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Cholesteatoma

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41. Treatment of cholesteatoma with intact ossicular chain: anatomic and functional results (PubMed)

Treatment of cholesteatoma with intact ossicular chain: anatomic and functional results In case of cholesteatoma with intact ossicular chain, the primary aims of surgery are complete removal of the cholesteatoma matrix and reconstruction of a dry and safe middle ear; if possible, ossicular chain continuity and therefore the preoperative hearing must be preserved. The aim of this retrospective study is to present the experience of the U.O.C. Otorinolaringoiatria Universitaria of University (...) of Bari "Aldo Moro" in treatment of intact ossicular chain cholesteatoma with Bondy modified radical mastoidectomy (BMRM) and canal wall up tympanoplasty (CWUT). The study group was composed of 65 subjects affected by cholesteatoma with intact ossicular chain. Mean age was 40.7 years (range 6-79), with 42 males and 23 females. 30 patients were treated by a BMRM and 35 by CWUT, in 22 cases without mastoidectomy and in 13 cases with mastoidectomy. Mean follow-up was 24.25 months. In the BMRM group

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2018 Acta Otorhinolaryngologica Italica

42. Bilateral tympanokeratomas (cholesteatomas) with bilateral otitis media, unilateral otitis interna and acoustic neuritis in a dog (PubMed)

Bilateral tympanokeratomas (cholesteatomas) with bilateral otitis media, unilateral otitis interna and acoustic neuritis in a dog An aural cholesteatoma, more appropriately named tympanokeratoma, is an epidermoid cyst of the middle ear described in several species, including dogs, humans and Mongolian gerbils. The cyst lining consists of stratified, keratinizing squamous epithelium with central accumulation of a keratin debris. This case report describes vestibular ganglioneuritis

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2018 Acta veterinaria Scandinavica

43. Microarray Analysis of Differentially-expressed MicroRNAs in Acquired Middle Ear Cholesteatoma (PubMed)

Microarray Analysis of Differentially-expressed MicroRNAs in Acquired Middle Ear Cholesteatoma Objectives: To analyze the miRNAs expression profiling between acquired middle ear cholesteatoma and normal skin, and to identify several novel miRNAs which may be involved in the etiopathogenesis of middle ear cholesteatoma. Methods: MiRNA microarray technology was adopted to analyze the miRNA expression profiling between acquired middle ear cholesteatoma and normal skin. qRT-PCR was used to validate (...) selected differentially expressed miRNAs. Results: The miRNA microarray technology showed totally 44 upregulated (miRNA-21-3p, miRNA-584-5p, miRNA-16-1-3p, etc) and 175 downregulated (miRNA-10a-5p, miRNA-152-5p, miRNA-203b-5p, etc) miRNAs in cholesteatoma tissues with 2-fold change compared with normal skin. The qRT-PCR validation was in accordance with the microarray results partly: miRNA-21-3p and miRNA-16-1-3p expressed significantly higher while miRNA-10a-5p exhibited an obviously decreased

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2018 International journal of medical sciences

44. Canal wall up surgery with mastoid and epitympanic obliteration in acquired cholesteatoma. (PubMed)

Canal wall up surgery with mastoid and epitympanic obliteration in acquired cholesteatoma. The objective of this study was to evaluate surgical outcome and residual and recurrence rates of canal wall up (CWU) surgery with obliteration of the mastoid and epitympanum.Retrospective cohort study in a tertiary referral center.Patients with (sequelae of) acquired cholesteatoma treated with primary or revision CWU surgery with obliteration of the epitympanum and mastoid were identified retrospectively (...) this difference was not statistically significant, a trend was observed (P = .066).Obliteration of the epitympanum and mastoid is a reliable and safe technique following CWU surgery for cholesteatoma, resulting in low residual and recurrence rates.4 Laryngoscope, 129:981-985, 2019.© 2018 The American Laryngological, Rhinological and Otological Society, Inc.

2018 Laryngoscope

45. Evolution of Acquired Middle Ear Cholesteatoma in Patients With Ectrodactyly, Ectodermal Dysplasia, Cleft Lip/Palate (EEC) Syndrome. (PubMed)

Evolution of Acquired Middle Ear Cholesteatoma in Patients With Ectrodactyly, Ectodermal Dysplasia, Cleft Lip/Palate (EEC) Syndrome. To review an institutional experience with the surgical and clinical management of acquired middle ear cholesteatoma in patients with ectrodactyly, ectodermal dysplasia, cleft lip/palate (EEC) syndrome.Retrospective chart review.Tertiary referral center.Eight patients with medical history significant for EEC syndrome who underwent surgery for acquired middle ear (...) cholesteatoma between 1996 and 2016.Appropriate surgical interventions at the time of admission.History of ventilation tube insertion, status of the contralateral ear, surgical technique, cholesteatoma recidivism, presence of postoperative external auditory canal stenosis, pre and postoperative audiograms.Cholesteatoma was diagnosed in all patients, 3 (37.5%) unilateral and 5 (62.5%) bilateral, totalizing 13 ears. Six ears (46.2%) underwent a canal wall up mastoidectomy but required conversion to a canal

2018 Otology and Neurotology

46. The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis (PubMed)

The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE.Videotoscopy of both ears in 432 patients with cholesteatomas classified as posterior epitympanic (PEC), posterior mesotympanic (PMC), two routes, or undetermined. Tympanic membrane (TM) retractions were classified by location and severity and TM (...) perforations according to signs of previous TM retraction.TM retraction was the most prevalent alteration in the CLE (42.6%). Cholesteatoma was observed in 17.4%. In patients with PEC, the retraction in the CLE was more frequent in the PF (66.7%) than in the PT (1.4%), and in those with two-route cholesteatoma, the retraction in the CLE most frequently involved both the PT and PF (65.6%; p < 0.0001).Our results confirm the essential role of TM retraction at least in the earlier phases of cholesteatoma

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2018 BioMed research international

47. Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting (PubMed)

Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting 30480211 2019 02 26 2473-974X 2 2 2018 Apr-Jun OTO open OTO Open Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting. 2473974X18765700 10.1177/2473974X18765700 Sepehri Elnaz E Department of ENT, Karolinska University Hospital, Sweden. von Unge Magnus M District Hospital Västmanland, Västerås and Centre for Clinical Research, RegionVästmanland - Uppsala University, Sweden (...) . Akershus University Hospital and University of Oslo, Norway. eng Case Reports 2018 04 02 United States OTO Open 101717942 2473-974X congenital mastoidal cholesteatoma treatment watchful waiting Competing interests: None. 2018 01 19 2018 01 19 2018 02 27 2018 11 28 6 0 2018 11 28 6 0 2018 11 28 6 1 epublish 30480211 10.1177/2473974X18765700 10.1177_2473974X18765700 PMC6239142 Otolaryngol Head Neck Surg. 2002 Oct;127(4):346-8 12402016 Otol Neurotol. 2006 Feb;27(2):282-3 16437002 Ann Otol Rhinol Laryngol

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2018 OTO Open

48. Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma (PubMed)

Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma As endoscopic instrumentation, techniques and knowledges have significantly improved recently, endoscopic ear surgery has become increasingly popular. Transcanal endoscopic ear surgery (TEES) can provide better visualization of hidden areas in the middle ear cavity during congenital cholesteatoma removal. We aimed to describe outcomes for TEES for congenital cholesteatoma in a pediatric population.Twenty-five children (age, 17 (...) months to 9 years) with congenital cholesteatoma confined to the middle ear underwent TEES by an experienced surgeon; 13 children had been classified as Potsic stage I, seven as stage II, and five as stage III. The mean follow-up period was 24 months. Recurrence of congenital cholesteatoma and surgical complication was observed.Congenital cholesteatoma can be removed successfully via transcanal endoscopic approach in all patients, and no surgical complications occurred; only one patient with a stage

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2018 Clinical and experimental otorhinolaryngology

49. Extended-spectrum Beta-lactamase-producing Escherichia coli Meningitis That Developed from Otitis Media with Cholesteatoma (PubMed)

Extended-spectrum Beta-lactamase-producing Escherichia coli Meningitis That Developed from Otitis Media with Cholesteatoma A 78-year-old man had a fever and exhibited disordered consciousness, which led to his transportation to our hospital. On arrival, he exhibited discharge from the ear. Because extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli was detected in the ear discharge and cerebrospinal fluid specimens, it was inferred to be the causal bacteria. Pulsed-field gel

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2018 Internal Medicine

50. Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis (PubMed)

Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis Cholesteatoma is a pathologically benign but clinically destructive middle ear disease, which is caused by excessive epidermal migration and uncontrolled hyperproliferation of keratinocytes of squamous epithelium, leading to various clinical manifestations and serious complications, such as hearing loss, dizziness, facial paralysis, meningitis, and hydrocephalus. However (...) , the pathogenesis of cholesteatoma is still not fully understood. Herein, we performed microarray analysis to identify the differentially expressed patterns of lncRNAs in cholesteatoma for the first time. Our data indicated that compared with matched normal skin tissue, lncRNA expression profiles were significantly altered in cholesteatoma. A total of 787 lncRNAs were identified (fold change ≥2.0, P<0.05), consisting of 181 upregulated and 606 downregulated lncRNAs. Furthermore, by constructing an lncRNA/miRNA

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2018 Oncology reports

51. Downregulation of MiR-203a Disinhibits Bmi1 and Promotes Growth and Proliferation of Keratinocytes in Cholesteatoma (PubMed)

Downregulation of MiR-203a Disinhibits Bmi1 and Promotes Growth and Proliferation of Keratinocytes in Cholesteatoma Background: Keratinocytes are the predominant cell type in a cholesteatoma, and microRNA (miR)-203a has been shown to be essential for the growth and differentiation of keratinocytes. The regulatory mechanisms of miR-203a and Bmi1-the predicted target of miR-203a that is associated with cholesteatoma-have not been clarified. Methods: Real-time PCR and western blot were carried out (...) for the detection of miRNAs, mRNAs, and proteins, including miR-203a, Bmi1, and phosphorylated (p-)Akt. Immunohistochemical staining was applied to observe the expression and distribution of Bmi1 and of p-Akt in cholesteatoma and in control retroauricular skin. The dual luciferase reporter assay was used to analyze the relationship between miR-203a and Bmi1. Ectopic miR-203a and Bmi1 were transfected into an immortalized line of human keratinocytes (HaCaT cells), and the roles of these molecules in cell

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2018 International journal of medical sciences

52. Introducing the "ChOLE" Classification and Its Comparison to the EAONO/JOS Consensus Classification for Cholesteatoma Staging. (PubMed)

Introducing the "ChOLE" Classification and Its Comparison to the EAONO/JOS Consensus Classification for Cholesteatoma Staging. : Many previous attempts have been made to classify or categorize cholesteatomas. Recently, the European Academy of Otology and Neurotology and the Japanese Otological Society proposed a classification system based primarily on extension and complications. The European Academy of Otology and Neurotology/Japanese Otological Society consensus statement makes an effort (...) to standardize reporting of surgical techniques. Internet-based multicenter studies are facilitated by increasing connectivity, but a mutually-agreed framework for reporting is necessary for results to be comparable across sites. New technologies compete with established standardized surgical approaches and need to be validated. It is definitively the right time to find a consensus on how to record and report surgical findings in cholesteatoma surgery. To stimulate this interesting discussion, we propose

2018 Otology and Neurotology

53. Cholesteatoma of the External Auditory Canal: Review of Staging and Surgical Strategy. (PubMed)

Cholesteatoma of the External Auditory Canal: Review of Staging and Surgical Strategy. External auditory canal cholesteatomas (EACC) is insidious in nature and rare entity. There are only few case series on EACCs and surgical strategy is not standardized.1) To elucidate etiology of EACC and cardinal features. 2) To suggest a practical staging of EACC. 3) To enumerate surgical management according to stage of EACC.Retrospective study in a quaternary referral center of 31 consecutive cases (...) with reconstruction. Subtotal petrosectomy was done in five cases. Intact canal wall mastoidectomy with canalplasty in two cases and radical mastoidectomy in two cases. Fascia, cartilage, muscle, and bone dust were used for reconstruction. Median follow-up period was 6 years and no recurrence of cholesteatoma was observed.EACC is unique entity. Intraoperative and radiological findings assist in correct and practical staging of EACC. Late stage presentations of EACC are common. Definitive surgical treatment in our

2018 Otology and Neurotology

54. Assessment of nasal functions and their relationship with cholesteatoma formation in patients with unilateral chronic otitis media. (PubMed)

Assessment of nasal functions and their relationship with cholesteatoma formation in patients with unilateral chronic otitis media. To evaluate the nasal functions of patients with unilateral chronic otitis media using rhinomanometry, comparing chronic otitis media sides with healthy sides, chronic otitis media patients with cholesteatoma and without cholesteatoma, and patients with healthy individuals.This prospective study included 102 patients with unilateral chronic otitis media (48 (...) with and 54 without cholesteatoma). The control group comprised 40 individuals without any ear or nasal pathologies. All patients underwent active anterior rhinomanometry to measure nasal airway resistance and a saccharin test to measure mucociliary transport times.There were no significant differences in nasal airway resistance and mucociliary transport time between the chronic otitis media sides and unaffected sides in the 102 patients (p = 0.72 and p = 0.28, respectively), between the non-suppurative

2018 Journal of Laryngology & Otology

55. Cholesteatoma in children and adults: are there really any differences? (PubMed)

Cholesteatoma in children and adults: are there really any differences? Cholesteatoma is widely considered to be more aggressive in children than adults, yet few studies have directly compared the operative findings and surgical outcomes between these two groups. This study aimed to assess differences between childhood and adult cholesteatoma.The operative caseload of a single consultant surgeon was reviewed between January 2006 and May 2017 using the online Common Otology Audit database (...) . Extracted data were categorised according to patient age (children, aged below 16 years, and adults, aged 16 years or over) and compared.This study included data from 71 operations on children and 281 operations on adults, performed for cholesteatoma. Childhood cholesteatoma demonstrated significantly more extension (into the sinus tympani, mastoid antrum and mastoid air cells) and ossicular erosion (of the malleus, incus and stapes superstructure) compared to adults. No significant differences were

2018 Journal of Laryngology & Otology

56. Functional and Anatomical Outcome of Inside Out Technique For Cholesteatoma Surgery. (PubMed)

Functional and Anatomical Outcome of Inside Out Technique For Cholesteatoma Surgery. To study the efficacy of inside-out technique in completely eradicating the cholesteatoma from middle ear and mastoid, preservation of hearing & and quality of life post mastoidectomy with regards to recurrent discharge, wax, granulations.Non-randomized, prospective, observational study performed at the Department of ENT in our hospital. In the study we included 100 patients presenting with chronic suppurative (...) otitis media with cholesteatoma, they underwent inside out mastoidectomy and were followed up till the end of the study to evaluate the efficacy of inside out mastoidectomy in eradicating the disease from the middle ear cleft. To assess preservation of hearing and to assess cavity problems.Of the 100 patients, 98 patients had a total clearance of disease by the inside out approach, and 2 patients, had doubtful clearance. All patients came for regular follow up and none of them had residual disease

2018 American Journal of Otolaryngology

57. Clinical analysis of pediatric primary external auditory canal cholesteatoma. (PubMed)

Clinical analysis of pediatric primary external auditory canal cholesteatoma. Pediatric primary external auditory canal cholesteatoma (EACC) is a rare disease. The present study aimed to explore the clinical features and prognosis of this disease.Clinical data of 41 ears with pediatric primary EACC were collected, and the clinical characteristics and prognosis were analyzed in this retrospective study.A total of 35 patients (median age of 13 years) were recruited in this study. Of these, 13 (...) II, 15 in stage III. A total of 40 ears underwent transcanal cholesteatoma removal (TCR) and 1 underwent both TCR and tympanoplasty. Finally, 33 ears were followed up postoperatively, and only 1 ear presented recurrence.The posterior wall of the EAC is the most commonly affected wall, and the involvement of multiple walls is common. Due to the remodeling of the EAC bone in pediatric patients, the high stage lesions can be treated by minimally invasive surgical debridement combined with a close

2018 International Journal of Pediatric Otorhinolaryngology

58. Cartilage Fascia Composite Canalplasty for External Auditory Canal Cholesteatoma: Case Analysis and Long-term Surgical Results. (PubMed)

Cartilage Fascia Composite Canalplasty for External Auditory Canal Cholesteatoma: Case Analysis and Long-term Surgical Results. To analyze surgical outcomes of cartilage-fascia composite canalplasty (CFCC) for external auditory canal cholesteatoma (EACC).Retrospective case review study.Tertiary referral center.A total of 13 patients with EACC (n = 14 ears due to one patient with bilateral EACC).Surgical method of CFCC using well designed-conchal cartilage and temporalis muscle fascia after (...) complete removal of EACC.Clinical characteristics and EACC stages were determined by oto-endoscopic examination and computed tomography (CT) findings. The surgical results of CFCC were analyzed.The median age of patients was 43 years (range, 12-75 yr), with a male to female ratio of 6 to 7. EACC stages were from II to IV. Cortical bone erosion in the inferior part of the bony EAC was the most common finding. All patients had satisfactory results: no more ear symptoms related with cholesteatoma

2018 Otology and Neurotology

59. Endoscopic versus microscopic approach in attic cholesteatoma surgery. (PubMed)

Endoscopic versus microscopic approach in attic cholesteatoma surgery. Compare the outcomes of primary exclusive endoscopic ear surgery with those of the microscopic ear surgery in a group of patients affected by attic cholesteatoma.Eighty patients suffered from attic cholesteatoma. Forty patients surgical treated with endoscopic ear surgery and forty patients surgical treated with microscopic ear surgery.No statistical differences were found in the parameters analysed (frequency of facial

2017 American Journal of Otolaryngology

60. Mycology of chronic suppurative otitis media-cholesteatoma disease: An evaluative study. (PubMed)

Mycology of chronic suppurative otitis media-cholesteatoma disease: An evaluative study. To detect the prevalence of fungus in chronic suppurative otitis media-cholesteatoma disease and to evaluate its clinical significance.Prospective observational study conducted in a sample size of 46 patients at a tertiary care university teaching hospital.Forty six patients suffering from chronic suppurative otitis media-cholesteatoma disease were recruited in this prospective study. Data was duly recorded (...) . Cholesteatoma sample was procured at the time of mastoid surgery and microbiologically analysed for fungal infestation. Clinical correlation to fungus infestation of cholesteatoma was statistically analysed.Out of the recruited 46 patients, post-operatively cholesteatoma was seen in 40 cases only. Seventeen i.e. 42.5% of these cases had fungal colonization of cholesteatoma. Further a statistically significant correlation between persistent otorrhoea and fungal infestation of cholesteatoma was observed

2017 American Journal of Otolaryngology

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