How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,776 results for

Chikungunya

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses (PubMed)

Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I producing cells. Herein, we demonstrated that DENV and CHIKV infected cells are sensed by pDCs, indirectly, resulting in selective IRF7

Full Text available with Trip Pro

2018 eLife

142. Fatal Human Case of Zika and Chikungunya Virus Co-Infection with Prolonged Viremia and Viruria (PubMed)

Fatal Human Case of Zika and Chikungunya Virus Co-Infection with Prolonged Viremia and Viruria Zika virus (ZIKV) infection usually presents as a mild and self-limited illness, but it may be associated with severe outcomes. We describe a case of a 30-year-old man with systemic erythematous lupus and common variable immunodeficiency who became infected with both Zika (ZIKV) and Chikungunya (CHIKV) virus during the 2016 outbreak in Rio de Janeiro, Brazil. The patient presented with intense wrist

Full Text available with Trip Pro

2018 Diseases

143. Morbilliform skin rash with prominent involvement of the palms in Chikungunya fever (PubMed)

Morbilliform skin rash with prominent involvement of the palms in Chikungunya fever An outbreak of chikungunya occurred in Central Italy in the summer of 2017. During the outbreak, two siblings with fever and joint pain developed a morbilliform skin rash with prominent involvement of the palms. Knowledge of the characteristics of chikungunya exanthem is important to adddress clinical diagnosis.

Full Text available with Trip Pro

2018 IDCases

144. Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope (PubMed)

Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope The global situation of diseases transmitted by arthropod-borne viruses such as Dengue (DENV), Yellow Fever (YFV), Chikungunya (CHIKV) and Zika (ZIKV) viruses is alarming and treatment of human infection by these arboviruses faces several challenges. The discovery of broad-spectrum antiviral molecules, able to inactivate different groups of viruses, is an interesting

Full Text available with Trip Pro

2018 Scientific reports

145. Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants (PubMed)

Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants Co-circulation of dengue virus (DENV) and chikungunya virus (CHIKV) is increasing worldwide but information on the viral dynamics and immune response to DENV-CHIKV co-infection, particularly in young infants, is scant.Blood samples were collected from 24 patients, aged 2 months to 82 years, during a CHIKV outbreak in Mexico. DENV and CHIKV were identified by RT-PCR; ELISA was used

Full Text available with Trip Pro

2018 Parasites & vectors

146. Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya Vaccine

Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya Vaccine Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya Vaccine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya Vaccine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03635086 Recruitment

2018 Clinical Trials

147. Trial of a Chikungunya Vaccine, PXVX0317 CHIKV-VLP, in Healthy Adults

Trial of a Chikungunya Vaccine, PXVX0317 CHIKV-VLP, in Healthy Adults Trial of a Chikungunya Vaccine, PXVX0317 CHIKV-VLP, in Healthy Adults - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trial (...) of a Chikungunya Vaccine, PXVX0317 CHIKV-VLP, in Healthy Adults The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03483961 Recruitment Status : Active, not recruiting First Posted : March 30, 2018 Last Update Posted : June 15, 2018 Sponsor: PaxVax, Inc. Information provided by (Responsible Party): PaxVax, Inc

2018 Clinical Trials

148. Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya

Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya (CHIKGENE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03690648 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

149. Resistance Exercise Program on the Functionality of Individuals With Chikungunya Fever

Resistance Exercise Program on the Functionality of Individuals With Chikungunya Fever Resistance Exercise Program on the Functionality of Individuals With Chikungunya Fever - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Resistance Exercise Program on the Functionality of Individuals With Chikungunya Fever The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03702348 Recruitment Status : Recruiting First Posted : October 11

2018 Clinical Trials

150. Lobular panniculitis associated with chikungunya fever: A case report (PubMed)

Lobular panniculitis associated with chikungunya fever: A case report Chikungunya fever is a mosquito-borne viral disease classically characterized by an acute onset of fever, arthralgia, and skin rash. In this article, we report the acute febrile illness of an adult female with arthropathy and morbilliform eruptions. The patient developed panniculitis lesions on both shins. This report aims to describe an infrequent cutaneous presentation of chikungunya fever.

Full Text available with Trip Pro

2018 IDCases

151. Estimating the risk of Dengue, Chikungunya and Zika outbreaks in a large European city (PubMed)

Estimating the risk of Dengue, Chikungunya and Zika outbreaks in a large European city Outbreaks of arbovirus infections vectored by invasive Aedes albopictus have already occurred and are predicted to become increasingly frequent in Southern Europe. We present a probabilistic model to assess risk of arbovirus outbreaks based on incident cases worldwide, on the probability of arrival of infected travelers, and on the abundance of the vector species. Our results show a significant risk (...) of Chikungunya outbreak in Rome from mid June to October in simulations with high human biting rates (i.e. when ≥50% of the population is bitten every day). The outbreak risk is predicted to be highest for Chikungunya and null for Zika. Simulated increase of incident cases in selected endemic countries has no major impact on the outbreak risk. The model correctly estimated the number of imported cases and can be easily adapted to other urban areas where Ae. albopictus is the only potential vector present.

Full Text available with Trip Pro

2018 Scientific reports

152. Evolution of Chikungunya virus in mosquito cells (PubMed)

Evolution of Chikungunya virus in mosquito cells It has been observed that replication of Chikungunya virus (CHIKV) in C6/36 Aedes albopictus cells has little effect on virus evolution. To characterize evolutionary patterns associated with CHIKV replication in mosquito cells, we performed serial passages of the LR2006 strain in Ae. albopictus cells (75 and 30 passages in C6/36 and U4.4 respectively) and Ae. aegypti cells (100 passages in AA-A20 and in AE) and studied genotypic changes

Full Text available with Trip Pro

2018 Scientific reports

153. A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses (PubMed)

A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses Zika and chikungunya viruses have caused major epidemics and are transmitted by Aedes aegypti and/or Aedes albopictus mosquitoes. The "Sementis Copenhagen Vector" (SCV) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modified CHO cells. Herein we describe a single-vector construct SCV vaccine (...) that encodes the structural polyprotein cassettes of both Zika and chikungunya viruses from different loci. A single vaccination of mice induces neutralizing antibodies to both viruses in wild-type and IFNAR-/- mice and protects against (i) chikungunya virus viremia and arthritis in wild-type mice, (ii) Zika virus viremia and fetal/placental infection in female IFNAR-/- mice, and (iii) Zika virus viremia and testes infection and pathology in male IFNAR-/- mice. To our knowledge this represents the first

Full Text available with Trip Pro

2018 Nature communications

154. Molecular characterization of chikungunya virus causing the 2017 outbreak in Dhaka, Bangladesh (PubMed)

Molecular characterization of chikungunya virus causing the 2017 outbreak in Dhaka, Bangladesh Chikungunya viruses from the 2017 outbreak in Dhaka, Bangladesh, were analysed phylogenetically. E1 sequences from 21 strains belonged to the Indian Ocean clade of the East/Central/South African (ECSA) genotype, forming a novel cluster with latest South Asian strains. They lacked the A226V substitution.

Full Text available with Trip Pro

2018 New Microbes and New Infections

155. Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil (PubMed)

Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil Dengue fever, chikungunya fever, and zika virus infections are increasing public health problems in the world, the last two diseases having recently emerged in Brazil. This ecological study employed spatial analysis of probable cases of dengue fever, chikungunya fever, and zika virus infections reported to the National Mandatory Reporting System (SINAN) in Maranhao State (...) from 2015 to 2016. The software GeoDa version 1.10 was used for calculating global and local Moran indices. The global Moran index identified a significant autocorrelation of incidence rates of dengue (I=0.10; p=0.009) and zika (I=0.07; p=0.03). The study found a positive spatial correlation between dengue and the population density (I=0.31; p<0.001) and a negative correlation with the Performance Index of Unified Health System (PIUHS) by basic care coverage (I=-0.08; p=0.01). Regarding chikungunya

Full Text available with Trip Pro

2018 Revista do Instituto de Medicina Tropical de São Paulo

156. Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases (PubMed)

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases This study showed that laboratory markers of recent infection by dengue, Zika or chikungunya arboviruses were detected in the biological samples of approximately one-third of patients with encephalitis, myelitis, encephalomyelitis or Guillain-Barré syndrome, in a surveillance programme in Piauí state, Brazil, between 2015-2016. Fever and myalgia had been associated with these cases. Since in non-tropical

Full Text available with Trip Pro

2018 Memórias do Instituto Oswaldo Cruz

157. Peptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach (PubMed)

Peptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach Chikungunya virus (CHIKV), causes massive outbreaks of chikungunya infection in several regions of Asia, Africa and Central/South America. Being positive sense RNA virus, CHIKV replication within the host resulting in its genome mutation and led to difficulties in creation of vaccine, drugs and treatment strategies. Vector control strategy has been a gold standard to combat spreading of CHIKV

Full Text available with Trip Pro

2018 Journal of translational medicine

158. Evidence of Chikungunya Virus Disease in Pakistan Since 2015 With Patients Demonstrating Involvement of the Central Nervous System (PubMed)

Evidence of Chikungunya Virus Disease in Pakistan Since 2015 With Patients Demonstrating Involvement of the Central Nervous System Several arboviruses are endemic to and co-circulate in Pakistan. In recent years, Pakistan has observed a rise in arboviral infections. A cross-sectional study for arboviral diseases, which included screening for Chikungunya virus (CHIKV), was initiated in 2015 to determine which pathogens were causing disease in patients presenting to health care services. Exposure

Full Text available with Trip Pro

2018 Frontiers in public health

159. A Case Report on Chikungunya Virus-Associated Encephalomyelitis (PubMed)

A Case Report on Chikungunya Virus-Associated Encephalomyelitis Chikungunya is a rerising alphavirus infection that has resulted from enhanced vector competence. Alphaviruses are divided into arthritogenic viruses (old world) and encephalitogenic viruses (new world) including equine encephalitis viruses. Chikungunya is a dengue-like illness characterized by acute febrile polyarthralgia, arthritis, malaise, body ache, rash, headache, and nausea. The illness is self-limiting. The neurological (...) manifestations are uncommon and incorporate meningoencephalitis, myelitis, Guillain-Barre syndrome, cranial nerve palsies, myelopathy, and neuropathy; MRI abnormalities in patients with encephalopathy from India have been reported in the form of multiple punctuate white matter lesions that are more prominent on diffusion-weighted MRI than on T2 or T1. Here, we present an intriguing case of chikungunya encephalomyelitis who presented to our tertiary care hospital with quadriparesis and urinary retention. He

Full Text available with Trip Pro

2018 Case reports in infectious diseases

160. Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review (PubMed)

Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review Arboviral infections are a public health concern and an escalating problem worldwide. Estimating the burden of these diseases represents a major challenge that is complicated by the large number of unapparent infections, especially those of dengue fever. Serological surveys are thus required to identify the distribution of these diseases and measure their impact. Therefore, we (...) undertook a scoping review of the literature to describe and summarize epidemiological practices, findings and insights related to seroprevalence studies of dengue, chikungunya and Zika virus, which have rapidly expanded across the globe in recent years.Relevant studies were retrieved through a literature search of MEDLINE, WHOLIS, Lilacs, SciELO and Scopus (2000 to 2018). In total, 1389 publications were identified. Studies addressing the seroprevalence of dengue, chikungunya and/or Zika written

Full Text available with Trip Pro

2018 PLoS neglected tropical diseases

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>