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Chlorazepate

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1. Chlorazepate

Chlorazepate Chlorazepate Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chlorazepate Chlorazepate Aka: Chlorazepate , Tranxene From (...) Related Chapters II. Class Long acting III. Dosing Dose: 7.5 to 15 mg PO qhs to tid Maximum Daily Dose: 90 mg IV. Pharmacokinetics Half Life: 40 to 50 hours Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Chlorazepate." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: clorazepate (C0008174) Concepts Pharmacologic Substance ( T121 ) , Organic

2018 FP Notebook

2. Chlorazepate

Chlorazepate Chlorazepate Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chlorazepate Chlorazepate Aka: Chlorazepate , Tranxene From (...) Related Chapters II. Class Long acting III. Dosing Dose: 7.5 to 15 mg PO qhs to tid Maximum Daily Dose: 90 mg IV. Pharmacokinetics Half Life: 40 to 50 hours Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Chlorazepate." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: clorazepate (C0008174) Concepts Pharmacologic Substance ( T121 ) , Organic

2015 FP Notebook

3. [Influence of chlorazepate dipotassium on psychomotor reactions]. (PubMed)

[Influence of chlorazepate dipotassium on psychomotor reactions]. 3860 1976 06 02 2013 11 21 0040-5957 30 5 1975 Sep-Oct Therapie Therapie [Influence of chlorazepate dipotassium on psychomotor reactions]. 679-84 Patay M M Le Clec'h G G Henry P P Van Den Driessche J J fre Clinical Trial English Abstract Journal Article Randomized Controlled Trial Recherche de l'influence de clorazépate dipotassique sur des réactions psychomotrices France Therapie 0420544 0040-5957 0 Anti-Anxiety Agents 0

1976 Therapie

4. Clinical and physiological assessment of chlorazepate, diazepam and placebo in anxious neurotics. (PubMed)

Clinical and physiological assessment of chlorazepate, diazepam and placebo in anxious neurotics. A 28-day double-blind assessment of chlorazepate dipotassium, diazepam and placebo was done on 30 outpatient neurotics with a primary symptom of anxiety. Acute, sub-acute and more chronic effects of the drug were assessed after 3 hours, 14 days and 28 days of drug administration. A battery of psychiatric ratings as well as physiological and psychophysiological assessments were done at each period (...) . The psychometric assessments showed a trend for diazepam to be the most anxiolytic of the three drugs, followed by chlorazepate and then placebo. These measurements did not reach uniform statistically significant differences. Psychological measurements demonstrated the same trends, but some of these reached statistically significant levels. These parameters also indicate a slightly different mode of action of the two drugs at equimolecular doses. Diazepam would depress baseline and stimulation arousal, whereas

1975 International journal of clinical pharmacology and biopharmacy

5. Clinical and experimental comparison of diazepam, chlorazepate and placebo. (PubMed)

Clinical and experimental comparison of diazepam, chlorazepate and placebo. A double blind clinical evaluation of chlorazepate (dipotassium-7-chloro-5-phenyl-2,2-dihydroxy-3-carboxy-1,2-dihydro-2H-1,4-benzodiazepine), diazepam and placebo on a patient group of young students, mean age 25 years, is reported. Both drugs were significantly better than placebo and according to global assessment chlorazepate was superior to diazepam. An analysis of the main target symptom revealed better effects (...) of chlorazepate on the following items: anxiety, feeling of muscular tension and gastro-intestinal disturbances. With respect to irritability and sleep disturbances both drugs were found to be equally effective. In patients' self-ratings chlorazepate was considered superior to diazepam in giving more alertness and less drowsiness during day time. The results are discussed with reference to EEG-studies and pharmaco-kinetic properties of chlorazepate and diazepam. Performance tests in simulated car-driving

1975 Psychopharmacologia

6. Comparison studies of chlorazepate administered as a divided daily dose and as a single dose at night. (PubMed)

Comparison studies of chlorazepate administered as a divided daily dose and as a single dose at night. The residual effects of dipotassium chlorazepate administered as either a single daily dose of 20 mg at bedtime or a divided daily dose (5 + 5 + 10 mg) were studied in a placebo-controlled, double-blind trial comprising 12 out-patients. The following tests were used to determine changes in perceptual wakefulness, performance ability, fine motor skills, and coordination: critical flicker fusion

1978 Psychopharmacology

7. A double-blind comparison of prazepam with diazepam, chlorazepate dipotassium and placebo in anxious out-patients. (PubMed)

A double-blind comparison of prazepam with diazepam, chlorazepate dipotassium and placebo in anxious out-patients. The study compared prazepam with diazepam, chlorazepate dipotassium, and placebo in the treatment of anxious out-patients. Patients were screened for participation in the study to be sure they met the criteria for inclusion. Patients were excluded if they had complicating physical or mental problems. All patients signed an informed consent. Seventy-three patients entered the study (...) group, one taking chlorazepate dipotassium, three on prazepam and one on diazepam. One diazepam patient reported nausea and vomitting. Scores on the Zung Self-Rating Scale for Anxiety showed all three drug groups to be superior to placebo. The Hopkins Symptom Check-list found prazepam and diazepam to be superior to placebo and chlorazepate. No differences among the groups were found in the Hamilton Anxiety Scale. Prazepam may offer advantages over the other available benzodiazepines since it may

1979 The Journal of international medical research

8. The effects of repeated nocturnal doses of clobazam, dipotassium chlorazepate and placebo on subjective ratings of sleep and early morning behaviour and objective measures of arousal, psychomotor performance and anxiety. (PubMed)

The effects of repeated nocturnal doses of clobazam, dipotassium chlorazepate and placebo on subjective ratings of sleep and early morning behaviour and objective measures of arousal, psychomotor performance and anxiety. 1. Repeated nocturnal doses of 30 mg clobazam and dipotassium chlorazepate 15 mg showed no significant effects compared to matching placebo on tests of psychomotor performance and serial subtraction of numbers given in the morning and afternoon of the day following treatment. 2 (...) . Both active preparations improved the perceived quality of sleep compared to placebo. 3. A reduction in rated anxiety scores was found with clobazam on the afternoon of the day following treatment together with an elevation of critical flicker fusion thresholds. 4. Dipotassium chlorazepate was found to impair performance of a low level conceptual task but not to influence performance at a more difficult level.

Full Text available with Trip Pro

1979 British journal of clinical pharmacology

9. [Dipotassic chlorazepate premedication. Its effects on preoperative narcosis: a double-blind study]. (PubMed)

[Dipotassic chlorazepate premedication. Its effects on preoperative narcosis: a double-blind study]. 38684 1979 10 17 2013 11 21 0003-3014 35 6 1978 Nov-Dec Anesthesie, analgesie, reanimation Anesth Analg (Paris) [Dipotassic chlorazepate premedication. Its effects on preoperative narcosis: a double-blind study]. 1101-13 Cara M M Salaün C C Saly S T ST Vodhin J J Debras C C fre Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial Prémédication avec le chlorazepate

1979 Anesthesie, analgesie, reanimation

10. Strategies for discontinuing benzodiazepines

) Elimination half-life (h) Approximate dose (mg) Short half-life ( 24 h) Chlorazepate Tranxilim® 30 - 48 7,5 Chlordiazepoxide Huberplex® 1.5 - 4 15 Diazepam Valium®, Diazepam® 20 – 100 5 Halazepam Alapryl® 30 – 100 10 Clonazepam rivotril® 20 – 80 0.5Strategie S for diScontinuing benzodiazepine S 5 should be taken into account if driving is considered and/ or any activity requiring focussed attention is planned. 12 The eMA’s Pharmacovigilance risk Assessment Com- mittee (PrAC) agreed that to mitigate

2015 Drug and Therapeutics Bulletin of Navarre (Spain)

11. Geriatric Trauma Management

Phenobarbital z Secobarbital* High rate of physical dependence; tolerance to sleep benefits; greater risk of overdose at low dosages Avoid High Strong 112012 AGS Beers Criteria for Potentially Inappropriate Medication Use in Older Adults 1 Organ System/ Therapeutic Category/Drug(s) Rationale Recommendation Quality of Evidence Strength of Recom- mendation Benzodiazepines SHORT- AND INTERMEDIATE- ACTING: z Alprazolam z Estazolam z Lorazepam z Oxazepam z Temazepam z Triazolam LONG-ACTING: z Chlorazepate z

2013 American College of Surgeons

12. [New preparation with antalgic sedative and anxiolytic activity in manifestations of interest to internal medicine. Double-blind controlled clinical study]. (PubMed)

[New preparation with antalgic sedative and anxiolytic activity in manifestations of interest to internal medicine. Double-blind controlled clinical study]. A controlled double-blind clinical trial using randomised blocks was carried out on 3 groups of 10 patients with internal diseases and a pain syndrome accompanied by anxiety. One group received the product under examination (FC 35aA) and the other two its components (dipotassic chlorazepate, paracetamol and codeine). FC 35aA gave the best

1977 Minerva medica

13. Neuropsychological outcomes in randomized controlled trials of antiepileptic drugs: a systematic review of methodology and reporting standards

, methylphenidate, oxiracetam, chlorazepate, sulthiame and tiagabine. Participants included in the review Included participants were child and adult patients who had seizures. Patients ages ranged from 4 to 88 years of age. Trials were excluded if they used only healthy volunteers. Patients after head injuries were excluded. Outcomes assessed in the review Changes in cognitive function using neuropsychological tests such as the Stroop Test, Finger Tapping Test, Digit Span, Weschler Adult Intelligence Test

1998 DARE.

14. Benzodiazepine use and motor vehicle accidents: systematic review of reported association

. Studies were retrieved if they looked at more than 30 BZD users and involved motor vehicles. Specific interventions included in the review The following BZDs were used: alprazolam, chlordiazapoxide, medazepam, chlorazepate, lorazepam, nitrazepam, flurazepam, oxazepam, flunitrazepam, diazepam, bromazepam, clonazepam, triazolam, temazepam, midazolam and zopiclone. Participants included in the review The participants in the studies of road accidents and BZD prescriptions were classified as either cases

1998 DARE.

15. [Comparison of premedication regimes. A randomized, controlled trial]. (PubMed)

[Comparison of premedication regimes. A randomized, controlled trial]. The effect of two premedication regimes with different benzodiazepines on anxiety, hemodynamic data, sympatho-adrenal activity, and bispectral index (BIS) was evaluated during the variable time period prior to induction of anesthesia.This prospective, double-blind study was performed with 50 ASA class I and II patients. Patients were randomized either to group I: evenings 22.00 hours 50 mg chlorazepate dipotassium (CD

2007 Der Anaesthesist

16. The use of short- and long-acting hypnotics in clinical medicine (PubMed)

with mean half-lives less than 8 h may have residual sequelae, whereas hypnotics with mean half-lives greater than 16 h are likely to lead to impared performance and/or anxiolytic effects the next day. 3 Potassium chlorazepate 15 mg, with its long-acting metabolite nordiazepam, would seem to be the drug of choice for insomnia secondary to anxiety. For the insomniac without significant psychopathology, temazepam 10-20 mg, triazolam 0.125-0.25 mg and for occasional use, diazepam 5-10 mg, provide

Full Text available with Trip Pro

1981 British journal of clinical pharmacology

17. [Anxiolysis, sedation, and stress reduction following oral premedication with midazolam in adults. A comparison with dipotassium clorazepate and placebo]. (PubMed)

[Anxiolysis, sedation, and stress reduction following oral premedication with midazolam in adults. A comparison with dipotassium clorazepate and placebo]. Benzodiazepines are the most commonly used anxiolytic agents. Among the benzodiazepines, midazolam has the advantage of a short elimination half-life, which is especially useful in outpatient surgery. However, in contrast to other commonly prescribed benzodiazepines, such as chlorazepate dipotassium, oral premedication with midazolam has

1996 Der Anaesthesist

18. Omeprazole for prophylaxis of acid aspiration in elective surgery. (PubMed)

Omeprazole for prophylaxis of acid aspiration in elective surgery. The aim of the study was to determine whether a single oral dose of omeprazole 40 mg is effective in increasing the pH of gastric residue above 2.5 at the time of anaesthetic induction in adult patients scheduled for elective gynaecological surgery. The patients were allocated to receive either chlorazepate dipotassium 25 mg alone or omeprazole 40 mg and chlorazepate dipotassium 25 mg on the night before surgery. Gastric volume

1990 Anaesthesia

19. [Treatment of resistant depression with the citalopram-lithium combination. Methodology of a double-blind multicenter study and preliminary results]. (PubMed)

of metabolism.A washout period of 3 days before initiating the treatment is included. After an open treatment phase of 28 days (D) with citalopram (20 mg D1-D3; 40 mg D4-D14; 40 or 60 mg D15-D28; concomitant medication allowed: chloral, chlorazepate), the nonresponding patients [less than 50% improvement in the total score on the 21 item-Hamilton Depression Rating Scale (HDRS)] are selected and treated with or without Li (randomized in double-blind conditions: citalopram/Li or citalopram/placebo) during

1991 L'Encéphale

20. [A comparative study of the efficacy and tolerance of dipotassium clorazepate and flunitrazepam for oral premedication]. (PubMed)

(F) and chlorazepate dipotassium (CD) have been explored with a view to side effects, tolerance, quality of sleep during the night, anxiolytic effect and sedation. The study involved 108 women patients aged from 20 to 60 years (ASA class I or II), all scheduled to undergo gynecological surgery in general anesthesia. There were also 20 women who received no premedication. The three groups of patients were further divided into early (operation started before 10:30 a.m.) and late-operation

1991 Der Anaesthesist

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