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Cholesteatoma

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101. Paraganglioma presenting as chronic otitis media with cholesteatoma: pitfalls and strategies. (PubMed)

Paraganglioma presenting as chronic otitis media with cholesteatoma: pitfalls and strategies. The coexistence of paraganglioma with cholesteatoma is a very rare clinical disorder. The clinical presentations are nonspecific. There may be radiological characteristics of either cholesteatoma or paraganglioma in the middle ear area, but the diagnosis of the coexistence of the 2 is usually made only postoperatively. Here is such a case that is made more interesting not only because it initially

2017 American Journal of Otolaryngology

102. Complications in primary and secondary acquired cholesteatoma: a prospective comparative study of 62 ears. (PubMed)

Complications in primary and secondary acquired cholesteatoma: a prospective comparative study of 62 ears. This study aimed to compare the clinicopathologic behavior of complications in primary and secondary acquired cholesteatoma and figure out the differences between them.This was a prospective cross-sectional study.This was a study conducted in a tertiary referral medical college hospital comprising of 62 ears, of which 32 were in the primary acquired cholesteatoma group (PACG) and 30 were (...) in the secondary acquired cholesteatoma group (SACG). We compared the 2 groups with respect to 7 prognostic variables, as follows: age distribution, sex, duration of ear discharge, pathology in the ear, predisposing disease focus in nose and throat, pattern of complications, and microbiology of ear.The presence of cholesteatoma increased the risk for complications by more than 2 times in PACG, but the presence of granulation tissue did not show the same risk. More than half of the ears with complication

2017 American Journal of Otolaryngology

103. Cartilage-wire-fascia compact total ossicular replacement prosthesis in one-stage cholesteatoma surgery. (PubMed)

Cartilage-wire-fascia compact total ossicular replacement prosthesis in one-stage cholesteatoma surgery. Retraction pocket and extrusion of the ossicular prosthesis remain significant problems after tympanoplasty in cholesteatoma surgery. This study presents an alternative surgical technique with a total compact ossicular prosthesis including cartilage, wire, and temporalis fascia.A total of 42 patients (27 adults, 15 children) underwent an ear operation for cholesteatoma requiring total

2017 American Journal of Otolaryngology

104. Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives (PubMed)

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different (...) theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords 'aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.' In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades

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2016 Clinical and experimental otorhinolaryngology

105. Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy (PubMed)

Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy The present study aimed to evaluate the possibility of using coherent anti-Stokes Raman spectroscopy (CARS) microscopy to determine the specific molecular morphology of cholesteatoma by detecting the natural vibrational contrast of the chemical bonds without any staining.Specimens from the mastoid and tympanic membrane with and without cholesteatoma were analyzed using CARS microscopy, two (...) -photon excited fluorescence (TPEF) microscopy, and the second harmonic generation (SHG) microscopy.In cholesteatoma tissues from the mastoid, a strong resonant signal at 2845 cm-1 was observed by CARS, which indicated the detection of the CH2 hydro-carbon lipid bonds that do not generate visible signals at 2940 cm-1 suggestive of CH3 bonds in amino acids. A strong resonant signal at 2940 cm-1 appeared in an area of the same specimen, which also generated abundant signals by TPEF and SHG microscopy

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2016 Journal of otology

106. Non-echoplanar diffusion weighted imaging in the detection of post-operative middle ear cholesteatoma: navigating beyond the pitfalls to find the pearl (PubMed)

Non-echoplanar diffusion weighted imaging in the detection of post-operative middle ear cholesteatoma: navigating beyond the pitfalls to find the pearl Non-echoplanar diffusion weighted magnetic resonance imaging (DWI) has established itself as the modality of choice in detecting and localising post-operative middle ear cleft cholesteatoma. Despite its good diagnostic performance, there are recognised pitfalls in its radiological interpretation which both the radiologist and otologist should (...) . Given the limitation in sensitivity in detecting small cholesteatoma less than 3 mm, serial monitoring with DWI over time is recommended to allow any small residual cholesteatoma pearls to grow and become large enough to be detected on DWI. Optimising image acquisition and discussing at a joint clinico-radiological meeting both foster good radiological interpretation to navigate beyond the pitfalls and ultimately good patient care.• Non-echoplanar DWI is the imaging of choice in detecting post

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2016 Insights into imaging

107. Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis (PubMed)

Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis 27235590 2016 07 04 2018 11 13 2210-2612 24 2016 International journal of surgery case reports Int J Surg Case Rep Bilateral primitive cholesteatoma of external auditory canal with congenital stenosis. 108-11 10.1016/j.ijscr.2016.04.046 S2210-2612(16)30106-7 Mahdoufi R R ENT-Neck and Face Surgery, Hospital August 20, 1953, University Hospital IBN ROCHD, Casablanca, Morocco. Electronic address: mahdoufir (...) Netherlands Int J Surg Case Rep 101529872 2210-2612 Cholesteatoma Congenital Stenosis child external auditory canal 2016 04 03 2016 04 27 2016 04 27 2016 5 29 6 0 2016 5 29 6 0 2016 5 29 6 1 ppublish 27235590 S2210-2612(16)30106-7 10.1016/j.ijscr.2016.04.046 PMC4887586 Laryngoscope. 1980 Mar;90(3):383-91 7359960 Otolaryngol Head Neck Surg. 1999 Sep;121(3):298-300 10471877 Acta Otolaryngol. 1997 Mar;117(2):293-7 9105469 Arch Otolaryngol. 1984 Oct;110(10):690-3 6477266 Arch Otolaryngol. 1961 Mar;73:252-61

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2016 International journal of surgery case reports

108. Intercellular Communication between Keratinocytes and Fibroblasts Induces Local Osteoclast Differentiation: a Mechanism Underlying Cholesteatoma-Induced Bone Destruction (PubMed)

Intercellular Communication between Keratinocytes and Fibroblasts Induces Local Osteoclast Differentiation: a Mechanism Underlying Cholesteatoma-Induced Bone Destruction Bone homeostasis is maintained by a balance in activity between bone-resorbing osteoclasts and bone-forming osteoblasts. Shifting the balance toward bone resorption causes osteolytic bone diseases such as rheumatoid arthritis and periodontitis. Osteoclast differentiation is regulated by receptor activator of nuclear factor κB (...) ligand (RANKL), which, under some pathological conditions, is produced by T and B lymphocytes and synoviocytes. However, the mechanism underlying bone destruction in other diseases is little understood. Bone destruction caused by cholesteatoma, an epidermal cyst in the middle ear resulting from hyperproliferation of keratinizing squamous epithelium, can lead to lethal complications. In this study, we succeeded in generating a model for cholesteatoma, epidermal cyst-like tissue, which has

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2016 Molecular and cellular biology

109. Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas

Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Usefulness of Non EPI-DWI-MRI / CT 3D Static Co-registration Prior to Surgery of Cholesteatomas The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02903550 Recruitment Status : Recruiting

2016 Clinical Trials

110. Effect of surgical intervention on middle-ear cholesteatoma with associated facial paralysis. (PubMed)

Effect of surgical intervention on middle-ear cholesteatoma with associated facial paralysis. To investigate the presenting symptoms, intra-operative findings and long-term facial nerve function in patients treated for cholesteatoma with associated facial paralysis.Fifteen patients with facial paralysis due to middle-ear cholesteatoma who underwent tympanomastoidectomy surgery from February 2000 to February 2015 were retrospectively reviewed. After removal of the cholesteatoma, a limited area

2016 Journal of Laryngology & Otology

111. Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation. (PubMed)

Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation. Mesna (i.e. sodium 2-mercaptoethanesulfonate; C2H5NaO3S2) has been used in otological surgery such as cholesteatoma dissection and tympanic membrane lateralisation in atelectatic ears. However, this study aimed to investigate its effect on cholesteatoma formation.A total of 20 Wistar rats were divided into two groups of 10 animals. The right and left ears of control animals were treated (...) intratympanic injection of 0.2 ml saline and the mesna group had a single intratympanic injection of 10 per cent mesna. Animals were killed 12 weeks after the last injection and the temporal bones were sent for histopathological evaluation.The cholesteatoma formation rate was 88 per cent in the propylene glycol control group, but was significantly lower in the mesna group (p = 0.01). There were no significant differences in granulation tissue formation (p = 0.498), cyst formation in the bulla (p = 0.381

2016 Journal of Laryngology & Otology

112. Soft-wall reconstruction of the canal wall with retrograde bone work for pediatric cholesteatoma: Long-term results. (PubMed)

Soft-wall reconstruction of the canal wall with retrograde bone work for pediatric cholesteatoma: Long-term results. To retrospectively evaluate the long-term results of surgery for retrograde bone work, using soft-wall reconstruction of the canal wall, for pediatric cholesteatoma.We retrospectively evaluated a series of 25 consecutive ears of 24 patients who were ≤16 years of age. All children underwent cholesteatoma surgery between October 2002 and August 2008. The type of cholesteatoma (...) , the length of follow-up, the incidence of residual and recurrent cholesteatoma, postoperative hearing results, and the form of the reconstructed external canal wall and tympanic membrane were assessed.There were 21 males and 3 females. The procedure was performed on both ears of one patient who had bilateral congenital cholesteatoma (CC). At the initial surgery, 16 cases (64%) had CC and nine (36%) had acquired cholesteatoma (AC). The mean age at surgery was 8.2 years and 10.4 years for CC and AC cases

2016 International Journal of Pediatric Otorhinolaryngology

113. Diffusion Weighted Magnetic Resonance Imaging for Residual and Recurrent Cholesteatoma: A Systematic Review & Meta-Analysis. (PubMed)

Diffusion Weighted Magnetic Resonance Imaging for Residual and Recurrent Cholesteatoma: A Systematic Review & Meta-Analysis. Diagnosis and management of recurrent or residual cholesteatoma can be problematic. Diffusion-weighted imaging magnetic resonance imaging (MRI) sequences have been used for follow-up of such lesions. More recent non-echoplanar imaging (non-EPI) sequences are thought to be superior to older echoplanar imaging (EPI) sequences.Evaluate whether diffusion-weighted magnetic (...) and specific for the detection of recurrent or residual cholesteatoma following ear surgery. Non-EPI techniques are superior to EPI techniques.© 2016 John Wiley & Sons Ltd.

2016 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

114. Surgical Strategy and Facial Nerve Outcomes in Petrous Bone Cholesteatoma. (PubMed)

Surgical Strategy and Facial Nerve Outcomes in Petrous Bone Cholesteatoma. To review the classification and management of petrous bone cholesteatomas (PBCs) at our center and the outcomes of facial nerve (FN) management in these lesions.This was a retrospective study. The setting was a quaternary referral center for skull base pathology in Italy. A total of 200 patients with 201 PBCs were included in the study. All patients diagnosed radiologically with PBCs were classified according

2016 Audiology & Neuro-Otology

115. Cochleariform Process Abutment on TBCT in Early Congenital Cholesteatoma. (PubMed)

Cochleariform Process Abutment on TBCT in Early Congenital Cholesteatoma. To study the influence of the cochleariform process abutment (CPA) of early congenital cholesteatomas (CC) (ECCs) on surgical outcomes.Retrospective case review.University hospital otology referral clinic.Two hundred consecutive pediatric ECC patients.The patients were classified into three groups based on the temporal bone computed tomography (TBCT) findings of ECC: A) the absence of CPA, B) the presence of CPA, and C

2016 Otology and Neurotology

116. Monitoring Progression of 12 Cases of Non-Operated Middle Ear Cholesteatoma With Non-Echoplanar Diffusion Weighted Magnetic Resonance Imaging: Our Experience. (PubMed)

Monitoring Progression of 12 Cases of Non-Operated Middle Ear Cholesteatoma With Non-Echoplanar Diffusion Weighted Magnetic Resonance Imaging: Our Experience. The aim of this study is to gain insight into the disease progression and behavior of primary cholesteatoma in a cohort of patients who did not have surgery using non-echoplanar diffusion-weighted magnetic resonance imaging (DW MRI) serial monitoring.Retrospective longitudinal observational study of 12 cases of middle ear cleft (...) cholesteatoma diagnosed between 2009 and 2014 where surgery was not performed for various reasons. All cases were monitored radiologically with non-echoplanar half-Fourier acquisition single-shot turbo spin-echo diffusion weighted imaging annually for a median period of 23 months (between 11 and 45 mo) to evaluate for changes in disease volume and direction of growth.Of the 12 cases, there was one outlier where the cholesteatoma growth was disproportionately high compared with the rest of the cases outside

2016 Otology and Neurotology

117. Postoperative diffusion weighted MRI and preoperative CT scan fusion for residual cholesteatoma localization. (PubMed)

Postoperative diffusion weighted MRI and preoperative CT scan fusion for residual cholesteatoma localization. To evaluate the ability of preoperative mastoid high resolution Computerized tomography (CT Scan) fusion with the postoperative diffusion weighted magnetic resonance imaging (Non-EPI DWI) to accurately localize the residual cholesteatoma thus sparing an unnecessary postoperative CT scan radiation.this is a prospective study performed in our tertiary care center. We followed up (...) prospectively a consecutive group of patients presenting with middle ear cholesteatoma using preoperative mastoid CT scans, postoperative mastoid CT scan and mastoid diffusion weighted MRI (DWI) between 2012 and 2013. Postoperative DWI were fused to both: the preoperative and postoperative mastoid CT scans. Fused images were evaluated for their ability to detect accurately the location of residual cholesteatoma if any. Results were correlated to the surgical findings.Twenty-eight patients were included

2016 International Journal of Pediatric Otorhinolaryngology

118. Minimally invasive transcanal myringotomy for pediatric early stage congenital cholesteatoma. (PubMed)

Minimally invasive transcanal myringotomy for pediatric early stage congenital cholesteatoma. Recently, minimally invasive transcanal myringotomy (MITM), which is a useful surgical technique for early stage congenital cholesteatoma (CC) in children, was introduced. The purpose of this study is to evaluate the short-term surgical results of MITM in pediatric early stage CC.We retrospectively reviewed the charts of 24 patients who underwent MITM between January 2013 and October 2015.The patients

2016 International Journal of Pediatric Otorhinolaryngology

119. Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. (PubMed)

Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. 27684485 2018 09 28 2018 10 01 1749-4486 42 4 2017 08 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Incidence of underlying congenital cholesteatoma in 28 patients with persistent unilateral otitis media with effusion. 901-904 10.1111/coa.12759 Wilmot V V VV (...) Royal Hospital for Sick Children, Edinburgh, UK. Sharma A A Royal Hospital for Sick Children, Edinburgh, UK. eng Journal Article 2016 10 14 England Clin Otolaryngol 101247023 1749-4478 Cholesteatoma, Congenital IM Child Child, Preschool Cholesteatoma congenital diagnosis epidemiology Female Humans Incidence Male Middle Ear Ventilation Otitis Media with Effusion complications diagnosis surgery Retrospective Studies Tomography, X-Ray Computed 2016 09 23 2016 9 30 6 0 2018 10 3 6 0 2016 9 30 6 0

2016 Clinical Otolaryngology

120. Role of Malleus relocation in cholesteatoma surgery: Our experience in 145 patients. (PubMed)

Role of Malleus relocation in cholesteatoma surgery: Our experience in 145 patients. 27086553 2018 09 17 2018 09 17 1749-4486 42 3 2017 06 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Title: Role of Malleus relocation in cholesteatoma surgery: our experience in 145 patients. 738-743 10.1111/coa.12658 Ashraf B B Mansoura Faculty of Medicine, Department of ORL (Otology (...) IM Adolescent Adult Child Cholesteatoma, Middle Ear pathology surgery Female Hearing Humans Male Malleus surgery Middle Aged Retrospective Studies Treatment Outcome 2016 04 11 2016 4 19 6 0 2018 9 18 6 0 2016 4 19 6 0 ppublish 27086553 10.1111/coa.12658

2016 Clinical Otolaryngology

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