who are not perceived to report directly to the government. One recent medium-quality review found that coaches at the level of the individual practice were quality- improvement experts trained in change implementation.(2) The review reported that other facilitators included dietitians, practice assistants, research staff, and practice-enhancement assistants.(2) One

2020 McMaster Health Forum

312. Cardiovascular Disease: Tailored Pharmacy-based Interventions to Improve Medication Adherence

or supported or recommend* or centered OR "Guideline Adherence" OR Intervention* or strategy or approach or process or policy or policies or encourage* or enforce* or equity or ”provider education” or “patient education” OR evaluat* or promotion* or preparation* 4 "Hypertension" OR "Blood Pressure" OR "Cholesterol" OR hypercholesterol* OR "aspirin" OR “acetylsalicylic acid” or “ASA” OR "high lipid levels" OR "high level lipids" OR "blood fat" OR "blood fats" OR "blood lipid" OR "blood lipids” OR "stroke (...) . Search Strategy – Effectiveness Review Database: PubMed #1 "Hypertension"[Mesh] OR "Blood Pressure"[Mesh] OR "Hypercholesterolemia"[Mesh] OR "Cholesterol"[Mesh] OR "Aspirin"[Mesh] OR "hypertension"[Title/Abstract] OR "blood pressure"[Title/Abstract] OR "cholesterol"[Title/Abstract] OR "hypercholesterol"[Title/Abstract] OR "hypercholesterolemia"[Title/Abstract] OR “acetylsalicylic acid”[Title/Abstract] or “ASA”[Title/Abstract] OR “aspirin"[Title/Abstract] OR "high blood pressure" OR "high cholesterol

2020 Community Preventive Services Task Force

313. The effectiveness of Virtual Hospital models of care

and received outpatient diabetes education and advice on lifestyle inter- ventions. Patients were then randomised and the interventio n lasted 6 months for all patients. Treatment at home by videoconferen ce only versus standard outpatient treatment HbA1c and blood glucose levels. 24 hour blood pressure, cholesterol levels and albuminuria. General Practitioner. 2 nurses in the tele- medicine group and 3 in standard care group did most consultation s. Doctor sometimes present or asked for advice in both (...) or in part subject to the inclusion of an acknowledgement of the source. It may not be reproduced for commercial usage or sale. Reproduction for purposes other than those indicated above requires written permission from the copyright owners. Enquiries regarding this report may be directed to the: Manager Knowledge Exchange Program Sax Institute www.saxinstitute.org.au knowledge.exchange@saxinstitute.org.au Phone: +61 2 9188 9500 Suggested Citation: Moore G, Du Toit A, Jameson B, Liu A, Harris M

2020 Sax Institute Evidence Check

314. 10 things I learned from the 46th Malaysia-Singapore Congress of Medicine

10 things I learned from the 46th Malaysia-Singapore Congress of Medicine Emergency Medicine Blog: 10 things I learned from the 46th Malaysia-Singapore Congress of Medicine Friday, July 20, 2012 10 things I learned from the 46th Malaysia-Singapore Congress of Medicine 10 things I learned from the 46th Malaysia-Singapore Congress of Medicine Although this congress has not much relevant topics pertaining to emergency medicine, I learned a number of things on cardiometabolic updates. Below (...) are some of the things I learned: 1. In a patient with STABLE coronary disease, a recent landmark trial called the COURAGE trial shows that the nearly 5-year incidence of death or MI was similar whether the patient undergoes PCI or optimized medical therapy alone, although PCI showed some advantage in relieving angina. Reference: Boden WE, O'Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, Knudtson M, Dada M, Casperson P, Harris CL, Chaitman BR, Shaw L, Gosselin G, Nawaz S, Title LM, Gau G

2012 Emergency Medicine Blog

315. The use of statins in the primary prevention of cardiovascular disease: an online tool for shared-decision making

as historical and that it is exclusively originating from the United States. This score is still widely used; it is recommended by the US National Cholesterol Education Program (NCEP) 40 guideline and the Canadian Cardiovascular Society (CCS) guideline. 41 2.2.2 The Systematic Coronary Risk Estimation (SCORE) The European Society of Cardiology (ESC) Committee for Practice Guidelines (CPG) advocates using the Systematic Coronary Risk Estimation (SCORE) model based on the large European SCORE database. 4, 6 (...) European guidelines on CVD prevention Recommended by SIGN NICE guidelines on lipid modification International Task Force for Prevention of Coronary Disease ACCF/AHA Guideline Adapted from 38 ; CVD : Cardiovascular disease ; SBP: systolic blood pressure ; NCEP: National Cholesterol Education Program ; CCS: Canadian Cardiovascular Society ; SIGN: Scottish Intercollegiate Guidelines Network ; NICE: National institute for health and care excellence ; ACCF/AHA: American College of Cardiology Foundation

2020 Belgian Health Care Knowledge Centre

316. Lessons Learned from the hGH Era. Full Text available with Trip Pro

Lessons Learned from the hGH Era. Today, many medical interventions that begin as treatments for disease often expand into therapies that reduce disability, lessen disadvantage, or even confer advantage. Forces that propel profitable drugs, devices, and procedures dominate over considerations of efficient and equitable distribution of resources. This dominance is fueled by industry-physician collaborations often biased by prior assumptions, reliant on surrogate outcomes, and advantageous (...) to marketing. Interventions are justified by "medicalization" of physiologic variations (e.g. short stature) as defects or disease, and nudged into "standard practice" by key opinion leaders. The story below of recombinant human growth hormone (hGH) treatment of short stature is one vivid example, but others (e.g. expansion of drug treatment to "optimize" cholesterol profiles, bone health, psychological well-being) can be found throughout medicine. In the new obesity era, lessons learned from the hGH era

2011 Journal of Clinical Endocrinology and Metabolism

317. Guidelines on Chronic Coronary Syndromes Full Text available with Trip Pro

revisions the Guidelines are approved by all the experts involved in the Task Force. The finalized document is approved by the CPG for publication in the European Heart Journal. The Guidelines were developed after careful consideration of the scientific and medical knowledge and the evidence available at the time of their dating. The task of developing ESC Guidelines also includes the creation of educational tools and implementation programmes for the recommendations including condensed pocket guideline (...) tomography-based fractional flow reserve GEMINI- ACS A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome GFR Glomerular filtration rate GLS Global longitudinal strain GOSPEL Global secondary prevention strategies to limit event recurrence after myocardial infarction HbA1c Glycated haemoglobin HF Heart failure ICA Invasive coronary angiography IMR Index of microcirculatory resistance

2019 European Society of Cardiology

318. Management of Dyslipidaemias Full Text available with Trip Pro

on cardiovascular morbidity and mortality 33 8.7.4 Adverse effects and interactions 33 8.8 n-3 fatty acids 33 8.8.1 Mechanism of action 33 8.8.2 Effects on lipids 33 8.8.3 Effect on cardiovascular morbidity and mortality 33 8.8.4 Safety and interactions 34 8.9 Nicotinic acid 34 8.10 Cholesteryl ester transfer protein inhibitors 34 8.11 Future perspectives 34 8.11.1 New approaches to reduce low-density lipoprotein cholesterol 34 8.11.2 New approaches to reduce triglyceride-rich lipoproteins and their remnants 34 (...) lipoprotein cholesterol levels 25 7.4 Lifestyle recommendations to improve the plasma lipid profile 25 7.4.1 Body weight and physical activity 25 7.4.2 Dietary fat 25 7.4.3 Dietary carbohydrate and fibre 26 7.4.4 Alcohol 26 7.4.5 Smoking 26 7.5 Dietary supplements and functional foods for the treatment of dyslipidaemias 26 7.5.1 Phytosterols 26 7.5.2 Monacolin and red yeast rice 26 7.5.3 Dietary fibre 27 7.5.4 Soy 27 7.5.5 Policosanol and berberine 27 7.5.6 n-3 unsaturated fatty acids 27 8 Drugs

2019 European Society of Cardiology

319. Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases developed in collaboration with the EASD Full Text available with Trip Pro

are essential to assess, diagnostic/therapeutic processes, use of resources and adherence to Guidelines. These registries aim at providing a better understanding of medical practice in Europe and around the world, based on data collected during routine clinical practice. The guidelines are developed together with derivative educational material addressing the cultural and professional needs for cardiologists and allied professionals. Collecting high-quality observational data, at appropriate time interval (...) by the CPG for publication in the European Heart Journal. The Guidelines were developed after careful consideration of the scientific and medical knowledge and the evidence available at the time of their dating. The task of developing ESC Guidelines also includes the creation of educational tools and implementation programmes for the recommendations including condensed pocket guideline versions, summary slides, booklets with essential messages, summary cards for non-specialists and an electronic version

2019 European Society of Cardiology

320. ASGE guideline on screening and surveillance of Barrett’s esophagus

preferences, resource utilization, and cost-effectiveness. (Gastrointest Endosc 2019;89:1075-105.) Guidelines for appropriate use of endoscopy are based on a critical review of the available data and expert consensusat the time the guidelines were drafted.Further controlled clinical studies may be needed to clarify aspects of this guideline. This guideline may be revised as necessary to account for changes in technology, new data,orotheraspects ofclinicalpractice.Therecommen- dations in this document were (...) of the patient’sconditionandavailablecoursesofaction.There- fore, clinical considerations may lead an endoscopist to takeacourseofactionthatvariesfromtheseguidelines. INTRODUCTION Bile duct stones (choledocholithiasis) most frequently result from the migration of gallstones from the gall- bladder into the biliary tree. Gallstones are the conse- quence of cholesterol supersaturation in bile, inadequate bile salt levels or function, and diminished contractilityof thebiliary epitheliumbecauseofthemulti- factorial effects of diet, hormones, and genetic

2020 American Society for Gastrointestinal Endoscopy

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