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Chikungunya

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101. Enzyme-linked immunosorbent assay using recombinant envelope protein 2 antigen for diagnosis of Chikungunya virus Full Text available with Trip Pro

Enzyme-linked immunosorbent assay using recombinant envelope protein 2 antigen for diagnosis of Chikungunya virus Chikungunya (CHIKV) virus is an important mosquito-borne virus causing outbreaks of acute febrile illness with arthropathy. The detection of specific antibodies against CHIKV is used for diagnosis after the acute viremic phase of the disease. However, a major challenge for serologic diagnosis of CHIKV and other alphaviruses is the cross-reactivity of antibodies to common antigens

2018 Virology journal

102. Clinical Forms of Chikungunya Virus Infection: The Challenge and Utility of a Consensus Definition Full Text available with Trip Pro

Clinical Forms of Chikungunya Virus Infection: The Challenge and Utility of a Consensus Definition 30076697 2018 11 14 1476-1645 99 2 2018 Aug The American journal of tropical medicine and hygiene Am. J. Trop. Med. Hyg. Clinical Forms of Chikungunya Virus Infection: The Challenge and Utility of a Consensus Definition. 552-553 10.4269/ajtmh.18-0468a Dramé Moustapha M Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France. Kanagaratnam Lukshe L Faculty of Medicine, University

2018 The American journal of tropical medicine and hygiene

103. Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika Full Text available with Trip Pro

Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika Once Aedes aegypti and Aedes albopictus mosquitoes that spread Chikungunya virus, dengue virus, and Zika virus are infected with Wolbachia, they have reduced egg laying rates, reduced transmission abilities, and shorter lifespans. Since most infected mosquitoes are only infectious in the last few days of their lives, shortening a mosquito's lifespan by a day or two can greatly (...) reduce their abilities to spread mosquito-borne viral diseases, such as Chikungunya, dengue fever, and Zika. We developed a mathematical model to compare the effectiveness of the wMel and wAlbB strains of Wolbachia for controlling the spread of these viruses. The differences among the diseases, mosquitoes, and Wolbachia strains are captured by the model parameters for the mosquito-human transmission cycle. Moreover, the model accounts for the behavior changes of infectious population created

2018 PLoS neglected tropical diseases

104. Lessons learned of emerging Chikungunya virus in two populations of social vulnerability of the Colombian tropics: epidemiological analysis Full Text available with Trip Pro

Lessons learned of emerging Chikungunya virus in two populations of social vulnerability of the Colombian tropics: epidemiological analysis Notwithstanding the strong epidemiological impact of the Chikungunya in the Colombian Caribbean, in 2014, not the entire population were affected in the same way. This study describe the demographic, socio-economic, clinical and epidemiological aspects of the de Chikungunya in Ovejas and Corozal, two neighboring municipalities with high vulnerability (...) in health in the Colombian Caribbean.A cross-sectional study was performed in February 2015. A convenience sampling was carried out in 971 families affected with chikungunya. Also, a socio-demographics, clinical and epidemiological questionnaire was carried out for people who met the definition of suspected Chikungunya clinical case. For the statistical analysis, data and variables, frequencies, proportions and means were compared in the two municipalities studied. A logistic regression model

2018 Archives of Public Health

105. Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic Full Text available with Trip Pro

Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic Chikungunya virus (CHIKV) has been detected sporadically since the 1950s and includes three distinct co-circulating genotypes. In late 2013, the Asian genotype of CHIKV was responsible for the Caribbean outbreak (CO) that rapidly became an epidemic throughout the Americas. There is a limited understanding of the molecular evolution of CHIKV in the Americas during this epidemic. We sequenced 185

2018 PLoS neglected tropical diseases

106. An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope Full Text available with Trip Pro

An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope Chikungunya virus (CHIKV) is the most common alphavirus infecting humans worldwide, causing acute and chronically debilitating arthralgia at a great economic expense.To facilitate our study of CHIKV, we generated a mCherry tagged replication-competent chimeric virus, CHIKV 37997-mCherry. Single particle cryoEM demonstrated icosahedral organization of the chimeric virus and the display of mCherry proteins

2018 PLoS neglected tropical diseases

107. Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus Full Text available with Trip Pro

Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus Chikungunya virus has emerged as one of the most important global arboviral threats over the last decade. Inspite of large scale morbidity, with long lasting polyarthralgia, so far no licensed vaccine or antiviral is available. CHIKV nsP2 protease is crucial for processing of viral nonstructural polypeptide precursor to release enzymes required for viral

2018 Scientific reports

108. Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 Full Text available with Trip Pro

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 Chikungunya virus (CHIKV), a mosquito-borne human pathogen, causes a disabling disease characterized by severe joint pain that can persist for weeks, months, or even years in patients. The nonstructural protein 3 (nsP3) plays essential roles during acute infection, but little is known about the function of nsP3 during chronic disease (...) and cellular protein complexes has implications for the study of the pathogenic consequences of lingering CHIKV infection and the development of strategies to mitigate the burden of chronic musculoskeletal disease brought about by a medically important arthropod-borne virus (arbovirus).IMPORTANCE Chikungunya virus (CHIKV) is a reemerging alphavirus transmitted by mosquitos and causes transient sickness but also chronic disease affecting muscles and joints. No approved vaccines or antivirals are available

2018 Journal of virology

109. Recurrent chikungunya retinitis Full Text available with Trip Pro

Recurrent chikungunya retinitis Chikungunya is a systemic viral disease transmitted to humans by infected mosquitoes in endemic areas of Africa, Asia and more recently in the Americas. Chikungunya infection produces a sudden onset of fever, joint pains and erythematous skin eruption. A plethora of ocular manifestations have been described ranging from a non-specific conjunctivitis to exudative retinal detachment. Ocular chikungunya seems to respond well to corticosteroid therapy, and outcomes

2018 BMJ case reports

110. Differential Transmission of Antiviral Drug-Resistant Chikungunya Viruses by Aedes Mosquitoes Full Text available with Trip Pro

Differential Transmission of Antiviral Drug-Resistant Chikungunya Viruses by Aedes Mosquitoes The chikungunya virus (CHIKV) is transmitted by female Aedes aegypti and Aedes albopictus mosquitoes, mostly present in (sub)tropical regions. No antivirals are available to treat CHIKV infections. If antiviral drugs are proven efficient to treat CHIKV-infected patients, it will be pivotal to determine whether drug-resistant viruses can be transmitted from one human to another by their mosquito vectors (...) phenotype and genotype were retained. Also in the saliva, the resistant genotype of MADTPres CHIKV was maintained. Our results illustrate that the fitness of drug-resistant variants should be evaluated in both hosts to be able to select antiviral drugs with a limited risk for the spread of drug resistance by mosquitoes.IMPORTANCE Because of its global reemergence and unusual morbidities associated with infection, the chikungunya virus (CHIKV) has become a substantial public health problem. However

2018 mSphere

111. Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases Full Text available with Trip Pro

Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes global epidemics of debilitating disease worldwide. To gain functional insight into the host cellular genes required for virus infection, we performed whole-blood RNA-seq, 37-plex mass cytometry of peripheral blood mononuclear cells (PBMCs), and serum cytokine measurements of acute- and convalescent-phase samples obtained from 42 children

2018 Molecular systems biology

112. Differences in genome characters and cell tropisms between two chikungunya isolates of Asian lineage and Indian Ocean lineage Full Text available with Trip Pro

Differences in genome characters and cell tropisms between two chikungunya isolates of Asian lineage and Indian Ocean lineage Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus within the family Togaviridae, which has attracted global attention due to its recent re-emergence. In one of our previous studies, we successfully isolated two CHIKV virus strains, SZ1050 and SZ1239, from the serum samples of two imported patients in 2010 and 2012, respectively. However, the differences

2018 Virology journal

113. The Challenges Imposed by Dengue, Zika, and Chikungunya to Brazil Full Text available with Trip Pro

The Challenges Imposed by Dengue, Zika, and Chikungunya to Brazil Brazil has a well-established immunization program in which vaccines are provided through the Public Health System free of charge to the whole population, obtaining high coverage and reducing the incidence of important infectious diseases in children and adults. However, the environmental changes and high mobility rates of the population occurring in the last decades have triggered the sequential introduction of a series (...) of vector-borne emerging infectious diseases, such as Dengue, Zika, and Chikungunya, that have imposed a considerable burden on the population, with yet unmet solutions. The first to be introduced in Brazil was the Dengue virus, reaching epidemic levels in 2010, with over 1 million cases annually, maintaining high infection rates until 2016. Brazil has invested in vaccine development. The Zika virus infection, initially assumed to have appeared during the World Cup in 2014, was later shown to have

2018 Frontiers in immunology

114. Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses Full Text available with Trip Pro

Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses Chikungunya virus (CHIKV) is a mosquito-transmitted RNA alphavirus causing major outbreaks of infectious chronic inflammatory rheumatisms (CIR). Recently, methotrexate (MTX), a disease modifying anti-rheumatic drug has been used successfully to treat patients suffering from rheumatoid-like arthritis post-CHIK but its

2018 PLoS neglected tropical diseases

115. Knowledge of Chikungunya Fever Among Medical Students of Jinnah Sindh Medical University, Karachi, Pakistan Full Text available with Trip Pro

Knowledge of Chikungunya Fever Among Medical Students of Jinnah Sindh Medical University, Karachi, Pakistan Objective Chikungunya is a viral disease characterized by severe arthralgia, fever, rash, muscle pain, and neurological symptoms. Warm and humid weather, poor sanitary conditions, and improper water storage and disposal can lead to an uncontrolled outbreak of the Chikungunya virus in South Asia. Because a vaccine against the Chikungunya virus has not yet been developed, we must rely (...) on appropriate awareness and suitable preventive measures to prevent its spread. A review of the literature shows that knowledge of the Chikungunya virus among medical students in Karachi is scarce. Because medical students are future medical practitioners, they should be adequately aware of this growing issue. Materials and methods We performed a single-center, cross-sectional study at the Jinnah Sindh Medical University in Karachi, Pakistan, in which 200 students were assessed on their knowledge

2018 Cureus

116. Vector competence of Aedes bromeliae and Aedes vitattus mosquito populations from Kenya for chikungunya virus Full Text available with Trip Pro

Vector competence of Aedes bromeliae and Aedes vitattus mosquito populations from Kenya for chikungunya virus Kenya has experienced outbreaks of chikungunya in the past years with the most recent outbreak occurring in Mandera in the northern region in May 2016 and in Mombasa in the coastal region from November 2017 to February 2018. Despite the outbreaks in Kenya, studies on vector competence have only been conducted on Aedes aegypti. However, the role played by other mosquito species (...) in transmission and maintenance of the virus in endemic areas remains unclear. This study sought to determine the possible role of rural Aedes bromeliae and Aedes vittatus in the transmission of chikungunya virus, focusing on Kilifi and West Pokot regions of Kenya.Four day old female mosquitoes were orally fed on chikungunya virus-infected blood at a dilution of 1:1 of the viral isolate and blood (10(6.4) plaque-forming units [PFU]/ml) using artificial membrane feeder (Hemotek system) for 45 minutes

2018 PLoS neglected tropical diseases

117. Ultrastructural Analysis of Chikungunya Virus Dissemination from the Midgut of the Yellow Fever Mosquito, Aedes aegypti Full Text available with Trip Pro

Ultrastructural Analysis of Chikungunya Virus Dissemination from the Midgut of the Yellow Fever Mosquito, Aedes aegypti The transmission cycle of chikungunya virus (CHIKV) requires that mosquito vectors get persistently infected with the virus, following its oral acqsuisition from a vertebrate host. The mosquito midgut is the initial organ that gets infected with orally acquired CHIKV. Following its replication in the midgut epithelium, the virus exits the midgut and infects secondary tissues (...) midgut preparations, mature chikungunya (CHIK) virions were found accumulating at the BL and within strands of the BL at 24⁻32 h post-infectious bloodmeal (pibm). From 48 h pibm onwards, virions no longer congregated at the BL and became dispersed throughout the basal labyrinth of the epithelial cells. Ingestion of a subsequent, non-infectious bloodmeal caused mature virions to congregate again at the midgut BL. Our study suggests that CHIKV needs a single replication cycle in the midgut epithelium

2018 Viruses

118. Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil Full Text available with Trip Pro

Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil Dengue fever, chikungunya fever, and zika virus infections are increasing public health problems in the world, the last two diseases having recently emerged in Brazil. This ecological study employed spatial analysis of probable cases of dengue fever, chikungunya fever, and zika virus infections reported to the National Mandatory Reporting System (SINAN) in Maranhao State (...) from 2015 to 2016. The software GeoDa version 1.10 was used for calculating global and local Moran indices. The global Moran index identified a significant autocorrelation of incidence rates of dengue (I=0.10; p=0.009) and zika (I=0.07; p=0.03). The study found a positive spatial correlation between dengue and the population density (I=0.31; p<0.001) and a negative correlation with the Performance Index of Unified Health System (PIUHS) by basic care coverage (I=-0.08; p=0.01). Regarding chikungunya

2018 Revista do Instituto de Medicina Tropical de São Paulo

119. The effectiveness of antiviral agents with broad-spectrum activity against chikungunya virus varies between host cell lines Full Text available with Trip Pro

The effectiveness of antiviral agents with broad-spectrum activity against chikungunya virus varies between host cell lines Chikungunya virus (CHIKV) is a mosquito-borne virus that has recently emerged in the Western Hemisphere. Approved antiviral therapies or vaccines for the treatment or prevention of CHIKV infections are not available. This study aims to evaluate the antiviral activity of commercially available broad-spectrum antivirals against CHIKV. Due to host cell-specific variability

2018 Antiviral chemistry & chemotherapy

120. Cellular and Molecular Immune Response to Chikungunya Virus Infection Full Text available with Trip Pro

Cellular and Molecular Immune Response to Chikungunya Virus Infection Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the fact that CHIKV has been around since 1952, our knowledge about immunopathology, innate and adaptive immune response involved

2018 Frontiers in cellular and infection microbiology

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