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Cholesteatoma

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81. A Rare Case Report and Literature Review of External Auditory Canal Cholesteatoma with Circumferential Destruction of Canal Wall Exposing Facial Nerve (PubMed)

A Rare Case Report and Literature Review of External Auditory Canal Cholesteatoma with Circumferential Destruction of Canal Wall Exposing Facial Nerve External auditory canal cholesteatoma (EACC) is a rare condition with an estimated incidence of 1.2 per 1000 new otological patients. It is often mistaken with keratosis obturans. We discuss an extensive primary EACC with an aural polyp in a male which was managed by modified radical mastoidectomy.

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2017 Case reports in otolaryngology

82. Application of high resolution computer tomography in external ear canal cholesteatoma diagnosis (PubMed)

Application of high resolution computer tomography in external ear canal cholesteatoma diagnosis To evaluate High Resolution Computer Tomography (HRCT) in the diagnosis of external ear canal cholesteatoma.In this retrospective study, HRCTs of 27 patients with external ear canal cholesteatoma were reviewed. The changes in the external ear canal, tympanic membrane (TM), scutum, tympanum and mastoid were measured and categorized.Fourteen patients showed no or mild destruction in the external ear (...) in the stage III group.HRCT can provide detail information about the extent of external ear canal cholesteatoma. Such information can be used to identify special situations with serious complications and to differentiate external ear canal cholesteatoma from middle ear cholesteatoma.

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2017 Journal of otology

83. Parotid gland cholesteatoma in a 23-year-old male: Case report (PubMed)

Parotid gland cholesteatoma in a 23-year-old male: Case report Cholesteatoma is a pathological tissue that may extend into all parts of temporal bone and rarely, as this study highlights, beyond its structures. Nevertheless, the spread outside the mastoid tip into the soft tissues of the neck or parotid space is very rare. The case of 23-year-old male with right parotid mass is presented. The patient had history (2006, 2009, and 2012) of three tympanoplastics for recurrent right ear (...) cholesteatoma. The parotid tumor was revealed incidentally in magnetic resonance imaging in January 2016, but the imaging was inconclusive. After 6 months, the patient developed right-sided facial nerve palsy. The second look of the right ear was performed with simultaneous parotid surgery. The ear was healed and free of cholesteatoma, but the parotid mass resembled the cholesteatoma confirmed later on by histological examination. The tumor extended from stylomastoid foramen. This case was unusual

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2017 SAGE Open Medical Case Reports

84. Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging

Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Detection (...) of Cholesteatoma Using Diffusion Magnetic Resonance Imaging The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03305796 Recruitment Status : Not yet recruiting First Posted : October 10, 2017 Last Update Posted : October 10, 2017 See

2017 Clinical Trials

85. Incidence of Facial Nerve Canal Dehiscence in Primary and Revision Cholesteatoma Surgery (PubMed)

Incidence of Facial Nerve Canal Dehiscence in Primary and Revision Cholesteatoma Surgery The aim of this retrospective study was to determine the incidence of facial canal dehiscence (FCD) in primary and revision cholesteatoma surgery in a tertiary referral center. Moreover, our second goal was to identify association between FCD and other intra-operative pathological findings in a group of patients with cholesteatoma surgery. Inclusion criteria were primary and revision canal wall up and canal (...) wall down tympanomastoidectomy in patients who suffers from chronic otitis media (COM) with cholesteatoma. An exclusion criterion was charts with in adequate documentation. In addition tympanoplasty cases were excluded due to evaluate both tympanic and mastoid segments of facial nerve canal. Preoperative clinical data and intra-operative findings were documented in a formatted questionnaire. We found the incidence of FCD in COM surgery was 18%. There was no difference between the primary

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2017 Indian Journal of Otolaryngology and Head & Neck Surgery

86. Diagnostic Bedside Vestibuloocular Reflex Evaluation in the Setting of a False Negative Fistula Test in Cholesteatoma of the Middle Ear (PubMed)

Diagnostic Bedside Vestibuloocular Reflex Evaluation in the Setting of a False Negative Fistula Test in Cholesteatoma of the Middle Ear Background. False negative fistula testing in patients with chronic suppurative otitis media is a dilemma when proceeding to surgery. It is imperative to rule out a dead labyrinth or a mass effect secondary to the cholesteatoma in an otherwise normally functioning inner ear. We present a case series of three patients in whom a bedside vestibuloocular reflex (...) (VOR) evaluation using a head impulse test was used successfully for further evaluation prior to surgery. Results. In all three cases with a false negative fistula test we were able to further evaluate at the bedside and were not only able to register the abnormal VOR but also localize its deterioration to a particular semicircular canal eroded by the fistula. Conclusion. Vestibuloocular reflex evaluation is mandatory in patients with suspected labyrinthine fistula due to cholesteatoma

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2017 Case reports in otolaryngology

87. A Case Report of a Giant Cholesteatoma (PubMed)

A Case Report of a Giant Cholesteatoma Cholesteatoma is a well demarcated, non-neoplastic, temporal bone cystic lesion with extensive keratinisation. Keratoma and epidermoid cyst are other possibly more accurate names suggested to describe the same. It can be classified as congenital or acquired. Its management is often complicated by its tendency to recidivism/recurrence. Long standing cholesteatomas can be a precursor for squamous cell carcinoma. We hereby present a case of giant (...) cholesteatoma in a 45-year-old female with radiological involvement of the left temporal region, periauricular region and infratemporal fossa with lytic destruction of left middle ear ossicles, mastoid and squamous part of temporal bone with intracranial extension. The enormity of the present lesion along with its bony erosions raised the strong clinical suspicion of malignancy. The underlying case report highlights the relevance of exhaustive sectioning and immunohistochemistry to reach the diagnosis.

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2017 Journal of clinical and diagnostic research : JCDR

88. The accuracy and sensitivity of diffusion-weighted magnetic resonance imaging with Apparent Diffusion Coefficients in diagnosis of recurrent cholesteatoma (PubMed)

The accuracy and sensitivity of diffusion-weighted magnetic resonance imaging with Apparent Diffusion Coefficients in diagnosis of recurrent cholesteatoma To evaluate the accuracy and sensitivity of diffusion-weighted magnetic resonance imaging with ADC value combined with MDCT in evaluating recurrent cholesteatoma.Thirty patients (20 females and 10 males), their age ranged from 10 to 40years, had undergone a tympanomastoid surgery for a cholesteatoma of the middle ear underwent MDCT and MR DWI (...) examination before second- or third-look surgery from May 2015 to October 2016.CT showed partial opacification of the tympanomastoid cavity in 10 ears and complete opacification in 21 ears. CT detects 10 cases out of 20 cases of recurrent cholesteatoma with sensitivity 47.6%, specificity 100%, and NPP 47.6%. DWI depicted 21 out of 20 cases proved cholesteatoma patients (sensitivity 100%, specificity 90%, PPV 95.2% and P value is 0.001). All MRI of patients without cholesteatoma were correctly interpreted

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2017 European Journal of Radiology Open

89. Retraction pocket excision with cartilage grafting as a preventive surgery for cholesteatoma (PubMed)

Retraction pocket excision with cartilage grafting as a preventive surgery for cholesteatoma The goal of the present study is to summarize our experience on surgical management of retraction pockets (RP) as a preventive tool against cholesteatomas.Twenty-five ears have been followed up for a mean period of 6.16 ± 4.35 years (from 1 to 17 years). The sample presented a mean age of 47.56 ± 19.11 years (from 16 to 73 years). All patients underwent cartilage graft surgery. Furthermore 10 (40 (...) %) underwent tympanoplasty (TPL) type I, 14 (56%) TPL type II and 1 (4%) TPL type V.Eleven ears (44%) showed cholesteatoma: all these cases were stage III according to Charachon staging, and stage IV or V according to Gersdorff classification. Twelve patients (48%) showed erosion of the ossicular chain. Of these, five were associated with cholesteatoma and seven only with retraction. The recurrence rate of cholesteatoma was 12%. None of the patients with a stage II or III RP (according to Gersdorff

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2017 Journal of otology

90. Accuracy of turbo spin-echo diffusion-weighted imaging signal intensity measurements for the diagnosis of cholesteatoma (PubMed)

Accuracy of turbo spin-echo diffusion-weighted imaging signal intensity measurements for the diagnosis of cholesteatoma We aimed to evaluate the diagnostic accuracy of turbo spin-echo diffusion-weighted imaging (TSE-DWI) at 3 T, for cholesteatoma (CS) diagnosis, using qualitative and quantitative methods with numerical assessment of signal intensity (SI), signal intensity ratios (SIR), and apparent diffusion coefficient (ADC) values.In this retrospective study, two blinded observers (...) independently evaluated the preoperative TSE-DWI images of 57 patients who were imaged with a presumed diagnosis of CS. Qualitative assessment with respect to the SI of the adjacent cortex and quantitative measurements of SI, SIR, and ADC values were performed.Surgery with histopathologic examination revealed 30 CS patients and 27 patients with non-cholesteatoma (NCS) lesions including chronic inflammation and cholesterol granuloma. On TSE-DWI, 96.7% of the CS lesions and none of the NCS lesions appeared

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2017 Diagnostic and Interventional Radiology

91. Diffusion weighted imaging for the detection and evaluation of cholesteatoma (PubMed)

Diffusion weighted imaging for the detection and evaluation of cholesteatoma Cholesteatoma is a collection of keratinous debris and stratified squamous epithelium. It is trapped in the middle ear and can lead to bony erosion. The disease is treated surgically often followed by a second-look procedure to check for residual tissue or recurrence. Cholesteatoma has specific signal-intensity characteristics on magnetic resonance imaging with very high signal intensity on diffusion weighted imaging (...) (DWI). Various DWI techniques exist: Echo-planar imaging (EPI)-based and non-EPI-based techniques as well as new approaches like multi-shot EPI DWI. This article summarizes all techniques, discusses the significance in detecting cholesteatoma and mentions actual studies. Further recommendations for daily clinical practise are provided.

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2017 World journal of radiology

92. Why does the acquired cholesteatoma trigger resorption of the temporal bone? (PubMed)

Why does the acquired cholesteatoma trigger resorption of the temporal bone? 28616835 2017 11 20 2018 12 02 1434-4726 274 12 2017 12 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery Eur Arch Otorhinolaryngol Why does the acquired cholesteatoma trigger resorption of the temporal bone? 4251-4252 10.1007/s00405-017-4633-5 (...) Eur Arch Otorhinolaryngol. 2017 Dec;274(12 ):4253 28791463 Eur Arch Otorhinolaryngol. 2017 May;274(5):2071-2078 27981350 Cholesteatoma Cholesteatoma, Middle Ear Humans Temporal Bone 2017 05 30 2017 06 02 2017 6 16 6 0 2017 11 29 6 0 2017 6 16 6 0 ppublish 28616835 10.1007/s00405-017-4633-5 10.1007/s00405-017-4633-5 PMC5663803 Am J Otolaryngol. 2010 Nov-Dec;31(6):404-9 20015790 Otolaryngol Pol. 2010 Jul-Aug;64(4):219-24 20873097 ORL J Otorhinolaryngol Relat Spec. 2011;73(2):93-9 21311206 Eur Arch

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2017 European Archives of Oto-Rhino-Laryngology

93. Advancing Cholesteatoma Secondary to Acquired Atresia of the External Auditory Canal: Clinical Perspectives (PubMed)

Advancing Cholesteatoma Secondary to Acquired Atresia of the External Auditory Canal: Clinical Perspectives Acquired atresia of External Auditory Canal (EAC) is seldom encountered in routine otolaryngology practice. Apart from resulting in moderate-to-severe conductive hearing impairment, it is a potentially dreaded condition which might lead to canal cholesteatoma. Suspected to develop as a consequence of a pre-existing chronic otitis externa/media, the EAC atresia leads to proximal (medial (...) ) accumulation of desquamated epithelium and denatured keratin (the canal cholesteatoma) that further leads to aggravation of the chronic otitis, thereby initiating a vicious cycle. The canal cholesteatoma might progress unhindered into the middle ear and mastoid cavity, with its characteristic bone-eroding property, producing complications. A high index of clinical suspicion along with proper imaging are therefore essential to apprehend the disease progression in a patient presenting with an apparently

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2017 Journal of clinical and diagnostic research : JCDR

94. Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity (PubMed)

Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin (...) 17 (CK17) in acquired nonrecurrent human cholesteatoma and correlate them with its bone destructive capacity.A prospective quantitative immunohistochemical study was carried out using fresh acquired cholesteatoma tissues (n=19), collected during cholesteatoma surgery. Deep meatal skin tissues from the same patients were used as control (n=8). Cholesteatoma patients were divided into 2 groups and compared (invasive and noninvasive) according to a grading score for bone resorption based upon

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2017 Clinical and experimental otorhinolaryngology

95. Cholesteatoma Induced Labyrinthine Fistula: Is Aggressiveness in Removing Disease Justified? (PubMed)

Cholesteatoma Induced Labyrinthine Fistula: Is Aggressiveness in Removing Disease Justified? Issues of complete disease clearance and hearing preservation in cholesteatoma induced labyrinthine fistula cases has been discussed and updated in this article. Successful disease clearance and hearing preservation in a case of cholesteatoma induced isolated cochlear promontory fistula encouraged us to retrospectively analyse 13 more cases of cholesteatoma induced labyrinthine fistula who presented (...) in emergency service as complicated chronic suppurtive otitis media. Pre-operatively nine patients experienced vertigo, two had profound sensori neural hearing loss and radiology was suggestive of labyrinthine fistula in 12 patients. Lateral semicircular canal was involved in 13 cases. In all cases cholesteatoma matrix was completely removed from the fistula site irrespective of the fistula size and hearing status. Hearing was preserved in 11 out of 12 patients. Gentle and meticulous removal of the matrix

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2017 Indian Journal of Otolaryngology and Head & Neck Surgery

96. Blind Sac Approach Using Silastic Block for Cochlear Implantation in Patients with Cholesteatoma (PubMed)

Blind Sac Approach Using Silastic Block for Cochlear Implantation in Patients with Cholesteatoma Cochlear implant (CI) surgery in cholesteatoma is challenging because of the risk of residual or recurrent infection. Although CI could be done with subtotal petrosectomy in single or staged surgery, this surgery needed additional surgical procedures to obliterate the mastoid cavity. This paper describes a new surgical technique for CI surgery in cholesteatoma without external auditory canal closure.

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2017 Journal of Audiology & Otology

97. Expression of Prostaglandin E2 Receptors in Acquired Middle Ear Cholesteatoma (PubMed)

Expression of Prostaglandin E2 Receptors in Acquired Middle Ear Cholesteatoma To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1-4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder.Specimens of human acquired cholesteatoma were obtained from 29 patients and 19 skin biopsies of normal external auditory canal were as controls. The mRNA and protein expression of EP receptors was assessed by quantitative real (...) -time polymerase chain reaction, immunohistochemistry and Western blot.In acquired cholesteatoma, EP1-EP4 receptors were mainly expressed on squamous epithelium and subepithelial infiltrated inflammatory cells. In external auditory canal skin, EP1-EP4 receptors were mainly expressed on squamous epithelium and glandular epithelium. The expression of EP4 receptor on mRNA and protein levels were significant lower in acquired cholesteatoma compared with controls. EP1-EP3 receptors had no significant

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2017 Clinical and experimental otorhinolaryngology

98. Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up (PubMed)

Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up 29071059 2018 11 13 2039-4330 7 2 2017 Jul 18 Audiology research Audiol Res Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up. 187 10.4081/audiores.2017.187 Ralli Giovanni G Department of Sense Organs, La Sapienza University, Rome. Nola Giuseppe G ENT Unit, G.B. Grassi Hospital (...) , Ostia, Rome. Taglioni Alberto A Anesthesiology Unit, G.B. Grassi Hospital, Ostia (RM). Grasso Michele M Department of Sense Organs, La Sapienza University, Rome. Ralli Massimo M Department of Oral and Maxillofacial Sciences, La Sapienza University, Rome, Italy. eng Journal Article 2017 10 03 Italy Audiol Res 101644681 2039-4330 Day case surgery canal wall down tympanoplasty cholesteatoma chronic suppurative otitis media tympanoplasty 2017 06 26 2017 08 02 2017 10 27 6 0 2017 10 27 6 0 2017 10 27 6 1

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2017 Audiology research

99. Rehabilitation of Abducens Nerve Palsy after Cholesteatoma Resection at Cerebellopontine Angle by Intraorbital Electroacupuncture (PubMed)

Rehabilitation of Abducens Nerve Palsy after Cholesteatoma Resection at Cerebellopontine Angle by Intraorbital Electroacupuncture 28639584 2018 10 29 2018 11 13 2542-5641 130 13 2017 07 05 Chinese medical journal Chin. Med. J. Rehabilitation of Abducens Nerve Palsy after Cholesteatoma Resection at Cerebellopontine Angle by Intraorbital Electroacupuncture. 1625-1626 10.4103/0366-6999.208247 Zhou Ling-Yun LY Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Harbin (...) 150001, China. Zhao Ming M Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China. Su Chang C Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China. eng Letter China Chin Med J (Engl) 7513795 0366-6999 IM Abducens Nerve Diseases etiology therapy Cerebellopontine Angle Cholesteatoma surgery Electroacupuncture Humans 2017 6 23 6 0 2017 6

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2017 Chinese medical journal

100. Cochlear Fistula in Chronic Otitis Media without Cholesteatoma (PubMed)

Cochlear Fistula in Chronic Otitis Media without Cholesteatoma Cochlear fistula in the chronic otitis media (COM) without cholesteatoma is an extremely rare with only a few cases reported in the literature to this date. We describe a case of cochlear fistula observed in a female with COM without cholesteatoma. This report presents the first clinical case of a transtympanic iatrogenic trauma by habitual cotton swabs probably causing cochlear fistula.

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2017 Journal of Audiology & Otology

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