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Cholesteatoma

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101. Giant Petrous Bone Cholesteatoma: Combined Microscopic Surgery and an Adjuvant Endoscopic Approach Full Text available with Trip Pro

Giant Petrous Bone Cholesteatoma: Combined Microscopic Surgery and an Adjuvant Endoscopic Approach Petrous bone cholesteatomas (PBCs) are epidermoid cysts, which have developed in the petrous portion of the temporal bone and may be congenital or acquired. Cholesteatomas arising in this region have a tendency to invade bone and functional structures and the middle and posterior fossae reaching an extensive size. Traditionally, surgery of a giant PBC contemplates lateral transtemporal or middle (...) fossa microscopic surgery; however, in recent years, endoscopic surgical techniques (primary or complementary endoscopic approach) are starting to receive a greater consensus for middle ear and mastoid surgeries. We report the rare case of an 83-year-old Caucasian male affected by a giant cholesteatoma that eroded the labyrinth and the posterior fossa dura and extended to the infralabyrinthine region, going beyond the theca and reaching the first cervical vertebra. The giant cholesteatoma

2016 Journal of neurological surgery reports

102. Application of high resolution computer tomography in external ear canal cholesteatoma diagnosis Full Text available with Trip Pro

Application of high resolution computer tomography in external ear canal cholesteatoma diagnosis To evaluate High Resolution Computer Tomography (HRCT) in the diagnosis of external ear canal cholesteatoma.In this retrospective study, HRCTs of 27 patients with external ear canal cholesteatoma were reviewed. The changes in the external ear canal, tympanic membrane (TM), scutum, tympanum and mastoid were measured and categorized.Fourteen patients showed no or mild destruction in the external ear (...) in the stage III group.HRCT can provide detail information about the extent of external ear canal cholesteatoma. Such information can be used to identify special situations with serious complications and to differentiate external ear canal cholesteatoma from middle ear cholesteatoma.

2017 Journal of otology

103. Advancing Cholesteatoma Secondary to Acquired Atresia of the External Auditory Canal: Clinical Perspectives Full Text available with Trip Pro

Advancing Cholesteatoma Secondary to Acquired Atresia of the External Auditory Canal: Clinical Perspectives Acquired atresia of External Auditory Canal (EAC) is seldom encountered in routine otolaryngology practice. Apart from resulting in moderate-to-severe conductive hearing impairment, it is a potentially dreaded condition which might lead to canal cholesteatoma. Suspected to develop as a consequence of a pre-existing chronic otitis externa/media, the EAC atresia leads to proximal (medial (...) ) accumulation of desquamated epithelium and denatured keratin (the canal cholesteatoma) that further leads to aggravation of the chronic otitis, thereby initiating a vicious cycle. The canal cholesteatoma might progress unhindered into the middle ear and mastoid cavity, with its characteristic bone-eroding property, producing complications. A high index of clinical suspicion along with proper imaging are therefore essential to apprehend the disease progression in a patient presenting with an apparently

2017 Journal of clinical and diagnostic research : JCDR

104. Expression of Prostaglandin E2 Receptors in Acquired Middle Ear Cholesteatoma Full Text available with Trip Pro

Expression of Prostaglandin E2 Receptors in Acquired Middle Ear Cholesteatoma To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1-4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder.Specimens of human acquired cholesteatoma were obtained from 29 patients and 19 skin biopsies of normal external auditory canal were as controls. The mRNA and protein expression of EP receptors was assessed by quantitative real (...) -time polymerase chain reaction, immunohistochemistry and Western blot.In acquired cholesteatoma, EP1-EP4 receptors were mainly expressed on squamous epithelium and subepithelial infiltrated inflammatory cells. In external auditory canal skin, EP1-EP4 receptors were mainly expressed on squamous epithelium and glandular epithelium. The expression of EP4 receptor on mRNA and protein levels were significant lower in acquired cholesteatoma compared with controls. EP1-EP3 receptors had no significant

2017 Clinical and experimental otorhinolaryngology

105. Accuracy of turbo spin-echo diffusion-weighted imaging signal intensity measurements for the diagnosis of cholesteatoma Full Text available with Trip Pro

Accuracy of turbo spin-echo diffusion-weighted imaging signal intensity measurements for the diagnosis of cholesteatoma We aimed to evaluate the diagnostic accuracy of turbo spin-echo diffusion-weighted imaging (TSE-DWI) at 3 T, for cholesteatoma (CS) diagnosis, using qualitative and quantitative methods with numerical assessment of signal intensity (SI), signal intensity ratios (SIR), and apparent diffusion coefficient (ADC) values.In this retrospective study, two blinded observers (...) independently evaluated the preoperative TSE-DWI images of 57 patients who were imaged with a presumed diagnosis of CS. Qualitative assessment with respect to the SI of the adjacent cortex and quantitative measurements of SI, SIR, and ADC values were performed.Surgery with histopathologic examination revealed 30 CS patients and 27 patients with non-cholesteatoma (NCS) lesions including chronic inflammation and cholesterol granuloma. On TSE-DWI, 96.7% of the CS lesions and none of the NCS lesions appeared

2017 Diagnostic and Interventional Radiology

106. Blind Sac Approach Using Silastic Block for Cochlear Implantation in Patients with Cholesteatoma Full Text available with Trip Pro

Blind Sac Approach Using Silastic Block for Cochlear Implantation in Patients with Cholesteatoma Cochlear implant (CI) surgery in cholesteatoma is challenging because of the risk of residual or recurrent infection. Although CI could be done with subtotal petrosectomy in single or staged surgery, this surgery needed additional surgical procedures to obliterate the mastoid cavity. This paper describes a new surgical technique for CI surgery in cholesteatoma without external auditory canal closure.

2017 Journal of Audiology & Otology

107. Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up Full Text available with Trip Pro

Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up 29071059 2018 11 13 2039-4330 7 2 2017 Jul 18 Audiology research Audiol Res Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up. 187 10.4081/audiores.2017.187 Ralli Giovanni G Department of Sense Organs, La Sapienza University, Rome. Nola Giuseppe G ENT Unit, G.B. Grassi Hospital (...) , Ostia, Rome. Taglioni Alberto A Anesthesiology Unit, G.B. Grassi Hospital, Ostia (RM). Grasso Michele M Department of Sense Organs, La Sapienza University, Rome. Ralli Massimo M Department of Oral and Maxillofacial Sciences, La Sapienza University, Rome, Italy. eng Journal Article 2017 10 03 Italy Audiol Res 101644681 2039-4330 Day case surgery canal wall down tympanoplasty cholesteatoma chronic suppurative otitis media tympanoplasty 2017 06 26 2017 08 02 2017 10 27 6 0 2017 10 27 6 0 2017 10 27 6 1

2017 Audiology research

108. Diffusion weighted imaging for the detection and evaluation of cholesteatoma Full Text available with Trip Pro

Diffusion weighted imaging for the detection and evaluation of cholesteatoma Cholesteatoma is a collection of keratinous debris and stratified squamous epithelium. It is trapped in the middle ear and can lead to bony erosion. The disease is treated surgically often followed by a second-look procedure to check for residual tissue or recurrence. Cholesteatoma has specific signal-intensity characteristics on magnetic resonance imaging with very high signal intensity on diffusion weighted imaging (...) (DWI). Various DWI techniques exist: Echo-planar imaging (EPI)-based and non-EPI-based techniques as well as new approaches like multi-shot EPI DWI. This article summarizes all techniques, discusses the significance in detecting cholesteatoma and mentions actual studies. Further recommendations for daily clinical practise are provided.

2017 World journal of radiology

109. Cochlear Fistula in Chronic Otitis Media without Cholesteatoma Full Text available with Trip Pro

Cochlear Fistula in Chronic Otitis Media without Cholesteatoma Cochlear fistula in the chronic otitis media (COM) without cholesteatoma is an extremely rare with only a few cases reported in the literature to this date. We describe a case of cochlear fistula observed in a female with COM without cholesteatoma. This report presents the first clinical case of a transtympanic iatrogenic trauma by habitual cotton swabs probably causing cochlear fistula.

2017 Journal of Audiology & Otology

110. Rehabilitation of Abducens Nerve Palsy after Cholesteatoma Resection at Cerebellopontine Angle by Intraorbital Electroacupuncture Full Text available with Trip Pro

Rehabilitation of Abducens Nerve Palsy after Cholesteatoma Resection at Cerebellopontine Angle by Intraorbital Electroacupuncture 28639584 2018 10 29 2018 11 13 2542-5641 130 13 2017 07 05 Chinese medical journal Chin. Med. J. Rehabilitation of Abducens Nerve Palsy after Cholesteatoma Resection at Cerebellopontine Angle by Intraorbital Electroacupuncture. 1625-1626 10.4103/0366-6999.208247 Zhou Ling-Yun LY Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Harbin (...) 150001, China. Zhao Ming M Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China. Su Chang C Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China. eng Letter China Chin Med J (Engl) 7513795 0366-6999 IM Abducens Nerve Diseases etiology therapy Cerebellopontine Angle Cholesteatoma surgery Electroacupuncture Humans 2017 6 23 6 0 2017 6

2017 Chinese medical journal

111. Retraction pocket excision with cartilage grafting as a preventive surgery for cholesteatoma Full Text available with Trip Pro

Retraction pocket excision with cartilage grafting as a preventive surgery for cholesteatoma The goal of the present study is to summarize our experience on surgical management of retraction pockets (RP) as a preventive tool against cholesteatomas.Twenty-five ears have been followed up for a mean period of 6.16 ± 4.35 years (from 1 to 17 years). The sample presented a mean age of 47.56 ± 19.11 years (from 16 to 73 years). All patients underwent cartilage graft surgery. Furthermore 10 (40 (...) %) underwent tympanoplasty (TPL) type I, 14 (56%) TPL type II and 1 (4%) TPL type V.Eleven ears (44%) showed cholesteatoma: all these cases were stage III according to Charachon staging, and stage IV or V according to Gersdorff classification. Twelve patients (48%) showed erosion of the ossicular chain. Of these, five were associated with cholesteatoma and seven only with retraction. The recurrence rate of cholesteatoma was 12%. None of the patients with a stage II or III RP (according to Gersdorff

2017 Journal of otology

112. Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity Full Text available with Trip Pro

Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin (...) 17 (CK17) in acquired nonrecurrent human cholesteatoma and correlate them with its bone destructive capacity.A prospective quantitative immunohistochemical study was carried out using fresh acquired cholesteatoma tissues (n=19), collected during cholesteatoma surgery. Deep meatal skin tissues from the same patients were used as control (n=8). Cholesteatoma patients were divided into 2 groups and compared (invasive and noninvasive) according to a grading score for bone resorption based upon

2017 Clinical and experimental otorhinolaryngology

113. Cholesteatoma Induced Labyrinthine Fistula: Is Aggressiveness in Removing Disease Justified? Full Text available with Trip Pro

Cholesteatoma Induced Labyrinthine Fistula: Is Aggressiveness in Removing Disease Justified? Issues of complete disease clearance and hearing preservation in cholesteatoma induced labyrinthine fistula cases has been discussed and updated in this article. Successful disease clearance and hearing preservation in a case of cholesteatoma induced isolated cochlear promontory fistula encouraged us to retrospectively analyse 13 more cases of cholesteatoma induced labyrinthine fistula who presented (...) in emergency service as complicated chronic suppurtive otitis media. Pre-operatively nine patients experienced vertigo, two had profound sensori neural hearing loss and radiology was suggestive of labyrinthine fistula in 12 patients. Lateral semicircular canal was involved in 13 cases. In all cases cholesteatoma matrix was completely removed from the fistula site irrespective of the fistula size and hearing status. Hearing was preserved in 11 out of 12 patients. Gentle and meticulous removal of the matrix

2017 Indian Journal of Otolaryngology and Head & Neck Surgery

114. Why does the acquired cholesteatoma trigger resorption of the temporal bone? Full Text available with Trip Pro

Why does the acquired cholesteatoma trigger resorption of the temporal bone? 28616835 2017 11 20 2018 12 02 1434-4726 274 12 2017 12 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery Eur Arch Otorhinolaryngol Why does the acquired cholesteatoma trigger resorption of the temporal bone? 4251-4252 10.1007/s00405-017-4633-5 (...) Eur Arch Otorhinolaryngol. 2017 Dec;274(12 ):4253 28791463 Eur Arch Otorhinolaryngol. 2017 May;274(5):2071-2078 27981350 Cholesteatoma Cholesteatoma, Middle Ear Humans Temporal Bone 2017 05 30 2017 06 02 2017 6 16 6 0 2017 11 29 6 0 2017 6 16 6 0 ppublish 28616835 10.1007/s00405-017-4633-5 10.1007/s00405-017-4633-5 PMC5663803 Am J Otolaryngol. 2010 Nov-Dec;31(6):404-9 20015790 Otolaryngol Pol. 2010 Jul-Aug;64(4):219-24 20873097 ORL J Otorhinolaryngol Relat Spec. 2011;73(2):93-9 21311206 Eur Arch

2017 European Archives of Oto-Rhino-Laryngology

115. Meta-analysis of magnetic resonance diffusion-weighted imaging in the diagnosis of middle ear cholesteatoma

Meta-analysis of magnetic resonance diffusion-weighted imaging in the diagnosis of middle ear cholesteatoma Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

116. Meta-analysis of diffusion-weighted magnetic resonance imaging in preoperative diagnosis, postoperative residual and recurrent monitoring of cholesteatoma in adult.

Meta-analysis of diffusion-weighted magnetic resonance imaging in preoperative diagnosis, postoperative residual and recurrent monitoring of cholesteatoma in adult. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

117. A pearl in the ear: Intracranial complications of pediatric cholesteatomas. (Abstract)

A pearl in the ear: Intracranial complications of pediatric cholesteatomas. A nine-year-old male had a cholesteatoma of the mastoid and middle ear found incidentally after myringotomy tube placement. Associated asymptomatic sigmoid plate dehiscence with sinus invasion or thrombosis and ossicular chain destruction complicated his case. He had canal wall down tympanomastoidectomy and was followed for 4.5 years. Disease recurrence necessitated revision. Our case highlights an unusual clinical (...) presentation, possible complications, and the aggressive quality of a benign lesion common in the pediatric population. To our knowledge, this is the first report of an asymptomatic lateral sinus obstruction secondary to an invasive cholesteatoma in this population.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

2017 International Journal of Pediatric Otorhinolaryngology

118. Bilateral congenital cholesteatoma: Surgical treatment and considerations. (Abstract)

Bilateral congenital cholesteatoma: Surgical treatment and considerations. To describe a multicenter study regarding surgical management of bilateral congenital cholesteatoma (BCC) and underline the importance of endoscopes in the management of this condition. In BCC, hearing preservation is more crucial than in unilateral cases. The endoscopic approach allows complete removal of cholesteatoma via a minimally invasive technique offering low residual disease rates while preserving the normal (...) physiology of the middle ear and possibly the ossicular chain.Retrospective chart and surgical video review of patients with BCC who underwent surgery at Otolaryngology Department of Modena and Verona University Hospitals and the Hospital for Sick Children, Toronto.From 2002 to November 2016, six patients were identified with bilateral congenital cholesteatoma and included in this study. Pre-operative assessments, surgical treatments and outcomes were collected and described.The median age

2017 International Journal of Pediatric Otorhinolaryngology

119. Endoscopic transcanal approach to the middle ear for management of pediatric cholesteatoma. (Abstract)

Endoscopic transcanal approach to the middle ear for management of pediatric cholesteatoma. To describe outcomes for endoscopic ear surgery (EES) for pediatric cholesteatoma at a tertiary pediatric hospital.Retrospective case series of 65 pediatric cholesteatoma cases in 38 ears. Subgrouping based on cholesteatoma type and EES type. Surgical findings, outcomes, and demographic data were evaluated.Endoscopes were used in 65 pediatric cholesteatoma cases in 38 primary ears (34 patients), followed (...) for an average of 2.6 years (9 months to 4.6 years). The endoscope was used as the primary visualization tool in 31 (81.6%) ears (EES 2 or 3), and as an adjunct to the microscope in seven ears (EES 1). Twenty-two (57.9%) ears and 35 (53.4%) cases were transcanal endoscopic ear surgery (EES 3 or TEES). Overall, there was recurrence in five (13.2%) ears and residual in four (10.5%) ears. Cholesteatoma was acquired in 27 ears, with average age 10.9 years; and congenital in 11 ears, with average age 3.8 years

2017 Laryngoscope

120. The Role of Rho/Rho-Kinase Pathway in the Pathogenesis of Cholesteatoma. (Abstract)

The Role of Rho/Rho-Kinase Pathway in the Pathogenesis of Cholesteatoma. To assess the role of Rho/Rho-kinase pathway in the pathogenesis of cholesteatoma.Thirty-eight patients with cholesteatoma, who had gone mastoidectomies were enrolled in this prospective study. Cholesteatomas matrix (CM) and a piece of the external ear canal skin (EECS as control) were taken and transferred to the liquid nitrogen and kept at -86 °C for Rho A and Rho-kinase (ROCK) analysis with Western blotting (...) significantly lower in CM than EECS as demonstrated by Western blotting.Given Rho-kinase could take essential roles in cell differentiation, the results of this study implicate that down-regulated Rho-kinase could be responsible for the keratinocyte undifferentiation seen in cholesteatoma pathogenesis.

2017 Otology and Neurotology

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