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Cholesteatoma

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141. Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. (Abstract)

Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. 27684485 2018 09 28 2018 10 01 1749-4486 42 4 2017 08 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. 901-904 10.1111/coa.12759 Wilmot V V VV (...) Royal Hospital for Sick Children, Edinburgh, UK. Sharma A A Royal Hospital for Sick Children, Edinburgh, UK. eng Journal Article 2016 10 14 England Clin Otolaryngol 101247023 1749-4478 Cholesteatoma, Congenital IM Child Child, Preschool Cholesteatoma congenital diagnosis epidemiology Female Humans Incidence Male Middle Ear Ventilation Otitis Media with Effusion complications diagnosis surgery Retrospective Studies Tomography, X-Ray Computed 2016 09 23 2016 9 30 6 0 2018 10 3 6 0 2016 9 30 6 0

2016 Clinical Otolaryngology

142. Acquired cholesteatoma epithelial hyperproliferation: Roles of cell proliferation signal pathways. (Abstract)

Acquired cholesteatoma epithelial hyperproliferation: Roles of cell proliferation signal pathways. To review the recent cell proliferation signal pathways in the etiopathogenesis of acquired middle ear cholesteatoma.PubMed (to September 2015).Articles about cell proliferation signal pathways in the etiopathogenesis of acquired cholesteatoma and treatment advances were searched in the PubMed database, from which 73 were included in this review.The exact underlying cellular and molecular (...) mechanism of acquired cholesteatoma still remains unknown. Recent research tends to regard the proliferation of cholesteatoma epithelial cells as the mechanism of cholesteatoma pathogenesis. Cell proliferation signal pathways including epidermal growth factor receptor/phosphoinositide 3-kinase/protein kinase B signal pathway, mitogen-activated protein kinase signal pathway, interleukin-6/signal transducer and activator of transcription 3 signal pathway, inhibitor of DNA binding/differentiation-1/nuclear

2016 Laryngoscope

143. Role of Malleus relocation in cholesteatoma surgery: Our experience in 145 patients. (Abstract)

Role of Malleus relocation in cholesteatoma surgery: Our experience in 145 patients. 27086553 2018 09 17 2018 09 17 1749-4486 42 3 2017 06 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Title: Role of Malleus relocation in cholesteatoma surgery: our experience in 145 patients. 738-743 10.1111/coa.12658 Ashraf B B Mansoura Faculty of Medicine, Department of ORL (Otology (...) IM Adolescent Adult Child Cholesteatoma, Middle Ear pathology surgery Female Hearing Humans Male Malleus surgery Middle Aged Retrospective Studies Treatment Outcome 2016 04 11 2016 4 19 6 0 2018 9 18 6 0 2016 4 19 6 0 ppublish 27086553 10.1111/coa.12658

2016 Clinical Otolaryngology

144. FleQ, a Transcriptional Activator, Is Required for Biofilm Formation In Vitro but Does Not Alter Virulence in a Cholesteatomas Model. Full Text available with Trip Pro

FleQ, a Transcriptional Activator, Is Required for Biofilm Formation In Vitro but Does Not Alter Virulence in a Cholesteatomas Model. Bacterial biofilm formation within cholesteatomas is responsible for increased persistence and tissue destruction and Pseudomonas aeruginosa deficient in biofilm formation (PAO1 ΔfleQ) are less virulent than the parent bacteria.Infected aural cholesteatomas have been demonstrated to be more destructive than uninfected cholesteatomas and infections are more (...) persistent. The chronicity and persistence of infections within cholesteatomas may be because of the presence of biofilm formation.Twenty-seven mutant strains of PAO1 were screened for surface adherence. These strains were also screened for static biofilm formation. The biofilms were quantified by staining with crystal violet. Aural cholesteatomas were then induced in Mongolian gerbils by ligation of the ear canal. At the time of ligation, the ear canals were inoculated with wild-type PAO1 and a biofilm

2016 Otology and Neurotology

145. Biochemical and Bioimaging Evidence of Cholesterol in Acquired Cholesteatoma. (Abstract)

Biochemical and Bioimaging Evidence of Cholesterol in Acquired Cholesteatoma. To quantify the barrier sterols and image the lipid structures in the matrix of acquired cholesteatoma and compare the distribution with that found in stratum corneum from normal skin, with the goal to resolve their potential influence on cholesteatoma growth.High-performance thin-layer chromatography (HPTLC) was used to achieve a quantitative biochemical determination of the sterols. The intercellular lipids were (...) visualized by Coherent Anti-Stokes Raman scattering (CARS) microscopy, which enables label-free imaging of the lipids in intact tissue samples.The results show that the total lipid content of the cholesteatoma matrix is similar to that of stratum corneum from skin and that the cholesteatoma matrix unquestionably contains cholesterol. The cholesterol content in the cholesteatoma matrix is increased by over 30% (w/w dry weight) compared to the control. The cholesterol sulfate content is below 1

2016 Rhinology and Laryngology

146. Reexamination of Etiology and Surgical Outcome in Patient With Advanced External Auditory Canal Cholesteatoma. (Abstract)

Reexamination of Etiology and Surgical Outcome in Patient With Advanced External Auditory Canal Cholesteatoma. To describe the etiology of advanced cases of external auditory canal (EAC) cholesteatoma (EACC), and to report the surgical management and outcomes based on canalplasty depending on the extent of adjacent structures involvement around the EAC.Retrospective case review.University hospital.Participants comprised 28 patients (12 males, 16 females) ranging in age from 9 to 86 years old (...) to the jugular bulb, multi-layered repair including bone paste, post-auricular pedicled musculo-periosteal flap, auto cartilage, and temporalis muscle fascia were required. Five patients required revision surgery (17%), including one case of recurrent (reconstructed) cholesteatoma and three cases of perforation of the tympanic membrane.In the majority of our series, underlying diseases followed with microangiopathy and angiogenesis could be possible candidates in the etiology of EACC. Enlarged bony

2016 Otology and Neurotology

147. Secondary Acquired Cholesteatoma: Presentation and Tympanoplasty Outcomes. (Abstract)

Secondary Acquired Cholesteatoma: Presentation and Tympanoplasty Outcomes. Comparing the clinical features and surgical outcomes of patients undergoing tympanoplasty for secondary acquired cholesteatoma (SAC) versus non-complicated tympanic membrane perforation (TMP).Retrospective patient review.Tertiary-care, academic center.All 41 patients with diagnosis of SAC confirmed at surgery between January 1, 2007 and June 30, 2014, and an age-matched cohort consisting of patients

2016 Otology and Neurotology

148. The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma. (Abstract)

The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma. Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian canal of the facial nerve. Extensive disease may extend (...) to the posterior and middle fossa dura, the otic capsule, the carotid artery, and the jugular bulb. Dehiscence of the Fallopian canal and direct involvement of the facial nerve epineurium by cholesteatoma are risk factors for intraoperative facial nerve injury during tympanomastoid surgery by exposing the facial nerve to mechanical trauma and inflammation during microdissection. We present two cases of recidivistic cholesteatoma with unusual medial involvement of the vertical segment of the facial nerve

2016 Otology and Neurotology

149. Cochleariform Process Abutment on TBCT in Early Congenital Cholesteatoma. (Abstract)

Cochleariform Process Abutment on TBCT in Early Congenital Cholesteatoma. To study the influence of the cochleariform process abutment (CPA) of early congenital cholesteatomas (CC) (ECCs) on surgical outcomes.Retrospective case review.University hospital otology referral clinic.Two hundred consecutive pediatric ECC patients.The patients were classified into three groups based on the temporal bone computed tomography (TBCT) findings of ECC: A) the absence of CPA, B) the presence of CPA, and C

2016 Otology and Neurotology

150. Monitoring Progression of 12 Cases of Non-Operated Middle Ear Cholesteatoma With Non-Echoplanar Diffusion Weighted Magnetic Resonance Imaging: Our Experience. (Abstract)

Monitoring Progression of 12 Cases of Non-Operated Middle Ear Cholesteatoma With Non-Echoplanar Diffusion Weighted Magnetic Resonance Imaging: Our Experience. The aim of this study is to gain insight into the disease progression and behavior of primary cholesteatoma in a cohort of patients who did not have surgery using non-echoplanar diffusion-weighted magnetic resonance imaging (DW MRI) serial monitoring.Retrospective longitudinal observational study of 12 cases of middle ear cleft (...) cholesteatoma diagnosed between 2009 and 2014 where surgery was not performed for various reasons. All cases were monitored radiologically with non-echoplanar half-Fourier acquisition single-shot turbo spin-echo diffusion weighted imaging annually for a median period of 23 months (between 11 and 45 mo) to evaluate for changes in disease volume and direction of growth.Of the 12 cases, there was one outlier where the cholesteatoma growth was disproportionately high compared with the rest of the cases outside

2016 Otology and Neurotology

151. Iatrogenic cholesteatoma arising from the vascular strip. (Abstract)

Iatrogenic cholesteatoma arising from the vascular strip. To highlight the phenomenon of cholesteatoma arising from the vascular strip following tympanoplasty and tympanomastoidectomy.Multi-institutional retrospective chart review.Consecutive adult and pediatric patients evaluated between 2000 and 2015 with acquired cholesteatoma arising from the skin of a prior vascular strip were identified. Patients with evidence of residual or recurrent cholesteatoma elsewhere in the middle ear, mastoid (...) , or ear canal were excluded.Seventeen cases (71% female, 53% right-sided) were identified, and the mean age at presentation was 39.2 years. Patients presented on average 12.9 years following prior otologic surgery, which was most commonly tympanoplasty without mastoidectomy (59%). However, younger patients presented with symptoms sooner following prior surgery (r = 0.61, r2 = 0.37, P = 0.0095). The most common presenting symptom was otorrhea (76%). All patients were found to have mastoid cholesteatoma

2016 Laryngoscope

152. Cholesteatoma in the Sellar Region Presenting as Hypopituitarism and Diabetes Insipidus. Full Text available with Trip Pro

Cholesteatoma in the Sellar Region Presenting as Hypopituitarism and Diabetes Insipidus. Clinically significant sellar cysts unrelated to pituitary adenomas are uncommon. Intracranial cholesteatomas are also rare and are most common in the middle ear and mastoid region. We report an even rarer case of cholesteatoma in the sellar region-a challenging diagnosis guided by clinical presentations, radiological signs, and biopsy, aiming at emphasize the importance of considering cholesteatoma when (...) making differential diagnoses of sellar lesions.We present a case of cholesteatoma in the sellar region in a 56-year-old man with hypopituitarism, diabetes insipidus, and cystic imaging findings. It was difficult to make an accurate diagnosis before surgery. We present detailed analysis of the patient's disease course and review pertinent literature.The patient underwent a surgical exploration and tumor resection through a transsphenoidal approach. Pathologic results revealed a cholesteatoma

2016 Medicine

153. Pooled analysis of the evidence for open cavity, combined approach and reconstruction of the mastoid cavity in primary cholesteatoma surgery. (Abstract)

Pooled analysis of the evidence for open cavity, combined approach and reconstruction of the mastoid cavity in primary cholesteatoma surgery. Cholesteatoma is keratinising epithelium within the middle-ear cleft or mastoid. This disease destroys the peripheral organs of balance and hearing, with possible intracranial sequelae. The management of cholesteatoma is surgical and the primary aim is to remove the disease and prevent recurrence. Secondary aims are to obtain a non-discharging, hearing (...) ear. Cholesteatoma surgery falls into two broad categories: open cavity surgery and combined approach surgery. A third surgical category is reconstruction of an open mastoid cavity after open surgery. This study performed a pooled analysis of the worldwide literature to compare the rates of cholesteatoma not being cured (i.e. recidivism), ear discharge and hearing change among open cavity, combined approach and reconstruction mastoid surgery for primary cholesteatoma.A literature search for all

2016 Journal of Laryngology & Otology

154. Repeated Postoperative Follow-up Diffusion-Weighted Magnetic Resonance Imaging to Detect Residual or Recurrent Cholesteatoma. (Abstract)

Repeated Postoperative Follow-up Diffusion-Weighted Magnetic Resonance Imaging to Detect Residual or Recurrent Cholesteatoma. In our institution, follow-up diffusion-weighted imaging (DWI) after cholesteatoma surgery is performed at least twice. The aim of this study was to determine the yield of the second follow-up DWI (D-W MRI-2) in patients in whom the first postoperative DWI (D-W MRI-1) was negative for residual or recurrent cholesteatoma.A retrospective analysis.Tertiary referral (...) center.Patients were included if 1) they had at least two postoperative DWI examinations after a canal wall up procedure with apparently complete cholesteatoma resection; 2) D-W MRI-1 was performed between 6 and 24 months after surgery and D-W MRI-2 performed at least 6 months after D-W MRI-1; 3) both DWI examinations were of good quality and covering the whole mastoid-middle ear region; 4) D-W MRI-1 was unequivocally negative for cholesteatoma; and 5) there was no clinical suspicion on otoscopy of recurrent

2016 Otology and Neurotology

155. Cost analysis and outcomes of a second-look tympanoplasty-mastoidectomy strategy for cholesteatoma. (Abstract)

Cost analysis and outcomes of a second-look tympanoplasty-mastoidectomy strategy for cholesteatoma. To analyze cost and compare cholesteatoma recidivism and hearing outcomes with single-stage and second-look operative strategies.Retrospective review and cost analysis.Adult and pediatric patients who underwent a tympanoplasty with mastoidectomy for cholesteatoma with a single-stage or second-look operative strategy were identified. Variables included procedure approach, residual or recurrent (...) cholesteatoma, ossicular chain reconstruction frequency, and operative complications. Audiologic outcomes included pre-/postoperative air bone gap (ABG) and word recognition score (WRS). Cost analysis included charges for consultation and follow-up visits, surgical procedures, computed tomography temporal bone scans, and audiology visits.One hundred and six patients had a tympanoplasty with mastoidectomy for cholesteatoma, with 80 canal wall-up procedures (CWU) as initial approach. Of these, 46 (57.5%) CWU

2016 Laryngoscope

156. Gustatory Dysfunction and Decreased Number of Fungiform Taste Buds in Patients With Chronic Otitis Media With Cholesteatoma. (Abstract)

Gustatory Dysfunction and Decreased Number of Fungiform Taste Buds in Patients With Chronic Otitis Media With Cholesteatoma. To compare the number of fungiform taste buds among patients with chronic otitis media (COM), those with pars flaccida retraction type cholesteatoma, and those with pars tensa retraction type cholesteatoma in combination with gustatory function.Thirty-seven patients with COM, 22 patients with pars flaccida retraction type cholesteatoma, and 17 patients with pars tensa (...) retraction type cholesteatoma were included. An average of 10 fungiform papillae (FP) per patient in the midlateral region of the tongue were observed by confocal laser scanning microscopy in vivo, and the average number of taste buds were counted. Just before the observation of FP, electrogustometry (EGM) was performed to evaluate gustatory function.A significant decrease of the average number of fungiform taste buds and significant elevation of EGM thresholds were clarified in the pars tensa retraction

2016 Rhinology and Laryngology

157. Combined Surgical Approach to Giant Cholesteatoma: A Case Report and Literature Review. Full Text available with Trip Pro

Combined Surgical Approach to Giant Cholesteatoma: A Case Report and Literature Review. Cholesteatomas can grow to a remarkable size before clinically making their presence felt. Managing giant cholesteatomas and their complications can become a challenge for the otological surgeon.We describe a case of a giant congenital cholesteatoma of the mastoid in an adult. The lesion extended to the sigmoid sinus, jugular bulb, carotid canal, occipital condyle, and the lateral portion of the first (...) cervical vertebra. Surgical excision was performed using a combined microscopic and endoscopic surgical approach.Our combined surgical technique enabled a more accurate removal of the cholesteatoma than a microscopic approach alone, with no surgical complications or damage to the structures affected by the disease.Using endoscopic instruments to manage giant cholesteatomas can help to avoid complications and improve surgical radicality.© The Author(s) 2016.

2016 Rhinology and Laryngology

158. Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas

Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02903550 Recruitment Status : Recruiting

2016 Clinical Trials

159. Cochlear implant and congenital cholesteatoma Full Text available with Trip Pro

Cochlear implant and congenital cholesteatoma The occurence of cholesteatoma and cochlear implant is rare. Secondary cholesteatomas may develop as a result of cochlear implant surgery. Primarily acquired cholesteatoma is not typically associated with congenital sensorineural hearing loss or cochlear implant in children. The occurrence of congenital cholesteatoma during cochlear implant surgery has never been reported before, partly because all patients are preoperatively submitted to imaging (...) studies which can theoretically exclude the disease.We have reported a rare case of congenital cholesteatoma, found during sequential second side cochlear implantation in a 3-year-old child. The child underwent a computed tomography (CT) scan and magnetic resonance imaging (MRI) at 12 months of age, before the first cochlear implant surgery, which excluded middle ear pathology. The mass was removed as an intact pearl, without visible or microscopic violation of the cholesteatoma capsule. All the areas

2016 Journal of Otolaryngology - Head & Neck Surgery

160. Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis Full Text available with Trip Pro

Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis 27235590 2016 07 04 2018 11 13 2210-2612 24 2016 International journal of surgery case reports Int J Surg Case Rep Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis. 108-11 10.1016/j.ijscr.2016.04.046 S2210-2612(16)30106-7 Mahdoufi R R ENT-Neck and Face Surgery, Hospital August 20, 1953, University Hospital IBN ROCHD, Casablanca, Morocco. Electronic address: mahdoufir (...) Netherlands Int J Surg Case Rep 101529872 2210-2612 Cholesteatoma Congenital Stenosis child external auditory canal 2016 04 03 2016 04 27 2016 04 27 2016 5 29 6 0 2016 5 29 6 0 2016 5 29 6 1 ppublish 27235590 S2210-2612(16)30106-7 10.1016/j.ijscr.2016.04.046 PMC4887586 Laryngoscope. 1980 Mar;90(3):383-91 7359960 Otolaryngol Head Neck Surg. 1999 Sep;121(3):298-300 10471877 Acta Otolaryngol. 1997 Mar;117(2):293-7 9105469 Arch Otolaryngol. 1984 Oct;110(10):690-3 6477266 Arch Otolaryngol. 1961 Mar;73:252-61

2016 International journal of surgery case reports

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