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Cholesteatoma

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161. Is There A Systemıc Inflammatory Effect of Cholesteatoma? Full Text available with Trip Pro

Is There A Systemıc Inflammatory Effect of Cholesteatoma? Introduction Inflammation causes squamous epithelial transformation of the mucosa in the middle ear cavity and plays a role in the onset, growth, spread, and recurrence of cholesteatoma. Objectives The objective of this study is to investigate the systemic inflammatory effect in chronic otitis with cholesteatoma. Methods The study included a total of 311 patients comprising 156 patients with a pathology diagnosis of cholesteatoma (...) and a control group of 155 with no active inflammation. The Neutrophil-to-lymphocyte Ratio (NLR) was calculated by dividing the neutrophil value by the lymphocyte value. Results The mean NLR was 1.94 ± 0.91 in the patients with cholesteatoma and 1.94 ± 0.85 in the control group. We determined no statistically significant difference between the groups in respect of NLR (p = 0.983). We calculated the NLR as 2.01 ± 1.00 in patients with ossicle erosion and 1.82 ± 0.69 in those without ossicle erosion, 1.86

2016 International archives of otorhinolaryngology

162. Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas

Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02903550 Recruitment Status : Recruiting

2016 Clinical Trials

163. Effect of surgical intervention on middle-ear cholesteatoma with associated facial paralysis. (Abstract)

Effect of surgical intervention on middle-ear cholesteatoma with associated facial paralysis. To investigate the presenting symptoms, intra-operative findings and long-term facial nerve function in patients treated for cholesteatoma with associated facial paralysis.Fifteen patients with facial paralysis due to middle-ear cholesteatoma who underwent tympanomastoidectomy surgery from February 2000 to February 2015 were retrospectively reviewed. After removal of the cholesteatoma, a limited area

2016 Journal of Laryngology & Otology

164. Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation. (Abstract)

Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation. Mesna (i.e. sodium 2-mercaptoethanesulfonate; C2H5NaO3S2) has been used in otological surgery such as cholesteatoma dissection and tympanic membrane lateralisation in atelectatic ears. However, this study aimed to investigate its effect on cholesteatoma formation.A total of 20 Wistar rats were divided into two groups of 10 animals. The right and left ears of control animals were treated (...) intratympanic injection of 0.2 ml saline and the mesna group had a single intratympanic injection of 10 per cent mesna. Animals were killed 12 weeks after the last injection and the temporal bones were sent for histopathological evaluation.The cholesteatoma formation rate was 88 per cent in the propylene glycol control group, but was significantly lower in the mesna group (p = 0.01). There were no significant differences in granulation tissue formation (p = 0.498), cyst formation in the bulla (p = 0.381

2016 Journal of Laryngology & Otology

165. Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. (Abstract)

Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. 27684485 2018 09 28 2018 10 01 1749-4486 42 4 2017 08 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. 901-904 10.1111/coa.12759 Wilmot V V VV (...) Royal Hospital for Sick Children, Edinburgh, UK. Sharma A A Royal Hospital for Sick Children, Edinburgh, UK. eng Journal Article 2016 10 14 England Clin Otolaryngol 101247023 1749-4478 Cholesteatoma, Congenital IM Child Child, Preschool Cholesteatoma congenital diagnosis epidemiology Female Humans Incidence Male Middle Ear Ventilation Otitis Media with Effusion complications diagnosis surgery Retrospective Studies Tomography, X-Ray Computed 2016 09 23 2016 9 30 6 0 2018 10 3 6 0 2016 9 30 6 0

2016 Clinical Otolaryngology

166. Efficacy of antibiotic prophylaxis prior to tympanoplasty for contaminated cholesteatoma. Full Text available with Trip Pro

Efficacy of antibiotic prophylaxis prior to tympanoplasty for contaminated cholesteatoma. To evaluate the efficacy of combined antistaphylococcal and antipseudomonal preoperative antibiotics for preventing surgical site infections following tympanoplasty and mastoidectomy with contaminated cholesteatoma.Retrospective chart review.Medical records of patients who underwent tympanoplasty ± mastoidectomy for cholesteatoma were reviewed. Only cases considered to have contaminated or dirty surgical (...) a surgical site infection rate of 11%, and those treated with perioperative antibiotics had a rate of 1% (P = 0.02).Administration of preoperative antibiotics to cover staphylococcal and pseudomonal species may prevent surgical site infections with tympanoplasty ± mastoidectomy for contaminated cholesteatoma.4. Laryngoscope, 126:2363-2366, 2016.© 2016 The American Laryngological, Rhinological and Otological Society, Inc.

2016 Laryngoscope

167. Secondary Acquired Cholesteatoma: Presentation and Tympanoplasty Outcomes. (Abstract)

Secondary Acquired Cholesteatoma: Presentation and Tympanoplasty Outcomes. Comparing the clinical features and surgical outcomes of patients undergoing tympanoplasty for secondary acquired cholesteatoma (SAC) versus non-complicated tympanic membrane perforation (TMP).Retrospective patient review.Tertiary-care, academic center.All 41 patients with diagnosis of SAC confirmed at surgery between January 1, 2007 and June 30, 2014, and an age-matched cohort consisting of patients

2016 Otology and Neurotology

168. The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma. (Abstract)

The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma. Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian canal of the facial nerve. Extensive disease may extend (...) to the posterior and middle fossa dura, the otic capsule, the carotid artery, and the jugular bulb. Dehiscence of the Fallopian canal and direct involvement of the facial nerve epineurium by cholesteatoma are risk factors for intraoperative facial nerve injury during tympanomastoid surgery by exposing the facial nerve to mechanical trauma and inflammation during microdissection. We present two cases of recidivistic cholesteatoma with unusual medial involvement of the vertical segment of the facial nerve

2016 Otology and Neurotology

169. A study of mastoid pneumatisation and the presence of cholesteatoma in 393 patients. (Abstract)

A study of mastoid pneumatisation and the presence of cholesteatoma in 393 patients. This study aimed to evaluate the relationship between cholesteatoma formation and the degree of mastoid pneumatisation, and to assess the relationship between the location of cholesteatoma and the degree of mastoid pneumatisation.Data on all patients undergoing mastoid exploration for cholesteatoma between 1993 and 2011 were collected prospectively. Basic demographics, the degree of mastoid pneumatisation (...) and cholesteatoma site were recorded.A total of 393 patients (222 males and 171 females) underwent surgery for cholesteatoma. Patients' mean age was 37 years (range, 6-79 years). Pneumatisation of the mastoid was sclerotic in 23 per cent (n = 90), diploic in 16.7 per cent (n = 66) and cellular in 60.3 per cent of cases (n = 237) (p < 0.001). Atticoantral disease was present in 88.9 per cent of sclerotic, 95.4 per cent of diploic and 91.1 per cent of cellular mastoids. Middle-ear cholesteatoma was present

2015 Journal of Laryngology & Otology

170. Transcanal CO<sub>2</sub> laser-enabled ablation and resection (CLEAR) for intratympanic membrane congenital cholesteatoma. (Abstract)

Transcanal CO2 laser-enabled ablation and resection (CLEAR) for intratympanic membrane congenital cholesteatoma. Cholesteatoma in the tympanic membrane is frequently regarded as congenital but there has been no case series review or comparison study with typical pediatric congenital cholesteatoma (CC).All pediatric CC cases from 2009 to 2014 were collected, and a total of 10 cases of intratymapnic membrane CC (ICC) out of 429 CC cases were reviewed. They were compared with 14 cases

2015 International Journal of Pediatric Otorhinolaryngology

171. Comparing diffusion weighted MRI in the detection of post-operative middle ear cholesteatoma in children and adults. (Abstract)

Comparing diffusion weighted MRI in the detection of post-operative middle ear cholesteatoma in children and adults. There is a limited evidence base for the use of diffusion weighted MRI (DWMRI) in the assessment of post-operative cholesteatoma in children. This is important to address as this technique is particularly relevant in a paediatric setting.We searched a prospectively collected database of patients undergoing DWMRI for the assessment of residual and recurrent cholesteatoma. Imaging

2015 International Journal of Pediatric Otorhinolaryngology

172. The role of tympanostomy tubes in surgery for acquired retraction pocket cholesteatoma. (Abstract)

The role of tympanostomy tubes in surgery for acquired retraction pocket cholesteatoma. 1. To determine whether intraoperative tympanostomy tubes (TT) during surgery for acquired retraction pocket cholesteatoma (ARPC) can decrease recurrence of ARPC and retraction pockets (RP). 2. To determine the need for subsequent TT in children that did not initially receive TT.Retrospective review of children who underwent primary surgery for ARPC.Tertiary care children's hospital.Audiometry, operative (...) subsequently required TT. Audiometric outcomes were not different between groups. TT placement did not significantly affect the odds of recurrent ARPC and RP (95% CI 0.12-1.83, p=0.28 for ARPC and 95% CI 0.30-4.60, p=0.82 for RP). However, the odds of recurrent ARPC and RP were significantly increased in children with stapes and malleus erosion by cholesteatoma. Children with stapes and malleus involvement had 5.28 and 11.8 times higher odds of recurrent ARPC compared to those without ossicular erosion (95

2015 International Journal of Pediatric Otorhinolaryngology

173. Identification of altered protein abundances in cholesteatoma matrix via mass spectrometry-based proteomic analysis Full Text available with Trip Pro

Identification of altered protein abundances in cholesteatoma matrix via mass spectrometry-based proteomic analysis Cholesteatoma are cyst-like structures lined with a matrix of differentiated squamous epithelium overlying connective tissue. Although epithelium normally exhibits self-limited growth, cholesteatoma matrix erodes mucosa and bone suggesting changes in matrix protein constituents that permit destructive behaviour. Differential proteomic studies can measure and compare (...) the cholesteatoma proteome to normal tissues, revealing protein alterations that may propagate the destructive process.Human cholesteatoma matrix, cholesteatoma-involved ossicles, and normal middle ear mucosa, post-auricular skin, and non-involved ossicles were harvested. These tissues were subjected to multiplex peptide labeling followed by liquid chromatography and tandem mass spectrometry analysis. Relative protein abundances were compared and evaluated for ontologic function and putative involvement

2015 Journal of Otolaryngology - Head & Neck Surgery

174. The value of otoendoscopy in the management of middle ear cholesteatoma Full Text available with Trip Pro

The value of otoendoscopy in the management of middle ear cholesteatoma The surgical management of cholesteatoma is a controversial issue, particularly regarding intact-canal-wall mastoidectomy (ICWM) versus canal-wall-down mastoidectomy (CWDM). The current experiment compared the quality of visualization in different middle ear structures using ICWM with otoendoscopy with findings of CWDM by microscopy.The patients diagnosed with cholesteatoma underwent tympanomastoidectomy (...) , and then the patients selected for CWDM were included in the study (25 patients: 11 females and 14 males). After removing the cholesteatoma from the involved areas, otoendoscopic examination was done with a 4 mm, 0° endoscope by a neurootologist. All five middle ear structures (lateral epitympanum, sinus tympani, posterior crus of the stapes, round window niche, and Eustachian tube orifice) suspected of occult cholesteatoma were evaluated in terms of having or lacking the pathology. Then, CWDM was performed and all

2015 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

175. TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction Full Text available with Trip Pro

TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and function of TLRs in cholesteatoma remain unclear.We observed inflammatory (...) cell infiltration of the matrix and prematrix of human acquired cholesteatoma, as well as dramatically increased expression of TLR4 and the pro-inflammatory cytokines TNF-α and IL-1β. TLR2 exhibited an up-regulation that was not statistically significant. TLR4 expression in human acquired cholesteatoma correlated with disease severity; the number of TLR4-positive cells increased with an increased degree of cholesteatoma, invasion, bone destruction, and hearing loss. Moreover, TLR4 deficiency

2015 Scientific reports

176. Residual Cholesteatoma After Endoscope-guided Surgery in Children. (Abstract)

Residual Cholesteatoma After Endoscope-guided Surgery in Children. Endoscopes can facilitate surgery within tympanomastoid recesses that are not visible with the operating microscope. This study investigates whether use of endoscopes to guide dissection of cholesteatoma leads to lower rates of residual cholesteatoma than using the endoscope only for inspection after microscope-guided dissection.Comparative cohort study.Tertiary pediatric center.Two hundred thirty-five patients with acquired (...) or congenital cholesteatoma in children <18 years having intact canal wall surgery and follow-up >12 months.Comparison of group (A) microscope surgery followed by endoscopic inspection, with group (B) endoscope-guided dissection.Residual cholesteatoma rates, controlling for site of initial cholesteatoma, detection by second-stage surgery, and length of follow-up.Analysis of all patients showed endoscopic dissection was associated with less residua in the middle ear (risk difference = 0.12; p = 0.026, Kaplan

2015 Otology and Neurotology

177. Does Checking the Placement of Ossicular Prostheses via the Posterior Tympanotomy Improve Hearing Results After Cholesteatoma Surgery? (Abstract)

Does Checking the Placement of Ossicular Prostheses via the Posterior Tympanotomy Improve Hearing Results After Cholesteatoma Surgery? Posterior tympanotomy (PT) is often performed during the surgical management of middle ear cholesteatoma with extension in the retrotympanum area. This PT can also be used to control the right position of the ossicular prosthesis masked by the tympanic membrane reconstruction.To compare audiologic results after ossiculoplasty performed via the outer ear canal (...) and via the PT for patients with cholesteatoma.Retrospective chart reviews were performed for 68 patients (68 ears) with cholesteatoma who underwent titanium ossicular prosthesis surgery between January 2007 and January 2011. We compared audiologic results between two groups: the WPT group (the group without checking the prosthesis via the PT) and the PT group (the group with placing and/or checking the prosthesis via the PT). A postoperative pure-tone average air-bone gap of 20 dB or less

2015 Otology and Neurotology

178. The Bony Obliteration Tympanoplasty in Pediatric Cholesteatoma: Long-term Safety and Hygienic Results. (Abstract)

The Bony Obliteration Tympanoplasty in Pediatric Cholesteatoma: Long-term Safety and Hygienic Results. To present the safety and hygienic results of a 5-year longitudinal study in a pediatric population undergoing surgery for extensive cholesteatoma using a canal wall up approach with bony obliteration of the mastoid and epitympanic space.Retrospective consecutive study.Thirty-three children (≤18 yr) undergoing surgery for cholesteatoma (34 ears) between 1997 and 2009.Therapeutic.Tertiary (...) referral center.1) Residual and recurrent cholesteatoma rates at 5-year postsurgery, 2) postoperative waterproofing and hygienic status of the ear, and 3) required operation rate to achieve the safety and hygienic goals.At 5 years no patients were lost in follow-up. This consecutive series design is rare in chronical otitis media treatment reporting. The standard residual rate at 5 years was 5.8%, representing two residual cholesteatomas in the middle ear. The standard recurrence rate at 5 years

2015 Otology and Neurotology

179. Efficacy and Safety of Transcanal Endoscopic Ear Surgery for Congenital Cholesteatomas: A Preliminary Report. (Abstract)

Efficacy and Safety of Transcanal Endoscopic Ear Surgery for Congenital Cholesteatomas: A Preliminary Report. Transcanal endoscopic ear surgery (TEES) can provide greater visual access during resection of middle ear disease than the operating microscope. The purpose of this study was to determine the safety and efficacy of TEES when used for the management of congenital cholesteatoma (CC) in children.Retrospective case review.Tertiary referral center.Twelve children with CC confined (...) to the middle ear underwent TEES. Seven children were Potsic stage I, four were stage II, and one was stage III. The mean follow-up period was 23.1 months.Transcanal middle ear surgery using endoscopes.Incidence of surgical complications and cholesteatoma recurrence.Twelve patients underwent TEES and four patients underwent microscopic surgery during the same period. No surgical complications occurred. Postoperative audiograms were available for 7 of 12 patients who had puretone averages ranging from 3.3

2015 Otology and Neurotology

180. The Efficacy of Color-Mapped Diffusion-Weighted Images Combined With CT in the Diagnosis and Treatment of Cholesteatoma Using Transcanal Endoscopic Ear Surgery. (Abstract)

The Efficacy of Color-Mapped Diffusion-Weighted Images Combined With CT in the Diagnosis and Treatment of Cholesteatoma Using Transcanal Endoscopic Ear Surgery. To assess the efficacy of a color-mapped diffusion-weighted image combined with a computed tomography scan (CMDWI-CT) in preoperatively evaluating the anatomical location of cholesteatomas and determining whether a patient is indicated for transcanal endoscopic ear surgery (TEES) to reduce intraoperative switching to microscopic ear (...) surgery (MES).Prospective case study.A single university hospital.Fifty-five patients scheduled for middle ear cholesteatoma surgery.The CMDWI-CT is produced in a multistep process. A color-mapped fusion image (CMFI) is created by performing MR cisternography on a 1-mm thin-slice nonecho planar diffusion-weighted imaging (non-EPI DWI) and then by performing color mapping on the resulting image to enhance cholesteatoma visualization. False positives are reduced by taking a T1-weighted image (T1WI

2015 Otology and Neurotology

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