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Cholesteatoma

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121. Congenital cholesteatoma: Different clinical presentation in two cases (Full text)

Congenital cholesteatoma: Different clinical presentation in two cases Congenital cholesteatoma (CC) of the middle ear is a rare entity that may be undiagnosed for years. The lesion can grow undetected until it produces symptoms such as reduced hearing or otalgia.Case report.We report two cases of young ladies with CC who presented with different otological symptoms. The first case complained of recurrent unilateral ear pain while the second case presented with unilateral reduced hearing

2016 Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia

122. Evidence against the mucosal traction theory in cholesteatoma. (PubMed)

Evidence against the mucosal traction theory in cholesteatoma. To investigate the distribution of ciliated epithelium in the human middle ear and its potential role in the formation of cholesteatoma.Comparative human temporal bone study.We selected temporal bones from 14 donors with a diagnosis of cholesteatoma, 15 with chronic otitis media without retraction pockets, 14 with chronic otitis media with retraction pockets, 14 with cystic fibrosis (CF), and 16 controls. We mapped the distribution (...) of the ciliated cells in the mucosal lining of the middle ear and tympanic membrane using three-dimensional reconstruction analysis, and counted the number of ciliated cells in the middle ear mucosa.Ciliated cells are extremely sparse in the epithelial lining of the lateral surface of the ossicles in the epitympanum and the medial surface of the tympanic membrane. Furthermore, there is a significant decrease in the number of ciliated cells in these areas in temporal bones with cholesteatoma, chronic otitis

2017 Laryngoscope

123. Endoscopic versus microscopic approach in attic cholesteatoma surgery. (PubMed)

Endoscopic versus microscopic approach in attic cholesteatoma surgery. Compare the outcomes of primary exclusive endoscopic ear surgery with those of the microscopic ear surgery in a group of patients affected by attic cholesteatoma.Eighty patients suffered from attic cholesteatoma. Forty patients surgical treated with endoscopic ear surgery and forty patients surgical treated with microscopic ear surgery.No statistical differences were found in the parameters analysed (frequency of facial

2017 American Journal of Otolaryngology

124. Cholesteatoma

Cholesteatoma Cholesteatoma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cholesteatoma Cholesteatoma Aka: Cholesteatoma From (...) Related Chapters II. Pathophysiology Benign squamous metaplasia of middle ear epithelium TM epithelium retracts into mastoid air cells Mass gradually expands and keratinizes Forms epithelial inclusion cyst Contains crystals and keratinous debris Results in destruction of middle ear ossicles III. Cause Congenital Cholesteatoma Acquired Cholesteatoma IV. Symptoms Ear fullness Chronic suppurative discharge from middle ear Via perforated V. Signs Middle ear deafness Pearly gray middle ear mass VI

2018 FP Notebook

125. Genetics and cholesteatoma

Genetics and cholesteatoma Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures Timing and effect measures Email

2015 PROSPERO

126. Cochlear implant and congenital cholesteatoma (Full text)

Cochlear implant and congenital cholesteatoma The occurence of cholesteatoma and cochlear implant is rare. Secondary cholesteatomas may develop as a result of cochlear implant surgery. Primarily acquired cholesteatoma is not typically associated with congenital sensorineural hearing loss or cochlear implant in children. The occurrence of congenital cholesteatoma during cochlear implant surgery has never been reported before, partly because all patients are preoperatively submitted to imaging (...) studies which can theoretically exclude the disease.We have reported a rare case of congenital cholesteatoma, found during sequential second side cochlear implantation in a 3-year-old child. The child underwent a computed tomography (CT) scan and magnetic resonance imaging (MRI) at 12 months of age, before the first cochlear implant surgery, which excluded middle ear pathology. The mass was removed as an intact pearl, without visible or microscopic violation of the cholesteatoma capsule. All the areas

2016 Journal of Otolaryngology - Head & Neck Surgery

127. Is There A Systemıc Inflammatory Effect of Cholesteatoma? (Full text)

Is There A Systemıc Inflammatory Effect of Cholesteatoma? Introduction Inflammation causes squamous epithelial transformation of the mucosa in the middle ear cavity and plays a role in the onset, growth, spread, and recurrence of cholesteatoma. Objectives The objective of this study is to investigate the systemic inflammatory effect in chronic otitis with cholesteatoma. Methods The study included a total of 311 patients comprising 156 patients with a pathology diagnosis of cholesteatoma (...) and a control group of 155 with no active inflammation. The Neutrophil-to-lymphocyte Ratio (NLR) was calculated by dividing the neutrophil value by the lymphocyte value. Results The mean NLR was 1.94 ± 0.91 in the patients with cholesteatoma and 1.94 ± 0.85 in the control group. We determined no statistically significant difference between the groups in respect of NLR (p = 0.983). We calculated the NLR as 2.01 ± 1.00 in patients with ossicle erosion and 1.82 ± 0.69 in those without ossicle erosion, 1.86

2016 International archives of otorhinolaryngology

128. Intercellular Communication between Keratinocytes and Fibroblasts Induces Local Osteoclast Differentiation: a Mechanism Underlying Cholesteatoma-Induced Bone Destruction (Full text)

Intercellular Communication between Keratinocytes and Fibroblasts Induces Local Osteoclast Differentiation: a Mechanism Underlying Cholesteatoma-Induced Bone Destruction Bone homeostasis is maintained by a balance in activity between bone-resorbing osteoclasts and bone-forming osteoblasts. Shifting the balance toward bone resorption causes osteolytic bone diseases such as rheumatoid arthritis and periodontitis. Osteoclast differentiation is regulated by receptor activator of nuclear factor κB (...) ligand (RANKL), which, under some pathological conditions, is produced by T and B lymphocytes and synoviocytes. However, the mechanism underlying bone destruction in other diseases is little understood. Bone destruction caused by cholesteatoma, an epidermal cyst in the middle ear resulting from hyperproliferation of keratinizing squamous epithelium, can lead to lethal complications. In this study, we succeeded in generating a model for cholesteatoma, epidermal cyst-like tissue, which has

2016 Molecular and cellular biology

129. Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis (Full text)

Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis 27235590 2016 07 04 2018 11 13 2210-2612 24 2016 International journal of surgery case reports Int J Surg Case Rep Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis. 108-11 10.1016/j.ijscr.2016.04.046 S2210-2612(16)30106-7 Mahdoufi R R ENT-Neck and Face Surgery, Hospital August 20, 1953, University Hospital IBN ROCHD, Casablanca, Morocco. Electronic address: mahdoufir (...) Netherlands Int J Surg Case Rep 101529872 2210-2612 Cholesteatoma Congenital Stenosis child external auditory canal 2016 04 03 2016 04 27 2016 04 27 2016 5 29 6 0 2016 5 29 6 0 2016 5 29 6 1 ppublish 27235590 S2210-2612(16)30106-7 10.1016/j.ijscr.2016.04.046 PMC4887586 Laryngoscope. 1980 Mar;90(3):383-91 7359960 Otolaryngol Head Neck Surg. 1999 Sep;121(3):298-300 10471877 Acta Otolaryngol. 1997 Mar;117(2):293-7 9105469 Arch Otolaryngol. 1984 Oct;110(10):690-3 6477266 Arch Otolaryngol. 1961 Mar;73:252-61

2016 International journal of surgery case reports

130. TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation (Full text)

TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation Triggering receptor expressed on myeloid cells (TREM) has been broadly studied in inflammatory disease. However, the expression and function of TREM-2 remain undiscovered in acquired cholesteatoma. The expression of TREM-2 was significantly higher in human acquired cholesteatoma than in normal skin from the external auditory canal, and its expression level (...) was positively correlated with the severity of bone destruction. Furthermore, TREM-2 was mainly expressed on dendritic cells (DCs). In human acquired cholesteatoma, the expression of proinflammatory cytokines (IL-1β, TNF-α and IL-6) and matrix metalloproteinases (MMP-2, MMP-8 and MMP-9) were up-regulated, and their expression levels were positively correlated with TREM-2 expression. Osteoclasts were activated in human acquired cholesteatoma. In an animal model, TREM-2 was up-regulated in mice

2016 Scientific reports

131. Cholesteatoma in ectopic kidney (Full text)

Cholesteatoma in ectopic kidney Cholesteatoma in the urinary system is a rarely seen benign condition. Rosina firstly defined this condition in the year 1953. Histopathologically it is characterized with keratinization, and squamous metaplasia of urothelial epithelium associated with desquamation of keratinized layers. Flank pain is the most common symptom that is caused by elimination of keratinous material. In our case we will discuss cholesteatoma developed in an ectopic kidney which has

2016 Turkish journal of urology

132. Non-echoplanar diffusion weighted imaging in the detection of post-operative middle ear cholesteatoma: navigating beyond the pitfalls to find the pearl (Full text)

Non-echoplanar diffusion weighted imaging in the detection of post-operative middle ear cholesteatoma: navigating beyond the pitfalls to find the pearl Non-echoplanar diffusion weighted magnetic resonance imaging (DWI) has established itself as the modality of choice in detecting and localising post-operative middle ear cleft cholesteatoma. Despite its good diagnostic performance, there are recognised pitfalls in its radiological interpretation which both the radiologist and otologist should (...) . Given the limitation in sensitivity in detecting small cholesteatoma less than 3 mm, serial monitoring with DWI over time is recommended to allow any small residual cholesteatoma pearls to grow and become large enough to be detected on DWI. Optimising image acquisition and discussing at a joint clinico-radiological meeting both foster good radiological interpretation to navigate beyond the pitfalls and ultimately good patient care.• Non-echoplanar DWI is the imaging of choice in detecting post

2016 Insights into imaging

133. Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy (Full text)

Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy The present study aimed to evaluate the possibility of using coherent anti-Stokes Raman spectroscopy (CARS) microscopy to determine the specific molecular morphology of cholesteatoma by detecting the natural vibrational contrast of the chemical bonds without any staining.Specimens from the mastoid and tympanic membrane with and without cholesteatoma were analyzed using CARS microscopy, two (...) -photon excited fluorescence (TPEF) microscopy, and the second harmonic generation (SHG) microscopy.In cholesteatoma tissues from the mastoid, a strong resonant signal at 2845 cm-1 was observed by CARS, which indicated the detection of the CH2 hydro-carbon lipid bonds that do not generate visible signals at 2940 cm-1 suggestive of CH3 bonds in amino acids. A strong resonant signal at 2940 cm-1 appeared in an area of the same specimen, which also generated abundant signals by TPEF and SHG microscopy

2016 Journal of otology

134. Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives (Full text)

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different (...) theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords 'aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.' In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades

2016 Clinical and experimental otorhinolaryngology

135. Sensorineural Hearing Loss in Cholesteatoma. (Full text)

Sensorineural Hearing Loss in Cholesteatoma. To determine whether middle ear cholesteatoma is associated with, sensorineural hearing loss, and whether patient age, cholesteatoma growth pattern, or, air bone gap size contribute to inner ear impairment.Cross-sectional comparative.A tertiary hospital.The subjects were 115 patients with middle ear cholesteatoma in one ear, and normal video-otoscopy in the contralateral ear (CLE).Otoendoscopy, pure-tone audiometry.Bone conduction (BC) threshold (...) differences between the normal CLE and the cholesteatoma ear. Comparisons of these differences between different cholesteatoma growth patterns. Correlation between the air bone gap size in the ear with cholesteatoma and the difference in bone conduction thresholds between both ears.The cholesteatoma ear was associated with greater BC thresholds than the CLE. With regard to different cholesteatoma growth patterns, the differences between associated BC thresholds were also significant in all groups at all

2016 Otology and Neurotology

136. Sanna Classification and Prognosis of Cholesteatoma of the Petrous Part of the Temporal Bone: A Retrospective Series of 81 Patients. (PubMed)

Sanna Classification and Prognosis of Cholesteatoma of the Petrous Part of the Temporal Bone: A Retrospective Series of 81 Patients. To determine how classification of petrous bone cholesteatomas (PBCs) using the 5-point Sanna classification can predict major structural involvement, facial nerve outcomes, hearing outcomes, postoperative complications, and disease recurrence.Retrospective case series.Tertiary referral center in Bergamo, Italy.Eighty-one sequential patients with radiologic

2016 Otology and Neurotology

137. Classification of Cholesteatoma According to Growth Patterns. (Full text)

Classification of Cholesteatoma According to Growth Patterns. Several classifications of cholesteatoma exist, but there are controversies about their clinical application.To classify cholesteatomas and describe the prevalence of the subtypes.A cross-sectional comparative study of 414 ears in 356 consecutive patients with middle ear cholesteatoma and no history of ear surgery treated at a tertiary hospital was conducted from March 8, 2000, to March 30, 2015. Data analysis was conducted from (...) patients (61.8%). A total of 272 (65.7%) ears were from adults. Of the 414 ears that underwent otoendoscopy, posterior epitympanic (142 [34.3%]) and posterior mesotympanic (140 [33.8%]) were the most frequent types of cholesteatoma observed, followed by undetermined (67 [16.2%]) and 2 routes (57 [13.8%]). Anterior epitympanic type was the least frequent (8 [1.9%]). Posterior epitympanic cholesteatoma was more prevalent in adults (111 [40.8%]), whereas posterior mesotympanic cholesteatoma was more

2016 JAMA otolaryngology-- head & neck surgery

138. Analysis of histopathological aspects and bone destruction characteristics in acquired middle ear cholesteatoma of pediatric and adult patients. (PubMed)

Analysis of histopathological aspects and bone destruction characteristics in acquired middle ear cholesteatoma of pediatric and adult patients. The aim of this study was to investigate the proliferative and apoptotic activity of middle ear cholesteatoma in pediatric and adult patients, in addition to comparing its histopathological aspects and the severity of advanced bone destruction.Medical records of 223 patients treated for chronic otitis media with cholesteatoma at the Otolaryngology (...) Department of Dokuz Eylul University between January 1992 and December 2013 were retrospectively evaluated. Sixty-one patients subjected to tympanomastoidectomy due to middle ear cholesteatoma, with sufficient specimens for histopathological examination, were included in the study. Sections of archived tissues in paraffin blocks were subjected to new histopathological examinations. The proliferative and apoptotic activities of cholesteatoma were determined by immunohistochemical staining for epithelial

2016 International Journal of Pediatric Otorhinolaryngology

139. Depression and cholesteatoma: Preliminary findings from a nationwide population-based retrospective cohort study. (PubMed)

Depression and cholesteatoma: Preliminary findings from a nationwide population-based retrospective cohort study. To estimate the risk of developing depressive disorder (DD) following diagnosis with cholesteatoma.In the study, we analyzed data from the Longitudinal Health Insurance Database of Taiwan. A total of 599 patients newly diagnosed with cholesteatoma between 1997 and 2007 were included with a comparison cohort of 2995 matched non-cholesteatoma enrollees. Each patient was followed for 3 (...) years to identify the subsequent development of DD. Cox proportional hazard regression analysis was performed to compute adjusted 3-year hazard ratios.The incidence of DD per thousand person-years was approximately twice as high among patients with cholesteatoma (11.32) as among those without cholesteatoma (5.85). After adjusting for potential confounders, patients with cholesteatoma were 1.99 times (95% CI=1.18-3.34, P=0.010) more likely to suffer from DD within 3 years compared to those without

2016 Journal of Affective Disorders

140. Management of pediatric cholesteatoma based on presentations, complications, and outcomes. (PubMed)

Management of pediatric cholesteatoma based on presentations, complications, and outcomes. To highlight important aspects and paradigms in the management of paediatric cholesteatoma in a developing world setting.A retrospective audit was conducted of paediatric cholesteatomas that underwent tympanomastoid surgery between 2008 and 2012 at the Red Cross War Memorial Children's Hospital in Cape Town. The following was audited: initial presentation; cholesteatoma complications; types of surgery (...) , intraoperative findings and outcomes of surgery in terms of hearing, otorrhoea and recidivism; and the reliability of follow-up and how this might influence the type of surgery.Fifty-seven children aged 2-13 years with 61 cholesteatomas (4 bilateral) were reviewed. Fifty-five mastoidectomies were done; 11% presented with complicated cholesteatoma. Referrals from primary care were significantly delayed (>6 months) in 76%. Canal wall down surgery was done in 71%. Forty-five percent had improved hearing (within

2016 International Journal of Pediatric Otorhinolaryngology

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