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Chikungunya

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161. The effectiveness of antiviral agents with broad-spectrum activity against chikungunya virus varies between host cell lines (PubMed)

The effectiveness of antiviral agents with broad-spectrum activity against chikungunya virus varies between host cell lines Chikungunya virus (CHIKV) is a mosquito-borne virus that has recently emerged in the Western Hemisphere. Approved antiviral therapies or vaccines for the treatment or prevention of CHIKV infections are not available. This study aims to evaluate the antiviral activity of commercially available broad-spectrum antivirals against CHIKV. Due to host cell-specific variability

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2018 Antiviral chemistry & chemotherapy

162. Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases (PubMed)

Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes global epidemics of debilitating disease worldwide. To gain functional insight into the host cellular genes required for virus infection, we performed whole-blood RNA-seq, 37-plex mass cytometry of peripheral blood mononuclear cells (PBMCs), and serum cytokine measurements of acute- and convalescent-phase samples obtained from 42 children

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2018 Molecular systems biology

163. The 2016-2017 Chikungunya Outbreak in Karachi (PubMed)

The 2016-2017 Chikungunya Outbreak in Karachi Chikungunya is an incipient disease, caused by Chikungunya virus (CHKV) that belongs to genus alphavirus of the family Togaviridae.In this study, during an outbreak of CHKV in Dec 2016 in Karachi, Pakistan, samples were collected from patients presenting with fever, tiredness and pain in muscles and joints. Total 126 sera were tested for the presence of Chikungunya infection through ELISA and Real-time Reverse Transcriptase PCR assay.This study

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2018 PLoS currents

164. Adherence to anti-vectorial prevention measures among travellers with chikungunya and malaria returning to Australia: comparative epidemiology (PubMed)

Adherence to anti-vectorial prevention measures among travellers with chikungunya and malaria returning to Australia: comparative epidemiology Compare the adoption and adherence to health protection behaviours prior to and during travel among international Australian travellers who return to Australia with notified chikungunya or malaria infection. This information could inform targeted health promotion and intervention strategies to limit the establishment of these diseases within (...) Australia.Seeking travel advice prior to departure was moderate (46%, N = 21/46) yet compliance with a range of recommended anti-vectorial prevention measures was low among both chikungunya and malaria infected groups (16%, N = 7/45). Reasons for not seeking advice between groups was similar and included 'previous overseas travel with no problems' (45%, N = 9/20) and 'no perceived risk of disease' (20%, N = 4/20). Most chikungunya cases (65%, N = 13/20) travelled to Indonesia and a further 25% (N = 5/20

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2018 BMC research notes

165. Differences in genome characters and cell tropisms between two chikungunya isolates of Asian lineage and Indian Ocean lineage (PubMed)

Differences in genome characters and cell tropisms between two chikungunya isolates of Asian lineage and Indian Ocean lineage Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus within the family Togaviridae, which has attracted global attention due to its recent re-emergence. In one of our previous studies, we successfully isolated two CHIKV virus strains, SZ1050 and SZ1239, from the serum samples of two imported patients in 2010 and 2012, respectively. However, the differences

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2018 Virology journal

166. Recurrent chikungunya retinitis (PubMed)

Recurrent chikungunya retinitis Chikungunya is a systemic viral disease transmitted to humans by infected mosquitoes in endemic areas of Africa, Asia and more recently in the Americas. Chikungunya infection produces a sudden onset of fever, joint pains and erythematous skin eruption. A plethora of ocular manifestations have been described ranging from a non-specific conjunctivitis to exudative retinal detachment. Ocular chikungunya seems to respond well to corticosteroid therapy, and outcomes

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2018 BMJ case reports

167. Exploring scenarios of chikungunya mitigation with a data-driven agent-based model of the 2014–2016 outbreak in Colombia (PubMed)

Exploring scenarios of chikungunya mitigation with a data-driven agent-based model of the 2014–2016 outbreak in Colombia New epidemics of infectious diseases can emerge any time, as illustrated by the emergence of chikungunya virus (CHIKV) and Zika virus (ZIKV) in Latin America. During new epidemics, public health officials face difficult decisions regarding spatial targeting of interventions to optimally allocate limited resources. We used a large-scale, data-driven, agent-based simulation

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2018 Scientific reports

168. Knowledge of Chikungunya Fever Among Medical Students of Jinnah Sindh Medical University, Karachi, Pakistan (PubMed)

Knowledge of Chikungunya Fever Among Medical Students of Jinnah Sindh Medical University, Karachi, Pakistan Objective Chikungunya is a viral disease characterized by severe arthralgia, fever, rash, muscle pain, and neurological symptoms. Warm and humid weather, poor sanitary conditions, and improper water storage and disposal can lead to an uncontrolled outbreak of the Chikungunya virus in South Asia. Because a vaccine against the Chikungunya virus has not yet been developed, we must rely (...) on appropriate awareness and suitable preventive measures to prevent its spread. A review of the literature shows that knowledge of the Chikungunya virus among medical students in Karachi is scarce. Because medical students are future medical practitioners, they should be adequately aware of this growing issue. Materials and methods We performed a single-center, cross-sectional study at the Jinnah Sindh Medical University in Karachi, Pakistan, in which 200 students were assessed on their knowledge

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2018 Cureus

169. Chikungunya and Zika Viruses: Global Emerging Health Threats (PubMed)

Chikungunya and Zika Viruses: Global Emerging Health Threats 30292248 2018 10 16 1476-1645 99 4 2018 Oct The American journal of tropical medicine and hygiene Am. J. Trop. Med. Hyg. Chikungunya and Zika Viruses: Global Emerging Health Threats. 1105-1106 10.4269/ajtmh.18-0613 Blitvich Bradley J BJ Department of Veterinary Microbiology and Preventive Medicine College of Veterinary Medicine Iowa State University Ames, Iowa E-mail: blitvich@iastate.edu. Brault Aaron C AC Division of Vector-Borne

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2018 The American journal of tropical medicine and hygiene

170. Neuromodulation treats Chikungunya arthralgia: a randomized controlled trial (PubMed)

Neuromodulation treats Chikungunya arthralgia: a randomized controlled trial The Chikungunya (CHIK) virus is epidemic in Brazil, with 170,000 cases in the first half of 2016. More than 60% of patients present relapsing and remitting chronic arthralgia with debilitating pain lasting years. There are no specific therapeutic agents to treat and rehabilitee infected persons with CHIK. Persistent pain can lead to incapacitation, requiring long-term pharmacological treatment. Advances in non

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2018 Scientific reports

171. Potential of Aedes aegypti populations in Madeira Island to transmit dengue and chikungunya viruses (PubMed)

Potential of Aedes aegypti populations in Madeira Island to transmit dengue and chikungunya viruses Aedes spp. mosquitoes mainly transmit the arboviruses dengue virus (DENV) and chikungunya virus (CHIKV) in urban areas, causing a severe public health problem. In 2012-2013, a major dengue outbreak occurred on Madeira Island where the mosquito Aedes aegypti was the only vector. Up to now, the competence of Ae. aegypti populations from Madeira to transmit DENV or CHIKV remains unknown. This study

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2018 Parasites & vectors

172. Thrombotic thrombocytopenic purpura associated with dengue and chikungunya virus coinfection: case report during an epidemic period (PubMed)

Thrombotic thrombocytopenic purpura associated with dengue and chikungunya virus coinfection: case report during an epidemic period The present report shows the occurrence of thrombotic thrombocytopenic purpura (TTP) associated with acute dengue and chikungunya virus coinfection, manifesting as a severe disease with high mortality potential. The patient was a 28 year-old man with clinical and epidemiological diagnosis of arboviruses infections who developed thrombocytopenia and anemia, after

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2018 Revista do Instituto de Medicina Tropical de São Paulo

173. The Surveillance of Chikungunya Virus in a Temperate Climate: Challenges and Possible Solutions from the Experience of Lazio Region, Italy (PubMed)

The Surveillance of Chikungunya Virus in a Temperate Climate: Challenges and Possible Solutions from the Experience of Lazio Region, Italy CHIKV has become an emerging public health concern in the temperate regions of the Northern Hemisphere as a consequenceof the expansion of the endemic areas of its vectors (mainly Aedes aegypti and Aedesalbopictus). In 2017, a new outbreak of CHIKV was detected in Italy with three clusters of autochthonous transmission in the Lazio Region (central Italy

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2018 Viruses

174. Integrated human-virus metabolic stoichiometric modelling predicts host-based antiviral targets against Chikungunya, Dengue and Zika viruses (PubMed)

Integrated human-virus metabolic stoichiometric modelling predicts host-based antiviral targets against Chikungunya, Dengue and Zika viruses Current and reoccurring viral epidemic outbreaks such as those caused by the Zika virus illustrate the need for rapid development of antivirals. Such development would be facilitated by computational approaches that can provide experimentally testable predictions for possible antiviral strategies. To this end, we focus here on the fact that viruses (...) are directly dependent on their host metabolism for reproduction. We develop a stoichiometric, genome-scale metabolic model that integrates human macrophage cell metabolism with the biochemical demands arising from virus production and use it to determine the virus impact on host metabolism and vice versa. While this approach applies to any host-virus pair, we first apply it to currently epidemic viruses Chikungunya, Dengue and Zika in this study. We find that each of these viruses causes specific

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2018 Journal of the Royal Society Interface

175. Awareness and knowledge of Chikungunya infection following its outbreak in Pakistan among health care students and professionals: a nationwide survey (PubMed)

Awareness and knowledge of Chikungunya infection following its outbreak in Pakistan among health care students and professionals: a nationwide survey The World Health Organization (WHO) declares Chikungunya (CHIK) infection to be endemic in South Asia. Despite its first outbreak in Pakistan, no documented evidence exists which reveals the knowledge or awareness of healthcare students and workers (HCSW) regarding CHIK, its spread, symptoms, treatment and prevention. Since CHIK is an emergent

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2018 PeerJ

176. The Challenges Imposed by Dengue, Zika, and Chikungunya to Brazil (PubMed)

The Challenges Imposed by Dengue, Zika, and Chikungunya to Brazil Brazil has a well-established immunization program in which vaccines are provided through the Public Health System free of charge to the whole population, obtaining high coverage and reducing the incidence of important infectious diseases in children and adults. However, the environmental changes and high mobility rates of the population occurring in the last decades have triggered the sequential introduction of a series (...) of vector-borne emerging infectious diseases, such as Dengue, Zika, and Chikungunya, that have imposed a considerable burden on the population, with yet unmet solutions. The first to be introduced in Brazil was the Dengue virus, reaching epidemic levels in 2010, with over 1 million cases annually, maintaining high infection rates until 2016. Brazil has invested in vaccine development. The Zika virus infection, initially assumed to have appeared during the World Cup in 2014, was later shown to have

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2018 Frontiers in immunology

177. Seroprevalence of Chikungunya Virus after Its Emergence in Brazil (PubMed)

Seroprevalence of Chikungunya Virus after Its Emergence in Brazil 30124419 2019 01 21 2019 01 21 1080-6059 24 9 2018 09 Emerging infectious diseases Emerging Infect. Dis. Seroprevalence of Chikungunya Virus after Its Emergence in Brazil. 1773 10.3201/eid2409.180724 Gérardin Patrick P Freitas André Ricardo Ribas ARR Sissoko Daouda D eng Letter Comment United States Emerg Infect Dis 9508155 1080-6040 IM Emerg Infect Dis. 2018 Apr;24(4):617-624 29553317 Brazil Chikungunya virus Seroepidemiologic (...) Studies Brazil alphavirus asymptomatic infection chikungunya virus chronic arthralgia cross-sectional study geographic information systems parasites population-based study prevalence seroprevalence serosurvey vector-borne infections viruses 2018 8 21 6 0 2018 8 21 6 0 2019 1 22 6 0 ppublish 30124419 10.3201/eid2409.180724 PMC6106406 Emerg Infect Dis. 2018 Apr;24(4):617-624 29553317 Arthritis Rheumatol. 2018 Apr;70(4):578-584 29266783 Trop Med Int Health. 2010 May;15(5):600-7 20214759 BMC Infect Dis

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2018 Emerging Infectious Diseases

178. Cellular and Molecular Immune Response to Chikungunya Virus Infection (PubMed)

Cellular and Molecular Immune Response to Chikungunya Virus Infection Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the fact that CHIKV has been around since 1952, our knowledge about immunopathology, innate and adaptive immune response involved

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2018 Frontiers in cellular and infection microbiology

179. Ultrastructural Analysis of Chikungunya Virus Dissemination from the Midgut of the Yellow Fever Mosquito, Aedes aegypti (PubMed)

Ultrastructural Analysis of Chikungunya Virus Dissemination from the Midgut of the Yellow Fever Mosquito, Aedes aegypti The transmission cycle of chikungunya virus (CHIKV) requires that mosquito vectors get persistently infected with the virus, following its oral acqsuisition from a vertebrate host. The mosquito midgut is the initial organ that gets infected with orally acquired CHIKV. Following its replication in the midgut epithelium, the virus exits the midgut and infects secondary tissues (...) midgut preparations, mature chikungunya (CHIK) virions were found accumulating at the BL and within strands of the BL at 24⁻32 h post-infectious bloodmeal (pibm). From 48 h pibm onwards, virions no longer congregated at the BL and became dispersed throughout the basal labyrinth of the epithelial cells. Ingestion of a subsequent, non-infectious bloodmeal caused mature virions to congregate again at the midgut BL. Our study suggests that CHIKV needs a single replication cycle in the midgut epithelium

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2018 Viruses

180. Plasmodium co-infection protects against chikungunya virus-induced pathologies (PubMed)

Plasmodium co-infection protects against chikungunya virus-induced pathologies Co-infection with Plasmodium and chikungunya virus (CHIKV) has been reported in humans, but the impact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure to Plasmodium suppresses CHIKV-associated pathologies in mice. Mechanistically, Plasmodium infection induces IFNγ, which reduces viraemia of a subsequent CHIKV infection and suppresses tissue viral load and joint inflammation

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2018 Nature communications

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