Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
How to Trip Rapid Review
Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)
Step 2: press
Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.
Is Cholesteatoma a Risk Factor for Graft Success Rate in Chronic Otitis Media Surgery? In developing countries, chronic otitis media (COM) and cholesteatoma are relatively prevalent. Within the field of otology, COM surgery remains one of the most common surgical treatments. Most recent studies evaluating the potential prognostic factors in COM surgery have addressed graft success rate and types of middle ear and mastoid pathology. There has been much controversy about this issue until (...) the present time. This study evaluated the effect of cholesteatoma on the GSR in COM surgery.The present retrospective, case-controlled study investigated 422 ears undergoing COM surgery. The minimum and maximum postoperative follow-up periods were 6 and 48 months, respectively. The study group consisted of patients with cholesteatomatous COM, while the control group included patients with non-cholesteatomatous COM, who had undergone ear surgery. Postoperative graft success rate and audiological test
Fascin expression in cholesteatoma: correlation with destruction of the ossicular chain and extent of disease. Fascin is an actin-bundling protein found in cell membrane protrusions and increases cell motility. The expression of fascin in epithelial neoplasms has been described only recently. No data are available concerning the role of this protein in invasive cholesteatoma. Thus, we investigated the expression of fascin in cholesteatoma tissue and the relationship between fascin expression (...) and intraoperative evaluation of the destruction of the ossicular chain and extent of disease.Cholesteatoma specimens of 28 patients and external auditory canal (EAC) skin specimens of the same patients (as the control group) were collected from mastoidectomies. Immunohistochemical technique was used to investigate the fascin expression in all cholesteatoma tissues and EAC skin specimens. Immunohistochemical staining was assessed semiquantitatively based on the thickness of epithelium. SPSS software version 16.0
Epidemiological study of cholesteatoma in Fukuoka City. To investigate the pathogenesis of cholesteatoma, we planned to conduct a cohort study. As a first step, we conducted an epidemiological study in Fukuoka City, Japan to determine the incidence of cholesteatoma treated both with and without surgery. We also conducted a case-control study to investigate the pathogenesis of cholesteatoma.The annual incidence of cholesteatoma, including cases treated without surgery, was 6.8-10.0 (...) in a population of 100 000. The results of the case-control study suggested that a past history of otitis media and habitual sniffing caused by a patulous eustachian tube play a role in the pathogenesis of cholesteatoma.The annual incidence of cholesteatoma, including cases treated without surgery, was considered to not be high enough to perform a cohort study. The results of the case-control study suggest that otitis media and habitual sniffing due to a patulous eustachian tube, contribute to the onset
The impact of ventilation tubes in otitis media on the risk of cholesteatoma on a national level. To estimate the impact of treatment with middle ear ventilation tube insertion (VTI) in children with otitis media (OM) on the risk of cholesteatoma on a national level.Data were obtained from the Danish National Patient Register, the National Health Service Register and Statistics Denmark. Cumulative incidence proportions were estimated by the Kaplan-Meier method and hazard ratios with Cox (...) regression analysis. The first surgically treated middle ear cholesteatoma in a child (STMEC1) was considered an event.A total of 217,206 children, born after December 31, 1996, who had VTI from January 1, 1997 to August 31, 2011 were identified. Of these, 374 subsequently had a STMEC1. A corresponding 36,981 children without any VTI were identified for comparison using a random 5% sample of the Danish population. Of these, 5 had a STMEC1. The cumulative incidence proportion with STMEC1 at 12 years
Osseous Eustachian Tube and Peritubal Cells in Patients with Unilateral Cholesteatoma Comparison Between Healthy and Diseased Sides Using High-Resolution Cone-Beam Computed Tomography. We investigated the factors that may possibly cause primary acquired cholesteatoma.University-affiliated hospital.In 20 adult patients with unilateral cholesteatoma, the sizes of the osseous eustachian tubes (ETs) and the extent of peritubal and mastoid cell development in healthy and diseased ears were examined (...) using high-resolution cone-beam computed tomography. The height and width of the ET were measured at the tympanic orifice, the isthmus, and the midpoint, as was the length of its axis. We also assessed the extent of development of peritubal and mastoid cells.There were no significant differences in the size of the osseous ET between the healthy and cholesteatoma sides, but significant correlations were found in height and width between the sides at the tympanic orifice and at the isthmus. In 80
Endoscopic exclusive transcanal approach to the tympanic cavity cholesteatoma in pediatric patients: Our experience. The aim of the present study is to describe our experience in the management of tympanic cavity cholesteatoma in pediatric patients, treated with endoscopic exclusive transcanal approach.A chart review of clinical data and videos from the operations of 54 pediatric patients, undergoing surgery between January 2007 and December 2013, was made. Patients presenting (...) with cholesteatoma involving the tympanic cavity (mesotympanum, epitympanum, protympanum and/or hypotympanum), with no mastoid involvement, were included in the first group and underwent an exclusive transcanalar endoscopic approach (TEA). In case of mastoid extension of the pathology, patients were included in the control group and underwent a canal wall up microscopic technique (CWU).In this study, 34 males and 20 females, including 5 bilateral cases, giving a total of 59 ears, were reviewed. Median age
NOD-Like Receptor Signaling in Cholesteatoma Background. Cholesteatoma is a destructive process of the middle ear resulting in erosion of the surrounding bony structures with consequent hearing loss, vestibular dysfunction, facial paralysis, or intracranial complications. The etiopathogenesis of cholesteatoma is controversial but is associated with recurrent ear infections. The role of intracellular innate immune receptors, the NOD-like receptors, and their associated signaling networks (...) was investigated in cholesteatoma, since mutations in NOD-like receptor-related genes have been implicated in other chronic inflammatory disorders. Results. The expression of NOD2 mRNA and protein was significantly induced in cholesteatoma compared to the external auditory canal skin, mainly located in the epithelial layer of cholesteatoma. Microarray analysis showed significant upregulation for NOD2, not for NOD1, TLR2, or TLR4 in cholesteatoma. Moreover, regulation of genes in an interaction network
Congenital Cholesteatoma Localized to the Mastoid Cavity and Presenting as a Mastoid Abscess Introduction. Congenital cholesteatoma is a pearly white mass that rarely originates from the mastoid process. Case Report. A 21-year-old male patient presented to our department with severe right mastoid pain and postauricular fluctuant swelling for 23 days. There was no preceding history of ear complaints and examination showed a normal right ear drum. Emergency exploration of the mastoid process (...) was done on the same day and revealed localized cholesteatoma limited only to the mastoid cavity. Conclusion. Despite a rarity, the mastoid process should be always put in mind as a site of origin for congenital cholesteatoma.
Atypical presentation of congenital cholesteatoma in an adult case with good hearing result Congenital cholesteatoma is thought to be caused by inadequate folding of the epidermoid formation inside the middle ear cleft. During development of the middle ear mucosa, stratified squamous epithelium accumulates in the embryonic life. Its typical appearance is a "pearl" beneath the anterosuperior quadrant of the tympanic membrane.We report 28 years-old case with congenital cholesteatoma (...) in the posterosuperior quadrant of middle ear cavity. The main complaint was the hearing loss which had developed slowly over several years.The case was surgically treated. Postoperative hearing result was satisfactory.Congenital cholesteatoma may occur in atypical locations and ages. Many authors prefer canal wall down tympanomastoidectomy. But it can also be treated successfully by intact canal wall tympanomastoidectomy with good hearing results.
Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study Clinically, we found the increased incidence of acquired colesteatoma in the patients with osteoporosis. In this study, we used a retrospective cohort to examine this association and to investigate the possible mechanism.We conducted a population-based retrospective cohort study by using the National Health Insurance Research Database (NHIRD). We identified an osteoporosis cohort comprising 37 124 (...) patients newly diagnosed with osteoporosis aged 20 years or older. Patients in the comparison cohort had no history of osteoporosis and were frequency matched with the patients in the osteoporosis cohort according to sex, age, and index year.The acquired cholesteatoma incidence rates for the osteoporosis and comparison cohorts were 1.12 and 0.83 per 1000 person-years, respectively. After we adjusted for confounding factors, the osteoporosis cohort exhibited a 1.32-fold increased acquired cholesteatoma
Mastoid obliteration surgery for cholesteatoma in 183 adult ears - a 5-year prospective cohort study. 25891851 2016 10 18 2016 12 30 1749-4486 40 6 2015 Dec Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Mastoid obliteration surgery for cholesteatoma in 183 adult ears--a 5-year prospective cohort study: Our Experience. 721-6 10.1111/coa.12444 Trinidade A A Department of ENT (...) , Ipswich General Hospital, Ipswich, UK. Skingsley A A Imperial College, London, UK. Yung M W MW Department of ENT, Ipswich General Hospital, Ipswich, UK. eng Letter England Clin Otolaryngol 101247023 1749-4478 IM Adolescent Adult Aged Cholesteatoma, Middle Ear surgery Female Follow-Up Studies Humans Male Mastoid surgery Middle Aged Prospective Studies Time Factors Treatment Outcome Tympanoplasty methods Young Adult 2015 04 05 2015 4 21 6 0 2015 4 22 6 0 2016 10 19 6 0 ppublish 25891851 10.1111/coa
Labyrinthine function after semicircular canal surgery on seventeen patients with cholesteatoma. 25929199 2016 10 25 2016 12 30 1749-4486 41 1 2016 Feb Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Labyrinthine function after semicircular canal surgery on seventeen patients with cholesteatoma. 76-9 10.1111/coa.12453 Hirvonen T P TP Department of Otolaryngology, University (...) of Helsinki and Helsinki University Hospital, Helsinki, Finland. Aalto H H Department of Otolaryngology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Jutila T T Department of Otolaryngology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. eng Letter England Clin Otolaryngol 101247023 1749-4478 IM Adolescent Adult Aged Cholesteatoma surgery Ear, Inner physiology Female Humans Male Middle Aged Semicircular Canals physiology surgery Young Adult 2015
Hearing Impairment in Children and Adults With Acquired Middle Ear Cholesteatoma: Audiometric Comparison of 385 Ears. Evaluate hearing impairment in acquired middle ear cholesteatoma and investigate audiometric differences between children and adults.Cross-sectional comparative study.Tertiary hospital.Three hundred twenty-three consecutive patients diagnosed as having acquired middle ear cholesteatoma in at least one ear (385 ears) between August 2000 and March 2013 and no surgical history (...) had profound hearing loss, without a significant difference between children and adults. The AC and BC thresholds were significantly greater in adults at all the frequencies (p ≤ 0.05), but the ABGs were not significantly different between the age groups.Acquired middle ear cholesteatoma is associated with significant hearing impairment, although profound hearing loss is rare. Adults have greater AC and BC thresholds than those in children but similar ABGs to children.
Pseudoaneurysm of the Petrosal Internal Carotid Artery in the Middle Ear as a Complication of Middle Ear Cholesteatoma We report the case of a 66-year-old man who had significant otorrhagia caused by a ruptured pseudoaneurysm in the petrous internal carotid artery (ICA). The patient had middle ear cholesteatoma, and computed tomography (CT) showed bony erosion and exposure of the ICA into the middle ear cavity. Further angiography of the right carotid artery revealed a pseudoaneurysm protruding
Magnetic resonance imaging at one year for detection of postoperative residual cholesteatoma in children: Is it too early? To compare the residual cholesteatoma detection accuracy of diffusion-weighted (DW) and T1 delayed sequences for magnetic resonance at one year postoperative with second-look surgery in pediatric patients who have undergone primary middle ear surgery for cholesteatoma.This was a prospective monocentric consecutive study conducted in a tertiary academic referral center (...) included. Sensitivity, specificity, positive predictive value, and negative predictive value for the first observer were of 40%, 86%, 67%, and 67%, respectively, and those for the second observer were 30%, 86%, 60%, and 63%, respectively. The only two cholesteatoma with a size superior to 3mm were diagnosed before surgery, but the majority of small cholesteatoma were not detected.MRI is a key examen to diagnosed the residual cholesteatoma but is limited by the size of the lesion under 3mm. Delaying
A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction. Although the migration of its squamous outer surface of the tympanic membrane has been well characterized, there is a paucity of data available concerning the migratory behavior of its medial mucosal surface. Existing theories of primary acquired cholesteatoma pathogenesis do not adequately explain the observed characteristics of the disease. We propose a new hypothesis, based upon a conjecture that mucosal membrane (...) interactions are the driving force in cholesteatoma.A retrospective chart review and a prospective observational cohort study in rats.After developing the new theory, it was tested through both clinical and experimental observations. To evaluate whether impairment of middle ear mucociliary migration would influence cholesteatoma formation, a retrospective chart review evaluating cholesteatoma occurrence in a sizable population of patients with either primary ciliary dyskinesia (PCD) or cystic fibrosis (CF
Computed Tomography Staging of Middle Ear Cholesteatoma To establish computed tomography (CT) staging of middle ear cholesteatoma and assess its impact on the selection of the surgical procedure.Prospective study was conducted on 61 consecutive patients (mean age 26.8 years) with middle ear cholesteatoma. CT scan of the temporal bone and surgery were performed in all patients. CT staging classified cholesteatoma according to its location in the tympanic cavity (T); extension into the mastoid (M (...) ); and associated complications (C). Cholesteatoma was staged as stage I (T1, T2), stage II (T3, M1, M2, C1), and stage III (C2).The overall sensitivity of CT staging of cholesteatoma compared to surgery was 88% with excellent agreement and correlation between CT findings and intra-operative findings (K=0.863, r=0.86, P=0.001). There was excellent agreement and correlation of CT staging with surgical findings for T location (K=0.811, r=0.89, P=0.001), good for M extension (K=0.734, r=0.88, P=0.001
Case of Chronic Suppuration of the Middle Ear and Cholesteatoma treated by Radical Mastoid Operation, with Retention of the Cholesteatoma Matrix 19980256 2010 06 24 2010 06 24 0035-9157 11 Otol Sect 1918 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Case of Chronic Suppuration of the Middle Ear and Cholesteatoma treated by Radical Mastoid Operation, with Retention of the Cholesteatoma Matrix. 77-8 Grant J D JD eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009
Effectiveness of MESNA on the success of cholesteatoma surgery. It is important that chronic otitis media with cholesteatoma be treated successfully in patients to protect them from having repeated surgeries with related surgical co-morbidities and hearing loss.To evaluate the effectiveness of MESNA usage on the residual cholesteatoma rates of the patients who underwent surgery due to chronic otitis media with cholesteatoma.Retrospective single-institution study of a prospectively collected (...) database.Tertiary University Hospital.Nine hundred and thirty-four patients underwent surgery due to chronic otitis media between September 2000 and March 2012 by the same surgeon. One hundred and forty-one cases out of 934 patients were selected who had cholesteatoma for the study. These randomly selected 141 cases were divided into two groups as follows: I. Forty-six cases were applied MESNA (Sodium 2-mercaptoethanesulfonate) intraoperatively, and II. Ninety-five cases were not applied MESNA intraoperatively
Escherichia coli positive infratentorial subdural empyema secondary to mastoiditis and underlying cholesteatoma Infratentorial subdural empyema is a neurosurgical emergency that is associated with an alarmingly high morbidity and mortality if appropriate management is delayed. It is an important differential to consider when confronted with a patient with a reduced Glasgow Coma Scale, focal neurology and symptoms of raised intracranial pressure in the presence of a head and neck infection (...) to mastoiditis due to underlying cholesteatoma, and a review of the pertinent literature.