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Cholesteatoma

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21. Evaluation of the Effect of Diclofenac Sodium and 5-Fluourasil in a 3D Cholesteatoma Cell Culture Model. (Abstract)

Evaluation of the Effect of Diclofenac Sodium and 5-Fluourasil in a 3D Cholesteatoma Cell Culture Model. Middle ear cholesteatoma is a benign disease with invasive and destructive clinical behaviors. It increases the rate of both chronic otitis media complications and revision surgeries. The most effective treatment of middle ear cholesteatoma is surgical excision, and there is no medical treatment for this disease. Exploring new medical treatment options may help to create treatment (...) alternatives instead of surgery.Required cholesteatoma tissues for cell culture were excised from 4 different participants who underwent surgery in our clinic and agreed to give tissue for the study. Cholesteatoma-derived keratinocytes and fibroblasts were cocultured in temperature-sensitive culture dishes to make a three-dimensional (3D) cholesteatoma model. Then, the effects of 1% and 2% diclofenac sodium on viability and cell proliferation rates were examined using WST-1 and annexin-V tests.Cell

2019 Otology and Neurotology

22. The Antrum-Malleus-Tegmen Score: A Pilot Study Assessing Preoperative Radiographic Predictors for Transcanal Endoscopic Cholesteatoma Dissection. (Abstract)

The Antrum-Malleus-Tegmen Score: A Pilot Study Assessing Preoperative Radiographic Predictors for Transcanal Endoscopic Cholesteatoma Dissection. Identify features on computed tomography (CT) that predict mastoidectomy conversion (MC) during transcanal endoscopic ear surgery (TEES).Retrospective case-control.University otology practice.Consecutive patients with cholesteatoma.TEES cholesteatoma dissection versus those requiring MC.Antrum opacification, depth of scutum involvement, and erosion (...) of the mastoid trabeculae, ossicular chain, and tegmen were evaluated. Univariable and multivariable regression analysis was performed. The Antrum-Malleus-Tegmen (AMT) score was created using receiver operating characteristic curves to assess feasibility of performing TEES for cholesteatoma dissection.There were 39 TEES and 19 MC cases. Groups had similar age (median 28.5 yr), gender, laterality, and revision surgery status. Median surgical time for MC cases was longer than TEES (231 min vs. 171 min, p

2019 Otology and Neurotology

23. Microbiome Analysis of Cholesteatoma by Gene Sequencing. (Abstract)

Microbiome Analysis of Cholesteatoma by Gene Sequencing. To compare the microbial flora of cholesteatoma and normal middle ears using gene-based sequencing analysis.Controlled ex vivo human study.Academic, tertiary medical center.Brush, swab, and tissue samples were each taken from cholesteatoma matrix and uninvolved tissue in patients with previously untreated, acquired cholesteatoma (n = 19) or middle ear mucosa from patients undergoing cochlear implantation with no history of cholesteatoma (...) or previous middle ear surgery (control; n = 12). DNA was isolated from specimens then 16S rRNA gene sequencing was performed.There was no difference in microbial yield between the sampling methods. Cholesteatoma specimens had lower relative abundance of 14 bacterial species compared with controls including Acidovorax sp., Bacillus sp., Masillia sp., Moraxella osloensis, Phenylobacterium conjunctum, Sphingomonas sp., and Staphylococcus epidermidis (all p < 0.05). Alternaria sp. were present on nearly all

2019 Otology and Neurotology

24. Value of DW-MRI in the preoperative evaluation of congenital cholesteatoma. (Abstract)

Value of DW-MRI in the preoperative evaluation of congenital cholesteatoma. This study evaluated the clinical value of diffusion-weighted magnetic resonance imaging (DW-MRI) in the diagnosis and staging of congenital cholesteatoma (CC).We retrospectively reviewed 24 patients with CC. All the patients underwent computed tomography (CT) and DW-MRI preoperatively; thereafter, surgery was performed. DW-MRI examination was performed with a 3 T MRI system using three-dimensional reversed fast imaging (...) with steady-state precession and diffusion-weighted magnetic resonance sequence. The preoperative and operative CT and DW-MRI findings were compared.Using DW-MRI, cholesteatoma was successfully detected in 17 (71%) of the 24 patients with CC. Among the seven patients with false-negative results, the cholesteatoma mass diameter was <5 mm in six patients and ≥5 mm in one patient. One of these patients had open type congenital cholesteatoma (OTCC). The detection rates for closed type cholesteatoma and OTCC

2019 International Journal of Pediatric Otorhinolaryngology

25. Negative Predictive Value of Non-Echo-Planar Diffusion Weighted MR Imaging for the Detection of Residual Cholesteatoma Done at 9 Months After Primary Surgery Is not High Enough to Omit Second Look Surgery. (Abstract)

Negative Predictive Value of Non-Echo-Planar Diffusion Weighted MR Imaging for the Detection of Residual Cholesteatoma Done at 9 Months After Primary Surgery Is not High Enough to Omit Second Look Surgery. To evaluate non echo-planar diffusion weighted magnetic resonance imaging (non-EP DW MRI) at 9 months after primary surgery to rule out residual cholesteatoma in patients scheduled before second-look-surgical exploration.Prospective observational study.Secondary teaching hospital.Patients who (...) were scheduled for second-look-surgery after primary canal wall up repair of cholesteatoma underwent 1.5 T MRI including non-EP DWI and high-resolution coronal T1 and T2-FS SE sequences.Imaging studies were evaluated for the presence of cholesteatoma by three independent observers. Intraoperative observations were regarded the standard of reference. Ear, nose, throat (ENT) surgeons were blinded for imaging findings. The primary outcome was the negative predictive value (NPV) of MR imaging

2019 Otology and Neurotology

26. Treatment using diffuse laser energy of cochlear and vestibular fistulas caused by cholesteatoma. (Abstract)

Treatment using diffuse laser energy of cochlear and vestibular fistulas caused by cholesteatoma. To measure the outcomes of laser treatment of cholesteatoma covering cochlear and vestibular fistulas.Cholesteatoma matrix over the fistula was denatured; the power density was sufficient only to gradually heat, but not vaporise, the keratin-forming matrix. The denaturing speed was controlled so that the integrity of the fistula cover was maintained. The change in bone conduction threshold (...) and the residual rate of cholesteatoma at the fistula were measured.Thirty-six fistulas were assessed. There were seven cochlear fistulas. All were 5 mm or less in maximum length. For the entire group, the average change in bone conduction threshold was -0.3 dB. For cochlear fistulas, the average change in bone conduction was + 0.2 dB. The distribution of hearing results for the entire group was Gaussian; the apparent changes in hearing could be attributed to errors associated with testing. All patients

2019 Journal of Laryngology & Otology

27. Localisation of basic fibroblast growth factor in cholesteatoma matrix: an immunochemical study. (Abstract)

Localisation of basic fibroblast growth factor in cholesteatoma matrix: an immunochemical study. To investigate the expression of basic fibroblast growth factor in the matrix of human acquired cholesteatoma compared to the deep meatal skin. This topic does not appear to have been fully investigated before.An immunochemical study was conducted. Cholesteatoma tissues from adult patients were collected during surgery (n = 19). Control specimens were taken from the deep meatal skin (n = 8 (...) ) and compared.A highly significant difference in basic fibroblast growth factor expression was identified between cholesteatoma and skin (mean ± standard error = 58.53 ± 3.6 per cent in cholesteatoma vs 40.6 ± 3.5 per cent in skin; p = 0.005). Both basal and parabasal keratinocytes were stained positive with basic fibroblast growth factor. Additionally, there was specific staining in the basal columnar middle-ear epithelium and mast cell membrane.Basic fibroblast growth factor plays an active role

2019 Journal of Laryngology & Otology

28. Non-microscopic Middle Ear Cholesteatoma Surgery: A Case Report of a Novel Head-Up Approach. Full Text available with Trip Pro

Non-microscopic Middle Ear Cholesteatoma Surgery: A Case Report of a Novel Head-Up Approach. To assess the feasibility of a postauricular transcortical mastoidectomy utilizing an exoscope, which offers 3D stereoscopic visualization.Clinical capsule report.Two consecutive patients with cholesteatoma involvement in the mastoid cavity were included in the study.After transcanal endoscopic surgery, postauricular mastoidectomy utilizing a surgical 3D exoscope was performed. Then, the cholesteatoma (...) in the mastoid cavity was removed through the mastoidectomy opening with endoscopes.The postauricular transcortical mastoidectomy utilizing a 3D exoscope was not only feasible, but importantly, the exoscope took little time to switch to and resulted in a smooth workflow. There was no cholesteatoma recurrence at 9 months.During endoscope-based surgery, in patients with cholesteatoma mastoid involvement, we can continue to perform the surgical procedure in a heads-up position utilizing a surgical 3D exoscope

2019 Otology and Neurotology

29. The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. (Abstract)

The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. To report the long-term follow-up with diffusion-weighted magnetic resonance imaging (DW MRI) after subtotal petrosectomy (SP) with blind sac closure of the external auditory canal for extensive cholesteatoma and chronic suppurative otitis media.Retrospective clinical record study.Tertiary referral center.Thirty-one patients (31 ears (...) ) with extensive cholesteatoma and 17 patients (19 ears) with chronic suppurative otitis media without cholesteatoma who underwent SP between July 1995 and December 2015.All 48 patients were followed clinically and with DW MRI to rule out residual cholesteatoma.Residual cholesteatoma, indicated by a marked hyperintensity on non-echoplanar (non-EP) DW MRI.In the cholesteatoma group the mean interval between surgery and the latest DW MRI was 3.9 years. Seven patients presented with a residual cholesteatoma pearl

2019 Otology and Neurotology

30. Is transcanal tympanoplasty an appropriate surgical treatment for congenital middle ear cholesteatoma with ossicular involvement? (Abstract)

Is transcanal tympanoplasty an appropriate surgical treatment for congenital middle ear cholesteatoma with ossicular involvement? The aims of this study are to analyze the clinical characteristics of congenital middle ear cholesteatoma (CMC), to evaluate the treatment results according to the types of surgical approach, and to suggest the appropriate surgical treatment option in each stage.One hundred fifteen children (≤15 years old) with surgically confirmed CMC, who underwent surgery

2019 International Journal of Pediatric Otorhinolaryngology

31. The benefit of trans-attic endoscopic control of ossicular prosthesis after cholesteatoma surgery. (Abstract)

The benefit of trans-attic endoscopic control of ossicular prosthesis after cholesteatoma surgery. To show the efficiency of using transmastoid atticotomy (TMA) endoscopy on the outcome of ossiculoplasty in patients with cholesteatoma. TMA is often performed as part of the surgical management of patients with middle ear cholesteatoma extending to the epitympanum. TMA can also be used as an access for endoscopic view to confirm the right alignment and stability of the ossicular prosthesis (...) because the reconstruction of the tympanic membrane will obscure the visualization of the prosthesis.A retrospective study was done at a tertiary referral institute, including 133 ears with cholesteatoma that underwent canal wall-up tympanomastoidectomy (CWU) with ossicular reconstruction using titanium prosthesis between August 2013 and August 2015. Post packing of the ear canal and position, stability, and axis of the prosthesis were checked using endoscope positioned in the attic through TMA

2019 Laryngoscope

32. Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab. (Abstract)

Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab. To describe an observed case of spontaneous regression of cholesteatoma in a patient on chronic anti-tumor necrosis factor-alpha (TNF-a) therapy and inspire further research into the role of TNF-a in cholesteatoma.Clinical assessment of disease in a single-patient case report.A 49-year-old woman suffered a severe case of Stevens-Johnson syndrome when she was 12 years old, leaving her with bilateral corneal (...) opacification and tympanic membrane perforations with extensive cholesteatoma. For her corneal opacification, a corneal prosthesis was placed, which was complicated by a foreign body reaction necessitating long-term therapy with infliximab, a monoclonal antibody against TNF-a that is therapeutic in some chronic inflammatory diseases. She was otherwise healthy and took no other medications. While on infliximab, the patient had spontaneous and complete resolution of her cholesteatoma without any surgical

2019 Rhinology and Laryngology

33. Bilateral Ear Canal Cholesteatoma with Underlying Type I First Branchial Cleft Anomalies. (Abstract)

Bilateral Ear Canal Cholesteatoma with Underlying Type I First Branchial Cleft Anomalies. To describe a case of bilateral ear canal cholesteatomas in the setting of underlying first branchial cleft cyst anomalies and to review the pathophysiology underlying the development of external auditory canal cholesteatomas from branchial cleft cyst abnormalities.We present a case study of a 61-year-old man who presented with chronic right-sided hearing loss and left-sided postauricular drainage (...) . Clinical evaluation, radiographic work-up, and pathologic analysis confirmed a diagnosis of bilateral ear canal cholesteatoma in the setting of underlying first branchial cleft cyst anomalies. The patient's clinical course, surgical treatment, and management considerations are discussed here.Ear canal cholesteatoma represents a rare clinical disease entity deserving a thorough initial assessment. Careful consideration of underlying diseases that result in chronic inflammation, such as branchial cleft

2019 Rhinology and Laryngology

34. The presentation and management of giant cholesteatoma: a systematic review and case report

The presentation and management of giant cholesteatoma: a systematic review and case report Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2018 PROSPERO

35. Clinical analysis of pediatric primary external auditory canal cholesteatoma. (Abstract)

Clinical analysis of pediatric primary external auditory canal cholesteatoma. Pediatric primary external auditory canal cholesteatoma (EACC) is a rare disease. The present study aimed to explore the clinical features and prognosis of this disease.Clinical data of 41 ears with pediatric primary EACC were collected, and the clinical characteristics and prognosis were analyzed in this retrospective study.A total of 35 patients (median age of 13 years) were recruited in this study. Of these, 13 (...) II, 15 in stage III. A total of 40 ears underwent transcanal cholesteatoma removal (TCR) and 1 underwent both TCR and tympanoplasty. Finally, 33 ears were followed up postoperatively, and only 1 ear presented recurrence.The posterior wall of the EAC is the most commonly affected wall, and the involvement of multiple walls is common. Due to the remodeling of the EAC bone in pediatric patients, the high stage lesions can be treated by minimally invasive surgical debridement combined with a close

2018 International Journal of Pediatric Otorhinolaryngology

36. Diffusion-weighted magnetic resonance imaging in the detection of residual and recurrent cholesteatoma in children: A systematic review and meta-analysis. (Abstract)

Diffusion-weighted magnetic resonance imaging in the detection of residual and recurrent cholesteatoma in children: A systematic review and meta-analysis. To examine the performance of diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of residual and recurrent cholesteatoma in children.A systematic review and meta-analysis was conducted as per PRISMA guidelines using the following databases from their date of inception: MEDLINE, PubMed, Embase, Cochrane Library, Web (...) ability to detect lesions less than 3 mm in size.Non-EPI DW-MRI is highly specific but carries uncertain sensitivity in the detection of residual and recurrent cholesteatoma in children. Further research is warranted to determine the specific role of DW-MRI in this patient group, namely when and how often children should be referred for imaging and in which cases the method can be used to completely replace second-look surgery.Copyright © 2018 Elsevier B.V. All rights reserved.

2018 International Journal of Pediatric Otorhinolaryngology

37. Cartilage Fascia Composite Canalplasty for External Auditory Canal Cholesteatoma: Case Analysis and Long-term Surgical Results. (Abstract)

Cartilage Fascia Composite Canalplasty for External Auditory Canal Cholesteatoma: Case Analysis and Long-term Surgical Results. To analyze surgical outcomes of cartilage-fascia composite canalplasty (CFCC) for external auditory canal cholesteatoma (EACC).Retrospective case review study.Tertiary referral center.A total of 13 patients with EACC (n = 14 ears due to one patient with bilateral EACC).Surgical method of CFCC using well designed-conchal cartilage and temporalis muscle fascia after (...) complete removal of EACC.Clinical characteristics and EACC stages were determined by oto-endoscopic examination and computed tomography (CT) findings. The surgical results of CFCC were analyzed.The median age of patients was 43 years (range, 12-75 yr), with a male to female ratio of 6 to 7. EACC stages were from II to IV. Cortical bone erosion in the inferior part of the bony EAC was the most common finding. All patients had satisfactory results: no more ear symptoms related with cholesteatoma

2018 Otology and Neurotology

38. Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma Full Text available with Trip Pro

Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma As endoscopic instrumentation, techniques and knowledges have significantly improved recently, endoscopic ear surgery has become increasingly popular. Transcanal endoscopic ear surgery (TEES) can provide better visualization of hidden areas in the middle ear cavity during congenital cholesteatoma removal. We aimed to describe outcomes for TEES for congenital cholesteatoma in a pediatric population.Twenty-five children (age, 17 (...) months to 9 years) with congenital cholesteatoma confined to the middle ear underwent TEES by an experienced surgeon; 13 children had been classified as Potsic stage I, seven as stage II, and five as stage III. The mean follow-up period was 24 months. Recurrence of congenital cholesteatoma and surgical complication was observed.Congenital cholesteatoma can be removed successfully via transcanal endoscopic approach in all patients, and no surgical complications occurred; only one patient with a stage

2018 Clinical and experimental otorhinolaryngology

39. Extended-spectrum Beta-lactamase-producing Escherichia coli Meningitis That Developed from Otitis Media with Cholesteatoma Full Text available with Trip Pro

Extended-spectrum Beta-lactamase-producing Escherichia coli Meningitis That Developed from Otitis Media with Cholesteatoma A 78-year-old man had a fever and exhibited disordered consciousness, which led to his transportation to our hospital. On arrival, he exhibited discharge from the ear. Because extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli was detected in the ear discharge and cerebrospinal fluid specimens, it was inferred to be the causal bacteria. Pulsed-field gel

2018 Internal Medicine

40. Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting Full Text available with Trip Pro

Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting 30480211 2019 02 26 2473-974X 2 2 2018 Apr-Jun OTO open OTO Open Congenital Mastoidal Cholesteatoma in an 87-Year-Old Woman Treated by Watchful Waiting. 2473974X18765700 10.1177/2473974X18765700 Sepehri Elnaz E Department of ENT, Karolinska University Hospital, Sweden. von Unge Magnus M District Hospital Västmanland, Västerås and Centre for Clinical Research, RegionVästmanland - Uppsala University, Sweden (...) . Akershus University Hospital and University of Oslo, Norway. eng Case Reports 2018 04 02 United States OTO Open 101717942 2473-974X congenital mastoidal cholesteatoma treatment watchful waiting Competing interests: None. 2018 01 19 2018 01 19 2018 02 27 2018 11 28 6 0 2018 11 28 6 0 2018 11 28 6 1 epublish 30480211 10.1177/2473974X18765700 10.1177_2473974X18765700 PMC6239142 Otolaryngol Head Neck Surg. 2002 Oct;127(4):346-8 12402016 Otol Neurotol. 2006 Feb;27(2):282-3 16437002 Ann Otol Rhinol Laryngol

2018 OTO Open

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