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Cholesteatoma

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121. Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. (PubMed)

Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. 27684485 2018 09 28 2018 10 01 1749-4486 42 4 2017 08 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. 901-904 10.1111/coa.12759 Wilmot V V VV (...) Royal Hospital for Sick Children, Edinburgh, UK. Sharma A A Royal Hospital for Sick Children, Edinburgh, UK. eng Journal Article 2016 10 14 England Clin Otolaryngol 101247023 1749-4478 Cholesteatoma, Congenital IM Child Child, Preschool Cholesteatoma congenital diagnosis epidemiology Female Humans Incidence Male Middle Ear Ventilation Otitis Media with Effusion complications diagnosis surgery Retrospective Studies Tomography, X-Ray Computed 2016 09 23 2016 9 30 6 0 2018 10 3 6 0 2016 9 30 6 0

2016 Clinical Otolaryngology

122. Role of Malleus relocation in cholesteatoma surgery: Our experience in 145 patients. (PubMed)

Role of Malleus relocation in cholesteatoma surgery: Our experience in 145 patients. 27086553 2018 09 17 2018 09 17 1749-4486 42 3 2017 06 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Title: Role of Malleus relocation in cholesteatoma surgery: our experience in 145 patients. 738-743 10.1111/coa.12658 Ashraf B B Mansoura Faculty of Medicine, Department of ORL (Otology (...) IM Adolescent Adult Child Cholesteatoma, Middle Ear pathology surgery Female Hearing Humans Male Malleus surgery Middle Aged Retrospective Studies Treatment Outcome 2016 04 11 2016 4 19 6 0 2018 9 18 6 0 2016 4 19 6 0 ppublish 27086553 10.1111/coa.12658

2016 Clinical Otolaryngology

123. Biochemical and Bioimaging Evidence of Cholesterol in Acquired Cholesteatoma. (PubMed)

Biochemical and Bioimaging Evidence of Cholesterol in Acquired Cholesteatoma. To quantify the barrier sterols and image the lipid structures in the matrix of acquired cholesteatoma and compare the distribution with that found in stratum corneum from normal skin, with the goal to resolve their potential influence on cholesteatoma growth.High-performance thin-layer chromatography (HPTLC) was used to achieve a quantitative biochemical determination of the sterols. The intercellular lipids were (...) visualized by Coherent Anti-Stokes Raman scattering (CARS) microscopy, which enables label-free imaging of the lipids in intact tissue samples.The results show that the total lipid content of the cholesteatoma matrix is similar to that of stratum corneum from skin and that the cholesteatoma matrix unquestionably contains cholesterol. The cholesterol content in the cholesteatoma matrix is increased by over 30% (w/w dry weight) compared to the control. The cholesterol sulfate content is below 1

2016 Rhinology and Laryngology

124. Acquired cholesteatoma epithelial hyperproliferation: Roles of cell proliferation signal pathways. (PubMed)

Acquired cholesteatoma epithelial hyperproliferation: Roles of cell proliferation signal pathways. To review the recent cell proliferation signal pathways in the etiopathogenesis of acquired middle ear cholesteatoma.PubMed (to September 2015).Articles about cell proliferation signal pathways in the etiopathogenesis of acquired cholesteatoma and treatment advances were searched in the PubMed database, from which 73 were included in this review.The exact underlying cellular and molecular (...) mechanism of acquired cholesteatoma still remains unknown. Recent research tends to regard the proliferation of cholesteatoma epithelial cells as the mechanism of cholesteatoma pathogenesis. Cell proliferation signal pathways including epidermal growth factor receptor/phosphoinositide 3-kinase/protein kinase B signal pathway, mitogen-activated protein kinase signal pathway, interleukin-6/signal transducer and activator of transcription 3 signal pathway, inhibitor of DNA binding/differentiation-1/nuclear

2016 Laryngoscope

125. Combined Surgical Approach to Giant Cholesteatoma: A Case Report and Literature Review. (PubMed)

Combined Surgical Approach to Giant Cholesteatoma: A Case Report and Literature Review. Cholesteatomas can grow to a remarkable size before clinically making their presence felt. Managing giant cholesteatomas and their complications can become a challenge for the otological surgeon.We describe a case of a giant congenital cholesteatoma of the mastoid in an adult. The lesion extended to the sigmoid sinus, jugular bulb, carotid canal, occipital condyle, and the lateral portion of the first (...) cervical vertebra. Surgical excision was performed using a combined microscopic and endoscopic surgical approach.Our combined surgical technique enabled a more accurate removal of the cholesteatoma than a microscopic approach alone, with no surgical complications or damage to the structures affected by the disease.Using endoscopic instruments to manage giant cholesteatomas can help to avoid complications and improve surgical radicality.© The Author(s) 2016.

2016 Rhinology and Laryngology

126. Gustatory Dysfunction and Decreased Number of Fungiform Taste Buds in Patients With Chronic Otitis Media With Cholesteatoma. (PubMed)

Gustatory Dysfunction and Decreased Number of Fungiform Taste Buds in Patients With Chronic Otitis Media With Cholesteatoma. To compare the number of fungiform taste buds among patients with chronic otitis media (COM), those with pars flaccida retraction type cholesteatoma, and those with pars tensa retraction type cholesteatoma in combination with gustatory function.Thirty-seven patients with COM, 22 patients with pars flaccida retraction type cholesteatoma, and 17 patients with pars tensa (...) retraction type cholesteatoma were included. An average of 10 fungiform papillae (FP) per patient in the midlateral region of the tongue were observed by confocal laser scanning microscopy in vivo, and the average number of taste buds were counted. Just before the observation of FP, electrogustometry (EGM) was performed to evaluate gustatory function.A significant decrease of the average number of fungiform taste buds and significant elevation of EGM thresholds were clarified in the pars tensa retraction

2016 Rhinology and Laryngology

127. Cholesteatoma in the Sellar Region Presenting as Hypopituitarism and Diabetes Insipidus. (PubMed)

Cholesteatoma in the Sellar Region Presenting as Hypopituitarism and Diabetes Insipidus. Clinically significant sellar cysts unrelated to pituitary adenomas are uncommon. Intracranial cholesteatomas are also rare and are most common in the middle ear and mastoid region. We report an even rarer case of cholesteatoma in the sellar region-a challenging diagnosis guided by clinical presentations, radiological signs, and biopsy, aiming at emphasize the importance of considering cholesteatoma when (...) making differential diagnoses of sellar lesions.We present a case of cholesteatoma in the sellar region in a 56-year-old man with hypopituitarism, diabetes insipidus, and cystic imaging findings. It was difficult to make an accurate diagnosis before surgery. We present detailed analysis of the patient's disease course and review pertinent literature.The patient underwent a surgical exploration and tumor resection through a transsphenoidal approach. Pathologic results revealed a cholesteatoma

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2016 Medicine

128. Repeated Postoperative Follow-up Diffusion-Weighted Magnetic Resonance Imaging to Detect Residual or Recurrent Cholesteatoma. (PubMed)

Repeated Postoperative Follow-up Diffusion-Weighted Magnetic Resonance Imaging to Detect Residual or Recurrent Cholesteatoma. In our institution, follow-up diffusion-weighted imaging (DWI) after cholesteatoma surgery is performed at least twice. The aim of this study was to determine the yield of the second follow-up DWI (D-W MRI-2) in patients in whom the first postoperative DWI (D-W MRI-1) was negative for residual or recurrent cholesteatoma.A retrospective analysis.Tertiary referral (...) center.Patients were included if 1) they had at least two postoperative DWI examinations after a canal wall up procedure with apparently complete cholesteatoma resection; 2) D-W MRI-1 was performed between 6 and 24 months after surgery and D-W MRI-2 performed at least 6 months after D-W MRI-1; 3) both DWI examinations were of good quality and covering the whole mastoid-middle ear region; 4) D-W MRI-1 was unequivocally negative for cholesteatoma; and 5) there was no clinical suspicion on otoscopy of recurrent

2016 Otology and Neurotology

129. Pooled analysis of the evidence for open cavity, combined approach and reconstruction of the mastoid cavity in primary cholesteatoma surgery. (PubMed)

Pooled analysis of the evidence for open cavity, combined approach and reconstruction of the mastoid cavity in primary cholesteatoma surgery. Cholesteatoma is keratinising epithelium within the middle-ear cleft or mastoid. This disease destroys the peripheral organs of balance and hearing, with possible intracranial sequelae. The management of cholesteatoma is surgical and the primary aim is to remove the disease and prevent recurrence. Secondary aims are to obtain a non-discharging, hearing (...) ear. Cholesteatoma surgery falls into two broad categories: open cavity surgery and combined approach surgery. A third surgical category is reconstruction of an open mastoid cavity after open surgery. This study performed a pooled analysis of the worldwide literature to compare the rates of cholesteatoma not being cured (i.e. recidivism), ear discharge and hearing change among open cavity, combined approach and reconstruction mastoid surgery for primary cholesteatoma.A literature search for all

2016 Journal of Laryngology & Otology

130. Cost analysis and outcomes of a second-look tympanoplasty-mastoidectomy strategy for cholesteatoma. (PubMed)

Cost analysis and outcomes of a second-look tympanoplasty-mastoidectomy strategy for cholesteatoma. To analyze cost and compare cholesteatoma recidivism and hearing outcomes with single-stage and second-look operative strategies.Retrospective review and cost analysis.Adult and pediatric patients who underwent a tympanoplasty with mastoidectomy for cholesteatoma with a single-stage or second-look operative strategy were identified. Variables included procedure approach, residual or recurrent (...) cholesteatoma, ossicular chain reconstruction frequency, and operative complications. Audiologic outcomes included pre-/postoperative air bone gap (ABG) and word recognition score (WRS). Cost analysis included charges for consultation and follow-up visits, surgical procedures, computed tomography temporal bone scans, and audiology visits.One hundred and six patients had a tympanoplasty with mastoidectomy for cholesteatoma, with 80 canal wall-up procedures (CWU) as initial approach. Of these, 46 (57.5%) CWU

2016 Laryngoscope

131. Iatrogenic cholesteatoma arising from the vascular strip. (PubMed)

Iatrogenic cholesteatoma arising from the vascular strip. To highlight the phenomenon of cholesteatoma arising from the vascular strip following tympanoplasty and tympanomastoidectomy.Multi-institutional retrospective chart review.Consecutive adult and pediatric patients evaluated between 2000 and 2015 with acquired cholesteatoma arising from the skin of a prior vascular strip were identified. Patients with evidence of residual or recurrent cholesteatoma elsewhere in the middle ear, mastoid (...) , or ear canal were excluded.Seventeen cases (71% female, 53% right-sided) were identified, and the mean age at presentation was 39.2 years. Patients presented on average 12.9 years following prior otologic surgery, which was most commonly tympanoplasty without mastoidectomy (59%). However, younger patients presented with symptoms sooner following prior surgery (r = 0.61, r2 = 0.37, P = 0.0095). The most common presenting symptom was otorrhea (76%). All patients were found to have mastoid cholesteatoma

2016 Laryngoscope

132. Secondary Acquired Cholesteatoma: Presentation and Tympanoplasty Outcomes. (PubMed)

Secondary Acquired Cholesteatoma: Presentation and Tympanoplasty Outcomes. Comparing the clinical features and surgical outcomes of patients undergoing tympanoplasty for secondary acquired cholesteatoma (SAC) versus non-complicated tympanic membrane perforation (TMP).Retrospective patient review.Tertiary-care, academic center.All 41 patients with diagnosis of SAC confirmed at surgery between January 1, 2007 and June 30, 2014, and an age-matched cohort consisting of patients

2016 Otology and Neurotology

133. The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma. (PubMed)

The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma. Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian canal of the facial nerve. Extensive disease may extend (...) to the posterior and middle fossa dura, the otic capsule, the carotid artery, and the jugular bulb. Dehiscence of the Fallopian canal and direct involvement of the facial nerve epineurium by cholesteatoma are risk factors for intraoperative facial nerve injury during tympanomastoid surgery by exposing the facial nerve to mechanical trauma and inflammation during microdissection. We present two cases of recidivistic cholesteatoma with unusual medial involvement of the vertical segment of the facial nerve

2016 Otology and Neurotology

134. FleQ, a Transcriptional Activator, Is Required for Biofilm Formation In Vitro but Does Not Alter Virulence in a Cholesteatomas Model. (PubMed)

FleQ, a Transcriptional Activator, Is Required for Biofilm Formation In Vitro but Does Not Alter Virulence in a Cholesteatomas Model. Bacterial biofilm formation within cholesteatomas is responsible for increased persistence and tissue destruction and Pseudomonas aeruginosa deficient in biofilm formation (PAO1 ΔfleQ) are less virulent than the parent bacteria.Infected aural cholesteatomas have been demonstrated to be more destructive than uninfected cholesteatomas and infections are more (...) persistent. The chronicity and persistence of infections within cholesteatomas may be because of the presence of biofilm formation.Twenty-seven mutant strains of PAO1 were screened for surface adherence. These strains were also screened for static biofilm formation. The biofilms were quantified by staining with crystal violet. Aural cholesteatomas were then induced in Mongolian gerbils by ligation of the ear canal. At the time of ligation, the ear canals were inoculated with wild-type PAO1 and a biofilm

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2016 Otology and Neurotology

135. Cholesteatoma

Cholesteatoma Cholesteatoma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cholesteatoma Cholesteatoma Aka: Cholesteatoma From (...) Related Chapters II. Pathophysiology Benign squamous metaplasia of middle ear epithelium TM epithelium retracts into mastoid air cells Mass gradually expands and keratinizes Forms epithelial inclusion cyst Contains crystals and keratinous debris Results in destruction of middle ear ossicles III. Cause Congenital Cholesteatoma Acquired Cholesteatoma IV. Symptoms Ear fullness Chronic suppurative discharge from middle ear Via perforated V. Signs Middle ear deafness Pearly gray middle ear mass VI

2018 FP Notebook

136. Sensorineural Hearing Loss in Cholesteatoma. (PubMed)

Sensorineural Hearing Loss in Cholesteatoma. To determine whether middle ear cholesteatoma is associated with, sensorineural hearing loss, and whether patient age, cholesteatoma growth pattern, or, air bone gap size contribute to inner ear impairment.Cross-sectional comparative.A tertiary hospital.The subjects were 115 patients with middle ear cholesteatoma in one ear, and normal video-otoscopy in the contralateral ear (CLE).Otoendoscopy, pure-tone audiometry.Bone conduction (BC) threshold (...) differences between the normal CLE and the cholesteatoma ear. Comparisons of these differences between different cholesteatoma growth patterns. Correlation between the air bone gap size in the ear with cholesteatoma and the difference in bone conduction thresholds between both ears.The cholesteatoma ear was associated with greater BC thresholds than the CLE. With regard to different cholesteatoma growth patterns, the differences between associated BC thresholds were also significant in all groups at all

2016 Otology and Neurotology

137. Sanna Classification and Prognosis of Cholesteatoma of the Petrous Part of the Temporal Bone: A Retrospective Series of 81 Patients. (PubMed)

Sanna Classification and Prognosis of Cholesteatoma of the Petrous Part of the Temporal Bone: A Retrospective Series of 81 Patients. To determine how classification of petrous bone cholesteatomas (PBCs) using the 5-point Sanna classification can predict major structural involvement, facial nerve outcomes, hearing outcomes, postoperative complications, and disease recurrence.Retrospective case series.Tertiary referral center in Bergamo, Italy.Eighty-one sequential patients with radiologic

2016 Otology and Neurotology

138. Depression and cholesteatoma: Preliminary findings from a nationwide population-based retrospective cohort study. (PubMed)

Depression and cholesteatoma: Preliminary findings from a nationwide population-based retrospective cohort study. To estimate the risk of developing depressive disorder (DD) following diagnosis with cholesteatoma.In the study, we analyzed data from the Longitudinal Health Insurance Database of Taiwan. A total of 599 patients newly diagnosed with cholesteatoma between 1997 and 2007 were included with a comparison cohort of 2995 matched non-cholesteatoma enrollees. Each patient was followed for 3 (...) years to identify the subsequent development of DD. Cox proportional hazard regression analysis was performed to compute adjusted 3-year hazard ratios.The incidence of DD per thousand person-years was approximately twice as high among patients with cholesteatoma (11.32) as among those without cholesteatoma (5.85). After adjusting for potential confounders, patients with cholesteatoma were 1.99 times (95% CI=1.18-3.34, P=0.010) more likely to suffer from DD within 3 years compared to those without

2016 Journal of Affective Disorders

139. Analysis of histopathological aspects and bone destruction characteristics in acquired middle ear cholesteatoma of pediatric and adult patients. (PubMed)

Analysis of histopathological aspects and bone destruction characteristics in acquired middle ear cholesteatoma of pediatric and adult patients. The aim of this study was to investigate the proliferative and apoptotic activity of middle ear cholesteatoma in pediatric and adult patients, in addition to comparing its histopathological aspects and the severity of advanced bone destruction.Medical records of 223 patients treated for chronic otitis media with cholesteatoma at the Otolaryngology (...) Department of Dokuz Eylul University between January 1992 and December 2013 were retrospectively evaluated. Sixty-one patients subjected to tympanomastoidectomy due to middle ear cholesteatoma, with sufficient specimens for histopathological examination, were included in the study. Sections of archived tissues in paraffin blocks were subjected to new histopathological examinations. The proliferative and apoptotic activities of cholesteatoma were determined by immunohistochemical staining for epithelial

2016 International Journal of Pediatric Otorhinolaryngology

140. Classification of Cholesteatoma According to Growth Patterns. (PubMed)

Classification of Cholesteatoma According to Growth Patterns. Several classifications of cholesteatoma exist, but there are controversies about their clinical application.To classify cholesteatomas and describe the prevalence of the subtypes.A cross-sectional comparative study of 414 ears in 356 consecutive patients with middle ear cholesteatoma and no history of ear surgery treated at a tertiary hospital was conducted from March 8, 2000, to March 30, 2015. Data analysis was conducted from (...) patients (61.8%). A total of 272 (65.7%) ears were from adults. Of the 414 ears that underwent otoendoscopy, posterior epitympanic (142 [34.3%]) and posterior mesotympanic (140 [33.8%]) were the most frequent types of cholesteatoma observed, followed by undetermined (67 [16.2%]) and 2 routes (57 [13.8%]). Anterior epitympanic type was the least frequent (8 [1.9%]). Posterior epitympanic cholesteatoma was more prevalent in adults (111 [40.8%]), whereas posterior mesotympanic cholesteatoma was more

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2016 JAMA otolaryngology-- head & neck surgery

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