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Cholesteatoma

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61. Introducing the "ChOLE" Classification and Its Comparison to the EAONO/JOS Consensus Classification for Cholesteatoma Staging. Full Text available with Trip Pro

Introducing the "ChOLE" Classification and Its Comparison to the EAONO/JOS Consensus Classification for Cholesteatoma Staging. : Many previous attempts have been made to classify or categorize cholesteatomas. Recently, the European Academy of Otology and Neurotology and the Japanese Otological Society proposed a classification system based primarily on extension and complications. The European Academy of Otology and Neurotology/Japanese Otological Society consensus statement makes an effort (...) to standardize reporting of surgical techniques. Internet-based multicenter studies are facilitated by increasing connectivity, but a mutually-agreed framework for reporting is necessary for results to be comparable across sites. New technologies compete with established standardized surgical approaches and need to be validated. It is definitively the right time to find a consensus on how to record and report surgical findings in cholesteatoma surgery. To stimulate this interesting discussion, we propose

2018 Otology and Neurotology

62. Canal wall up surgery with mastoid and epitympanic obliteration in acquired cholesteatoma. (Abstract)

Canal wall up surgery with mastoid and epitympanic obliteration in acquired cholesteatoma. The objective of this study was to evaluate surgical outcome and residual and recurrence rates of canal wall up (CWU) surgery with obliteration of the mastoid and epitympanum.Retrospective cohort study in a tertiary referral center.Patients with (sequelae of) acquired cholesteatoma treated with primary or revision CWU surgery with obliteration of the epitympanum and mastoid were identified retrospectively (...) this difference was not statistically significant, a trend was observed (P = .066).Obliteration of the epitympanum and mastoid is a reliable and safe technique following CWU surgery for cholesteatoma, resulting in low residual and recurrence rates.4 Laryngoscope, 129:981-985, 2019.© 2018 The American Laryngological, Rhinological and Otological Society, Inc.

2018 Laryngoscope

63. Clinical and cost utility of an intraoperative endoscopic second look in cholesteatoma surgery. (Abstract)

Clinical and cost utility of an intraoperative endoscopic second look in cholesteatoma surgery. This study aimed to determine the clinical and cost-effectiveness of endoscopes during cholesteatoma surgery. More specifically, this study hypothesized that endoscope use would reduce cholesteatoma recurrence rates and cost.Case series involving the prospective enrollment of 110 consecutive cholesteatoma patients over a 2-year period.Patients underwent cholesteatoma surgery with microscopy. During (...) dissection, the location of the cholesteatoma was assessed. At the end of dissection and before reconstruction, the same subunits were visualized with straight and angled endoscopes for residual cholesteatoma. Hearing was analyzed before surgery and at the last possible examination. Costs were analyzed using Medicare reimbursement rates from the Centers for Medicare and Medicaid Services.Intraoperative endoscopic surveillance was able to detect residual cholesteatoma in 18 patients. With a 0° endoscope

2018 Laryngoscope

64. Bilateral Congenital Cholesteatoma. (Abstract)

Bilateral Congenital Cholesteatoma. To report the first large case series of extremely rare bilateral congenital cholesteatoma (CC).A retrospective cohort study.University hospital otology referral clinic.Six hundred four children with surgically confirmed CC.The bilateral CCs were compared with the unilateral CCs.The incidence of bilateral CC was 3.6% (22/615) per case or 1.8% (11/604) per child. Bilateral CC did not differ from unilateral CC regarding its demographics, and invasiveness (...) by the proportion of advanced CC as 31.8% (7/22) versus 28.2% (167/594). But the invasiveness or location randomly differed between the ears, that advanced CC per child was higher as 45.4% (5/11). Bilateral exploration was attempted with a concern for hearing loss, which featured a combination of laser myringotomy to treat early CC and endaural laser-assisted single-stage inside-out cholesteatoma surgery to treat advanced CC. Bilateral exploration was difficult in three children with initially negative

2018 Otology and Neurotology

65. Curved adjustable fibre-optic diode laser in microscopic cholesteatoma surgery: description of use and review of the relevant literature. (Abstract)

Curved adjustable fibre-optic diode laser in microscopic cholesteatoma surgery: description of use and review of the relevant literature. The use of lasers in cholesteatoma surgery is common and well accepted. The most commonly used laser fibres are straight and non-adjustable; these have several limitations. This paper describes the use of an alternative laser fibre.This 'How I Do It' paper describes and illustrates the use of an alternative curved adjustable fibre-optic diode laser (...) in microscopic cholesteatoma surgery.The curved, adjustable laser fibre allows accurate and atraumatic disease removal when the use of a straight laser fibre may be less effective or accurate. It reduces potential damage to delicate structures without the need for extra drilling or bone removal.It is suggested that the curved adjustable laser fibre is superior to the traditional straight fibre for cholesteatoma surgery.

2018 Journal of Laryngology & Otology

66. Bilateral congenital cholesteatoma: A case report and review of the literature. (Abstract)

Bilateral congenital cholesteatoma: A case report and review of the literature. Congenital cholesteatoma (CC) occurs less commonly than acquired cholesteatoma (AC), and bilateral CC (BCC) is even more rare with only 38 such cases having been reported in the past 42 years. Because of the rarity of this condition, providers confronted with cases of BCC may find it difficult to treat while balancing complete removal of disease, optimal hearing outcomes, and minimized surgical burden (...) in the pediatric patient. This review alerts physicians that BCC occurs, highlights past presentations and management strategies, describes the considerations in treatment and offers an algorithm helpful in the management of BCC.Review of a single case with extensive review of published reports from 1975 to 2017 pertaining to management of BCC.A five-year-old boy presented with bilateral congenital cholesteatoma. Tympanomastoidectomy was performed to remove cholesteatoma in the left ear then in the right ear

2018 International Journal of Pediatric Otorhinolaryngology

67. Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma Full Text available with Trip Pro

Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma As endoscopic instrumentation, techniques and knowledges have significantly improved recently, endoscopic ear surgery has become increasingly popular. Transcanal endoscopic ear surgery (TEES) can provide better visualization of hidden areas in the middle ear cavity during congenital cholesteatoma removal. We aimed to describe outcomes for TEES for congenital cholesteatoma in a pediatric population.Twenty-five children (age, 17 (...) months to 9 years) with congenital cholesteatoma confined to the middle ear underwent TEES by an experienced surgeon; 13 children had been classified as Potsic stage I, seven as stage II, and five as stage III. The mean follow-up period was 24 months. Recurrence of congenital cholesteatoma and surgical complication was observed.Congenital cholesteatoma can be removed successfully via transcanal endoscopic approach in all patients, and no surgical complications occurred; only one patient with a stage

2018 Clinical and experimental otorhinolaryngology

68. Extended-spectrum Beta-lactamase-producing Escherichia coli Meningitis That Developed from Otitis Media with Cholesteatoma Full Text available with Trip Pro

Extended-spectrum Beta-lactamase-producing Escherichia coli Meningitis That Developed from Otitis Media with Cholesteatoma A 78-year-old man had a fever and exhibited disordered consciousness, which led to his transportation to our hospital. On arrival, he exhibited discharge from the ear. Because extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli was detected in the ear discharge and cerebrospinal fluid specimens, it was inferred to be the causal bacteria. Pulsed-field gel

2018 Internal Medicine

69. Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting Full Text available with Trip Pro

Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting 30480211 2019 02 26 2473-974X 2 2 2018 Apr-Jun OTO open OTO Open Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting. 2473974X18765700 10.1177/2473974X18765700 Sepehri Elnaz E Department of ENT, Karolinska University Hospital, Sweden. von Unge Magnus M District Hospital Västmanland, Västerås and Centre for Clinical Research, RegionVästmanland - Uppsala University, Sweden (...) . Akershus University Hospital and University of Oslo, Norway. eng Case Reports 2018 04 02 United States OTO Open 101717942 2473-974X congenital mastoidal cholesteatoma treatment watchful waiting Competing interests: None. 2018 01 19 2018 01 19 2018 02 27 2018 11 28 6 0 2018 11 28 6 0 2018 11 28 6 1 epublish 30480211 10.1177/2473974X18765700 10.1177_2473974X18765700 PMC6239142 Otolaryngol Head Neck Surg. 2002 Oct;127(4):346-8 12402016 Otol Neurotol. 2006 Feb;27(2):282-3 16437002 Ann Otol Rhinol Laryngol

2018 OTO Open

70. The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis Full Text available with Trip Pro

The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE.Videotoscopy of both ears in 432 patients with cholesteatomas classified as posterior epitympanic (PEC), posterior mesotympanic (PMC), two routes, or undetermined. Tympanic membrane (TM) retractions were classified by location and severity and TM (...) perforations according to signs of previous TM retraction.TM retraction was the most prevalent alteration in the CLE (42.6%). Cholesteatoma was observed in 17.4%. In patients with PEC, the retraction in the CLE was more frequent in the PF (66.7%) than in the PT (1.4%), and in those with two-route cholesteatoma, the retraction in the CLE most frequently involved both the PT and PF (65.6%; p < 0.0001).Our results confirm the essential role of TM retraction at least in the earlier phases of cholesteatoma

2018 BioMed research international

71. Treatment of cholesteatoma with intact ossicular chain: anatomic and functional results Full Text available with Trip Pro

Treatment of cholesteatoma with intact ossicular chain: anatomic and functional results In case of cholesteatoma with intact ossicular chain, the primary aims of surgery are complete removal of the cholesteatoma matrix and reconstruction of a dry and safe middle ear; if possible, ossicular chain continuity and therefore the preoperative hearing must be preserved. The aim of this retrospective study is to present the experience of the U.O.C. Otorinolaringoiatria Universitaria of University (...) of Bari "Aldo Moro" in treatment of intact ossicular chain cholesteatoma with Bondy modified radical mastoidectomy (BMRM) and canal wall up tympanoplasty (CWUT). The study group was composed of 65 subjects affected by cholesteatoma with intact ossicular chain. Mean age was 40.7 years (range 6-79), with 42 males and 23 females. 30 patients were treated by a BMRM and 35 by CWUT, in 22 cases without mastoidectomy and in 13 cases with mastoidectomy. Mean follow-up was 24.25 months. In the BMRM group

2018 Acta Otorhinolaryngologica Italica

72. A giant cholesteatoma of the mastoid extending into the foramen magnum: A case report and review of literature Full Text available with Trip Pro

A giant cholesteatoma of the mastoid extending into the foramen magnum: A case report and review of literature Cholesteatomas are very rare benign, progressive lesions that have embryologic derivation and usually result in progressive exfoliation and confinement of squamous epithelium behind an intact or preciously infected tympanic membrane. To the best of our understanding no reports demonstrates the extension of cholesteatoma from the temporal bone into the foramen magnum. We therefore (...) present a case of cholesteatoma extending down into the foramen magnum. We report a case of 67- year-old man with a giant cholesteatoma extending into the foramen magnum without substantial destruction of the mastoid and petrous temporal bones. The patient's major symptoms were recurrent tinnitus in the left ear and dizziness with unilateral conductive hearing loss. A working diagnosis of cholesteatomas was made combining the symptoms and magnetic resonance imaging findings. He was then successfully

2018 Neurology international

73. Downregulation of MiR-203a Disinhibits Bmi1 and Promotes Growth and Proliferation of Keratinocytes in Cholesteatoma Full Text available with Trip Pro

Downregulation of MiR-203a Disinhibits Bmi1 and Promotes Growth and Proliferation of Keratinocytes in Cholesteatoma Background: Keratinocytes are the predominant cell type in a cholesteatoma, and microRNA (miR)-203a has been shown to be essential for the growth and differentiation of keratinocytes. The regulatory mechanisms of miR-203a and Bmi1-the predicted target of miR-203a that is associated with cholesteatoma-have not been clarified. Methods: Real-time PCR and western blot were carried out (...) for the detection of miRNAs, mRNAs, and proteins, including miR-203a, Bmi1, and phosphorylated (p-)Akt. Immunohistochemical staining was applied to observe the expression and distribution of Bmi1 and of p-Akt in cholesteatoma and in control retroauricular skin. The dual luciferase reporter assay was used to analyze the relationship between miR-203a and Bmi1. Ectopic miR-203a and Bmi1 were transfected into an immortalized line of human keratinocytes (HaCaT cells), and the roles of these molecules in cell

2018 International journal of medical sciences

74. Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis Full Text available with Trip Pro

Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis Cholesteatoma is a pathologically benign but clinically destructive middle ear disease, which is caused by excessive epidermal migration and uncontrolled hyperproliferation of keratinocytes of squamous epithelium, leading to various clinical manifestations and serious complications, such as hearing loss, dizziness, facial paralysis, meningitis, and hydrocephalus. However (...) , the pathogenesis of cholesteatoma is still not fully understood. Herein, we performed microarray analysis to identify the differentially expressed patterns of lncRNAs in cholesteatoma for the first time. Our data indicated that compared with matched normal skin tissue, lncRNA expression profiles were significantly altered in cholesteatoma. A total of 787 lncRNAs were identified (fold change ≥2.0, P<0.05), consisting of 181 upregulated and 606 downregulated lncRNAs. Furthermore, by constructing an lncRNA/miRNA

2018 Oncology reports

75. Cholesteatoma in children and adults: are there really any differences? (Abstract)

Cholesteatoma in children and adults: are there really any differences? Cholesteatoma is widely considered to be more aggressive in children than adults, yet few studies have directly compared the operative findings and surgical outcomes between these two groups. This study aimed to assess differences between childhood and adult cholesteatoma.The operative caseload of a single consultant surgeon was reviewed between January 2006 and May 2017 using the online Common Otology Audit database (...) . Extracted data were categorised according to patient age (children, aged below 16 years, and adults, aged 16 years or over) and compared.This study included data from 71 operations on children and 281 operations on adults, performed for cholesteatoma. Childhood cholesteatoma demonstrated significantly more extension (into the sinus tympani, mastoid antrum and mastoid air cells) and ossicular erosion (of the malleus, incus and stapes superstructure) compared to adults. No significant differences were

2018 Journal of Laryngology & Otology

76. External auditory canal cholesteatoma and benign necrotising otitis externa: clinical study of 95 cases in the Capital Region of Denmark. (Abstract)

External auditory canal cholesteatoma and benign necrotising otitis externa: clinical study of 95 cases in the Capital Region of Denmark. To identify epidemiological and pathophysiological factors, and treatment strategies, in external auditory canal cholesteatoma and benign necrotising otitis externa.A retrospective case study was conducted of patients suffering from external auditory canal cholesteatoma and benign necrotising otitis externa admitted to tertiary hospitals, in the Capital (...) Region of Denmark, over a five-year period.Eighty-three patients (95 ears) with external auditory canal cholesteatoma or benign necrotising otitis externa were identified. A minimum incidence rate of 0.97 per 100 000 inhabitants per year was demonstrated. Sixty-eight per cent of cases had a history of smoking. Most lesions (74 per cent) were localised in the floor of the ear canal. Treatment time was 3.2 months for patients who had surgery and 6.0 months for those who received conservative

2018 Journal of Laryngology & Otology

77. Application of Regenerative Treatment for Tympanic Membrane Perforation With Cholesteatoma, Tumor, or Severe Calcification. (Abstract)

Application of Regenerative Treatment for Tympanic Membrane Perforation With Cholesteatoma, Tumor, or Severe Calcification. To apply regenerative treatment for tympanic membrane (TM) perforation to patients with severe calcification of the TM, cholesteatomas, or tumors localized to the tympanic cavity.Controlled clinical pilot study.General hospitals.Forty-five patients (age: 8-85; M = 19, F = 26) were selected from patients with or without TM perforation for the regenerative treatment. Twenty (...) -five patients had cholesteatomas, 3 had tumors, and 17 had severe TM calcification. Patients were classified into three groups based on TM perforation size: less than 1/3 of the TM as Grade I (n = 5), 1/3 to 2/3 as Grade II (n = 19), and over 2/3 as Grade III (n = 21). Twenty patients who underwent standard tympanoplasty type I were selected as historical controls.Materials for the TM repair included gelatin sponge with basic fibroblast growth factor and fibrin glue. After lesions were removed

2018 Otology and Neurotology

78. Hearing outcome following mastoid surgery for cholesteatoma in children

Hearing outcome following mastoid surgery for cholesteatoma in children Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2020 PROSPERO

79. Clinical Aspects and Surgical Outcomes of Congenital Cholesteatoma in 93 Children: Increasing Trends of Congenital Cholesteatoma from 1997 through 2012 Full Text available with Trip Pro

Clinical Aspects and Surgical Outcomes of Congenital Cholesteatoma in 93 Children: Increasing Trends of Congenital Cholesteatoma from 1997 through 2012 The recent increase in the reported incidence of congenital cholesteatoma (CC) may be secondary to the widespread use of otoendoscopy as well as an increased awareness of these lesions among primary care physicians. However, little research about CC has been conducted in a large group of patients. This study aimed to analyze the clinical

2016 Journal of Audiology & Otology

80. Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging

Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Detection (...) of Cholesteatoma Using Diffusion Magnetic Resonance Imaging The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03305796 Recruitment Status : Not yet recruiting First Posted : October 10, 2017 Last Update Posted : October 10, 2017 See

2017 Clinical Trials

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